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Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19 Warman, Fadil Ahmadhia; Yulia, Dwi; Kadri, Husnil; Mulyana, Roza; Yusri, Elfira; Putra, Syandrez Prima
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p125-137.2025

The neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268).Â This study concludes a significant correlation between NLR and PLR with the severity of COVID-19.

Hubungan Indeks Massa Tubuh dengan Tekanan Darah pada Lansia di Nagari Sumaniak Arief, Muhammad; Pertiwi, Dian; Mulyana, Roza
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1085

Latar Belakang: Salah satu jenis penyakit tidak menular yang risikonya meningkat seiring pertambahan usia, yaitu hipertensi. Hipertensi dapat terjadi akibat proses yang dipengaruhi oleh banyak faktor yang salah satunya adalah indeks massa tubuh.Objektif: Penelitian ini bertujuan untuk mengetahui hubungan antara indeks massa tubuh dengan tekanan darah pada lansia di Nagari Sumaniak, Kabupaten Tanah Datar.Metode: Penelitian ini adalah penelitian cross sectional menggunakan data sekunder lansia di Nagari Sumaniak, Kabupaten Tanah Datar pada bulan Oktober 2021 dengan jumlah responden sebanyak 41 responden. Uji analisis yang digunakan adalah Spearman Rank Correlation.Hasil: Hasil penelitian menunjukkan hubungan indeks massa tubuh dan tekanan darah (p = 0,708) dengan rerata indeks massa tubuh 24,4426±4,362 kg/m2, tekanan darah sistolik 146,83±23,406 mmHg, dan tekanan darah diastolik 90,32±12,168 mmHg.Kesimpulan: Tidak terdapat hubungan yang bermakna antara indeks massa tubuh dengan tekanan darah pada lansia di Nagari Sumaniak, Kabupaten Tanah Datar. Kata Kunci: indeks massa tubuh, tekanan darah, lansia

Gambaran Fungsi Kognitif pada Pasien Pasca Stroke di Poliklinik RS Otak Dr. Drs. M. Hatta Bukittinggi Tahun 2022 Zaffarsyah, Muhammad Irsyad; Permana, Hendra; Yanis, Amel; Nurhayati, Nurhayati; Mulyana, Roza
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1154

Latar belakang: troke merupakan penyakit neurologis yang menyerang otak secara langsung. Stroke menjadi penyebab kematian dan kecacatan nomor dua di dunia. Kecacatan dapat terjadi tidak hanya pada fungsi motorik dan sensorik, tetapi juga dapat terjadi gangguan pada fungsi kognitif yang terjadi akibat adanya perkembangan Cerebral Small Vessel Disease. Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien pasca stroke di poliklinik neurologi RS Otak Dr. Drs. M. Hatta Bukittinggi berdasarkan karakteristik, fungsi kognitif, dan distribusi frekuensi gangguan fungsi kognitif pada pasien pasca stroke iskemik dan stroke hemoragik. Objektif: Penelitian ini merupakan penelitian deskriptif yang dilakukan di RS Otak Dr. Drs. M. Hatta Bukittinggi pada tahun 2022. Sampel diambil dengan menggunakan teknik consecutive sampling dengan total berjumlah 65 subjek. Sampel penelitian ini adalah pasien pasca stroke di Poliklinik Neurologi RS Otak Dr. Drs. M. Hatta, Bukittinggi. Sampel diambil dengan data primer menggunakan MMSE dan data sekunder dari rekam medis pasien. Hasil: Penelitian ini menunjukan dari 65 sampel didapatkan 53 pasien iskemik dan 12 pasien hemoragik dengan fungsi kognitif normal pasien iskemik 37,7% dan iskemik 33,3%, gangguan kognitif ringan pasien iskemik 37,7% dan pasien hemoragik 33,3%, dan gangguan kognitif berat pasien iskemik 24,5% dan hemoragik 33,3%. Kesimpulan: Penelitian ini mendapati hasil kejadian stroke iskemik lebih banyak daripada stroke hemoragik. Hasil karakteristik pasien pasca stroke ditemukan variatif karena perbedaan tingkat keparahan dan faktor risiko. Ditemukan frekuensi tingkat gangguan fungsi kognitif terbanyak pada pasien tanpa gangguan kognitif dan ringan. Kata kunci: fungsi kognitif, stroke, iskemik, hemoragik, MMSE

The Correlation Between Sarcopenia And Transthyretin Levels Among Community-Dwelling Older Adults In Padang, West Sumatra Arief Fahrurozi, R. Ifan; Martini, Rose Dinda; Mulyana, Roza; Triansyah, Fandi
Eduvest - Journal of Universal Studies Vol. 4 No. 11 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i11.49959

The objective of this study was to evaluate the correlation between sarcopenia and transthyretin levels among community-dwelling older adults in Padang. This study employed a cross-sectional design and included 45 community-dwelling individuals aged 60 years and above who visited Andalas Primary Health Care in Padang, West Sumatra, Indonesia. Characteristics of sociodemographic and lifestyle habits were collected using a general questionnaire. Sarcopenia was defined in accordance with the criteria set forth by the Asian Working Group for Sarcopenia (AWGS) criteria encompass three components: low muscle mass, as determined by an index of appendicular skeletal mass/height2 less than 7,0 kg/m2 for males and less than 5,7 kg/m2 for females; low physical performance, as indicated by a gait speed less than 1,0 m/s; low muscle strength, defined as handgrip strength less than 26 kg for males and less than 18 kg for females. Accordingly, sarcopenia was defined as the presence of low muscle mass in conjunction with low physical performance and/or low muscle strength. Transthyretin levels were considered as independent variables in order to evaluate the potential correlation between transthyretin and sarcopenia status using bivariate analysis. The overall prevalence of sarcopenia was 51.1%, with four cases (40%) observed in males and 19 cases (54.3%) in females classified as having sarcopenia. The prevalence of sarcopenia was significantly lower among participants with normal nutritional status. A comparison of the participants with and without sarcopenia revealed that the former exhibited higher levels of transthyretin (p = 0,000).

Diagnosis and Management of Osteosarcopenia Jersivindo Ranazeri; Rose Dinda Martini; Mulyana, Roza; Fandi Triansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.904

Osteosarcopenia is a syndrome defined as a combination of low bone density and muscle mass as well as decreased strength and/or functional capacity. Osteoporosis and sarcopenia often coexist in the elderly, leading to a significantly worse prognosis. The epidemiology of osteosarcopenia is quite limited because the term is still new. Osteosarcopenia is more common in women than men and in malnutrition. Age-related immunological changes such as hormonal imbalance, chronic inflammation, increased oxidative stress, imbalance in protein metabolism, increased fat deposition, decreased physical activity, and poor nutritional status contribute to sarcopenia. Decreased bone density in osteoporosis can occur due to an imbalance between osteoblasts and osteoclasts. The diagnosis of osteosarcopenia is made based on the presence of osteoporosis and sarcopenia. Instrument strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC–F) are recommended for assessing sarcopenia and the fracture risk assessment tool (FRAX) for the risk of osteoporotic fracture. Management of osteosarcopenia is carried out holistically, including management of osteoporosis and sarcopenia both non-pharmacologically and pharmacologically.

Analysis of Risk Factors for Cognitive Frailty: A Meta-Analysis Hendriani, Nani; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1086

Background: Cognitive frailty (CF) is a syndrome characterized by cognitive and physical decline in older adults, which increases the risk of disability, dependency, and mortality. This study aims to identify and analyze risk factors for CF incidence through a systematic review and meta-analysis. Methods: A literature search was conducted on PubMed, Scopus, and Web of Science databases until June 2024. Observational studies reporting associations between potential risk factors and CF incidence in the elderly population were included. Two independent researchers performed study selection, data extraction, and risk of bias assessment. Meta-analysis was performed using a random effects model, and heterogeneity between studies was evaluated. Results: A total of 25 studies (n=45,678 participants) met inclusion criteria. Meta-analysis showed that advanced age (OR=1.89; 95% CI 1.65-2.16), female gender (OR=1.38; 95% CI 1.19-1.60), history of cardiovascular disease (OR=1.52; 95% CI 1.23-1.87), diabetes mellitus (OR=1.45; 95% CI 1.18-1.78), depression (OR=2.08; 95% CI 1.72-2.51), and low physical activity (OR=1.63; 95% CI 1.35-1.97) are risk factors significant for the incidence of CF. Low educational level (OR=1.71; 95% CI 1.43-2.04), low socioeconomic status (OR=1.58; 95% CI 1.29-1.93), and smoking history (OR=1.31; 95% CI 1.05-1.64) were also associated. with an increased risk of CF. Conclusion: This study identified several modifiable and nonmodifiable risk factors for CF occurrence. Interventions targeting these risk factors may help prevent or delay the development of CF in older adults.

Diagnosis and Management of Osteosarcopenia Jersivindo Ranazeri; Rose Dinda Martini; Mulyana, Roza; Fandi Triansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.904

Osteosarcopenia is a syndrome defined as a combination of low bone density and muscle mass as well as decreased strength and/or functional capacity. Osteoporosis and sarcopenia often coexist in the elderly, leading to a significantly worse prognosis. The epidemiology of osteosarcopenia is quite limited because the term is still new. Osteosarcopenia is more common in women than men and in malnutrition. Age-related immunological changes such as hormonal imbalance, chronic inflammation, increased oxidative stress, imbalance in protein metabolism, increased fat deposition, decreased physical activity, and poor nutritional status contribute to sarcopenia. Decreased bone density in osteoporosis can occur due to an imbalance between osteoblasts and osteoclasts. The diagnosis of osteosarcopenia is made based on the presence of osteoporosis and sarcopenia. Instrument strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC–F) are recommended for assessing sarcopenia and the fracture risk assessment tool (FRAX) for the risk of osteoporotic fracture. Management of osteosarcopenia is carried out holistically, including management of osteoporosis and sarcopenia both non-pharmacologically and pharmacologically.

Analysis of Risk Factors for Cognitive Frailty: A Meta-Analysis Hendriani, Nani; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1086

Background: Cognitive frailty (CF) is a syndrome characterized by cognitive and physical decline in older adults, which increases the risk of disability, dependency, and mortality. This study aims to identify and analyze risk factors for CF incidence through a systematic review and meta-analysis. Methods: A literature search was conducted on PubMed, Scopus, and Web of Science databases until June 2024. Observational studies reporting associations between potential risk factors and CF incidence in the elderly population were included. Two independent researchers performed study selection, data extraction, and risk of bias assessment. Meta-analysis was performed using a random effects model, and heterogeneity between studies was evaluated. Results: A total of 25 studies (n=45,678 participants) met inclusion criteria. Meta-analysis showed that advanced age (OR=1.89; 95% CI 1.65-2.16), female gender (OR=1.38; 95% CI 1.19-1.60), history of cardiovascular disease (OR=1.52; 95% CI 1.23-1.87), diabetes mellitus (OR=1.45; 95% CI 1.18-1.78), depression (OR=2.08; 95% CI 1.72-2.51), and low physical activity (OR=1.63; 95% CI 1.35-1.97) are risk factors significant for the incidence of CF. Low educational level (OR=1.71; 95% CI 1.43-2.04), low socioeconomic status (OR=1.58; 95% CI 1.29-1.93), and smoking history (OR=1.31; 95% CI 1.05-1.64) were also associated. with an increased risk of CF. Conclusion: This study identified several modifiable and nonmodifiable risk factors for CF occurrence. Interventions targeting these risk factors may help prevent or delay the development of CF in older adults.

Handgrip Strength: An Early Warning Sign for Mobility Decline? A Meta-Analysis of Diagnostic Accuracy Studies R. Ifan Arief Fahrurozi; Rose Dinda Martini; Roza Mulyana; Fandi Triansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1160

Background: Mobility limitations significantly impact the quality of life of older adults. Early identification of individuals at risk is crucial for timely intervention. This meta-analysis investigates the diagnostic accuracy of handgrip strength (HGS) in predicting future mobility decline in older adults. Methods: A systematic search of PubMed, Scopus, and Web of Science was conducted for diagnostic accuracy studies published between 2018 and 2024, evaluating the ability of baseline HGS to predict incident mobility limitations in older adults (≥60 years). Mobility limitations were defined as difficulties in performing activities of daily living (ADLs) or instrumental activities of daily living (IADLs). The primary outcomes were sensitivity, specificity, and diagnostic odds ratio (DOR) of HGS for predicting mobility decline. A bivariate random-effects model was used to pool data. Results: Seven diagnostic studies with a total of 3,870 participants were included. The pooled sensitivity of HGS for predicting mobility decline was 0.72 (95% CI: 0.65-0.78), and the pooled specificity was 0.70 (95% CI: 0.66-0.74). The pooled DOR was 4.85 (95% CI: 3.21-7.32), indicating good discriminatory ability. Conclusion: This meta-analysis demonstrates that HGS has moderate sensitivity and specificity for predicting future mobility decline in older adults. HGS assessment can be a valuable tool for identifying individuals at risk, although further research is needed to determine optimal cut-off points and combine HGS with other risk factors for improved prediction.

THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi). Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak alergi.

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