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All Journal Medula JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian kepada Masyarakat Sains Medisina Jurnal Mahasiswa Ilmu Kesehatan Jurnal Praba: Jurnal Rumpun Kesehatan Umum Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Femmy Andrifianie
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Linda Septiani; terza aflika happy; Risti Graharti; Femmy Andrifianie; Endah Setyaningrum
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Potensi Tanaman Obat Indonesia sebagai Kandidat Terapi Pendukung pada Demam Berdarah Dengue Terza Aflika Happy; Linda Septiani; Risti Graharti; Femmy Andrifianie
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.2030

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in Indonesia, with high morbidity and mortality rates. Since the current management of DHF is primarily supportive, identifying effective complementary therapies has become an important research priority. Indonesia possesses extraordinary biodiversity, including numerous medicinal plants rich in bioactive secondary metabolites with potential therapeutic properties. This study aimed to review the potential of Indonesian medicinal plants as candidates for supportive therapy in DHF based on available scientific evidence. A literature review was conducted by analyzing national and international publications related to medicinal plants and dengue infection. The findings indicate that several Indonesian medicinal plants, including Phyllanthus niruri L., Psidium guajava, Carica papaya L., and Ipomoea batatas, demonstrate promising potential as supportive therapies for DHF. Their therapeutic effects are mainly attributed to bioactive compounds such as flavonoids, quercetin, saponins, tannins, alkaloids, and polyphenols, which exhibit antiviral, anti-inflammatory, antioxidant, and immunomodulatory activities. These compounds may also promote thrombopoiesis by stimulating granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3, thereby contributing to platelet recovery. In addition, they help reduce oxidative stress, suppress excessive pro-inflammatory cytokine production, and preserve vascular endothelial integrity, potentially preventing disease progression and plasma leakage. Overall, Indonesian medicinal plants represent promising candidates for complementary supportive therapy in DHF. Nevertheless, further preclinical investigations and well-designed clinical trials are required to confirm their efficacy, safety, optimal dosage, and mechanisms of action before they can be recommended for routine clinical practice.
Co-Authors Abda Abda Ade Putri Selviana Agaphe Suluh Brahmantio Andi Nafisah Atri Sri Ulandari Emantis Rosa Endah Setyaningrum Ergidona Nurizqi Ergidona Nurizqi Syiffatulhaya Ervina Damayanti Evy Afriyani Ihsanti Dwi Rahayu Intan Kusumaningtyas Istiqomatul Qur'ani Linda Septiani Linda Septiani Luhut Uji Arto Naenggolan M. Fitra Wardhana Mallarangeng, Andi Nafisah Tendri Adjeng Natalia Michelle Simatupang Natasya Karren Zeta Ni Komang Sumantri Nur Mawar Agustina Oktafany Oktafany Oktoba, Zulpakor Ramadhan Triyandi Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reny Arienta Putri Risti Graharti Siti Khalimatus Sa'diah Suryadi Islami Suryani Agustina Daulay Sutarto Sutarto Syazili Mustofa Syiffatulhaya Syiffatulhaya Terza Aflika Happy Terza Aflika Happy Tri Umiana Soleha Ummi Khoirotunnisa Winda Winda