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All Journal JMM (Jurnal Masyarakat Mandiri) JURNAL FARMASIMED (JFM) Jurnal Surya Jurnal Penelitian Farmasi dan Herbal Jurnal Farmasi Jurnal Abdi Masyarakat Indonesia Generics: Journal of Research in Pharmacy NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Abadi: Jurnal Ahmad Dahlan Mengabdi Jurnal Pengabdian Masyarakat Bangsa Journal of Business Management ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat Journal of Clinical Pharmacy and Pharmaceutical Science Generics : Journal of Research in Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Aditya Sindu Sakti
Departemen Farmasi Bahan Alam, Universitas Khairun
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Article Review: In Vitro, In Vivo, And Clinical Trial Data on Proanthocyanidin Compounds Cici Sayyidatul Adhimi; Aditya Sindu Sakti; Elasari Dwi Pratiwi; Khan, Muhammad Adil
Jurnal Surya Vol 16 No 2 (2024): VOL 16 NO 02 AUGUST 2024
Publisher : Universitas Muhammadiyah Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38040/js.v16i2.1011

Abstract

Proanthocyanidins, also known as condensed tannins, are oligomeric flavonoids found in various plants such as seeds, fruits, and leaves, and they offer health benefits. In vitro, in vivo, and clinical trials can demonstrate and confirm the appropriate dosage for their development in the health sector. The aim of this review article is to provide a systematic overview of the health benefits of proanthocyanidin compounds. The review process was conducted online using websites such as Google Scholar, NCBI, ScienceDirect, NIH, and PubMed with the keywords “in vitro, in vivo, and clinical trials of proanthocyanidin compounds”. The review results indicate that in vitro, in vivo, and clinical studies on proanthocyanidin compounds show health benefits such as antidiabetic, antioxidant, antibacterial, immunostimulant, insomnia therapy, analgesic effects, anthelmintic agents, and potential for COVID-19 prevention and treatment.
Edukasi dan Sosialisasi tentang Pentingnya Mencegah Stunting pada Anak di Satuan PAUD Sejenis (SPS) Melati Putih Desa Parengan, Kecamatan Maduran, Kabupaten Lamongan Sakti, Aditya Sindu; Novitasari, Laela; Chalid, Nurdin; Ambar Pramudita, Galuh; Ainun Syajidah, Hanna
Ahmad Dahlan Mengabdi Vol 2 No 1 (2023): ABADI: Jurnal Ahmad Dahlan Mengabdi Edisi Maret 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Institut Teknologi dan Bisnis Ahmad Dahlan Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58906/abadi.v2i1.89

Abstract

Stunting atau poor linear growth merupakan permasalah kesehatan yang dapat meningkatkan morbiditas dan mortalitas, di Kabupaten Lamongan prevalensi stunting pada anak masih cukup tinggi, salah satu penyebab utama terjadinya stunting adalah kurangnya informasi dan pengetahuan mengenai stunting. Tujuan dari kegiatan edukasi dan sosialisasi tentang pentingnya mencegah stunting pada anak ini adalah untuk meningkatkan pengetahuan masyrakat mengenai stunting sehingga dapat menurunkan kejadian stunting di Kabupaten Lamongan. Metode edukasi dan sosialisasi yang digunakan yaitu penyuluhan dengan menggunakan media berupa leaflet. Hasil dari kegiatan ini menujukkan bahwa edukasi dan sosialisasi tentang pentingnya mencegah stunting pada anak dapat menjadi salah satu upaya yang efektif untuk meningkatkan pengetahuan masyrakat mengenai stunting, penggunaan media leaflet dapat digunakan sebagai salah satu opsi yang efisien untuk menyampaikan edukasi dan sosialisasi kepada masyarakat.
Comparison of Continuous Percolation and Ultrasound-Assisted Extraction (UAE) Methods on Total Phenolic Content of 70% Ethanol Extract of Purslane (Portulaca oleracea L.) Aditya Sindu Sakti; Fransisca Dita Mayangsari; Sri Bintang Sahara Mahaputra Kusuma Negara; Elasari Dwi Pratiwi; Sandrawati
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dxzsgc71

Abstract

Background: Portulaca oleracea L., commonly known as Krokot, is rich in phenolic compounds with notable pharmacological benefits. Optimizing extraction methods is critical to maximize its bioactive potential. Objective: This study aimed to compare the efficiency of Continuous Percolation (CP) and Ultrasound-Assisted Extraction (UAE) in obtaining total phenolic content (TPC) from 70% ethanol extract of P. oleracea. Methods: Dried powdered P. oleracea was subjected to CP and UAE using a 1:10 (w/v) plant-to-solvent ratio. Qualitative screening with FeCl₃ confirmed the presence of phenolics. TPC was quantified using the Folin–Ciocalteu method, expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis included normality testing, Levene’s test, and the Mann–Whitney U test. Results: UAE yielded significantly higher TPC (420.04 ± 0.40 mg GAE/g) compared to CP (354.30 ± 0.00 mg GAE/g; p = 0.034), although CP produced a higher extract mass. Statistical results confirmed the superiority of UAE in selectively extracting phenolic constituents. Conclusion: UAE is more effective than CP in extracting phenolic compounds from P. oleracea, likely due to enhanced cavitation-induced mass transfer. This method is recommended for maximizing phenolic recovery in plant-based extractions, especially for thermolabile compounds.
Nanostructured Lipid Carrier (NLC) Based Gel as Patchouli Oil Delivery : Physical Characteristic and In Vivo Skin Irritation Test Mayangsari, Fransisca Dita; Aditya Sindu Sakti; Merry Anggelya Mentari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vc33d509

Abstract

Patchouli oil (PO) contained patchoulol, which has antioxidant activity, making it a valuable ingredient in anti-aging products. However, this oil is volatile and chemically unstable. Therefore, it needs to be formulated into a Nanostructured Lipid Carriers based gel (NBG). This study aims to observe the effect of PO’s concentration on the physical characteristics and skin irritation of NBG preparations. NBG consists of 50% NLC and 50% gel. There are three formulas observed in this study, namely NBG-0 (0% PO), NBG-2 (2% PO), NBG-4 (4% PO). NLC prepared using the High Shear Homogenization method. Based on the physical characteristics test, it is known that all formulas have differences in the aroma aspect, where NBG-0 odorless, while NBG-2 and NBG-4 have a patchouli scent. All formula do not have differences in color and consistency. All formula have a pH in the range of 5.92 - 6.21. Statistically, increasing the concentration of PO decreases the pH of NBG. The three formulas have a viscosity in the range of 4.493 - 9.880 cP. Statistically, viscosity of NBG increasased by increasing concentration of PO. Based on in vivo skin irritation tests using white mice, it is known that all formulas have the same IIP (Primary Irritation Index) value. Based on the study, it can be concluded that the concentration of PO (0%, 2%, 4%) affects the aroma, pH and viscosity aspects but does not affect the color and consistency of NBG. Increasing the PO concentration in NBG up to 4% did not cause skin irritation.
Pelatihan Pemanfaatan Tanaman Obat Keluarga (TOGA) dan Sediaan Farmasi sebagai Upaya Pertolongan Pertama Pasca Bencana di Kecamatan Ibu Maluku Utara Sandrawati, Sandrawati; Siregar, Khoiryah Miagori; Sakti, Aditya Sindu; Yulimanida, Herri; Rope, Mohammad Reza Vitra; Muhlis, Widyawati; Anggaraini, Yessy Puspa; Dihir, Sri Defi
ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat
Publisher : UPT Publikasi dan Penerbitan Universitas San Pedro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59632/abdiunisap.v3i2.469

Abstract

Pelatihan pemanfaatan Tanaman Obat Keluarga (TOGA) dan sediaan farmasi sebagai upaya pertolongan pertama pasca bencana dilaksanakan di Desa Tongute Goin, Kecamatan Ibu, Kabupaten Halmahera Barat, Provinsi Maluku Utara. Kegiatan ini bertujuan untuk meningkatkan kapasitas masyarakat dalam memanfaatkan sumber daya lokal untuk mendukung ketahanan kesehatan di wilayah rawan bencana. Metode pelaksanaan meliputi tahapan persiapan, pelaksanaan, dan evaluasi yang bersifat partisipatif dengan melibatkan 42 peserta dari berbagai kelompok masyarakat. Materi pelatihan mencakup pengolahan TOGA secara higienis, pembuatan sediaan farmasi sederhana (antiseptik daun sirih, minuman herbal imunostimulan, dan salep luka ringan), serta penggunaan alat kesehatan dasar seperti nebulizer dan oksigen portabel. Evaluasi efektivitas kegiatan dilakukan melalui pre-test dan post-test. Hasil menunjukkan peningkatan signifikan pada tingkat pemahaman peserta, dari rata-rata 23,37% sebelum pelatihan menjadi 92,31% sesudah pelatihan. Peningkatan terbesar terjadi pada aspek penanganan darurat dan dukungan pernapasan. Kegiatan ini terbukti efektif dalam meningkatkan literasi kesehatan, keterampilan praktis, dan kesiapsiagaan masyarakat terhadap bencana, sekaligus memperkuat nilai gotong royong dan kemandirian desa melalui pembentukan kader TOGA.
Review: Modern Extraction Methods for Extraction Proanthocyanidins from Natural Products Manzil, Li’izzah Diana; Sakti, Aditya Sindu
Generics: Journal of Research in Pharmacy Vol 6, No 1 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i1.28200

Abstract

Proanthocyanidins are widely distributed in many plant species and are recognized for their beneficial health effects, particularly their antioxidant and anti-inflammatory activities. This literature review aims to evaluate modern extraction techniques used to isolate proanthocyanidins from natural sources. Conventional methods, such as maceration and Soxhlet extraction, often result in reduced yields because proanthocyanidins are heat-sensitive and susceptible to oxidation. To address these limitations, this review explores alternative modern extraction approaches. Relevant peer-reviewed articles were identified through a comprehensive search of five academic databases: ScienceDirect, PubMed, Google Scholar, NCBI, and BMC. The modern extraction techniques examined include Ultrasound-Assisted Extraction (UAE), Microwave-Assisted Extraction (MAE), Enzyme-Assisted Extraction (EAE), and Pressurized Liquid Extraction (PLE). Evidence from 23 selected studies shows that UAE and MAE are among the most effective and efficient methods for extracting proanthocyanidins from natural matrices. These findings underscore the potential of modern extraction technologies to improve both the yield and quality of proanthocyanidins, supporting their broader application in pharmaceutical and nutraceutical fields.
Pemberdayaan Ibu Dasawisma melalui Pengelolaan Minyak Jelantah menjadi Sabun Herbal Lokal di Kelurahan Cobodoe Rachman, Eva Syariefah; Nur, Amran; Sakti, Aditya Sindu; Sandrawati, Sandrawati; Tjiroso, Bambang
ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat
Publisher : UPT Publikasi dan Penerbitan Universitas San Pedro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59632/abdiunisap.v3i2.508

Abstract

Kegiatan pengabdian ini bertujuan meningkatkan literasi lingkungan ibu-ibu Dasawisma dalam pengelolaan minyak jelantah berbasis potensi rempah lokal di Kelurahan Cobodoe. Pendekatan Participatory Learning and Action (PLA) digunakan melalui penyuluhan partisipatif dan diskusi terarah tanpa praktik langsung. Evaluasi dilakukan menggunakan pre-test dan post-test untuk menilai perubahan pemahaman peserta sebelum dan sesudah kegiatan. Hasil evaluasi menunjukkan peningkatan pemahaman peserta terhadap dampak lingkungan minyak jelantah, prinsip dasar pembuatan sabun, serta pemanfaatan rempah lokal. Kegiatan ini efektif meningkatkan kesadaran pengelolaan limbah rumah tangga dan berpotensi menjadi model edukasi lingkungan berbasis komunitas yang berkelanjutan.
Purchase Decisions of Local Cosmetic Products among Generation Z: The Role of Brand Awareness, Brand Trust, and Brand Attitude Rachman, Eva Syariefah; Amarullah, Dudi; Astria, Nikita; Sakti, Aditya Sindu; Krois, Adysabzan T.
Journal of Business Management Vol. 3 No. 2 (2025): December
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/jobm.v3i2.177

Abstract

The growth of the local cosmetics industry in Indonesia has shown significant growth in recent years, especially among Generation Z. This study aims to analyze the influence of brand awareness and brand trust on purchasing decisions for local cosmetic products, with brand attitude as a mediating variable. The research method uses a quantitative approach with an online survey of 164 Generation Z respondents who have purchased local cosmetics. Data analysis uses Structural Equation Modeling Partial Least Squares (SEM-PLS). The results show that brand awareness and brand trust have a significant positive effect on brand attitude. Brand attitude also has a significant effect on purchasing decisions. In addition, brand attitude is proven to mediate the influence of brand awareness and brand trust on purchasing decisions. These findings emphasize the importance of brand strengthening strategies to build positive consumer attitudes as a basis for forming purchasing decisions.
Review: Modern Extraction Methods for Extraction Proanthocyanidins from Natural Products Manzil, Li’izzah Diana; Sakti, Aditya Sindu
Generics: Journal of Research in Pharmacy Vol 6, No 1 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i1.28200

Abstract

Proanthocyanidins are widely distributed in many plant species and are recognized for their beneficial health effects, particularly their antioxidant and anti-inflammatory activities. This literature review aims to evaluate modern extraction techniques used to isolate proanthocyanidins from natural sources. Conventional methods, such as maceration and Soxhlet extraction, often result in reduced yields because proanthocyanidins are heat-sensitive and susceptible to oxidation. To address these limitations, this review explores alternative modern extraction approaches. Relevant peer-reviewed articles were identified through a comprehensive search of five academic databases: ScienceDirect, PubMed, Google Scholar, NCBI, and BMC. The modern extraction techniques examined include Ultrasound-Assisted Extraction (UAE), Microwave-Assisted Extraction (MAE), Enzyme-Assisted Extraction (EAE), and Pressurized Liquid Extraction (PLE). Evidence from 23 selected studies shows that UAE and MAE are among the most effective and efficient methods for extracting proanthocyanidins from natural matrices. These findings underscore the potential of modern extraction technologies to improve both the yield and quality of proanthocyanidins, supporting their broader application in pharmaceutical and nutraceutical fields.
IMPLEMENTASI MIKROBIOLOGI FARMASI, UPAYA PENCEGAHAN DAN PENANGANAN DINI DEMAM BERDARAH MELALUI KEGIATAN PENYULUHAN DI LAMONGAN Sakti, Aditya Sindu; Octavia, Devi Ristian; Sari, Popy Dwi Permata; Fadhila, Salsabila Nur; Wibowo, Alfina Wijayanti; Sholichatin, Haeny; Akhyar, Miftakhul; Maharani, Tiara Anisa; Lutfiana, Era; Putri, Amalia Winanda
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 2 (2024): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i2.22249

Abstract

Abstrak: Dusun Pereng, Lamongan merupakan dusun yang memiliki banyak sawah tambak sehingga rentan terjadinya KLB demam berdarah, pengetahuan masyarakat terkait upaya pencegahan dan penanganan dini demam berdarah dapat menurunkan kejadian dan keparahan demam berdarah . Kegiatan penyuluhan ini bertujuan untuk meningkatkan pengetahuan ibu rumah tangga di Dusun Pereng, Lamongan mengenai upaya pencegahan dan penanganan demam berdarah dengan memanfaatkan potensi herbal unggulan desa. Mitra yang terlibat dalam kegiatan penyuluhan ini adalah ibu rumah tangga di RT 01 RW 03, Dusun Pereng, Lamongan sebanyak 12 orang . Metode yang digunakan adalah penyuluhan dengan bantuan media visual berupa poster, evaluasi perubahan tingkat pengetahuan mitra dilakukan dengan menggunakan kuesioner pre-test post-test. Peningkatan pengetahuan secara signifikan (p>0.05) hanya terjadi pada 42% mitra ibu rumah tangga. Peningkatan pengetahuan mitra dengan metode penyuluhan kurang memberikan pengaruh yang bermakna terhadap pengetahuan mitra mengenai upaya pencegahan dan penanganan demam berdarah.Abstract: Pereng is a village in Lamongan that has many ponds so it is prone to outbreaks of dengue fever. Public knowledge about prevention and early treatment of dengue fever can reduce the incidence and severity of dengue fever. This educational health campaign aims to increase the knowledge of housewives in Pereng, Lamongan regarding the prevention and treatment of dengue fever by utilizing the potential of the village's superior herbs. The partners involved in this educational health campaign were 12 housewives in RT 01 RW 03, Pereng village, Lamongan. The method used is an educational health campaign using the visual media of poster. Evaluation of the level of knowledge from housewife respondents was performed using a pre-test post-test questionnaire. A significant increase in knowledge (p>0.05) only occurred in 42% of housewife respondents. Increasing partners' knowledge using outreach methods performed did not have a significant influence on the knowledge of housewife respondents. 
Co-Authors Abdul Hamid ABDUL ROKHMAN Abulkhair Abdullah Adhimi, Cici Sayyidatul Ainun Syajidah, Hanna Akhyar, Miftakhul Al-Hadi, Muhammad Muflih Zaki Amalia Puspa Wahyu Ambar Pramudita, Galuh Amran Nur Anggaraini, Yessy Puspa Arrofiqi, Mochammad Rasyad Astria, Nikita Bambang Tjiroso, Bambang Bheta Sari Dewi Chalid, Nurdin Cici Sayyidatul Adhimi Deta Hilar Nurrohmah Devi Ristian Octavia Dihir, Sri Defi Dudi Amarullah Elasari Dwi Pratiwi Fachry Abda El Rahman Fadhila, Salsabila Nur Firdiyansyah, Moh. Rofiqi Fransisca Dita Mayangsari Galuh Ambar Pramudita Hanna Ainun Syajidah Hidayat, Ferdian Imam, Fathul Rizky S. Imtiyaaz, Moh Thaariq Zelda Irma Susanti Jazilah Khikmia Suwandi Khan, Muhammad Adil khusnul khotimah Krois, Adysabzan T. Kusumo, Djati Wulan Laela Novitasari Lutfiana, Era M. Ahsanul Farihin Maharani, Tiara Anisa Manzil, Li’izzah Diana Marhamah Marhamah Mentari, Merry Anggelya Merry Anggelya Mentari Miftah, Siraj Nur Rafi Muhammad Nurul Fadel Muhammad Syaiful Amin Muhammad, Apriyanti Muhlis, Widyawati Novitasari, Laela Nurdin Chalid Nurin, Eka Filza Nurul Izzah H. L. Pasi Nur’aini Al Wahida Octavia, Devi Ristian Putri, Amalia Winanda Rachman, Eva Syariefah Rope, Mohammad Reza Vitra Sandrawati Sandrawati, Sandrawati Sari, Popy Dwi Permata Setianingsih, Elfrida Rosselly Sholichatin, Haeny Siregar, Khoiryah Miagori Siti Mutamimah, Siti Sri Bintang Sahara Mahaputra Kusuma Negara Sri Bintang Sahara Mahaputra Kusumanegara Sundari TOKA, WAHYUNITA DO Wibowo, Alfina Wijayanti Yulimanida, Herri Zuhri, Mukhammad Syaifuddin