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Ayusari, Amelya Augusthina
Nutrition Department, Faculty Of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Dr. Moewardi Hospital Surakarta City, Indonesia Nutrition, Metabolism And Medicine Research Group
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Nexus Biomedika

 1 
Study on Antiinflammatory Effect of Ethanolic Extract of Ginger Leaves (Zingiber officinale) in Albino Rats (Rattus norvegicus) Riyanti, Gisti Respati; Ediningsih, Endang; Ayusari, Amelya Augusthina
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Inflammation is a local protective response which is potentially hazard. Ginger (Zingiber officinale) contains flavonoid which has anti-inflammatory effect. Existing research has used ginger rhizomes as its material, whereas flavonoid in ginger leaves is bigger than the rhizome. This research aimed to investigate the anti-inflammatory effect of ethanolic extract of ginger leaves in albino rats (Rattus norvegicus). Methods: This research was a laboratory experimental with posttest only controlled group design. This research was conducted at Setia Budi University. The subjects were 25 albino male rats ± 3 months old, weight ± 150 gr, which were taken by purposive sampling. The subjects were divided equally into 5 groups randomly, which negative control group (KN) were given normal saline and positive control (KP) were given indomethacin whereas test group 1 (KU1), test group 2 (KU2) and test group 3 (KU3), in order, were given 20 mg, 40 mg and 80 mg of ethanolic extract of ginger leaves per 100 gr of body weight orally. Inflammation induction was done by injection of 0.05 mlcarrageenan 1% of sub plantar. Rats’ foot edema volume was observed every hour for 6 hours after injection. Statistical analysis of the data was done including one way-Anova, Kruskal-Wallis and Mann Whitney test. Results: The greatest inhibition of edema volume was at the 6th hour, KP (74.07%), KU3 (74.07%), KU2 (66.67%) and KU1 (48.15%). The Kruskal-Wallis test showed significant differences among 5 groups with p=0.002 (p<0.05). The Mann-Whitney test showed p=0.068 for KP- KU1, p=0.429 for KP- KU2 and p=0.910 for KP-KU3. Conclusions: The ethanolic extract of ginger leaves has anti-inflammatory effect in albino rats equivalent to indomethacin on the sixth hour after carrageenan induction. Keywords: ginger leaves, Zingiber officinale, anti-inflammatory, carrageenan, albino rats  
The Diuretic Effect of Yellow Seeded-Watermelon (Citrullus lanatus) Extract in Male White Rats (Rattus norvegicus) Desiana, Dyah Tantry; Doewes, Muchsin; Ayusari, Amelya Augusthina
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Watermelon (Citrullus lanatus) contains flavonoid and pottasium that have diuretic effect. This research aimed to find out the diuretic effect of yellow seeded-watermelon extract on the male white rats (Rattus norvegicus). Methods: This research was a laboratory experimental study using Posttest Only Group Design, done at Laboratory of Setia Budi University Surakarta from November 2014 to January 2015. The research subjects were 30 male white rats of Wistar Strain with age of ± 3 months old and ± 200 grams in weight. Samples were taken by purposive sampling. Watermelon was gotten from Jurug Fruit Market Surakarta. Before the treatment, rats were adapted for 5 days and fasted for 18 hours but still provided with drinking water. Yellow seeded-watermelon extract was given orally. The negative control group (KN) was given distilled water 3 ml and the positive control group (KP) was given hydrochlorothiazide 0.3 mg/200 gr of body weight.Test group I (KUI), II (KUII) and III (KUIII), in order,were given yellow seeded-watermelon extract at dose 35 mg, 70 mg and 140 mg per 200 gr of body weight. Rat urine volume was measured every 4 hours for 16 hours. Data were analyzed by Kruskal-Wallis and Mann Whitney test. Results: The average of rat urine volume of KN, KP,KUI, KUII and KUIIIwere 1.247 ml, 5.987 ml, 2.315 ml, 3.357 ml and 4.570 ml, in order. The Mann Whitney test showed there were significant difference among KN, KP, KUI, KUII and KUIII at the first, second and third four hours. Conclusions: Yellow seeded-watermelon (Citrullus lanatus) extract has diuretic effect on the male white rats (Rattus norvegicus). The highest diuretic effect was at dose of 140 mg/200 gr of body weight. Keywords: Citrullus lanatus extract, diuretic effect, hydrochlorothiazide
The Diuretic Effect of Yellow Seeded-Watermelon (Citrullus lanatus) Extract in Male White Rats (Rattus norvegicus) Dyah Tantry Desiana; Muchsin Doewes; Amelya Augusthina Ayusari
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (50.24 KB)

Abstract

Background: Watermelon (Citrullus lanatus) contains flavonoid and pottasium that have diuretic effect. This research aimed to find out the diuretic effect of yellow seeded-watermelon extract on the male white rats (Rattus norvegicus). Methods: This research was a laboratory experimental study using Posttest Only Group Design, done at Laboratory of Setia Budi University Surakarta from November 2014 to January 2015. The research subjects were 30 male white rats of Wistar Strain with age of 3 months old and 200 grams in weight. Samples were taken by purposive sampling. Watermelon was gotten from Jurug Fruit Market Surakarta. Before the treatment, rats were adapted for 5 days and fasted for 18 hours but still provided with drinking water. Yellow seeded-watermelon extract was given orally. The negative control group (KN) was given distilled water 3 ml and the positive control group (KP) was given hydrochlorothiazide 0.3 mg/200 gr of body weight.Test group I (KUI), II (KUII) and III (KUIII), in order,were given yellow seeded-watermelon extract at dose 35 mg, 70 mg and 140 mg per 200 gr of body weight. Rat urine volume was measured every 4 hours for 16 hours. Data were analyzed by Kruskal-Wallis and Mann Whitney test. Results: The average of rat urine volume of KN, KP,KUI, KUII and KUIIIwere 1.247 ml, 5.987 ml, 2.315 ml, 3.357 ml and 4.570 ml, in order. The Mann Whitney test showed there were significant difference among KN, KP, KUI, KUII and KUIII at the first, second and third four hours. Conclusions: Yellow seeded-watermelon (Citrullus lanatus) extract has diuretic effect on the male white rats (Rattus norvegicus). The highest diuretic effect was at dose of 140 mg/200 gr of body weight. Keywords: Citrullus lanatus extract, diuretic effect, hydrochlorothiazide
Study on Antiinflammatory Effect of Ethanolic Extract of Ginger Leaves (Zingiber officinale) in Albino Rats (Rattus norvegicus) Gisti Respati Riyanti; Endang Ediningsih; Amelya Augusthina Ayusari
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Inflammation is a local protective response which is potentially hazard. Ginger (Zingiber officinale) contains flavonoid which has anti-inflammatory effect. Existing research has used ginger rhizomes as its material, whereas flavonoid in ginger leaves is bigger than the rhizome. This research aimed to investigate the anti-inflammatory effect of ethanolic extract of ginger leaves in albino rats (Rattus norvegicus). Methods: This research was a laboratory experimental with posttest only controlled group design. This research was conducted at Setia Budi University. The subjects were 25 albino male rats 3 months old, weight 150 gr, which were taken by purposive sampling. The subjects were divided equally into 5 groups randomly, which negative control group (KN) were given normal saline and positive control (KP) were given indomethacin whereas test group 1 (KU1), test group 2 (KU2) and test group 3 (KU3), in order, were given 20 mg, 40 mg and 80 mg of ethanolic extract of ginger leaves per 100 gr of body weight orally. Inflammation induction was done by injection of 0.05 mlcarrageenan 1% of sub plantar. Rats foot edema volume was observed every hour for 6 hours after injection. Statistical analysis of the data was done including one way-Anova, Kruskal-Wallis and Mann Whitney test. Results: The greatest inhibition of edema volume was at the 6th hour, KP (74.07%), KU3 (74.07%), KU2 (66.67%) and KU1 (48.15%). The Kruskal-Wallis test showed significant differences among 5 groups with p=0.002 (p<0.05). The Mann-Whitney test showed p=0.068 for KP- KU1, p=0.429 for KP- KU2 and p=0.910 for KP-KU3. Conclusions: The ethanolic extract of ginger leaves has anti-inflammatory effect in albino rats equivalent to indomethacin on the sixth hour after carrageenan induction. Keywords: ginger leaves, Zingiber officinale, anti-inflammatory, carrageenan, albino rats
Co-Authors ., Maryani ., Suyatmi Adigama Priamas Agatha Adika Putri, Claudia Ahadina Rahma Zulardi Ainal Fadly Alamanda Murasmita Alifah, Noor Alifiana Jatiningrum Amalina Shabrina Arifah, Umi Azizah, Shofura Bella Nadhifa Budiyanti Wiboworini Budiyanti Wiboworini Budiyanti Wiboworini Budiyanti Wiboworini Budiyanti Wiboworini Chofsoh Z, Anifa Coana Sukmagautama Desiana, Dyah Tantry Deyona Annisa Putri Dhia Ramadhani Diffah Hanim Doewes, Muchsin Dono Indarto DONO INDARTO Dwi Rahayu Dwi Rahayu Dwi Rahayu Dwi Rahayu Dyah Tantry Desiana Ediningsih, Endang Ediningsih, Endang Endang Dewi Lestari, Endang Dewi Endang Ediningsih Esha R, Andrini Fadly, Ainal Gisti Respati Riyanti Graciella Angelica Lucas Hanifah Fathimatuzzahrah Hanim, Diffah Hastami, Yunia Intaniar Intaniar Jatiningrum, Alifiana Joko Sudarsono Joko Sudarsono Joko Sudarsono Kisrini Kisrini Kisrini Kisrini Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Kusmadewi Eka Damayanti Latifah ., Latifah Lestari, Endang Dewi Lilik Wijayanti M. Yogi Riyantama Isjoni Maryani . Mashuri, Yusuf Ari Maulina, Rufidah Mila Ulfia Monica Fradisha Zukhri Muchsin Doewes Muhammad Daffa Ardiawan Murasmita, Alamanda Myrtha, Risalina Noviyati Rahardjo Putri Nur Aini, Ardelia Priamas, Adigama Purbaningrum, Ayunita Putri, Deyona Annisa R AJ Sri Wulandari Ramadhani, Dhia Ratna Kusumawati Ratna Kusumawati Risalina Myrtha Risalina Myrtha Risalina Myrtha Risalina Myrtha Riyanti, Gisti Respati Siti Nurhidayati Sukmagautama, Coana Sulistyani Kusumaningrum Suselo, Yuliana Heri Suselo, Yuliana Heri Sutartinah Sri Handayani Sutartinah Sri Handayani Sutartinah Sri Handayani Suyatmi . Ulfia, Mila Ulul Albab umi arifah, umi Widardo Widardo Widardo Widardo Widardo Widardo Widardo Widardo Widardo Widardo widardo, Widardo Wulandari, R AJ Sri Yulia Lanti Yulia Lanti Yulia Lanti Yulia Lanti Retno Dewi yulia lanti retno dewi Yuliana Heri Suselo Zukhri, Monica Fradisha Zulardi, Ahadina Rahma