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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Pendidikan Informatika dan Sains JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JURNAL PENGABDI Chemistry Indonesian Journal of Chemical Research Pharmacology and Clinical Pharmacy Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Acta Chimica Asiana Sasambo Journal of Pharmacy Cermin Dunia Kedokteran Pharmaceutical Sciences and Research (PSR) Journal Pharmacy of Tanjungpura
Hariyanto IH
Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Jl. Prof. Dr. Hadari Nawawi, Pontianak, Kalimantan Barat, 78124, Indonesia Departemen Farmakologi Dan Farmasi Klinik, Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura
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Pengaruh penambahan susu kacang kedelai terhadap karakteristik fisik, kimia dan mikrobiologi yoghurt Hariyanto IH; Albianus Febri Tarung; Siti Nani Nurbaeti
Sasambo Journal of Pharmacy Vol. 4 No. 2 (2023): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i2.277

Abstract

The quality of yogurt is affected by the addition of durian fruit puree in milk. The aim of this study is to investigate how different concentrations of soy milk affect the physical, chemical, and microbiological properties of yogurt in comparison to the Indonesian National Standard (SNI). This research was conducted by making durian-flavored yogurt with variations of soy milk at concentrations of 8% (F1), 20% (F2), and 25% (F3). Yogurt was analyzed for organoleptic, pH, viscosity, syneresis, lactic acid content, protein content, and the number of lactic acid bacteria (LAB). The data was processed using SPSS one-way ANOVA statistics. The results showed that only the pH value did not meet the requirements of SNI for yogurt, with a range of 3.80-4.50 for all group concentrations. The viscosity numbers of F1, F2, F3, and control were 634.66, 614.66, 608, and 760.66 cp, respectively. F3 has shown the best stability in form based on syneresis results with a value of 91.93% compared to other groups, such as 90.69%, 91.65%, and 89.59% for F1, F2, and control, respectively. Lactic acid and protein compounds of all groups fulfill the SNI standard with a range of 1.7-1.83% and 3,03-3.23%, respectively. Similar results were shown in the LAB standard as well, showing the LAB numbers were >107 colonies/gram for all formulas. Soymilk addition increases the protein matrix stability determined in syneresis percentage.
Edukasi melalui Buku Saku dan Video Animasi Diabetes Mellitus terhadap Kader Prolanis Kota Pontianak: Education through Pocket Book and Video of Diabetes Mellitus towards Non-Medical Officer of Pontianak City Hariyanto IH; Hadi Kurniawan; Fajar Nugraha
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 5 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i5.4858

Abstract

The prevalence of diabetes mellitus (DM) was increased in Pontianak. The Technical Implementation Unit (UPT) of Puskesmas Perumnas II, as one of the primary health centers in Pontianak, has applied the Diabetes Mellitus Chronic Disease Management Program (Prolanis) to overcome this problem. The Puskesmas Perumnas II involves non-medical workers through training to serve as officers who assist in implementing the Prolanis program. In this program, Pharmacists provide knowledge for non-medical workers through education and counseling related to DM treatment. In this community service activity (PKM), we aim to educate these non-health officers of Prolanis in Puskesmas Perumnas II regarding the knowledge of prevention and management of diabetes mellitus. As the method, we prepared the timeline activity, including orientation and coordination with Puskesmas Perumnas II, selecting the non-health officers of Prolanis as the participants, providing the materials (pocketbook and video), implementation of activities (conducting pre-tests, materials, and media transfers to participants, discussions, debriefings, post-tests, and evaluation through questionnaires), and data analysis. We found that participants' knowledge was increased related to DM and its treatment based on the average of pre-test and post-test results, such as 59.75 and 73.25, respectively. Evaluation of this education method through questionnaires showed that participants felt the material provided was very interesting, and participants gained new knowledge through the educational media provided.
The Effect of Probiotic Starter Culture Variation on the Quality of Yogurt Based on Indonesian National Standard Ih, Hariyanto; Cristin, Bella; Nurbaeti, Siti Nani
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.259-264

Abstract

Yogurt is usually made by two lactic acid bacteria such as Streptococcus thermophilus and Lactobacillus bulgaricus. However, three to seven lactic acid bacteria are also used in several products. Therefore, this study aimed to examine the effect of variations in the number of starter bacteria and compare to Indonesian National Standard (SNI). The experimental method was used with starter variations, including a combination of two (Lactobacillus bulgaricus and Streptococcus thermophilus); three (Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus); and seven bacteria (Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacterium longum, and Bifidobacterium infantis). The results showed that the yogurt with two and seven bacteria was within the range of SNI value standard. The pH, viscosity, syneresis, lactic acid content, total protein, and total number of bacteria for yogurt with two bacteria were 3.92, 453.76 cP, 88.05%, 1.27%, 3.26%, and 2.47 x 1012 Cfu/mL, respectively. The values for yogurt with seven bacteria were 4.11, 478.23 cP, 97,45%, 0,98%, 2.7%, and 1.53 x 1010, respectively, while formulas with three bacteria did not reach the pH standard. However, the atypical taste was given by the seven starter bacteria and the use of various bacteria starters affected the quality of yogurt. Specifically, formulas composed of two bacteria showed the best results according to SNI.
Profil kadar metabolit sekunder: Steroid, alkaloid, dan tanin ekstrak daun bintangur (Calophyllum soulattri) Kurniawan, Hadi; Nurbaeti, Siti Nani; IH, Hariyanto; Nugraha, Fajar; Fajriaty, Inarah
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.336

Abstract

Bintangur leaf is one of the potential plants to be developed into a standardized herbal medicine which has many benefits such as antioxidant, anti-inflammatory and antibacterial. The aim of this study is to determine the steroid, tannin, and alkaloids of bintangur leaf extract. Preparation of bintangur leaves was conducted by soxhletation extraction technique with 96% ethanol as solvent. Determination of tannin tannic acid equivalent, and alkaloid quinine equivalent was analyzed by UV-Vis spectrophotometry method. While the analysis of steroid content β-sitosterol equivalent using a TLC Scanner. The results of the analysis showed that steroid content was 11061,49 µgBSE/g, alkaloid was 307,16 µgQE/g, and tannin was 6,586 %w/w TAE.
Study of Anthocyanin Molecule Blocking as Anti-Hypertensive through the Pathway of the Renin-Angiotensin-Aldosterone System (RAAS) Budiarto, Dwi; Wijianto, Bambang; IH, Hariyanto
Indonesian Journal of Chemical Research Vol 11 No 1 (2023): Edition for May 2023
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.11-bud

Abstract

Anthocyanins are flavonoid-derived compounds that can reduce blood pressure. This study aims to determine the affinity value of the compound to bind to Angiotensin Converting Enzyme (ACE) and bind to Angiotensin II type 1 Receptor (AT1R) and to determine the distance and shape of the bond that occurs. The results of anthocyanin-derived compounds Delphinidin, Petunidin, Malvidin, Cyanidin, Peonidin, and Pelargonidin have anti-hypertensive potential through the Renin Angiotensin Aldosterone (RAAS) pathway based on molecular docking calculations. The affinity value of each, against Angiotensin Converting Enzyme (ACE) -7.7; -7.8; -7.7; -7.7; -7.8, and -7.7, the best affinity value in anthocyanin-derived compounds is shown in the Malvidin test compound which has three types of hydrogen bonds at a distance of ± 2 Å (ASP377, TYR520, ASP415) and has 1 type of bond that is the same as the lisinopril control (TYR520). While the affinity value to Angiotensin Receptor (AT1R) is -7.7; -7.7; -7.8; -7.7; -7.8, and -7.6, respectively, the best affinity value is shown in the Malvidin test ligand compound of -7.8 kcal/mol which has four types of hydrogen bonds ± 2 Å distance (TYR92, SER105, ARG167, TRP84) and has one kind of bond in common with lisinopril control (TYR520).
STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO) Irawan, Dandi; Wijianto, Bambang; IH, Hariyanto
Jurnal Kimia Riset Vol. 8 No. 2 (2023): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v8i2.50785

Abstract

Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression. The study aimed to examine the potential of 8 alkaloid compounds in kratom as antidepressants towards four target proteins: Serotonin Transporter (SERT), Dopamine Transporter (DOPAT), Leucine Transporter (LEUT), and Monoamine Oxidase (MAO) via molecular docking. The Pyrx program is used with exhaustiveness 106 as the protocol, and the grid is adapted to the active site of each receptor. The affinity values "‹"‹of the alkaloid compounds in kratom are mitragynine, 7-hydroxy mitragynine, speciociliatine, paynantheine, speciogynine, corynantheidine, mitraciliatine, and 9-hydroxycorynantheidine, for MAO were -7.1, -6.1, -5.7, -6.7, -5.7, -7.7, -5.7, and -5.7 kcal/ mole. All compounds bind to amino acid residues in the target protein through hydrogen and pi (Ï€) bonds. All the tested alkaloid compounds have the potential to be re-uptake inhibitors SERT, DOPAT, LEUT, and Monoamine Oxidase (MAO).
PERANCANGAN HEWAN MODEL MALNUTRISI ENERGI PROTEIN UNTUK PENGUJIAN PRODUK ANTISTUNTING IH, Hariyanto; Fajriati, Inarah; Nugraha, Fajar; Hadi, Kurniawan; Nurbaeti, Siti Nani; Ardianto, Verdi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.47063

Abstract

Produk antistunting menjadi inovasi dalam mengatasi permasalahan malnutrisi, namun keterbatasan pemodelan hewan uji menjadi salah satu hambatan dalam pengembangan produk tersebut. Penelitian ini bertujuan menciptakan hewan model malnutrisi melalui formulasi pakan rendah protein. Formulasi pakan rendah protein dari tepung maizena dan tapioka diberikan kepada hewan uji yang dibagi ke dalam 3 kelompok, yaitu kelompok normal, kelompok maizena dan kelompok tapioka. Induksi pakan dilakukan 15 hari dimana kelompok normal diberikan pakan CP551, sedangkan dua kelompok uji masing-masing diberikan pakan formulasi. Perubahan bobot badan tikus dianalisis selama 15 hari perlakuan. Parameter malnutrisi, yaitu kadar hemoglobin, albumin dan protein total pada darah hari ke-0 (sebelum perlakuan) dan hari ke-15 (setelah perlakuan) diukur dan dibandingkan. Hasil pengamatan bobot badan menunjukkan kedua pakan formulasi rendah protein dapat menciptakan kondisi malnutrisi setelah dibandingkan terhadap kelompok normal (p<0,05). Persentase penurunan kadar hemoglobin, albumin dan protein total terbesar ditunjukkan oleh kelompok maizena dengan nilai penurunan masing-masing sebesar 5,68%; 12,70% dan 7,64% dibandingkan kelompok tapioka dengan penurunan masing-masing sebesar 0,53%; 2,30% dan 4,74%. Namun, tidak terdapat perbedaan signifikan perubahan bobot badan antara dua kelompok uji (p>0,05). Formulasi pakan rendah protein dari tepung maizena dan tapioka dapat menciptakan kondisi malnutrisi pada hewan uji dengan formulasi terbaik diberikan oleh pakan maizena.
Penyuluhan dan Pendampingan Pembuatan Jamu Serbuk Instan Imunostimulan di Desa Tebang Kacang IH, Hariyanto; Isnindar, Isnindar; Nurbaeti, Siti Nani; Luliana, Sri; Yuswar, Muhammad Akib; Kurniawan, Hadi; Ropiqa, Meri
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.72379

Abstract

Abstrak: Masyarakat indonesia telah lama menggunakan tanaman obat keluarga (TOGA) sebagai upaya pencegahan timbulnya penyakit dan menjaga kesehatannya. Salah satunya adalah meniran (Phillanthus niruri L.) dan jahe (Zingiber Officinale) dimana kombinasi tanaman tersebut telah terbukti dapat meningkatkan daya tahan tubuh. Namun dalam pegolahannya masih dalam bentuk yang sederhana, oleh karena itu diperlukan edukasi dan pendampingan pemanfaatan TOGA menjadi bentuk yang lebih praktis, mudah dan memiliki nilai ekonomi yang tinggi seperti serbuk instan. Oleh karena itu tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan edukasi dan pendampingan pembuatan meniran dan jahe menjadi serbuk instan sebagai imunostimulan di desa tebang kacang. Sasaran dari kegiatan PKM ini adalah ibu-ibu kader PKK yang ada di Desa Tebang Kacang. Metode dari PKM ini adalah penyuluhan dan workshop dengan tahapan kegiatan yaitu persiapan kegiatan, pelaksanaan kegiatan (penyuluhan dan workshop atau pendampingan pembuatan jamu serbuk instan), serta evaluasi kegiatan. Hasil kegiatan menunjukkan  adanya peningkatan pengetahuan peserta yang ditunjukkan dari nilai post-test rata-rata peserta, yaitu 65, jika dibandingkan terhadap nilai rata-rata pre-test, yaitu sebesar 53,33. Evaluasi kepuasan peserta dari kuesioner juga menunjukkan bahwa, materi yang disampaikan mudah dipahami, bermanfaat, menambah keterampilan, produk yang dihasilkan memiliki rasa yang enak dan dapat meningkatkan perekonomian desa.  Kata Kunci:  Serbuk Instan, Imunostimulan , Meniran, Jahe dan Desa Tebang Kacang  Abstract: Indonesians have long used family medicinal plants (TOGA) to prevent disease and maintain health. A few of them are meniran (Phillanthus niruri L.) and ginger (Zingiber Officinale). Their combination has been proven to increase the body's immune system. However, their processing was still in a simple form; therefore, education and assistance are needed to use TOGA in a more practical, easier, and highly economical value, such as instant powder. Therefore, this community service activity aims to educate and assist in making meniran and ginger into instant powder as an immunostimulant in the Tebang Kacang village. The targets of this program are PKK cadre mothers in Tebang Kacang Village. The method of this PKM is counseling and workshops with activity stages, namely preparation of activities, implementation of activities (counseling and workshops or assistance in making instant powdered herbal medicine), and evaluation of activities. The activity results showed an increase in participants' knowledge as indicated by the participants' average post-test score, which was 65%, compared to the average pre-test score, which was 53.33.% Evaluation of participant satisfaction from the questionnaire also shows that the material presented is easy to understand, valuable, increases skills, the product produced has a good taste, and can improve the village economy.  Keywords: Instant Powder, Immunostimulant, Meniran, Ginger and Tebang Kacang Village.  
Knowledge and Behavior Regarding Antibiotic Stewardship in Health Workers at Sultan Syarif Mohammad Alkadrie Hospital, Indonesia Restika, Risma A.; Mardhia, Mardhia; Mahyarudin, Mahyarudin; Liana, Delima F.; IH, Hariyanto
Pharmacology and Clinical Pharmacy Research Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i3.56573

Abstract

Antimicrobial resistance is a global public health concern. The World Health Organization reports that antimicrobial resistance constitutes a serious threat to public health worldwide. One of the risk factors in the development of antimicrobial resistance cases is the irrational use of antibiotics. Knowledge and behavior of health worker about antibiotic stewardship play a role in preventing antibiotic resistance cases. This study aimed to demonstrate knowledge and behavior regarding antibiotic stewardship in health workers at Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. This was a cross-sectional descriptive study using consecutive sampling with total of 39 respondents. Data were collected through questionnaires with total of 45 questions. Knowledge and behavior of respondents were categorized as good, moderate, and low. The data was analyzed using the spearman rank correlation coefficient. The results showed that most health workers had good knowledge 97.44% (38/39) and good behavior 87.18% (34/39) related to antibiotic stewardship with a spearman p-value >0.05. Antibiotic stewardship is important for health workers to prevent an increase in antibiotic resistance cases and their impact on public health worldwide. As we know, increasing antibiotic resistance is a globally major problem as health system depends on effective antibiotics to treat bacterial infections.
Evaluation of Antibiotic Use in the Internal Medicine Ward and ICU at Universitas Tanjungpura Hospital Pontianak with ATC/DDD Rifdah, Dzuria Adhana; Ih, Hariyanto; Liana, Delima Fajar; Mardhia, Mardhia; Mahyarudin, Mahyarudin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.92330

Abstract

Background: Evaluating the wise use of antibiotics is needed to control antibiotic resistance in hospitals.Objectives: This study aimed to analyze patient characteristics, antibiotic profiles, and quantitative use of antibiotics in inpatients prescribed by internal medicine specialists in the internal medicine ward and Intensive Care Unit (ICU) at Universitas Tanjungpura Hospital Pontianak from August to October 2022.Methods: This study method is descriptive observational, and data collection was done retrospectively using a purposive sampling technique. There were 143 samples that met the inclusion criteria, and then using the Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) method, the samples were analyzed quantitatively.Results: Most patient characteristics were female patients (60.14%), patients aged 56-65 (26.57%), and the most common diagnosis was typhoid fever (32.74%). Of the 13 types of antibiotics used, cephalosporin was the most commonly prescribed antibiotic group to patients (58.48%), with the most types of antibiotics in ceftriaxone (42,69%) and intravenous administration of antibiotics was the standard route given to patients. The results of the quantitative analysis of all antibiotic prescriptions obtained a total value of 88.55 DDD/100 patient-days. Antibiotics with the most considerable DDD/100 patient-days value were ceftriaxone (44.71), followed by meropenem (10.46) and levofloxacin (9.28). Furthermore, the value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method.Conclusion: The value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method as qualitative evaluation to obtain information regarding the rationality of prescribing antibiotics.
Co-Authors Albianus Febri Tarung Andres Andres Andres Andres Ardianto, Verdi Bambang WIJIANTO Budiarto, Dwi Carissa, Ingrid Devi Cristin, Bella Delima Fajar Liana Eka K. Untari Esy Nansy Fajar Nugraha Fajar Nugraha Fajriati, Inarah Fajriaty, Inarah Faradilla, Aulia Filomina Dila Putri Fitaloka, Fahira Amanda Hadi Kurniawan Hadi Kurniawan, Hadi Hadi, Kurniawan Hafrizal Riza, Hafrizal Hasni, Ali Almurtadho Ingrid Devi Carissa Irawan, Dandi Isnindar Isnindar Karamigi, Iota Rias Liana, Delima F. Luliana, Sri Lusi Ariska Triani Mahyarudin, Mahyarudin Mardhia Mardhia Mardhia, Mardhia Muhammad Andre Reynaldi Muhammad Asroruddin Muhammad Asroruddin, Muhammad Najini, Robby Nansy, Esy Putri, Lidya Hafidzah Putri, Rizka A. Restika, Risma A. Rifdah, Dzuria Adhana Rise Desnita, Rise Risky Setyaningrum Riyadh Aqilsya Amaryl Dyas Rizka A. Putri Ropiqa, Meri Setyaningrum, Risky Shoma Rizkifani Siti Nani Nurbaeti Syaifitri, Ramidiani Untari, Eka K. Varera, Reski Agus Variandini Aldhila Kharis Variandini Aldhila Kharis, Variandini Aldhila Yuswar, Muhammad Akib