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All Journal Jurnal Ilmiah Aplikasi Isotop Radiasi Medika Tadulako IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) al-Afkar, Journal For Islamic Studies Jurnal Ilmiah Kesehatan QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jurnal Ekonomi Bisnis Indonesia Jurnal Abdimas Madani dan Lestari (JAMALI) Edu Masda Journal Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Health Science Jurnal Pijar MIPA Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Inovasi Pengabdian dan Pemberdayaan Masyarakat Jurnal Adijaya Multidisiplin Jurnal Farmasi Kryonaut Therapy : Journal of Health Science ISTA Online Technologi Journal
Siva Fauziah, Siva
Institut Sains Dan Teknologi Al-Kamal
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Efektivitas ekstrak Etanol Rosemary (Rosemarinus officinalis L.) pada tikus jantan putih (Rattus Norvegicus L.) sebagai agen Hepatoprotektor Komarudin, Dede; Adriana, Yulis; Ruslihagi, Farid; Fauziah, Siva; Putri, Annisa Septyana; Aulia, Gina; Nasar, Nur Afni Syariah
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1622

Abstract

Latar Belakang: Hati adalah organ penting dalam tubuh manusia.kerusakan pada hati disebabkan oleh banyak faktor termasuk obat-obatan tertentu, paparan polutan, dan bahan kimia lingkungan seperti parasetamol, karbon tetraklorida, dan lain-lain. triklorometil membentuk radikal triklorometilperoksi Peroksidasi lipid, gangguan homeostasis Ca2, dan N-acetylcysteine Tanaman Rosmarinus officinalis L. kadang-kadang dikenal sebagai rosemary atau rosmarin, merupakan anggota famili Lamiaceae dan rosemary memiliki efek antioksidan serta hepatoprotektif. Tujuan: Studi ini untuk menguji efektivitas antioxidant ekstrak Rosemary dan sebagai agen hepatoprotektor pada tikus jantan putih. Metode: Penelitian ini dilakukakan secara eksperimental dengan melakukan  ekstraksi etanol 80% Rosemary untuk menguji efektivitas antioksidan yang diujikan kepada hewan tikus 30 ekor terbagi menjadi 6 kelompok dan terdiri dari 5 ekor tikus yang masing-masing hanya di induksi karbon tertaklorida (CCL4): induksi CCL4 & obat pembanding; induksi CCL4  dan ekstrak rosemary dosis 80%, 100% dan 120% serta tikus yang hanya di beri makan dan minum kemudian untuk mengetahui penurunan dan dosis optimalnya berdasarkan kadar AST (Aspartate Aminotransferase) dan ALT (Alanine Aminotransferase). Hasil : Pengukuran setelah diinduksi CCL4 didapatkan kadar rata-rata AST & ALT masing-masing kelompok 1-6 yaitu 60 & 25,6; 155,8 & 154,6; 165 & 153,2; 149,8 & 139,4; 150,6  &147,2; 168,8 & 151 U/L. Pengukuran kadar AST dan ALT setelah dilakukan pemantauan dan perlakuan pada hari ke 1 berturut-turut yaitu 60 & 25,6; 155,8 & 154,6; 165 & 153,2; 149,8 & 139,4; 150,6 & 147,2; 168,8 & 151 U/L. Pada hari ke 7 yaitu 57,6 & 23; 113,4 & 92,4; 160,2 & 149; 114,4 & 102,8; 118.6 & 88,4; 96 & 84,6 U/L.  Pada hari ke 14 yaitu 57 & 22,4; 60 & 27; 128,2 & 123,4; 103,2 & 56,6; 70 & 38,8; 58,2 23,4 U/L. Kesimpulan: Ekstrak Rosemary berpotensi sebagai Hepatoprotektor karena dapat menurunkan aktivitas kadar ALT dan AST pada tikus putih jantan yang telah diinduksikan CCl4 dengan dosis optimum yang dapat digunakan sebagai hepatoprotektor pada dosis 100-120%.
THE INFLUENCE OF DIFFERENCES IN THE CONCENTRATION OF 70% ETHANOL EXTRACT OF YARROW LEAVES (Achillea millefolium L) IN GEL FORMULATION ON PHYSICAL PROPERTIES, PHYSICAL STABILITY, AND ANTIBACTERIAL ACTIVITY AGAINST Pseudomonas aeruginosa IN VITRO Nasar, Nur Afni Syariah; Nafisah, Lina; Fu'adah, Intan Tsamrotul; Pomalingo, Dwina Ramadhani; Fauziah, Siva
Edu Masda Journal Vol 9, No 2 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i2.297

Abstract

                                                 ABSTRACTMany infections are caused by bacteria, viruses, fungi, or other minor groups. One of the bacteria that can cause skin infections is Pseudomonas aeruginosa. Yarrow (Achillea millefolium L) is a plant that is empirically used to treat bleeding wounds on the skin. This research was conducted by testing the antibacterial activity of 70% ethanol extract and in gel dosage form at concentrations of 5%, 10%, and 15% using the disc diffusion method. The reference substance/positive control used is gentamicin, and the negative control is sterile distilled water. The research results show that antibacterial activity at a concentration of 5% provides an inhibition zone against Pseudomonas aeruginosa bacteria of 16.46 mm, while the gel formulation at a concentration of 15% effectively inhibits the growth of Pseudomonas aeruginosa bacteria with an inhibition zone of 22.69 mm. Stability testing of the gel formulation during storage did not show any changes in colour, taste, odour, or form organoleptically. Homogeneous gel preparations with appropriate pH, spreadability, and viscosity remained stable for 28 days at different temperatures.                                           ABSTRAKBanyak infeksi disebabkaan oleh bakteri virus, jamur, atau beberapa kelompok minor lainnya. Salah satu bakteri yang dapat menyebabkan infeksi kulit adalah bakteri Pseudomonas aeruginosa. Daun Seribu (Achillea millefolium L) merupakan tumbuhan yang secara empiris digunakan untuk mengobati luka pendarahan pada kulit. Penelitian ini dilakukan dengan uji aktivitas antibakteri terhadap ekstrak etanol 70% dan dalam bentuk sediaan gel dengan konsentrasi 5%, 10% dan 15% dengan menggunakan metode difusi cakram. Sebagai zat pembandingnya/Kontrol positif yang digunakan adalah gentamicin dan sebagai kontrol negatif adalah aquadest steril. Hasil penelitian  menunjukan bahwa aktivitas antibakteri dengan konsentrasi 5% memberikan zona hambat pada bakteri Pseudomonas aeruginosa  16,46 mm sedangkan dalam bentuk sediaan gel dengan konsentrasi 15% efektif menghambat pertumbuhan bakteri Pseudomonas aeruginosa dengan zona hambat 22,69 mm. Uji stabilitas sediaan gel  pada penyimpanan secara organoleptik tidak terjadi perubhan warna, rasa, bau dan bentuk. Sediaan gel homogen dengan pH, daya sebar dan viskositas sesuai selama 28 hari dengan suhu yang berbeda.
Swamedikasi, DAGUSIBU, dan Waspada Bahan Berbahaya Kosmetik: Pengabdian Masyarakat di Dusun Kepuhsari, Surakarta: Indonesia Ainurofiq, Ahmad; Fatimi, Hana Anisa; Prabowo, Imam; Larasati, Rizky Dwi; Choiri, Syaiful; Az Zahro, Fatimah Aqilah; Usmarini, Razita Fathya; Maharani, Vania; Fauziah, Siva; Purbowati, Dwi; Rinaldi, Rafli; Jauhari, Muh Rizqi Fadlah
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 08, Issue 1, Maret 2026
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol8.iss1.art18

Abstract

Inappropriate self-medication limited public understanding of the DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) concept, and the widespread use of harmful cosmetic products remain major challenges in improving community health. This community service activity aimed to increase the knowledge of residents in Dusun Kepuhsari RW 38 regarding rational self-medication, proper application of the DAGUSIBU principle (Get, Use, Store, and Dispose of Medicine Correctly), and the risks associated with hazardous cosmetic ingredients. The activity was carried out through an educational and participatory approach consisting of a pretest, leaflet distribution, direct delivery of material by resource persons, interactive Q&A sessions, distribution of door prizes, and a posttest. The results showed an overall increase in participants' understanding across all three topics. Knowledge of self-medication increased by 1.2 times, while understanding of DAGUSIBU improved by 1.44 times. Education on harmful cosmetics also led to a significant improvement in participants' awareness of product legality, identification of dangerous substances, and associated health risks. Through this educational program, the community is expected to become more informed and responsible in using both medicines and cosmetics safely and wisely.
UJI AKTIVITAS ANTIOKSIDANDAN PENETAPAN KADAR FLAVONOID TOTALDARI EKSTRAK ETANOL 70% DAUN KAPUK RANDU (CEIBA PENTANDRA(L.)GEARTN) DENGANMETODE DPPH Siva Fauziah; Nova Puspita Sari
ISTA Online Technologi Journal Vol. 1 No. 1 (2020): Agustus 2020
Publisher : Institut Sains dan Teknologi Al-Kamal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62702/ion.v1i1.23

Abstract

Abstrak Daun kapuk randu mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menetapkan kadar flavonoid totaldan menguji aktivitas antioksidan dari ekstrak etanol 70% daun kapuk randu (Ceiba pentandra (L.)Gaertn.) dengan menggunakan spektrofotometer UV-Vis. Penentuan kadar flavonoid total ekstrak etanol 70% daun kapuk randu (Ceiba pentandra (L.)Gaertn.) ditentukan berdasarkan nilai absorbansi yang diukur pada panjang gelombang sinar tampak 429,0 nm dengan menggunakan pembanding kuersetin. Uji akivitas antioksidan ekstrak etanol 70% daun kapuk randu (Ceiba pentandra (L.)Gaertn.) ini dilakukan dengan mengukur aktivitas peredaman ekstrak terhadap radikal DPPH (1,1-difenil-2-pikrilhidrazil) secara spektrofotometer UV-Vis pada panjang gelombang 515,0 nm. Hasil penelitian menunjukan kadar flavonoid total yang diperoleh pada ekstrak etanol 70% daun kapuk randu yaitu12,69%. Hasil dari uji aktivitas antioksidan ekstrak etanol 70% daun kapuk randu diperoleh nilai IC50 sebesar 59,296 ppm. Disimpulkan bahwa ekstrak etanol 70% daun kapuk randu memiliki potensi sebagai antioksidan yang kuat. Abstract Kapok leaves contain flavonoid compounds which have antioxidant activity. Research of determination of total flavonoid content and antioxidant activity of 70% ethanol extract in kapok leaf (Ceiba pentandra (L.)Gaertn.) by using UV-Vis spectrophotometer. Determination of total flavonoid levels of 70% ethanol extract kapok leaf (Ceiba pentandra (L.)Gaertn.) Extract was determined based on the absorbance value measured at the wavelength of visible light 429.0 nm using a comprator quercetin. Antioxidant activity test for ethanol 70% kapok leaf extract (Ceiba pentandra (L.)Gaertn.) was carried out by measuring the reducing activity of the extract against DPPH radical (1,1-diphenyl-2-picrylhydrazyl) by UV-Vis spectrophotometer at a wavelength of 515.0 nm. The results showed total flavonoid levels obtained on70% ethanol extract kapok leaf (Ceiba pentandra (L.)Gaertn.) is 12,69%. The results of the kapok leaf antioxidant activity test obtained IC50 values in 70% ethanol extract kapok leaf (Ceiba pentandra (L.)Gaertn.) is59,296 ppm. It was concluded that 70% ethanol extract kapok leaf (Ceiba pentandra (L.)Gaertn.) it has potential as a powerful antioxidant.
EVALUASI PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN ANAK DI INSTALASI RAWAT JALAN RSUD BALARAJA KABUPATEN TANGERANG PERIODE JANUARI – DESEMBER 2020 Komalasari, Sri; Siva Fauziah; Nurfitriyana
IONTech Journal Vol. 6 No. 1 (2025): Februari 2025
Publisher : Institut Sains dan Teknologi Al-Kamal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62702/ion.v6i1.91

Abstract

Tuberculosis (TB) is a highly contagious infectious disease caused by the bacterium Mycobacterium tuberculosis. Indonesia is one of the countries with the highest number of tuberculosis sufferers in the world. With the increasing incidence of TB in adults, the number of children infected with TB will increase and the number of children with TB disease will also increase. It is difficult to diagnose TB in children, causing over-diagnosis and over-treatment in the treatment of TB in children. This study aims to determine the characteristics of tuberculosis patients and determine the accuracy of tuberculosis drug treatment for children including the right diagnosis, the right drug, the right dose and the duration of treatment. This research is a type of non-experimental research with a descriptive research design by taking data from medical records retrospectively. The sampling technique used is purposive sampling . The total sample obtained was 52 patients who had met the inclusion and exclusion criteria. The data obtained were then compared for compliance with the 2016 National Guideline for Tuberculosis Management. The results of the analysis of 52 samples showed that the suitability of pediatric lung treatment in the outpatient installation of Balaraja Hospital, Tangerang Regency based on the accuracy of diagnosis as many as 52 patients (100%), accuracy In the intensive phase there were 52 patients (100%) while in the follow-up phase there were 50 patients (100%), the accuracy of the dose was 84.62% and the overall frequency of treatment of OAT in patients showed 100% therapeutic accuracy. The use of anti – tuberculosis drugs for children include the right diagnosis, right drug, right dose, and frequency of treatments of OAT is in conformity with Pedoman Nasional Penanggulangan Tuberkulosis.
Co-Authors Adityo Hartono Ahmad Ainurofiq, Ahmad Amalia, Siska Andriansyah, Lucky Anggraeni, Anggi Sekar Aulia, Gina Az Zahro, Fatimah Aqilah Azwar Anas Badriah, Liah Citra Dewi Dede Komarudin Devinda, Rinova Dinda Nur Fajri Hidayati Bunga Djoharsjah Djoharsjah Dwi Atmanto Dwi Purbowati Ekadipta Ekadipta Ermin Katrin Fatimi, Hana Anisa Febri Hidayat Ferial, Jihan Hafiz, Muhamad Handono Handoyo Hendig Winarno Hernawati, Diana Herul, Herul Iin Hardiyati Imam Prabowo, Imam Intan Tsamrotul Fu’adah Iyon Muhdiyati Jauhari, Muh Rizqi Fadlah Kiki Deniati Komalasari, Sri Larasati, Rizky Dwi Maharani, Vania Megan Asri Humaira Muftiyah, Alvi Nur Mulyani Putri, Anissa Mustika Tripatmasari Nada Widiyanti Nafisah, Lina Nasar, Nur Afni Syariah Nisa, Ima Vera Nova Puspita Sari Nurfitriyana NURINA AYUNINGTYAS Nurul Fauziah Paujiah, Lutfia Pomalingo, Dwina Ramadhani Puji Sari Putri D, Bunga Putri, Annisa Septyana Rafli Rinaldi Rahmawati, Rahmawati Ratih Pramintari Ruslihagi, Farid Sholihah, Anna Zahratas Siti Muti’ah, Siti Siti Nurbaya Susanto Susanto Syaiful Choiri Usmarini, Razita Fathya Veranita, Weri Yulis Adriana