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Identification of Bisphenol-A (BPA) in Polycarbonate (PC) Baby Bottles in Jayapura, Papua Barus, Andre Anusta; Appa, Felycitae Ekalaya; Bakri, Nur Fadilah; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman B.
Sebatik Vol. 29 No. 1 (2025): June 2025
Publisher : STMIK Widya Cipta Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46984/sebatik.v29i1.2570

Bisphenol-A (BPA) is found in various types of food packaging, such as plastic bottles, paper-based packaging, and the inner lining of canned foods. BPA is widely used in the production of polycarbonate (PC) plastics due to its strength and heat resistance. However, BPA can migrate into food or beverages through physical mechanisms, resulting from the diffusion of loosely bound BPA within the polymer matrix, or through chemical mechanisms triggered by hydrolysis reactions at high temperatures or extreme pH conditions. This study aims to evaluate the migration levels of BPA from polycarbonate (PC) packaging into water at various temperatures using UV-Vis spectrophotometry. The experiment was conducted by adding water into polycarbonate baby bottles at temperatures of 60–100°C, allowing it to sit for 30 minutes before analysis. The test results were compared with the safe BPA consumption limit set by the European Food Safety Authority (EFSA), which is 4 µg/kg body weight per day, as well as the BPOM standard, which establishes a BPA migration limit of 0.6 mg/kg per day. The results showed that BPA was not detected in water that had been in contact with polycarbonate baby bottles at the tested temperatures. Absorbance measurements indicated negative values, suggesting that the detected BPA levels were below the method's detection limit. This indicates that BPA migration is extremely low or undetectable, suggesting that its use under normal conditions can be considered safe.

Collagen Deposition Effect of Superoxide Dismutase Corn Kernel Extract (Zea mays L.) as Skin Photoaging Treatment Pratiwi, Mustika Endah; Barus, Andre Anusta; Boli Tobi, Claudius Hendraman
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21048

Intensive exposure to UV-A rays can develop photoaging in human skin. To aid this condition, several potential anti-photoaging mechanisms that have been investigated can be implemented, including collagen promotion. Collagen production in the skin has been studied promoted by an enzymatic antioxidant, superoxide dismutase (SOD). Here, we found out the collagen deposition effect from SOD crude extract of corn kernel in 3T3 fibroblast cells as alternative ingredients of anti-photoaging. Soluble protein content and SOD activity assay were executed first to prop up the main test. Collagen deposition effect was measured using staining method with picric acid solution. The result showed the highest Soluble protein and SOD activity was in 100% precipitation of corn kernel SOD extract (20.91 mg/ml and 65.50% respectively). The highest collagen deposition percentage obtained was 106.7% in 100 mg/ml corn kernel SOD extract. The collagen deposition percentage obtained was not significantly different from 2.5 mg/ml ascorbic acid. Based on viewing collagen condition under a microscope, there was an improvement in collagen, which was indicated by the interconnected collagen fibers when the extract and ascorbic acid were given. The research that has been conducted concludes that corn kernel SOD extract has anti-photoaging activity through collagen deposition effect.

Collagen Deposition Effect of Superoxide Dismutase Corn Kernel Extract (Zea mays L.) as Skin Photoaging Treatment Pratiwi, Mustika Endah; Barus, Andre Anusta; Boli Tobi, Claudius Hendraman
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21048

Intensive exposure to UV-A rays can develop photoaging in human skin. To aid this condition, several potential anti-photoaging mechanisms that have been investigated can be implemented, including collagen promotion. Collagen production in the skin has been studied promoted by an enzymatic antioxidant, superoxide dismutase (SOD). Here, we found out the collagen deposition effect from SOD crude extract of corn kernel in 3T3 fibroblast cells as alternative ingredients of anti-photoaging. Soluble protein content and SOD activity assay were executed first to prop up the main test. Collagen deposition effect was measured using staining method with picric acid solution. The result showed the highest Soluble protein and SOD activity was in 100% precipitation of corn kernel SOD extract (20.91 mg/ml and 65.50% respectively). The highest collagen deposition percentage obtained was 106.7% in 100 mg/ml corn kernel SOD extract. The collagen deposition percentage obtained was not significantly different from 2.5 mg/ml ascorbic acid. Based on viewing collagen condition under a microscope, there was an improvement in collagen, which was indicated by the interconnected collagen fibers when the extract and ascorbic acid were given. The research that has been conducted concludes that corn kernel SOD extract has anti-photoaging activity through collagen deposition effect.

Quantitative Analysis of Flavonoid Content, Total Phenolic and Toxicity Test of Extract Smilax rotundifolia Leaves From Papua Appa, Felycitae E.; Tobi, Claudius H.B.; Suprapti, Kevry; Bakri, Nur F.; Barus, Andre A.; Pratiwi, Mustika E.
Jurnal Biologi Papua Vol 17 No 1 (2025)
Publisher : Jurusan Biologi FMIPA Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jbp.4539

This study investigates Bungkus leaf (Smilax rotundifolia), a well-known plant in Papua commonly referred to as the three-finger leaf. Indigenous Papuans traditionally use this plant to enlarge genitals, buttocks, and breasts, as well as to treat syphilis. The plant is known to contain flavonoid and phenolic compounds with pharmacological activity. This study aimed to determine the total flavonoid and total phenolic content of the 70% ethanol extract of Bungkus leaf. The research began with simplicia preparation, followed by extraction using 70% ethanol. Qualitative tests, including phytochemical screening and thin-layer chromatography (TLC), were conducted, followed by quantitative analysis using UV-Vis spectrophotometry. The results showed total flavonoid content of 54.696 mg QE/g ± 0.565 and total phenolic content of 32.908 mg GAE/g ± 0.263. The study concluded that the total flavonoid content was higher than the total phenolic content. Toxicity testing categorized the extract as toxic, with an LC50 value of 442.92 ppm.

PENYULUHAN PEMANFAATAN OBAT BAHAN ALAM DAN PEMBUATAN LAHAN TOGA SEBAGAI UPAYA PROMOSI KESEHATAN PADA MASYARAKAT KAMPUNG YEWENA Tobi, Claudius Hendraman B.; Pratiwi, Mustika Endah; Rumanasen, David Waranda; Dimara, Makdalena Irpa; Hisyam, Muhammad; Sumardi, Sitti Rosnafian; Abraham, Abraham
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 8, No 2 (2025): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v8i2.57943

The “back to nature” trend has begun to increase along with public awareness of the health hazards caused by chemicals in food and medicines. The use of plants as medicine has been carried out by tribes in Papua for hundreds of years and continues to this day. This use needs to be accompanied by knowledge about the proper use of traditional medicine so that there are no adverse side effects that can endanger life. The purpose of writing this manuscript is to share information about the knowledge of the Yewena Village community, Depapre District, Jayapura Regency, about TOGA and its use. Community service activities were carried out through counseling and workshop methods. The number of participants in the activity was 29 people. The results of the counseling activity on the use of natural medicine and TOGA showed that the participants experienced an increase in knowledge after participating in the counseling, based on the percentage of correct answers to the pre-test and post-test questions, which increased from 37.24% to 98.69%. The workshop was carried out in the form of creating a TOGA demonstration area around the Yewena Village Hall. The Yewena Village community, as counseling participants, experienced an increase in knowledge about the use of natural medicine and TOGA after the counseling activity. It is hoped that writing about TOGA and its use will become more widespread and numerous so that more people will have the awareness and willingness to use natural medicines properly and correctly. Tren kembali ke alam (back to nature) mulai meningkat bersamaan dengan kesadaran masyarakat terhadap bahaya kesehatan yang diakibatkan oleh bahan kimia dalam makanan maupun obat-obatan. Pemanfaatan tanaman sebagai obat telah dilakukan oleh suku-suku di Papua sejak ratusan tahun lalu hingga kini. Pemanfaatan tersebut perlu dibarengi dengan pengetahuan mengenai penggunaan obat tradisional secara baik dan benar agar tidak terjadi efek samping yang merugikan yang dapat membahayakan jiwa. Penulisan naskah ini bertujuan untuk memberikan informasi mengenai bagaimana pengetahuan masyarakat Kampung Yewena, Distrik Depapre, Kabupaten Jayapura tentang TOGA dan pemanfaatannya. Kegiatan pengabdian dilakukan melalui metode penyuluhan dan workshop. Peserta kegiatan berjumlah 29 orang. Hasil kegiatan penyuluhan pemanfaatan obat bahan alam dan TOGA adalah peserta kegiatan mengalami peningkatan pengetahuan setelah mengikuti penyuluhan berdasarkan persentase jawaban benar pada pertanyaan pre-test dan post-test yaitu dari 37.24% menjadi 98.69%. Workshop yang dilakukan berupa pembuatan lahan percontohan TOGA di sekitar balai Kampung Yewena. Masyarakat Kampung Yewena sebagai peserta penyuluhan mengalami peningkatan pengetahuan mengenai pemanfaatan obat bahan alam dan TOGA setelah kegiatan penyuluhan. Diharapkan penulisan mengenai TOGA dan pemanfaatannya lebih luas dan banyak lagi sehingga semakin banyak masyarakat yang memiliki kesadaran dan kemauan untuk menggunakan obat bahan alam secara baik dan benar.

Skrinning Fitokimia dan Uji Sitotoksik Ekstrak Etanol Daun Diwoka (Piper macropiper Pennant) asal Wamena, Papua: Phytochemical Screening and Citotoxic Assay of Diwoka Leaves (Piper macropiper Pennant) Ethanolic Extract from Wamena, Papua Tabuni, Frengchy Jalsan Charles; Tobi, Claudius Hendraman Boli; Dirgantara, Septriyanto; Pratiwi, Mustika Endah; Rumanasen, David Waranda; Appa, Felycitae Ekalaya; Barus, Andre Anusta
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2532

Many plant species in Indonesia have not been identified and their utilities have not been studied. One of the traditional medicinal plants from Papua whose potential as a drug ingredient has not been widely explored is Diwoka (Piper macropiper Pennant). The study of bioactive compounds includes phytochemical and pharmacological approaches that begin with toxicity studies. This study aimed to determine the compounds contained in the ethanol extract of Diwoka leaves and its safety. The phytochemical screening method used was the reagent method and the cytotoxic test method used was the Brine Shrimp Lethality Test (BSLT). The results of the study showed that the ethanol extract of Diwoka leaves contains alkaloids, flavonoids, saponins, tannins and terpenoids. The cytotoxic test of the ethanol extract of Diwoka leaves on shrimp larvae showed a cytotoxicity potential included in the “toxic” category (LC50 = 79.33 ppm). This study is a preliminary study that shows that the ethanol extract of Diwoka leaves has secondary metabolite compounds that have the potential to have pharmacological activity and can be developed as natural medicine. Keywords: BSLT, Diwoka, Papua, Piper macropiper Pennant., Cytotoxic Abstrak Banyak spesies tanaman di Indonesia yang belum teridentifikasi dan diteliti manfaatnya. Salah satu tumbuhan obat tradisional asal Papua yang belum banyak dieksplorasi potensinya sebagai bahan obat adalah Diwoka (Piper macropiper Pennant). Studi senyawa bioaktif mencakup pendekatan fitokimia dan farmakologis yang diawali dengan studi toksisitas. Penelitian ini bertujuan untuk mengetahui senyawa terkandung dalam ekstrak etanol daun Diwoka serta keamanannya. Metode skrining fitokimia yang digunakan adalah metode reagen dan metode uji sitotoksik yang digunakan adalah Brine Shrimp Lethality Test (BSLT). Hasil penelitian menunjukkan bahwa ekstrak etanol daun Diwoka mengandung golongan senyawa alkaloid, flavonoid, saponin, tanin dan terpenoid. Uji sitotoksik ekstrak etanol daun Diwoka terhadap larva udang menunjukkan potensi sitotoksik dalam kategori “toksik” (LC50 = 79.33 ppm). Penelitian ini merupakan penelitian pendahuluan yang menunjukkan hasil bahwa ekstrak etanol daun Diwoka memiliki senyawa metabolit sekunder yang berpotensi memiliki aktivitas farmakologi dan dapat dikembangkan sebagai obat bahan alam. Kata Kunci: BSLT, Diwoka, Papua, Piper macropiper Pennant., Sitotoksik

Formulasi Sabun Herbal Transparan dari Ekstrak Terpurifikasi Daun Beluntas (Pluchea indica L.) untuk Mengatasi Bakteri Penyebab Bau Badan Hasan, Tessa Ayuni; Tobi, Claudius Hendraman B.; Pratiwi, Mustika Endah
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.664

Salah satu aspek kebersihan diri yang harus diperhatikan adalah bau badan. Bau badan berasal dari kombinasi antara keringat dan bakteri di bagian-bagian tertentu pada tubuh. Salah satu cara untuk menghilangkan bau badan yaitu dengan membersihkan diri menggunakan sabun. Formulasi sabun untuk mengatasi bau badan dapat menggunakan ekstrak dari tanaman yang memiliki aktivitas antibakteri, salah satunya daun beluntas (Pluchea indica L.). Penelitian ini bertujuan untuk memformulasikan ekstrak terpurifikasi daun beluntas ke dalam sediaan sabun herbal transparan sebagai sabun antibakteri. Penelitian ini dimulai dari ekstraksi dan purifikasi daun beluntas, kemudian dilanjutkan dengan pembuatan sabun herbal transparan menggunakan ekstrak terpurifikasi daun beluntas dengan konsentrasi 0.312% (FI), 0.625% (FII) dan 1.25% (FIII), pengujian mutu fisik sabun herbal transparan ekstrak terpurifikasi daun beluntas dengan parameter pH, stabilitas busa, kadar air dan kekerasan sabun serta pengujian aktivitas antibakteri sabun herbal transparan menggunakan metode dilusi padat. Hasil penelitian menunjukkan bahwa ekstrak terpurifikasi daun beluntas dapat diformulasikan ke dalam sabun herbal transparan dan memiliki mutu fisik yang memenuhi standar sabun padat. Ketiga formula sabun herbal transparan ekstrak terpurfikasi daun beluntas memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Sabun herbal transparan ekstrak terpurifikasi daun beluntas berpotensi menjadi sabun herbal untuk mencegah dan mengatasi bau badan.

Edukasi Perencanaan Menu Berdasarkan Prinsip Gizi Seimbang bagi Lansia dengan Hipertensi di Panti Bina Lanjut Usia Pos 7 Sentani Bre Boli, Elisabet; Afelya, Titi; Astuti, Dwi; Pratiwi, Mustika Endah; Tobi, Claudius Hendraman B.
ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 2 (2023): ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat
Publisher : UPT Publikasi dan Penerbitan Universitas San Pedro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59632/abdiunisap.v1i2.169

Kebutuhan gizi lansia akan meningkat sejalan dengan peningkatan kejadian sakit, seperti hipertensi. Hipertensi pada lansia membutuhkan lebih banyak perhatian, terutama dalam hal asupan gizi sehari-hari. Panti Bina Lanjut Usia Pos 7 sebagai institusi bagi lansia masih menerapkan prinsip 4 sehat 5 sempurna dalam perencanaan menu. Penting dilakukan perbaikan perencanaan menu gizi seimbang bagi lansia dengan hipertensi. Kegiatan ini bertujuan agar peserta mampu menyusun menu gizi seimbang bagi lansia dengan hipertensi di Panti Bina Lansia Pos 7 Sentani. Metode kegiatan adalah edukasi face to face dan diskusi, serta praktik penyusunan menu. Sasaran kegiatan adalah . Kegiatan akan dilaksanakan dalam 4 tahapan, yaitu advokasi terhadap pihak Panti Bina Lansia Pos 7 Sentani, survei ketersediaan pangan, penerapan perencanaan menu, dan monitoring serta evaluasi. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan dan keterampilan menyusun menu gizi seimbang para penjamah makanan di Panti Bina Lansia Pos 7 melalui pemberian edukasi. Penjamah makanan Panti Bina Lansia Pos 7 menyusun menu bergizi seimbang selama 3 hari yang terdiri dari makanan-makanan lokal. Meskipun demikian, keberadaan ahli gizi perlu untuk terus memantau perencanaan gizi seimbang yang tepat bagi seluruh lansia dan masalah kesehatan yang dialaminya.

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