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Comparison of C-Reactive Protein Level and Pain Score in 2% Lidocaine Premedication with Tourniquet Handling and 2% Lidocaine Mixture in Propofol Injection Thamrin, Muhammad Husni; Novianto, Bambang; Leofirsta, Hendra
Journal of Anaesthesia and Pain Vol. 6 No. 2 (2025): May
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Background: Propofol is a widely used anesthetic induction agent, yet post-injection pain is a frequent adverse effect. Common strategies to reduce this pain include venous occlusion following lidocaine administration and the admixture of lidocaine with propofol. This study investigates whether lidocaine pretreatment with tourniquet application provides superior pain relief compared to the admixture method. Method: We conducted a single-center, randomized controlled, single-blind trial involving patients scheduled for elective surgery. Participants were randomly assigned to receive either lidocaine pretreatment with tourniquet application (n=15) or a lidocaine-propofol admixture (n=15). The primary outcomes were pain scores and C-reactive protein (CRP) levels, while secondary outcomes included heart rate and blood pressure measurements. Result: 30 patients underwent elective surgery in Dr. Moewardi General Hospital between October and November 2023. Post propofol injection, increments in pain severity were observed in both treatment groups. However, lower pain severity was observed in the tourniquet handling group.  After injection, moderate and severe CRP levels were recorded in the lidocaine-propofol admixture (33.3% and 6.7%, respectively), whereas no moderate or severe CRP levels were discovered in the tourniquet handling group. The tourniquet handling group experienced less discomfort after propofol injection (3.139 ± 0.743 vs. 4.27±0.704, p=0.001). Lower CRP levels were evaluated in the experimental group (0.279 ± 0.121 to 1.68 ± 2.49, p=0.002). Conclusion: Lidocaine pretreatment with tourniquet occlusion or one minute before delivering propofol as an anesthetic induction agent was more effective than the lidocaine-propofol admixture in relieving pain after propofol injections.
Illocutionary Speech Acts in the Novel Irtitām Lam Yusma‘ Lahu Dawiyy by Bothayna Al-Essa: A Pragmatic Analysis Study Binta Thaila Khotrunnada; Buana, Cahya; Raharja, Hatta; Thamrin, Muhammad Husni
Maharaat: Jurnal Pendidikan Bahasa Arab Vol. 8 No. 2 (2026): April
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mht.v8i2.31295

Abstract

This study analyzes illocutionary speech acts in the novel “Irtitām Lam Yusma‘ Lahu Dawiyy” (A Crash That He Did Not Hear) by Bothayna Al-Essa, using John Searle's speech act theory as the analytical framework. The research employs a descriptive qualitative approach with library research as the method. Data were collected through an in-depth reading of the novel, the identification of utterances containing illocutionary speech acts, and classification according to Searle's theory. The findings show that three examples of utterances were found for each type of illocutionary speech act: assertives, directives, expressives, and commissives, along with one utterance classified as a declarative illocutionary speech act. This study concludes that language in the novel not only functions as a means of communication but also serves as a tool for building emotional relationships and representing sociocultural tensions. Theoretically, this research contributes to the study of Arabic literary pragmatics, while practically, it can be utilized in the teaching of Arabic language and literature at the university level.
Perbedaan Skala Analog Visual Nyeri dan Kadar Protein C-reaktif Sensitivitas Tinggi Setelah Pemberian Fentanil dan Ketamin Perioperatif pada Pasien Pasca-laparotomi: Sebuah Uji Klinis Terkontrol Acak Buta Ganda: Penelitian Mahendra, Adiptya Cahya; Thamrin, Muhammad Husni; Putro, Bambang Novianto; Dzikri, Dykall Naf’an
Cermin Dunia Kedokteran Vol 53 No 08 (2026): Agustus 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i08.1783

Abstract

Introduction: Postoperative pain remains a significant challenge in perioperative management. This study aims to analyze the differences in pain scores using the visual analog scale (VAS) and high-sensitivity C-reactive protein (hsCRP) levels between perioperative ketamine administration and perioperative fentanyl administration in post-laparotomy patients. Methods: A double-blind randomized controlled trial was conducted on 24 laparotomy patients divided into ketamine (n = 12) and fentanyl (n = 12) groups. The ketamine group received a 0.2 mg/kg bolus followed by a 0.1 mg/kg/hour infusion, while the fentanyl group received a 0.5 mcg/kg/hour infusion during surgery; drug administration was stopped immediately after extubation. VAS scores were assessed at 4 and 8 hours postoperatively, and hsCRP levels were measured preoperatively and 6 hours postoperatively. Statistical analysis used independent t-tests, Mann-Whitney U tests, and Pearson correlation. Results: The ketamine group showed significantly lower VAS scores at 4 hours postoperatively (2.92 vs 5.25; p = 0.017), but no significant difference at 8 hours (6.00 vs 5.75; p = 0.514). Postoperative hsCRP levels were lower in the ketamine group compared to fentanyl (4.58 vs 7.77; p = 0.006). A positive correlation was found between increased VAS scores and elevated hsCRP (r = 0.566; p = 0.004). Conclusion: Ketamine provides significantly superior early postoperative analgesia and more effectively suppresses the acute inflammatory response than fentanyl. However, its analgesic advantage diminishes by 8 hours, indicating the need for a multimodal strategy for sustained postoperative pain management.
EVALUASI KERUSAKAN PERKERASAN MENGGUNAKAN METODE PAVEMENT CONDITION INDEX (PCI) PADA RUNWAY DI BANDAR UDARA HANG NADIM BATAM Thamrin, Muhammad Husni; Rivai, Indartono
JURNAL TEKNIK SIPIL-ARSITEKTUR Vol. 23 No. 1 (2024): EDISI BULAN MEI 2024
Publisher : FTSP Universitas Jayabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dalam suatu bandara tedapat komponen-komponen infrastruktur yang mendukung berjalannya transportasi udara diantaranya runway, yang dimana merupakan tempat terjadinya take-off dan landing pesawat yang berupa rigid atau fleksibel. Adapun kegiatan operasi penerbangan dari tahun ketahun tetap berjalan sehingga perlu adanya evalusi terhadap kondisi pekerkerasan runway. Mengevaluasi kondisi runway diperlukan yang bertujuan untuk mengetahui indeks kondisi permukaan melalui survey yang dilakukan secara visual pada permukaan perkerasan, menganalisa tingkat keparahan kondisi perkerasan dan juga menghitung hasil keseluruhan nilai. Dalam pengujian ini menggunakan metode Pavement Condition Index (PCI).Untuk penentuan data dan penentuan sample mengacu kepada ASTM D5340-98. Hasil Analisa kondisi permukaan perkerasan runway Bandar Udara Hang Nadim menggunakan metode Pavement Condition Index (PCI) manual diperoleh sebesar 78 dalam kategori “Satisfactory” atau “Memuaskan”. Hal ini disebabkan karena tingkat keakuratan dalam pembacaan grafik DV dan CDV yang dimana pemilihan nilai CDV dipilih nilai CDV terbesar pada setiap segmen atau sampel