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All Journal ACTA VETERINARIA INDONESIANA Media Kedokteran Hewan ARSHI Veterinary Letters Vitek : Bidang Kedokteran Hewan Veterinary Biomedical and Clinical Journal Jurnal Veteriner dan Biomedis Current Biomedicine Nusantara Journal of Multidisciplinary Science Genbinesia Journal of Biology
Amaq Fadholly
Division Of Pharmacology And Toxicology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Veterinary

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Efikasi Infusa Daun Sawo Duren (Chrysophyllum Cainito L.) Sebagai Antidiare Pada Mencit (Mus Musculus) Istiqmal, Kahfi Aulia; Agungpriyono, Srihadi; Fadholly, Amaq
Jurnal Veteriner dan Biomedis Vol. 3 No. 2 (2025): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.3.2.%p.

Abstract

Daun sawo duren (Chrysophyllum cainito L.) atau kenitu mengandung senyawa berupa alkaloid, fenol, sterol, triterpen dan flavonoid. Senyawa tersebut memiliki potensi sebagai sediaan antidiare. Penelitian ini bertujuan mengetahui efikasi antidiare infusa daun sawo duren dengan menggunakan metode proteksi intestinal dan mengetahui kandungan metabolit sekunder daun sawo duren menggunakan pemeriksaan fitokimia. Penelitian ini juga mencari konsentrasi sedian infusa daun sawo duren yang paling efektif sebagai antidiare pada mencit. Mencit jantan sebanyak 30 ekor dikelompokkan menjadi tiga kelompok yang terdiri atas dua kelompok kontrol yaitu kontrol positif berupa suspensi loperamide HCl dan kontrol negatif menggunakan Oleum ricini. Tiga kelompok perlakuan lainnya menggunakan infusa dengan konsentrasi bertingkat (25%, 50%, 100%). Data hasil penelitian antidiare diolah menggunakan aplikasi minitab-18 dengan metode uji one way ANOVA dan uji tukey. Hasil penelitian menunjukkan infusa daun sawo duren dengan konsentrasi 25%, 50%, dan 100% memiliki aktivitas antidiare.
Uji Toksisitas Akut Ekstrak Daun Ketepeng Cina (Cassia alata) pada Tikus (Rattus norvegicus) Ramadhan, Maharani Kartika; Fadholly, Amaq
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.%p

Abstract

The leaves of Cassia alata exhibit potential properties as antioxidants, immunostimulants, antimicrobials, anti-dengue agents, and laxatives. This study aimed to determine the LD50 value of the administration of Cassia alata leaves extract using the Thompson-Weil method. A total of 25 rats (Rattus norvegicus) were utilized in the study, divided into five dose groups. One group served as the control (P0), receiving only distilled water, while the four treatment groups were administered doses of 500 (P1), 1000 (P2), 1500 (P3), and 2000 (P4) mg/kg BW. Toxic symptoms and changes in body weight were observed for 14 days. The results showed that there was one death at a dose of 1500 mg/kg BW and two deaths at a dose of 2000 mg/kg BW. The administration of Cassia alata leaf extract resulted in toxic symptoms, including reduced motor activity, respiratory difficulties, and weight loss. The LD50 value obtained was 1.9 g/kg BW. The extract of Cassia alata leaves exhibit a toxic effect on rats.
A bioinformatics approach to design a novel epitope-based vaccine against Simian Immunodeficiency Virus (Retroviridae: Lentivirus) Dhea Kharisma, Viol; Ansori, Arif Nur Muhammad; Ullah, Md. Emdad; Dings, Tim Godefridus Antonius; Probojati, Rasyadan Taufiq; Fadholly, Amaq; Turista, Dora Dayu Rahma; Tacharina, Martia Rani; Zainul, Rahadian
Genbinesia Journal of Biology Vol. 2 No. 1 (2022): November 2022
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v2i1.26

Abstract

Simian Immunodeficiency Viruses (SIV) have been found to naturally infect African nonhuman primates (NHP). This causative agents are important and one of the special interest as the root cause of the HIV/AIDS pandemic, one of the most threatening infectious diseases worldwide. The aim of this study was to design an epitope-based vaccine using bioinformatics approaches of the circulating SIV in Kenya, Africa. In this study, we used 17 partial SIV envelope glycoprotein genes retrieved from GenBank® (National Center for Biotechnology Information, USA). We analysed the candidate epitopes using the Immune Epitope Database and Analysis Resource. Then, we performed the protective antigens prediction usingVaxiJen. Interestingly, this study revealed the data of B cell epitope prediction, protective antigens prediction, and molecular phylogenetic of circulating SIV in Kenya, Africa. In sum, this study can be used to design a novel epitope-based vaccine against SIV. We suggest further studies to conduct confirmatory experiments (in vitro and in vivo).
Sitotoksisitas Ekstrak Cabe Merah Keriting (Capsicum annum) Terhadap Hela Cell Lines Fadholly, Amaq
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.56-60.

Abstract

Kanker merupakan suatu penyakit sel yang ditandai dengan hilangnya fungsi kontrol sel terhadap regulasi daur sel maupun fungsi homeostatis sel pada organisme multiseluler. Penelitian ini bertujuan untuk menganalisis efek sitotoksik dan nilai IC50 dari esktrak Capsium annuum pada cell line HeLa sebagai salah satu sel uji untuk kanker serviks. Uji aktivitas sitotoksik ekstrak Capsicum annuum dilakukan dengan memberikan 5 seri konsentrasi bahan uji yaitu 50 μg/ml, 100 μg/ml, 200 μg/ml, dan 400 μg/ml pada HeLa cell lines yang kemudian diinkubasikan selama 24 jam. Penghitungan sel dilakukan setelah pemberian MTT dan SDS stopper. Persentase inhibisi yang dihasilkan dari masing-masing konsentrasi sampel uji secara berturut-turut adalah 17,98%, 23,88%, 32,64%, dan 45,62%. Ekstrak Capsicum annuum mempunyai nilai IC50 sebesar 1,098 μg/mL. Berdasarkan data dari National Cancer Institute nilai IC50 dari Capsicum annuum terhadap HeLa cell lines termasuk dalam kategori sitotoksisitas lemah. Sehingga dapat disimpulkan ekstrak Capsicum annuum tidak bersifat sitotoksik terhadap HeLa cell lines.
UJI TOKSISITAS AKUT EKSTRAK DAUN SENDOK (Plantago major) PADA MENCIT(Mus musculus) Fadholly, Amaq
VITEK : Bidang Kedokteran Hewan Vol. 15 No. 2 (2025): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/b932sg11

Abstract

The leaves of Plantago major possess potential mostly for antioxidant, immunostimulant, and laxative properties. The study is to examine the impact of Plantago major leaves extract administration on 25 mice to ascertain the LD50 value in the acute toxicity assessment. Twenty-five female mice were allocated into five groups according to normal control group, negative control group and the dosage of Plantago major leaves extract, with doses of 10, 15, and 20 g/kg body weight. Observations were conducted over a 14-day period, encompassing characteristics such as body weight, physiological responses, clinical symptoms, absolute and relative organ weights, and daily mortality counts. Mortality and clinical signs were examined for 14 days after the treatment. The administration of Plantago major leaves extract to mice did not significantly affect body weight, not absolute or relative organ weight. The collected organs exhibited no severe lesions. The LD50 value of Plantago major leaves extract was determined to be more than 20 g/kg BW. It is concluded that LD50 value is considered as relatively harmless.
Perbandingan Aktivitas Analgesik Ekstrak Daun Sirih Hijau dan Daun Sirih Merah serta Kombinasinya pada Mencit yang Diinduksi Asam Asetat Amaq Fadholly
Nusantara Journal of Multidisciplinary Science Vol. 3 No. 11 (2026): NJMS - Juni 2026
Publisher : PT. Inovasi Teknologi Komputer

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Nyeri merupakan respons fisiologis yang dapat menurunkan kualitas hidup sehingga diperlukan pengembangan analgesik berbahan alam yang lebih aman. Penelitian ini bertujuan mengevaluasi aktivitas analgesik ekstrak daun sirih hijau (Piper betle L.), daun sirih merah (Piper crocatum Ruiz & Pav.), dan kombinasinya pada mencit yang diinduksi asam asetat. Pengujian dilakukan menggunakan metode geliat dengan lima kelompok perlakuan, yaitu kontrol negatif, kontrol positif (ibuprofen), ekstrak daun sirih hijau, ekstrak daun sirih merah, dan kombinasi ekstrak. Jumlah geliat diamati selama 90 menit dan digunakan untuk menghitung persentase inhibisi analgesik. Hasil penelitian menunjukkan bahwa seluruh kelompok perlakuan mampu menurunkan jumlah geliat dibandingkan kontrol negatif. Persentase inhibisi analgesik pada kelompok ibuprofen, ekstrak daun sirih hijau, ekstrak daun sirih merah, dan kombinasi ekstrak berturut-turut sebesar 62,16%, 32,43%, 29,39%, dan 30,07%. Ekstrak daun sirih hijau menunjukkan aktivitas analgesik tertinggi di antara kelompok ekstrak yang diuji. Dapat disimpulkan bahwa ekstrak daun sirih hijau, daun sirih merah, dan kombinasinya memiliki aktivitas analgesik pada mencit yang diinduksi asam asetat, dengan ekstrak daun sirih hijau memberikan efek paling baik
Single supplementation of goat colostrum, probiotics, and prebiotics for diarrhea management in cats Dwi Budiono; Heryudianto Vibowo; Henny Endah Anggraeni; Anisa Rahma; Tekad Urip Pambudi Sujarnoko; Amaq Fadholly; Pradnya Calista; Hendri Zonathan; Kukuh Amru Dhiya Rahmat; Ivan Taufiq Nugraha
ARSHI Veterinary Letters Vol. 8 No. 3 (2024): ARSHI Veterinary Letters - August 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.3.61-62

Abstract

Diarrhoea in cats is a change in the condition of faeces from paste to liquid consistency caused by several factors, such as food changes and bacterial, viral, and parasitic infections. Handling diarrhoea in cats is performed immediately so that the symptoms subside. One effective prevention and control effort is the provision of colostrum-based supplements, probiotics and prebiotics. In a case of diarrhoea at the Depok Pet Center clinic, two cats aged 1.5 years (Ayu) and 5 years (Gentong) were given colostrum-based supplements, probiotics, and prebiotics. The initial symptoms of the Ayu cat were diarrhoea and liquid faeces, while the Gentong cat had decreased appetite, weakness, and paste-shaped faeces. Supplementation was carried out for two days. On day three, the condition of the faeces of both cats were solid and shaped, but some parts of the faeces were still mushy. On day six, the condition of the faeces of both cats was good, marked by being shaped and solid.
Renal Histopathology of White Rats Treated with Cassia alata Leaf Extract Amaq Fadholly; Nahla Fifi Azizah; Eva Harlina; Yumna Annisa Kurnia Budihardjo; Cyntia Rafi Adinugroho; Afifah Alawiyah Rahmah
Media Kedokteran Hewan Vol. 37 No. 3 (2026): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v37i3.2026.398-410

Abstract

Cassia alata is a medicinal plant widely used as a traditional laxative. Despite its therapeutic benefits, prolonged use may induce toxic effects, necessitating safety evaluation through subchronic toxicity studies. This study aimed to assess the effects of ethanolic C. alata leaf extract on renal histopathology in white rats (Rattus norvegicus). Thirty-six male and female Sprague-Dawley rats were allocated into six groups: negative control (NC), extract-treated groups receiving 100 (D1), 300 (D2), and 900 mg/kg BW (D3), satellite negative control (SNC), and high-dose satellite (SD3). The extract was administered orally for 28 days. Kidney tissues were collected and examined histopathologically using hematoxylin-eosin staining. Evaluated lesions included glomerular alterations (atrophy and edema) and tubular changes consisting of hydropic degeneration, proteinaceous casts, and necrosis. Statistical analysis revealed no significant differences in glomerular lesions among treatment groups (p>0.05). In contrast, cortical tubular hydropic degeneration and necrosis increased after extract treatment (p<0.05), particularly at the highest dose. No significant differences were observed between the 100 mg/kg BW group and the control group. These findings indicate that ethanolic C. alata leaf extract is relatively safe at 100 mg/kg BW under subchronic conditions but may induce dose-dependent renal tubular histopathological alterations at higher doses.
Uji Toksisitas Akut Kombinasi Infusa Bunga Rosella dan Daun Suji pada Mencit Betina Amaq Fadholly
Jurnal Veteriner dan Biomedis Vol. 4 No. 2 (2026): September
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.4.2.%p

Abstract

Bunga rosella (Hibiscus sabdariffa L.) dan daun suji (Dracaena angustifolia Roxb.) merupakan tanaman herbal yang banyak dimanfaatkan masyarakat sebagai bahan pangan dan pengobatan tradisional karena kandungan senyawa bioaktifnya yang berpotensi sebagai antioksidan dan antiinflamasi. Meskipun demikian, informasi mengenai keamanan penggunaan kombinasi kedua tanaman tersebut masih terbatas sehingga diperlukan pengujian toksisitas akut. Penelitian ini bertujuan mengevaluasi keamanan kombinasi infusa bunga rosella dan daun suji serta menentukan nilai Lethal Dose 50 (LD₅₀) pada mencit betina. Sebanyak 20 ekor mencit betina galur ddY dibagi menjadi lima kelompok. Kelompok kontrol diberikan akuades, sedangkan kelompok perlakuan diberikan kombinasi infusa dengan dosis 1, 5, 10, dan 15 g/kg BB secara peroral. Pengamatan dilakukan selama 14 hari meliputi mortalitas, gejala klinis, respons fisiologis, bobot badan, bobot organ, dan makroanatomi organ. Hasil penelitian menunjukkan tidak terdapat mortalitas maupun gejala klinis pada seluruh kelompok perlakuan hingga dosis tertinggi 15 g/kg BB. Analisis statistik menunjukkan tidak terdapat perbedaan nyata (p>0,05) pada bobot badan, frekuensi denyut jantung, frekuensi napas, suhu tubuh, serta bobot absolut dan relatif organ dibandingkan kelompok kontrol. Pengamatan makroanatomi menunjukkan seluruh organ memiliki kenampakan normal tanpa adanya perubahan patologis. Berdasarkan hasil tersebut, kombinasi infusa bunga rosella dan daun suji dikategorikan sebagai bahan yang praktis tidak toksik dengan nilai LD₅₀ lebih dari 15 g/kg BB.
Co-Authors Adi Sofyan Ansori, Muhammad Afifah Alawiyah Rahmah Andriyanto Andriyanto Anggraeni, Henny Endah Anisa Rahma Aulia Andi Mustika Aurellia, Sharon Cyntia Rafi Adinugroho Dhea Kharisma, Viol Diah Nugrahani Pristihadi Dings, Tim Godefridus Antonius Dwi Budiono Eva Harlina Fedik Abdul Rantam Firdaus, Munira Laeli Hanum, Nur Aisah Hendri Zonathan Heryudianto Vibowo Iryanto, Anetonia Felicia Istiqmal, Kahfi Aulia Ivan Taufiq Nugraha Kukuh Amru Dhiya Rahmat Kurniasih Lina Noviyanti Sutardi Nahla Fifi Azizah Pradnya Calista Purohita, Adwisto Saktika Putri, Imelya Andira Putri, Ramadita Aisyah Rahadian Zainul Ramadhan, Maharani Kartika Rasyadan Taufiq Probojati Sajidah, Halilah Wafa’ Saragih, Mariah Mada Rahma Nauli Srihadi Agungpriyono Tacharina, Martia Rani Tekad Urip Pambudi Sujarnoko Tri Untari Turista, Dora Dayu Rahma Ullah, Md. Emdad Yumna Annisa Kurnia Budihardjo