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All Journal Jurnal Ilmiah Aplikasi Isotop Radiasi Medika Tadulako IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) al-Afkar, Journal For Islamic Studies Jurnal Ilmiah Kesehatan QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jurnal Ekonomi Bisnis Indonesia Edu Masda Journal Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Health Science Jurnal Pijar MIPA Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Inovasi Pengabdian dan Pemberdayaan Masyarakat Jurnal Adijaya Multidisiplin Jurnal Farmasi Kryonaut Therapy : Journal of Health Science
Siva Fauziah, Siva
Institut Sains Dan Teknologi Al-Kamal
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Evaluasi pola penggunaan antibiotik pada pasien demam tifoid di instalasi rawat inap RSU Tangerang Selatan dengan metode Gyssens Fauziah, Siva; Komarudin, Dede
Indonesian Journal of Health Science Vol 4 No 5 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i5.1015

Abstract

Latar Belakang: Bakteri Salmonella typhi menyebabkan demam tifoid, penyakit menular yang sebagian besar menyerang saluran pencernaan, Demam tifoid yang disebabkan oleh bakteri Salmonella typhi paling baik diobati dengan antibiotic. Tujuan: evaluasi penggunaan antibiotik pada pasien demam thypoid engan metode gyssens di instalasi rawat inap Rumah Sakit Umum kota Tangerang Selatan.  Metode: Penelitian ini menggulnakan pendekatan penelitian observasional deskriptif non-eksperimental. Pengambilan data di lakukan secara retrospektif dengan analisis tingkat rasionalitas. Pengambilan data didapatkan dari data rekam medis dan resep pasien yang terdiagnosa demam thypoid. Hasil: Rasionalitas penggunaan antibiotik dianalisis dengan menggunakan metode Gyssens di mana Pemberian obat antibiotik yang sering di berikan yaitu cefixime dan ceftriaxone dengan golongan antibiotik cephalosporin generasi ketiga sebanyak 21 pasien dan mendapatkan persentase sebesar 25%, sedangkan rasionalitas penggunaan antibiotik pada pasien demam tifoid yang menjalani rawat inap di RSU kota Tangerang selatan dari 84 rekam medis pasien, terdapat 75% penggunaan antibiotik rasional di kategori 0 dan terdapat 25% yang tidak rasional termasuk pada kategori IVA (ada alternatif lebih efektif). Kesimpulan: Mayoritas pasien demam tifoid di RSU Kota Tangerang Selatan menerima antibiotik yang rasional. Namun, masih terdapat 25% pasien yang menerima antibiotik tidak rasional yang dapat meningkatkan risiko resistensi antibiotik sehingga perlu dilakukan upaya untuk meningkatkan penggunaan antibiotik yang rasional, seperti edukasi kepada tenaga medis dan pasien.
THE RELATIONSHIP BETWEEN DYSMENORRHEA KNOWLEDGE AND DYSMENORRHEA HANDLING BEHAVIOR IN YOUNG WOMEN AT SMAN 1 TAMBUN UTARA IN 2022 Fauziah, Siva; Dinda Nur Fajri Hidayati Bunga; Kiki Deniati
Soscience: Jurnal Ilmu Sosial Science Vol 1 No 2 (2024): JANUARY 2024
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/therapy.v1i2.37

Abstract

Many young women ignore pain during menstruation. Dysmenorrhea has a bad impact on young women, namely causing disturbances in teaching and learning activities, not paying attention to the explanations given by the teacher, and the tendency to sleep in class during teaching and learning activities. Health conditions during menstruation are influenced by the level of knowledge. A person with insufficient knowledge will tend to ignore health and in the end, he will have dangerous actions for himself. research Objectives:To determine the relationship between knowledge about dysmenorrhea and behavior in handling dysmenorrhea in adolescent girls at SMAN 1 Tambun Utara in 2022. Research Methods: The design in this study was Analytical Observation with a Cross-Sectional research design, using the independent variable knowledge of dysmenorrhea and the dependent variable handling behavior, the sampling technique in this study is probability sampling type simple random sampling with a sample of 205 respondents. The instrument in this study used a digital questionnaire and statistical tests were carried out using Chi-Square. Research Results: Based on the output of the chi-square statistical test, the Asymp Significance value is 0.000. It can be concluded that the Asymp Significance value (0.000) < value (0.05), indicates that H0 is rejected. Thus it can be interpreted that "the relationship of knowledge about dysmenorrhea with behavior in handling dysmenorrhea in adolescent girls at SMAN 1 Tambun Utara in 2022. Conclusion: There is a relationship between knowledge about dysmenorrhea and behavior in dealing with dysmenorrhea in adolescent girls at SMAN 1 Tambun Utara in 2022.
Pemberdayaan Masyarakat Desa melalui Penggunaan Media Tanam Inovatif dan Budidaya Pertanian Modern Guna Meningkatkan Produktivitas Tanaman Fauziah, Siva; Ferial, Jihan; Tripatmasari, Mustika
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): December
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/linov.v9i4.2361

Abstract

Lahan pertanian mengalami penurunan karena meningkatnya laju pertumbuhan penduduk hingga alih fungsi lahan dari pertanian ke pemukiman sehingga lahan terbatas dan kualitas tanah menurun untuk bercocok tanam. Kondisi ini menjadi alasan diadakannya sosialisasi untuk memperkenalkan media tanam 3in1 Agrocoota yang inovatif terbuat dari campuran cocopeat, arang sekam, dan daun mimba kepada masyarakat Desa Gondanglor, Kecamatan Sugio, Kabupaten Lamongan. Kegiatan ini dilaksanakan pada Sabtu, 26 Oktober 2024 yang dihadiri oleh 21 orang dari kelompok tani Dusun Ngingkrang. Sosialisasi ini mendapat respon positif dan antusiasme dari masyarakat desa. Kegiatan ini mengajarkan cara memanfaatkan media tanam ramah lingkungan melalui sosialisasi serta dilakukan pengisian kuisioner sebagai tolak ukur. Kuisioner kemudian diolah menggunakan metode analisis statistika deskriptif yang dipilih karena penyajian informasinya lebih mudah dipahami (Sari, 2018). Metode ini disajikan dalam bentuk data kuantitatif berupa Diagram Pie. Hasil kegiatan menunjukkan adanya peningkatan kesadaran dan minat masyarakat sebesar 90% untuk bersedia menggunakan media tanam ini sebagai bentuk implementasi pertanian berkelanjutan pada skala rumah tangga untuk mendukung kemandirian pangan serta menjaga kelestarian lingkungan. Media tanam ini dapat digunakan secara berkelanjutan di desa Gondanglor dengan potensi ketersediaan bahan baku cocopeat sebesar 47% dan sekam padi 52% sehingga masyarakat dapat membuat media tanam ini secara mandiri. Empowering Village Communities Through the Use of Innovative Planting Media and Modern Agricultural Cultivation to Increase Crop Productivity  Abstract Agricultural land is experiencing a decline due to the increasing rate of population growth and the conversion of land from agriculture to residential areas so that land is limited and the quality of the land decreases when it is suitable for planting. This condition was the reason for holding an outreach to introduce the innovative 3in1 Agrocoota planting medium made from a mixture of cocopeat, husk charcoal and neem leaves to the people of Gondanglor Village, Sugio District, Lamongan Regency. This activity was held on Saturday, October 26 2024, and was attended by 21 people from the Ngingkrang Hamlet farmer group. This socialization received a positive and enthusiastic response from the village community. This activity teaches how to use environmentally friendly planting media through outreach and filling out questionnaires as a benchmark. The questionnaire was then processed using descriptive statistical analysis methods which were chosen because the presentation of the information was easier to understand (Sari, 2018). This method is presented in the form of quantitative data in the form of a Pie Chart. The results of the activity showed that there was an increase in public awareness and interest by 90% in being willing to use this planting medium as a form of implementing sustainable agriculture on a household scale to support food independence and preserve the environment. This planting medium can be used sustainably in Gondanglor village with the potential availability of 47% of cocopeat raw materials and 52% of rice husks so that people can make this planting medium independently.
The Influence of the Giving Question and Getting Answer Learning Model on the Learning Activity of Class IV Students in the PKN Subject at MI Mathlaul Anwar Azwar Anas; Siva Fauziah
al-Afkar, Journal For Islamic Studies Vol. 7 No. 4 (2024)
Publisher : Perkumpulan Dosen Fakultas Agama Islam Indramayu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/afkarjournal.v7i4.1190

Abstract

The problem in this study is the lack of student learning activity at MI Mathlaul Anwar. The purpose of this study is to describe the steps of the learning model of Giving Questions and Getting Answers, increasing student learning activities, and increasing learning activities in PKN subjects. This research uses descriptive quantitative research. The sampling technique used is the saturated sampling technique. The subjects of this study were fourth grade students totaling 81 students. The data collection technique used is a questionnaire. Based on the results of the study, it can be concluded that the value of the correlation coefficient of the variables X and Y obtained from tcount is 15.248 which is greater at a significant level of 5%, then Ho is rejected and Ha is accepted. The result of the coefficient of determination is 0.746 or 74.6%, which means that the Giving Question and Getting Answer learning model has an influence of 74.6% on student activity. The results showed that the Giving Question and Getting Answer learning model had an effect on students' active learning in Civics subjects.
Profile of Learners Argumentation Ability on Socio-Scientific Issues Fauziah, Siva; Hernawati, Diana; Rizal, Rahmat; Badriah, Liah
Jurnal Pijar Mipa Vol. 20 No. 1 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i1.8214

Abstract

This study aims to determine the profile of students' argumentation skills at MTs Idrisiyyah, Tasikmalaya Regency, in the context of Socio-Scientific Issues (SSI), which includes issues related to science and society based on the components of scientific argumentation from the Toulmin model. The study used a quantitative descriptive method; as many as 63 Grade VIII learners participated. The results of the analysis showed that the ability to claim was excellent (86%), but argumentation support such as data (64%), warrant (32%), qualifier (30%), and backing (27%) was still low. This finding indicates that although learners can convey claims well, they have difficulty supporting these claims with strong data and arguments. The results of this study are expected to be a reference for educators in designing more effective learning strategies related to the development of argumentation skills in the context of SSI.
Daun Gandarusa (Justicia gendarussa Burm. F) sebagai alternatif antibiotik: Studi potensi fraksi aktif terhadap Staphylococcus aureus Komarudin, Dede; Adriana, Yulis; Fauziah, Siva; Mulyani Putri, Anissa
Indonesian Journal of Health Science Vol 5 No 1 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i1.1330

Abstract

Latar Belakang: Tanaman gandarussa (Justicia gendarussa Burm. F.) diketahui memiliki flavonoid, alkaloid, triterponoid, tannin, justicin, steroid, dan gendarusin A dan B. Secara empiris, tanaman ini dapat digunakan sebagai obat untuk memar, bengkak, sakit pinggang, nyeri sendi, demam, antibakteri, bisul, borok, dan patah tulang. Tujuan: Studi ini mengukur zona hambat bakteri Staphylococcus aureus ekstrak daun talas untuk mengetahui sifat antibakteri ekstrak etanol daun gandarusa. Metode: Penelitian uji daya hambat dengan metode difusi sumuran pada ekstrak etanol, fraksi n-heksana dan fraksi etil asetat. Ciprofloxacin menjadi kontrol positif dan etanol sebagai kontrol negatif. Konsentrasi 75; 50; 25;10; 5; 2.5 digunakan untuk control, ekstrak dan fraksi. Data deskriptif menggunakan data kualitatif dan kuantitatif . Hasil : Nilai rata-rata diameter zona hambat ciprofloxacin (kontrol positif) memiliki zona daya hambat bakteri yang sangat kuat, 25,79 mm. Sedangkan nilai diameter zona hambat terhadap konsentraksi ekstrak etanol, fraksi n-heksana & fraksi etil asetat berturut-turut pada konsentrasi 75% ( 25,18 mm; 30,02 mm & 25,36 mm),  konsentrasi 50% (22,1 mm; 26,62 mm & 25.44 mm), konsentrasi 25% (19,22 mm;  23,8 mm & 21,18 mm), konsentrasi 10% ( 18,27 mm; 16,95 mm & 17.75 mm), konsentrasi 5% (13,36 mm; 12,31 mm & 14,43 mm) dan konsentrasi 2.5% (6,1 mm; 12,73 mm & 12,5 mm). Kesimpulan: Ciprofloxacin 25 μg/ml (kontrol positif) memiliki zona daya hambat pada bakteri Staphylococcus aureus dengan rata-rata nilai 25,79 mm yang termasuk kedalam kategori sangat kuat. Rata-rata nilai tertinggi ekstrak etanol daun gandarusa (Justicia gendarusa Burm. F), fraksi n-heksan dan fraksi etil asetat memiliki daya hambat pada bakteri Staphylococcus aureus berturut-turut sebesar 25,18 mm; 30,02 mm dan 25,36 mm yang termasuk kedalam kategori sangat kuat. Ekstrak dan fraksi aktif dari daun gandarusa (Justicia gendarusa Burm. F) dapat digunakan sebagai alternatif penghambatan pada bakteri Staphylococcus aureus.
Antibacterial activity of deodorant stick formula from ethyl acetate fraction of beluntas leaves (Pluchea indica L.) against Pseudomonas aeruginosa and Streptococcus pyogenes bacteria that cause body odor. Adriana, Yulis; Fauziah, Siva
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 1 (2025): February 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Beluntas contains flavonoids, tannins and steroids which can inhibit growth and reduce the risk of infection by microorganisms. Empirically, beluntas leaves are used by people to overcome unpleasant body odor, usually body odor is caused by the Pseudomonas aeruginosa and Streptococcus pyogenes. Stick deodorant is a cosmetic made from; sodium stearate (steric acid and sodium hydroxide) and as a solvent using propylene glycol. The aim of this research was to formulate the ethyl acetate fraction of beluntas leaves into a stick deodorant and test the antibacterial activity of Pseudomonas aeruginosa and Streptococcus pyogenes using the well diffusion method and test physical, chemical and quality parameters. microbiology. Stick deodorant were made into three formulations with different concentrations of the ethyl acetate fraction of beluntas leaves, namely Formula I with a concentration of 20%, Formula II is 30% and Formula III is 40% with the harding agent stearic acid: NaoH 10% (8.5:7.5). The quality test of the three formulation sticks deodorants met the requirements for pH test (range 6-7.0), homogeneity test, melting point test (range 55.40-60.9 °C), Microbiology test and water capacity test (aw). The results of the inhibition test against Streptococcus pyogenes were between 23.33-8.33 mm in the very strong inhibition category, the comparison deodorant had no inhibitory area and gentamycin 0.01% as a positive control had an inhibitory area of 29.66 mm in the very strong category. The inhibitory power against Pseudomonas aeruginosa is 11.5-18.92 mm in the strong inhibitory category, the comparison deodorant has no inhibitory area and 0.01% gentamycin as a positive control has inhibitory area of 21.66 mm in the very strong category.Keywords: Ethyl acetate fraction, stick deodorant, Pluchea indica.L, Pseudomonas aeruginosa, Streptococcus pyogenes, inhibition test
Analysis of Differentially Expressed Genes (DEG) and Upstream Regulator Proteins Indicates That Inhibition of Transforming Growth Factor Beta 1 (TGFB1) is A Potential Target for Acne Inversa Veranita, Weri; Fauziah, Siva; Nurbaya, Siti
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 3, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acne inversa (AI) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and scarring, primarily in intertriginous areas. This study aims to identify potential therapeutic targets for managing acne inversa based on the analysis of differentially expressed genes (DEG). The expression targets of these genes were then validated for their potential as biomarkers, and upstream regulator proteins (URPs) were identified from the resulting DEG. DEG analysis on the GEO dataset GSE122592 (acne inversa vs. healthy donor skin) revealed five DEG that can serve as biomarkers for acne inversa, with a sensitivity and specificity of (100%). These DEG—IL10, GZMB, FASLG, PRF1, and HLA-DPB10—are genes associated with autoimmune thyroiditis (AIT). AIT has previously been significantly linked to acne vulgaris. URP analysis indicates that inhibition of Transforming Growth Factor Beta 1 (TGFB1) is a therapeutic target that could be used to downregulate these five DEGs, returning their expression to healthy skin levels.
Analysis of Differentially Expressed Genes (DEGS) Related to Interleukin-17 Signaling for Biomarker Identification and Therapeutic Targets in Atopic Eczema Fauziah, Siva; Veranita, Weri; Nurbaya, Siti; Sari, Puji
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Atopic eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition characterized by itchy, red, and swollen skin. It is often associated with other atopic diseases such as asthma and hay fever. Interleukin-17 (IL-17), a pro-inflammatory cytokine, plays a crucial role in various inflammatory and autoimmune conditions, including atopic eczema. This study aims to identify potential therapeutic targets for managing atopic eczema based on the analysis of differentially expressed genes (DEGs). The expression of these gene targets was subsequently validated for their potential as biomarkers. Additionally, upstream regulator protein (URP) searches for the resulting DEGs were conducted. DEG analysis of the Gene Expression Omnibus (GEO) dataset, GSE6012 (atopic eczema vs. healthy donor skin), revealed that genes related to IL-17 signaling—FOSL1, MMP1, DEFB4B, S100A7, S100A8, and S100A9—can serve as biomarkers for atopic eczema with sensitivity and specificity values of 1.000. URP analysis suggested that inhibition of IL1A and NOG, as well as TGFB1 activity, are potential therapeutic targets to downregulate these six DEGs, thereby restoring their expression to the levels observed in healthy skin.
Rational use of NSAIDs and the incidence of potential drug interactions in inpatients with osteoarthritis at the Tangerang City General Hospital Fauziah, Siva; Aulia, Gina; Nasar, Nur Afni Syariah; Putri, Annisa Septyana; Komarudin, Dede
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1621

Abstract

Background: Osteoarthritis (OA) is a disease that affects articular cartilage, subchondral bone, synovium, capsule, and ligaments. This disease is an overlapping disorder with different etiologies but similar biological, morphological, and clinical outcomes. The rationality of drug use in osteoarthritis must be optimized to achieve optimal therapeutic outcomes. The potential for drug interactions must also be understood to prevent unwanted effects from therapy. Objective: To determine the rationality of drug use and the potential for drug interactions in osteoarthritis patients at Tangerang City General Hospital, focusing on the four principles of appropriate drug use: appropriate patient, appropriate drug, appropriate indication, and appropriate dose. This study is a descriptive observational study with a cross-sectional design and uses retrospective data. Method: The study sample was selected using purposive sampling, considering inclusion and exclusion criteria. The study sample meeting the inclusion criteria consisted of 31 medical records (patients). The data obtained were then compared with the reference standards of the Indonesian Rheumatology Association (IRA). Results: Patient characteristics based on age showed the highest proportion in early elderly (46–55 years) at 41.9%, female gender at 71%, with joint pain location in the feet at 65%, other joints at 23%, and hands at 12.9%. The profile of prescribed osteoarthritis medications was as follows: sodium diclofenac 41.9%, meloxicam 38.7%, ketorolac 12.9%, and mefenamic acid 6.5%. The rationality of patient accuracy, medication, indications, and dosage yielded 100% data related to NSAID use in osteoarthritis patients, with the highest potential for drug interactions occurring in the combination of sodium diclofenac and bisoprolol at 18.2% at a moderate severity level. The mechanism of interaction involves NSAIDs potentially weakening the antihypertensive effects of beta-blockers. The mechanism of NSAID-induced inhibition of renal prostaglandin synthesis results in uninhibited pressor activity, leading to hypertension. Additionally, NSAIDs can cause fluid retention, which also affects blood pressure. Conclusion: The rational use of NSAIDs in terms of the right patient, right drug, right indication, and right dose was 100%, and the total number of PIAO cases found was 11 (28.2%). Of all the cases identified, 8 cases were moderate in severity and 3 cases were minor. The most common drug interactions were between Sodium Diclofenac and Bisoprolol, accounting for 18.2%. Keywords: Drug rationality NSAIDs, Osteoarthritis, Potential drug interactions.
Co-Authors Adityo Hartono Amalia, Siska Andriansyah, Lucky Anggraeni, Anggi Sekar Aulia, Gina Azwar Anas Badriah, Liah Citra Dewi Dede Komarudin Devinda, Rinova Dinda Nur Fajri Hidayati Bunga Djoharsjah Djoharsjah Dwi Atmanto Ekadipta Ekadipta Ermin Katrin Febri Hidayat Ferial, Jihan Fu'adah, Intan Tsamrotul Hafiz, Muhamad Handono Handoyo Hendig Winarno Hernawati, Diana Herul, Herul Iin Hardiyati Iyon Muhdiyati Kiki Deniati Megan Asri Humaira Muftiyah, Alvi Nur Mulyani Putri, Anissa Mustika Tripatmasari Nada Widiyanti Nafisah, Lina Nasar, Nur Afni Syariah Nisa, Ima Vera NURINA AYUNINGTYAS Nurul Fauziah Paujiah, Lutfia Pomalingo, Dwina Ramadhani Puji Sari Putri D, Bunga Putri, Annisa Septyana Rahmawati, Rahmawati Ratih Pramintari Ruslihagi, Farid Sholihah, Anna Zahratas Siti Muti’ah, Siti Siti Nurbaya Susanto Susanto Veranita, Weri Yulis Adriana