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Faizal Hermanto
Department Of Pharmacology And Toxicology, Faculty Of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Resveratrol Reduce the Severity of Anemia and Thrombocytopenia in Plasmodium berghei ANKA-Infected Mice Hermanto, Faizal; Refiani , Aqila; Ahsanul Haq, Fahmi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.266-271

Abstract

Background: Malaria is an infectious disease with a high mortality rate. One of the complications of malaria is blood disorders. Hematological disorders such as anemia and thrombocytopenia are common in malaria infection. Resveratrol has been reported to have antimalarial activity. Objective: This study aimed to evaluate the effect of resveratrol in reducing the severity of anemia and thrombocytopenia in Plasmodum berghei-infected mice. Methods: The study began with parasite inoculation in mice. After the mice were infected, and randomly grouped into negative control, chloroquine 20 mg/kg (positive control), and resveratrol with doses 25, 50, and 100 mg/kg. The mice's blood profile was measured on day 0 and day 4 using a hematology analyzer. Results: The results showed that after administration of resveratrol at various doses, the number of RBC, hemoglobin, hematocrit and platelets was higher than the control. Conclusion: It can be concluded that resveratrol can reduce the severity of anemia and thrombocytopenia in mice infected with P. berghei.
Co-Authors Achmad Zainuddin Ade Kania Ningsih, Ade Kania Adiningsih, Martha Afifah Bambang Sutjiatmo, Afifah Bambang Ahsanul Haq, Fahmi Akhirul Kahfi Syam Andreanus A Soemardji Ari Sri Windyaswari, Ari Sri Arif Rahman Hakim Arifianti Essen, Amanda Choirunissa, Anna Diah Lia Aulifa Elin Yulinah Sukandar Euis Julaeha Fahrauk Faramayuda, Fahrauk Fani Wahyuni, Fani Febrinella, Catellya Fikri Alatas Gusdilla, Windy Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hasna Hestiary Ratih Lilis Siti Aisyah, Lilis Siti Linda Purnamawati Suherman Lutfi, Mutiara Hadi Mochammad Luthfi Pramukti, Mochammad Luthfi Muchtaridi Muchtaridi Nur Melsandy Pratama, Gumilar Puspa Sari Dewi Putra , Erwin Ekadharma Rachmawan, Lucky Rachmawan, R. Lucky Rachmawati, Ita Rani Sugandi, Rani Refiani , Aqila Ririn Puspadewi, Ririn Riskia Putri Peratiwi, Riskia Putri Riza Amelia Riza Amelia Rizwan, Akmal Rochmah, Nur Syifa Sembiring, Rinawati Shalsabina, Vina Simatupang, Elivas Siti Nur Aeni, Siti Nur Soraya Riyanti, Soraya Sri Wahyuningsih Sri Wahyuningsih Suci Nar Vikasari, Suci Nar SURYANI Susy Tjahjani Tati Herlina Tri Reksa Saputra, Tri Reksa Unang Supratman Yenny Febriani Yun, Yenny Febriani Yuliana Agustin Zamzami Adnan, Risky