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All Journal ACTA VETERINARIA INDONESIANA ARSHI Veterinary Letters Vitek : Bidang Kedokteran Hewan Veterinary Biomedical and Clinical Journal Jurnal Veteriner dan Biomedis Current Biomedicine Genbinesia Journal of Biology
Amaq Fadholly
Division Of Pharmacology And Toxicology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Efikasi Infusa Daun Sawo Duren (Chrysophyllum Cainito L.) Sebagai Antidiare Pada Mencit (Mus Musculus) Istiqmal, Kahfi Aulia; Agungpriyono, Srihadi; Fadholly, Amaq
Jurnal Veteriner dan Biomedis Vol. 3 No. 2 (2025): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.3.2.%p.

Abstract

Daun sawo duren (Chrysophyllum cainito L.) atau kenitu mengandung senyawa berupa alkaloid, fenol, sterol, triterpen dan flavonoid. Senyawa tersebut memiliki potensi sebagai sediaan antidiare. Penelitian ini bertujuan mengetahui efikasi antidiare infusa daun sawo duren dengan menggunakan metode proteksi intestinal dan mengetahui kandungan metabolit sekunder daun sawo duren menggunakan pemeriksaan fitokimia. Penelitian ini juga mencari konsentrasi sedian infusa daun sawo duren yang paling efektif sebagai antidiare pada mencit. Mencit jantan sebanyak 30 ekor dikelompokkan menjadi tiga kelompok yang terdiri atas dua kelompok kontrol yaitu kontrol positif berupa suspensi loperamide HCl dan kontrol negatif menggunakan Oleum ricini. Tiga kelompok perlakuan lainnya menggunakan infusa dengan konsentrasi bertingkat (25%, 50%, 100%). Data hasil penelitian antidiare diolah menggunakan aplikasi minitab-18 dengan metode uji one way ANOVA dan uji tukey. Hasil penelitian menunjukkan infusa daun sawo duren dengan konsentrasi 25%, 50%, dan 100% memiliki aktivitas antidiare.
Uji Toksisitas Akut Ekstrak Daun Ketepeng Cina (Cassia alata) pada Tikus (Rattus norvegicus) Ramadhan, Maharani Kartika; Fadholly, Amaq
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.%p

Abstract

The leaves of Cassia alata exhibit potential properties as antioxidants, immunostimulants, antimicrobials, anti-dengue agents, and laxatives. This study aimed to determine the LD50 value of the administration of Cassia alata leaves extract using the Thompson-Weil method. A total of 25 rats (Rattus norvegicus) were utilized in the study, divided into five dose groups. One group served as the control (P0), receiving only distilled water, while the four treatment groups were administered doses of 500 (P1), 1000 (P2), 1500 (P3), and 2000 (P4) mg/kg BW. Toxic symptoms and changes in body weight were observed for 14 days. The results showed that there was one death at a dose of 1500 mg/kg BW and two deaths at a dose of 2000 mg/kg BW. The administration of Cassia alata leaf extract resulted in toxic symptoms, including reduced motor activity, respiratory difficulties, and weight loss. The LD50 value obtained was 1.9 g/kg BW. The extract of Cassia alata leaves exhibit a toxic effect on rats.
A bioinformatics approach to design a novel epitope-based vaccine against Simian Immunodeficiency Virus (Retroviridae: Lentivirus) Dhea Kharisma, Viol; Ansori, Arif Nur Muhammad; Ullah, Md. Emdad; Dings, Tim Godefridus Antonius; Probojati, Rasyadan Taufiq; Fadholly, Amaq; Turista, Dora Dayu Rahma; Tacharina, Martia Rani; Zainul, Rahadian
Genbinesia Journal of Biology Vol. 2 No. 1 (2022): November 2022
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i1.26

Abstract

Simian Immunodeficiency Viruses (SIV) have been found to naturally infect African nonhuman primates (NHP). This causative agents are important and one of the special interest as the root cause of the HIV/AIDS pandemic, one of the most threatening infectious diseases worldwide. The aim of this study was to design an epitope-based vaccine using bioinformatics approaches of the circulating SIV in Kenya, Africa. In this study, we used 17 partial SIV envelope glycoprotein genes retrieved from GenBank® (National Center for Biotechnology Information, USA). We analysed the candidate epitopes using the Immune Epitope Database and Analysis Resource. Then, we performed the protective antigens prediction usingVaxiJen. Interestingly, this study revealed the data of B cell epitope prediction, protective antigens prediction, and molecular phylogenetic of circulating SIV in Kenya, Africa. In sum, this study can be used to design a novel epitope-based vaccine against SIV. We suggest further studies to conduct confirmatory experiments (in vitro and in vivo).
Single supplementation of goat colostrum, probiotics, and prebiotics for diarrhea management in cats Budiono, Dwi; Vibowo, Heryudianto; Anggraeni, Henny Endah; Rahma, Anisa; Sujarnoko, Tekad Urip Pambudi; Fadholly, Amaq; Calista, Pradnya; Zonathan, Hendri; Rahmat, Kukuh Amru Dhiya; Nugraha, Ivan Taufiq
ARSHI Veterinary Letters Vol. 8 No. 3 (2024): ARSHI Veterinary Letters - August 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.3.61-62

Abstract

Diarrhoea in cats is a change in the condition of faeces from paste to liquid consistency caused by several factors, such as food changes and bacterial, viral, and parasitic infections. Handling diarrhoea in cats is performed immediately so that the symptoms subside. One effective prevention and control effort is the provision of colostrum-based supplements, probiotics and prebiotics. In a case of diarrhoea at the Depok Pet Center clinic, two cats aged 1.5 years (Ayu) and 5 years (Gentong) were given colostrum-based supplements, probiotics, and prebiotics. The initial symptoms of the Ayu cat were diarrhoea and liquid faeces, while the Gentong cat had decreased appetite, weakness, and paste-shaped faeces. Supplementation was carried out for two days. On day three, the condition of the faeces of both cats were solid and shaped, but some parts of the faeces were still mushy. On day six, the condition of the faeces of both cats was good, marked by being shaped and solid.
Sitotoksisitas Ekstrak Cabe Merah Keriting (Capsicum annum) Terhadap Hela Cell Lines Fadholly, Amaq
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.56-60.

Abstract

Kanker merupakan suatu penyakit sel yang ditandai dengan hilangnya fungsi kontrol sel terhadap regulasi daur sel maupun fungsi homeostatis sel pada organisme multiseluler. Penelitian ini bertujuan untuk menganalisis efek sitotoksik dan nilai IC50 dari esktrak Capsium annuum pada cell line HeLa sebagai salah satu sel uji untuk kanker serviks. Uji aktivitas sitotoksik ekstrak Capsicum annuum dilakukan dengan memberikan 5 seri konsentrasi bahan uji yaitu 50 μg/ml, 100 μg/ml, 200 μg/ml, dan 400 μg/ml pada HeLa cell lines yang kemudian diinkubasikan selama 24 jam. Penghitungan sel dilakukan setelah pemberian MTT dan SDS stopper. Persentase inhibisi yang dihasilkan dari masing-masing konsentrasi sampel uji secara berturut-turut adalah 17,98%, 23,88%, 32,64%, dan 45,62%. Ekstrak Capsicum annuum mempunyai nilai IC50 sebesar 1,098 μg/mL. Berdasarkan data dari National Cancer Institute nilai IC50 dari Capsicum annuum terhadap HeLa cell lines termasuk dalam kategori sitotoksisitas lemah. Sehingga dapat disimpulkan ekstrak Capsicum annuum tidak bersifat sitotoksik terhadap HeLa cell lines.
UJI TOKSISITAS AKUT EKSTRAK DAUN SENDOK (Plantago major) PADA MENCIT(Mus musculus) Fadholly, Amaq
VITEK : Bidang Kedokteran Hewan Vol. 15 No. 2 (2025): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/b932sg11

Abstract

The leaves of Plantago major possess potential mostly for antioxidant, immunostimulant, and laxative properties. The study is to examine the impact of Plantago major leaves extract administration on 25 mice to ascertain the LD50 value in the acute toxicity assessment. Twenty-five female mice were allocated into five groups according to normal control group, negative control group and the dosage of Plantago major leaves extract, with doses of 10, 15, and 20 g/kg body weight. Observations were conducted over a 14-day period, encompassing characteristics such as body weight, physiological responses, clinical symptoms, absolute and relative organ weights, and daily mortality counts. Mortality and clinical signs were examined for 14 days after the treatment. The administration of Plantago major leaves extract to mice did not significantly affect body weight, not absolute or relative organ weight. The collected organs exhibited no severe lesions. The LD50 value of Plantago major leaves extract was determined to be more than 20 g/kg BW. It is concluded that LD50 value is considered as relatively harmless.
Co-Authors Adi Sofyan Ansori, Muhammad Andriyanto Andriyanto Anggraeni, Henny Endah Anisa Rahma, Anisa Aulia Andi Mustika Aurellia, Sharon Calista, Pradnya Dhea Kharisma, Viol Diah Nugrahani Pristihadi Dings, Tim Godefridus Antonius Dwi Budiono Fedik Abdul Rantam Firdaus, Munira Laeli Hanum, Nur Aisah Heryudianto Vibowo Iryanto, Anetonia Felicia Istiqmal, Kahfi Aulia Kurniasih Lina Noviyanti Sutardi Nugraha, Ivan Taufiq Purohita, Adwisto Saktika Putri, Imelya Andira Putri, Ramadita Aisyah Rahadian Zainul Rahmat, Kukuh Amru Dhiya Ramadhan, Maharani Kartika Rasyadan Taufiq Probojati Sajidah, Halilah Wafa’ Saragih, Mariah Mada Rahma Nauli Srihadi Agungpriyono Tacharina, Martia Rani Tekad Urip Pambudi Sujarnoko Tri Untari Turista, Dora Dayu Rahma Ullah, Md. Emdad Zonathan, Hendri