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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Riset Kefarmasian Indonesia HERBAPHARMA : Journal of Herb Farmacological JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Pharmaceutical Education Jurnal EduHealth Jurnal Ilmiah Farmasi Simplisia Natural: Jurnal Pelaksanaan Pengabdian Bergerak Bersama Masyarakat Jurnal Pharma Bhakta
Sony Andika Saputra
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Pharmaceutical Education

 1 
Uji Aktifitas Antioksidan, flavonoid Total dan Formulasi Sediaan Krim Ekstrak Bangle (Zingiber cassumunar) Lailiyah, Munifatul; Andika Saputra, Sony; Aryantini, Dyah
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28181

Abstract

Bangle rhizome (Zingiber cassumunar) is a plant with essential oil, flavonoid, and curcumin content which is efficacious as a traditional medicine and has antioxidant activity. The purpose of this study was to determine the antioxidant activity and test the total flavonoid content contained in the rhizome extract (Zingiber cassumunar) using UV-Vis spectrophotometry. Then a cream preparation was made and tested for physical quality including, organoleptic, homogeneity, pH, adhesive power, and spreadability. The extraction method uses the maceration method of bangle rhizomes (Zingiber cassumunar) using an alcohol solvent until a thick extract is obtained, then a quantitative test is carried out for the content of total flavonoid compounds in the form of determining total flavonoid levels and free radical scavenging activity using the DPPH method. The results showed that the bangle rhizome extract (Zingiber cassumunar) had a yield value of 26.25%. The extract of bangle rhizome (Zingiber cassumunar) has a total flavonoid value of 86.7±0.4 mg QE/g extract, which means it contains high flavonoid compounds and has an IC50 value of 48.29±7.9 (µg/mL) with a powerful category. The physical quality test of the three formulations meets the criteria for physical quality test requirements. The total flavonoid compound content value in the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 86.7 mg QE / g extract which means it contains high flavonoid compounds. The IC50 value of the 96% ethanol extract of bangle rhizome (Zingiber cassumunar) is 48.29µg/mL which means it has extreme free radical scavenging activity. Formulations, 1, 2, and 3 meet the physical quality test.
Efektivitas Serum Anti Acne dari Limbah Kulit Durian (Durio Zibethinus Murr.) dengan Pengujian Berbagai Bakteri Saputra, Sony Andika; Lailiyah, Munifatul; Mu'arofah, Binti
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28254

Abstract

Durian skin waste contains flavonoid compounds, triterpenoid tannins and alkaloids which have anti-bacterial activity that causes acne. This research aims to determine the characteristics of the anti-acne serum preparation formula from durian (Durio Zibethinus Murr) skin waste, the anti-bacterial activity and the stability of the preparation. The research method was preceded by making simplicia powder for the inner skin, which was then extracted using the maceration method with 96% ethanol solvent. The extract obtained was used as a preparation formula with concentrations of 5, 10 and 15%. The serum preparations obtained were evaluated for physical quality, tested for antibacterial activity and product stability during storage as well as freeze and thaw tests. The organoleptic results showed that the higher the concentration of the extract in the brown preparation, the homogeneity test showed that the serum was homogeneous. The pH test before and freeze and thaw test was found to be 5.45-5.87 and the pH was 5.20-5.74. The spreadability test before and after the freeze and thaw test was 8.15-8.88 cm and 7.78-8.4 cm. The anti-bacterial test showed that at a concentration of 15% in the serum preparation formulation the results were the same as the positive control with the MIC (MIC) value. Minimum Barrier) with P.acne, Staphylococcus aureus, Pseudomonas bacteria with barrier values of 18 mm, 18 and 15 mm. Based on the research results, it can be concluded that the durian skin extract serum preparation has good quality characteristics and has activity against acne-causing bacteria.
Co-Authors Anang Setyo Wiyono Anggraeta Ayu Fernanda Arya Ulilalbab Azkiy Syifa’ Istighfarin Dia, Cynthia Ayu Dian Sri Lestrasi Dyah Aryantini, Dyah Eka Desy Karismawati Eko Yudha Prasetyo Erfan Tri Prasongko Erivina, Adella Erna Rahmawati Esti Ambar Widyaningrum Evi Kurniawati, Evi Fita Sari, Fita Galuh Sitatorik Herlinda Mawardika Ida Kristianingsih Indra Fauzi Sabban ISMIY NOER WAHYUNI KRISNA KHARISMA PERTIWI Lailiyah, Munifatul Lestari, Tri Puji Mu'arofah, Binti Munifatul Lailiyah Nelli Nafidatul Isfanah Rahmaningrum, Puji Laili Restuaji, Ibnu Muhariawan Shoviantari, M.Farm., Apt., Fenita Sugiyartono, Sugiyartono