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All Journal The Indonesian Biomedical Journal Jurnal Medika Malahayati Human Care Journal Jurnal Ilmiah Kesehatan Wellness And Healthy Magazine Jurnal Aisyah : Jurnal Ilmu Kesehatan Attractive : Innovative Education Journal Jurnal Kesehatan Tambusai Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Excellent Midwifery Journal
Eka Tri Wulandari, Eka Tri
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Co-Authors Bambang Purwanto Berliana, Zahra Betri, Heni Brahmana, Ivanna Beru Brian Wasita Damayanti, Alfina Desi Kumalasari Dhini, Ulfa Rahma Enjelina, Ria Eti Poncorini Pamungkasari Ferawati Ferawati Fitriyana, Feni Komalasari Komalasari Leny Hikmah Rentiana Lilik Yuliawati LINDA PUSPITASARI - A11111054, LINDA PUSPITASARI Maisaroh, Ria Maulia Isnaini MULYOTO PANGESTU Nasiroh, Nasiroh Novita, Andis Dian Nugerahaeni, Sucia Dwi Nurrohmah Nurrohmah, Nurrohmah Oktaviana, Metalia P, Layla Chaeriyah Psiari Kusuma Wardani Reni Nuraeni, Reni Retnawati, Heni Retno, Sri Nowo Ririn Wulandari Rita Cempaka Siti Maesaroh Siti Maesaroh Siti Rohani Soetrisno Soetrisno Sri Lestariningsih Sukarni Sukarni Sumitri Sumitri, Sumitri Taufik Jamaan Tisnawati, Riya Uki Retno Budihastuti Viniwati, Lise Marlina Wahyuningrum, Erika Septi Wulan Dari, Wulan