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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Dentika Dental Journal Althea Medical Journal Global Medical and Health Communication Journal of Medicine and Health Medika Kartika : Jurnal Kedokteran dan Kesehatan Majalah Biomorfologi (Biomorphology Journal) An Idea Health Journal Journal of Medicine and Health
Andri Rezano
Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Ethanol Extract of Pomegranate Peel (Punica Granatum) in Inhibiting HeLa Cell Proliferation Latifah Rahman Nurfazriah; Diah Dhianawaty; Andri Rezano; Ludovicus Edwinanto
An Idea Health Journal Vol 4 No 01 (2024)
Publisher : PT.Mantaya Idea Batara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53690/ihj.v4i01.445

Abstract

Cervical cancer is one of the causes of death in women in Indonesia. Many studies have been conducted to determine the anti-cancer effects of natural ingredients. Pomegranate peel contains ellagic acid which has anti-cancer effects. In this study, the anti-cancer activity of pomegranate peel was examined against HeLa cell lines. Pomegranate peel was obtained from Malang, East Java, extracted using 70% ethanol. Cell viability and IC50 values were examined using the MTT test after incubation for 24, 48, and 72 hours. The percentage of living cells was calculated using a hemocytometer using Trypan Blue staining. DNA fragmentation was examined using electrophoresis as a marker of apoptosis activation. The IC50 value in pomegranate peel extract was at a concentration of 450 µg/ml. The results of the percentage of viability cells using hemocytomete at an IC50 concentration of 52%. Smears in DNA fragmentation examination were seen in samples incubated for 24 hours, indicating apoptosis activation. Pomegranate peel extract has anticancer activity against HeLa cell lines, with a mechanism involving apoptosis. This potential indicates that pomegranate peel extract can be further developed as a natural anticancer agent
Co-Authors Achadiyani Afrida Aizzatun Istiqomah Agustinus Agustinus Almira Zada Ananda Hanifah Husna Ardella Tri Novianti Asep Wiryasa Bambang Purwanto Cennikon Pakpahan Chen En Pan Chrestella Odillia Christian Christopher Sunnu Dahlan, Mohamad Rinaldi Darsini, Ninik Diah Dhianawaty Diah Dhianawaty Diah Dhianawaty Edwinanto, Ludovicus Endry Septiadi Eni Maria Sisca Erlangga Ing Geni Bisma Pratama Hansen Wangsa Herman Herry Herman Hesti Lina Wiraswati I'tishom, Reny Irma Ruslina I’tishom, Reny Jefry Albari Tribowo Juanarta, Pieter Kiki A. Rizki Latifah Rahman Nurfazriah Latifah Rahman Nurfazriah Liana Awalia Lutfunnisa Ludovicus Edwinanto Maharani Simanjuntak Maitra Djiang Wen Maitra Djiang Wen Marhendra Satria Utama Maulida Hayati Melia Juwita Adha Mohamad Rinaldi Dahlan Monica Risnadena Priyas Moniq W. Aryantie Nabila Alifia Ahmad Nadiyah Nadiyah Nur Agustina Ningsih Nurfazriah, Latifah Rahman Nurul Mufliha Patahuddin Pieter Juanarta Pitaloka, Pritha Praditya Virza Ramadhan Qhonita Anif Febian Ramadhan, Praditya Virza Ria Margiana Ria Margiana Rina Puspasari Herdiawan Riyadi Adrizain Riyadi Adrizain Rizqy D. Monica Savira Ekawardhani Siti Silvia Nur Shofa Shamantri Sudigdo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Supardi Supardi Supardi Supardi Susiana, Okta Margarita Syamsul Arifin Tiara Kirana Tono Djuwantono Tri Hartini Yuliawati Vellyana Lie Veronica Oladitha Siagian Vita Murniati Tarawan Vitriana Vitriana Widya Juwita Windi Nurdiawan Wiryawan Permadi Wiryawan Permadi Yenni Zuhairini Yosefa Resti Radinda