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All Journal Jurnal Kedokteran Diponegoro Jurnal Kesehatan Andalas Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Majalah Kedokteran Andalas Human Care Journal Jurnal Ners Indonesian Journal of Health Sciences Research and Development (IJHSRD) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Eduvest - Journal of Universal Studies Jurnal Penyakit Dalam Indonesia Jurnal Mahasiswa Ilmu Kesehatan Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan
Roza Mulyana
Division Of Geriatric, Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Kadar Transthyretin Plasma pada Lanjut Usia Sarkopenia dan Non-Sarkopenia Fahrurozi, R. Ifan A.; Martini, Rose D; Mulyana, Roza; Murni, Arina W; Decroli, Eva; Miro, Saptino; Viotra, Deka; Yoga, Vesri
Jurnal Penyakit Dalam Indonesia Vol. 12, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Sarcopenia is a geriatric syndrome marked by an age-related decline in muscle mass, which is affected by protein intake. Transthyretin is a visceral protein used to evaluate nutritional status and acts as a positive regulator of muscle mass. This study aimed to assess the difference in plasma transthyretin levels between elderly groups with and without sarcopenia. Methods. This was an analytical observational study with a cross-sectional approach. Subjects were elderly patients who visited the Internal Medicine Polyclinic of Dr. M. Djamil Hospital Padang and met the inclusion and exclusion criteria from August to September 2024. Subjects were classified into sarcopenic and non-sarcopenic groups, followed by an examination of plasma transthyretin levels. Sarcopenia was diagnosed using bio-impedance analysis (BIA) measurement, handgrip strength with a Jamar hydraulic hand dynamometer, and physical performance with a walking speed test. Plasma transthyretin levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Comparative analysis was performed using the unpaired T-test using SPSS 29.0. Results. Among total of 46 subjects who participated in this study, the majority of elderly individuals with sarcopenia were predominantly female. The mean plasma transthyretin level in the sarcopenic elderly group was 10.9 (3.3) mg/dL, while in the non-sarcopenic elderly group was 20.3 (2.5) mg/dL. Comparative analysis demonstrated a significant difference in plasma transthyretin levels between sarcopenic and non-sarcopenic elderly individuals (p < 0.001). Plasma transthyretin levels in the sarcopenic elderly group were lower compared to the non-sarcopenic elderly group. Conclusion. There is a significant difference in plasma transthyretin levels between sarcopenic and non-sarcopenic elderly individuals.
FACTORS ASSOCIATED WITH MORTALITY OF ELDERLY PATIENTS WITH COVID-19 INFECTION AT M. DJAMIL HOSPITAL, PADANG, WEST SUMATRA, INDONESIA : COVID-19 INFECTION Mulyana, Roza; Elvira, Dwitya; Martini, Rose Dinda
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 7 No. 2 (2025): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol7.Iss2/329

Abstract

Background: To analyze the factors influencing the mortality incidence of elderly patients with COVID-19 infection in Padang, West Sumatra, Indonesia. Methods: This is a retrospective study at M. Djamil Hospital, Padang. Data was collected from the medical records of COVID-19 patients treated during July-September 2021. Results: Of the 243 elderly patients who experienced COVID-19, the most deaths were male (58.6%) with an average age of 69.64 ± 7.74 years. Multivariate analysis showed that patients with critical-severe clinical symptoms (odds ratio (OR) 12.95; 95% confidence interval (CI) 6.66–25.19), heart disease (OR 6.94; 95% CI 1.63–29.60), respiratory rate ≥30 breaths per minute (OR 3.48; 95% CI 1.04–11.60), pulse ≥100 beats per minute (OR 2.88; 95% CI 1.03–8.04), using a ventilator or high-flow nasal cannula (OR 19.78; 95% CI 5.92–66.10), prothrombin time >13.16 second (OR 12.35; 95% CI 2.43–62.77), interleukin-6 >6 pg/mL (OR 15.19; 95%CI 2.53–91.26), and random blood glucose >199 mg/dL (OR 3.45; 95% CI 1.02–11.68) have a high risk of death. Conclusion: Elderly patients with COVID-19 infection with critical-severe clinical symptoms accompanied by heart disease, using ventilator or high-flow nasal cannula, longer prothrombin time, high level of interleukin-6, and random blood glucose have higher risk of mortality.
CHEMOTHERAPY-INDUCED THROMBOCYTOPENIA LEADING TO LIFE-THREATENING HYPOVOLEMIC SHOCK IN CERVICAL CANCER: A CASE REPORT Nurul Fadila; Raveinal Raveinal; Fadrian Fadrian; Roza Mulyana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 5 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i5.47148

Abstract

Hypovolemic shock due to acute hemorrhage is a life-threatening condition, particularly in cancer patients undergoing chemotherapy. Although recent studies have established protocols for managing hypovolemic shock in trauma and sepsis, the role of chemotherapy-induced thrombocytopenia in exacerbating post-procedural bleeding risks remains underexplored. This case emphasizes the clinical complexity of managing hemorrhagic shock in advanced-stage cervical cancer patients following percutaneous nephrostomy (PCN). Case Presentation: A 52-year-old female with stage IVB cervical cancer and liver metastasis presented with hypovolemic shock following PCN. She exhibited severe hematuria and chemotherapy-induced thrombocytopenia, leading to prolonged bleeding and subsequent shock. Initial management involved aggressive fluid resuscitation, blood transfusions, and correction of thrombocytopenia. Despite the challenges of managing shock in a patient with concurrent chronic kidney disease (CKD) stage IV, prompt intervention led to significant clinical improvement, stabilization of vital signs, and eventual discharge. Conclusion: This case highlights the importance of early intervention in managing hypovolemic shock in oncology patients with multiple comorbidities, including chemotherapy-induced thrombocytopenia and CKD. A multidisciplinary approach and close monitoring are crucial for improving outcomes in such high-risk patients. Further research is needed to establish tailored management protocols for this patient population.
HUBUNGAN DERAJAT NYERI LOW BACK PAIN DENGAN TINGKAT KEBUGARAN JASMANI PADA LANJUT USIA DI WILAYAH KERJA PUSKESMAS PADANG KANDIS KECAMATAN GUGUAK KABUPATEN LIMAPULUH KOTA Muhammad Bintang Alvinanda; Roza Mulyana; Afriwardi Afriwardi; Fika Tri Anggraini; Rose Dinda Martini; Malinda Meinapuri
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 2 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i2.2619

Abstract

Low back pain (LBP) is pain felt in the lower back. Many factors can cause a decrease in physical fitness, one of which is LBP. This study aims to determine the relationship between the degree of LBP pain and the level of physical fitness in elderly people in the Padang Kandis Community Health Center, West Sumatra Province. This study is an observational analytical study with a cross-sectional design. The subjects of this study were 47 elderly people who met the inclusion and exclusion criteria and were selected using the consecutive sampling method. Data collection was carried out through a survey including a VAS (Visual Analog Scale) questionnaire, LBP (Low Back Pain), PAR-Q (Physical Activity Readiness Questionnaire), and a Six Minute Walking test. Data analysis was carried out using the Chi-Square test. The results of the data analysis obtained a p value = 0.457 (p > 0.05) for the relationship between the degree of LBP pain and the level of physical fitness. The conclusion of this study is that there is no relationship between the level of LBP and the level of physical fitness in elderly people in the Padang Kandis Community Health Center, Guguak District, Lima Puluh Kota Regency, West Sumatra Province.   Low back pain (LBP) adalah rasa sakit yang dirasakan di punggung bagian bawah. Banyak faktor yang dapat menyebabkan penurunan kebugaran jasmani salah satunya adalah LBP. Penelitian ini bertujuan untuk mengetahui hubungan derajat nyeri LBP dengan tingkat kebugaran jasmani pada lansia yang berada di wilayah kerja Puskesmas Padang Kandis Provinsi Sumatera Barat.  Penelitian ini merupakan penelitian analitik observasional dengan desain cross-sectional. Subjek penelitian ini didapatkan sebanyak 47 lansia yang memenuhi kriteria inklusi dan eksklusi yang telah dipilih dengan metode consecutive sampling. Pengumpulan data dilakukan melalui survei yang meliputi kuesioner VAS (Visual Analog Scale), LBP (Low Back Pain), PAR-Q (Physical Activity Readiness Questionnaire) dan tes Six Minute Walking. Analisis data dilakukan dengan uji Chi-Square. Hasil analisis data didapatkan nilai p = 0,457 (p > 0,05) untuk hubungan antara derajat nyeri LBP dengan tingkat kebugaran jasmani.  Kesimpulan penelitian ini tidak terdapat hubungan antara tingkat LBP dengan tingkat kebugaran jasmani pada lansia di wilayah kerja kerja Puskesmas Padang Kandis Kecamatan Guguak Kabupaten Lima Puluh Kota Provinsi Sumatera Barat.   
Hubungan Mindfulness Attention Awareness dan Dukungan Sosial Keluarga dengan Kesejahteraan Psikologis serta Kualitas Hidup Wanita Menopause Sisi Ermoniza; Bobby Indra Utama; Roza Mulyana
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.58859

Abstract

Abstrak Periode menopause menjadi tantangan kesehatan global yang semakin krusial. Wanita menopause mengalami perubahan fisik dan psikologis akibat penurunan hormon estrogen yang dapat memengaruhi kesejahteraan psikologis dan kualitas hidup. Penelitian ini bertujuan menganalisis hubungan Mindfulness Attention Awareness (MAAS) dan dukungan sosial keluarga dengan kesejahteraan psikologis serta kualitas hidup wanita menopause. Desain penelitian menggunakan cross-sectional dengan pendekatan kuantitatif analitik. Sampel berjumlah 98 wanita menopause di wilayah kerja Puskesmas Dadok Tunggul Hitam, Kota Padang, yang dipilih secara purposive sampling. Instrumen yang digunakan meliputi kuesioner MAAS (Mindfulness), MSPSS (dukungan sosial keluarga), MRS (kesejahteraan psikologis), dan MENQOL modifikasi (kualitas hidup). Analisis data menggunakan uji Chi-Square. Hasil penelitian menunjukkan sebanyak 55,1% wanita menopause memiliki Mindfulness rendah, 61,2% memiliki dukungan sosial baik, 58,2% memiliki kesejahteraan psikologis baik, dan 53,1% memiliki kualitas hidup tinggi. Terdapat hubungan signifikan antara Mindfulness dengan kesejahteraan psikologis (p=0,000; OR=8,986), Mindfulness dengan kualitas hidup (p=0,002; OR=3,747), serta dukungan sosial keluarga dengan kualitas hidup (p=0,001; OR=4,333). Namun, tidak terdapat hubungan signifikan antara dukungan sosial keluarga dengan kesejahteraan psikologis (p=0,192). Mindfulness berhubungan dengan kesejahteraan psikologis dan kualitas hidup, sedangkan dukungan sosial keluarga hanya berhubungan dengan kualitas hidup. Hasil penelitian ini dapat menjadi dasar pengembangan program intervensi berbasis Mindfulness serta penguatan dukungan keluarga bagi wanita menopause. Kata Kunci: Mindfulness, dukungan sosial keluarga, kesejahteraan psikologis, kualitas hidup, wanita menopause Abstract The menopausal period is becoming an increasingly critical global health challenge. Menopausal women experience physical and psychological changes due to decreased estrogen hormone levels, which can affect psychological well-being and quality of life. This study aimed to analyze the relationship between Mindfulness Attention Awareness (MAAS) and family social support with psychological well-being and quality of life of menopausal women. This study used a cross-sectional design with a quantitative analytic approach. A sample of 98 menopausal women in the working area of the Dadok Tunggul Hitam Public Health Center, Padang City, was selected using purposive sampling. The instruments used included the MAAS questionnaire (Mindfulness), MSPSS (Family Social Support), MRS (Psychological Well-being), and a modified MENQOL (Quality of Life). Data analysis used the Chi-Square test. The results showed that 55.1% of menopausal women had low mindfulness, 61.2% had good family social support, 58.2% had good psychological well-being, and 53.1% had high quality of life. There were significant relationships between mindfulness and psychological well-being (p=0.000; OR=8.986), mindfulness and quality of life (p=0.002; OR=3.747), and family social support and quality of life (p=0.001; OR=4.333). However, there was no significant relationship between family social support and psychological well-being (p=0.192). Mindfulness is associated with psychological well-being and quality of life, while family social support is only associated with quality of life. These findings can serve as a basis for developing mindfulness-based intervention programs and strengthening family support for menopausal women at public health centers. Keywords: Mindfulness, family social support, psychological well-being, quality of life, menopausal women.
Profile of Hydrogen Peroxide (H2O2) Levels in Hyperglycaemic Wistar Rats (Rattus novergicus) After Olive Oil (Olea europaea) Administration Yorencia Akmal; Husnil Kadri; Almurdi Almurdi; Ety Yerizel; Roza Mulyana; Erlina Rustam
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.59195

Abstract

Objective: Objective: To examine the effect of olive oil on hydrogen peroxide ROS levels that cause diabetes mellitus/hyperglycaemia in Wistar rats after being induced with the diabetogenic substance alloxan over a period of 14 days. Hydrogen peroxide (H2O2) is one indicator of ROS (Reactive Oxygen Species) to determine the state of cell oxidative stress. The increase in ROS in the body is caused by an imbalance between ROS and anti-oxidant enzymes, so that triggers biological cell damage, including oxidation of carbohydrates, proteins, fats, DNA. Oxidation of β-pancreas cells causes a decrease in the sensitivity of cell tissue to insulin, so that blood glucose concentrations increase. Blood sugar levels ≥ 200 mg/dL indicate chronic diabetes mellitus or hyperglycaemia. Olive oil contains secondary metabolite compounds such as phenolic and can neutralise H2O2 in blood serum. Methods: This study used 24 male Wistar rats, and grouped into three groups, namely negative control (K-), positive control (K+) and treatment (P) with observation for 14 days. Results: from the results of statistical analysis based on the Mann Whitney test and Kruskal Wallis test, the average difference was obtained at p ≤ 0.05. From the data analysis showed the effect of olive oil antioxidants in reducing H2O2 levels gave significantly different effects on each group, respectively, K (-) 4.838 mmol/mL, K (+) 20.888 mmol/mL and P 18.193 mmol/mL. Conclusion: Olive oil administration has an effect on reducing hydrogen peroxide (H2O2) levels in hyperglycaemic Wistar rats.
The Correlation Between Sarcopenia And Transthyretin Levels Among Community-Dwelling Older Adults In Padang, West Sumatra R. Ifan Arief Fahrurozi; Rose Dinda Martini; Roza Mulyana; Fandi Triansyah
Eduvest - Journal of Universal Studies Vol. 4 No. 11 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i11.49959

Abstract

The objective of this study was to evaluate the correlation between sarcopenia and transthyretin levels among community-dwelling older adults in Padang. This study employed a cross-sectional design and included 45 community-dwelling individuals aged 60 years and above who visited Andalas Primary Health Care in Padang, West Sumatra, Indonesia. Characteristics of sociodemographic and lifestyle habits were collected using a general questionnaire. Sarcopenia was defined in accordance with the criteria set forth by the Asian Working Group for Sarcopenia (AWGS) criteria encompass three components: low muscle mass, as determined by an index of appendicular skeletal mass/height2 less than 7,0 kg/m2 for males and less than 5,7 kg/m2 for females; low physical performance, as indicated by a gait speed less than 1,0 m/s; low muscle strength, defined as handgrip strength less than 26 kg for males and less than 18 kg for females. Accordingly, sarcopenia was defined as the presence of low muscle mass in conjunction with low physical performance and/or low muscle strength. Transthyretin levels were considered as independent variables in order to evaluate the potential correlation between transthyretin and sarcopenia status using bivariate analysis. The overall prevalence of sarcopenia was 51.1%, with four cases (40%) observed in males and 19 cases (54.3%) in females classified as having sarcopenia. The prevalence of sarcopenia was significantly lower among participants with normal nutritional status. A comparison of the participants with and without sarcopenia revealed that the former exhibited higher levels of transthyretin (p = 0,000).
GAMBARAN POLA MAKAN DAN STATUS GIZI PADA PRA LANSIA DAN LANSIA DI NAGARI SUMANIAK KABUPATEN TANAH DATAR Haegha Satya Negara; Firdawati Firdawati; Noverika Windasari; Roza Mulyana; Rahmani Welan
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 4 (2026): SINERGI : Jurnal Riset Ilmiah, April 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i4.2482

Abstract

Background: The elderly are generally sixty years old and above, experiencing the aging process which results in a decrease in physical function and has an impact on quality of life which can be seen from diet. A healthy diet is important for the health of the elderly, which is reflected in nutritional status. This study aims to determine the description of diet and nutritional status in pre-elderly and elderly people in Nagari Sumaniak, Tanah Datar Regency. Objective: The purpose of this study was to determine the description of diet and nutritional status in pre-elderly and elderly people in Nagari Sumaniak, Tanah Datar Regency. Methods: This type of research is descriptive with a cross sectional design and total sampling technique. The research sample totalled 40 respondents obtained from secondary data from community service results in October 2021 using the Food Frequency Questionnaire and Body Mass Index values. Results: The results showed that most of the respondents were aged 60-74 years which fell into the elderly category (52.5%). Most of the respondents were female (72.5%) with the last level of education in elementary school (32.5%) and still working (87.5%). The description of diet mostly has a good diet (57.5%) and nutritional status in the obesity category (40%). Conclusion: The conclusion of this study is that most respondents have a good diet but are classified as obese. Advice to health workers to prioritise the promotion and prevention of groups at risk of obesity and poor diet.baik.
Co-Authors Afriwardi Afriwardi Ajat Sudrajat Almurdi Almurdi Amatullah, Afifah Amel Yanis Amir , Arni Arief, Muhammad Arina Widya Murni Asir, Taufik Rizkian Auliangi Tamayo Beni Indra, Beni Bobby Indra Utama Deka Viotra Delmi Sulastri Dian Pertiwi Drajad Priyono Dwitya Elvira, Dwitya Edo Yudistira Elfira Yusri Elmatris Sy Erlina Rustam Ety Yerizel Eva Decroli Fadrian, Fadrian Fahrurozi, R. Ifan A. Fahrurozi, R. Ifan Arief Fandi Triansyah Fandi Triansyah Fika Tri Anggraini Firdawati Firdawati Haegha Satya Negara Harun Harnavi Hendra Permana Husna Fauziah Husnil Kadri Iqbal Muhammad Helmi Jersivindo Ranazeri Kuntjoro Harimurti Laksono Trisnantoro Malinda Meinapuri Martini, Rose D Martini, Rose D Muhammad Bintang Alvinanda Muhammad Imam Arrasyid Muhammad Ridho Azhari Murni, Arina W Nani Hendriani, Nani Natasya Alamanda Martias Netti Suharti Nidya Angryni Noto Dwimartutie Noverika Windasari Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurhayati, Nurhayati Nurul Fadila Putri, Rauffi Hayatul R. Ifan Arief Fahrurozi R. Ifan Arief Fahrurozi Rahmani Welan Rahmatini . Raveinal Raveinal RAVEINAL RAVEINAL Rika Susanti Rivani Sintia Suratman Rose Dinda Martini Rose Dinda Martini Roza Kurniati Rudy Afriant Saptino Miro Saptino Miro, Saptino Sasqia Trizolla Sisi Ermoniza Siti Setiati Syahrul, Muhammad Zulfadli Syandrez Prima Putra Tamayo, Auliangi Triansyah, Fandi Vesri Yoga Vyora Ulvyana Warman, Fadil Ahmadhia Willya Eka Putri Yorencia Akmal yossa tamia marisa Yudistira, Edo Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yulistini Yunia Habsari Yusri, Elfira Zaffarsyah, Muhammad Irsyad Zahara Findi