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All Journal Jurnal Veteriner Indonesia Medicus Veterinus Jurnal Ilmu Ternak International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Ilmiah Teknik Elektro Komputer dan Informatika (JITEKI) Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Perikanan dan Kelautan Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal Creative Research Journal Majalah Farmasetika Jurnal Kedokteran Hewan Jurnal Agripet
Mas Rizky A.A. Syamsunarno
Fakultas Kedokteran Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Global Medical and Health Communication

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Effect of Moringa Leave Ethanol Extract on Accelerating Wound Healing Process Jaya, Fidi Bhawana; Syamsunarno, Mas Rizky Anggun Adipurna; Sahiratmadja, Edhyana; Sulistiyorini, Ifa
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.11620

Abstract

TGF-β and VEGF are vital in cell proliferation and regeneration, as evidenced in processes like wound healing. The leaves of Moringa oleifera Lam exhibit anti-inflammatory and cell regenerative properties that may facilitate the transition from the inflammatory to the proliferative phase, enhancing wound repair. This research sought to discern the potential of orally administered moringa leaf extract in augmenting systemic wound healing, focusing on TGF-β and VEGF serum as in vivo molecular markers. This research was conducted at the Animal Laboratory of the Faculty of Medicine, Universitas Padjadjaran, and the Laboratory of Molecular Genetics, Universitas Padjadjaran, from January to March 2022. We divided thirty Swiss Webster mice into two categories: healthy and wound-treated. Wounded mice received 100 mg/kgBW Na CMC as a negative control, 500 mg/kgBW zinc syrup as a positive control, and M. oleifera leaves ethanol extract (MOLE) in doses of 280 and 560 mg/kgBW orally from day 3 to day 6. Wound progression was documented and measured on days 0, -1, -3, and -6. Day-6 blood samples were obtained, and TGF-β and VEGF serum levels were gauged using ELISA. Results from day 6 revealed that wound coverage in the 280 and 560 mg/kgBW MOLE groups was 13.76±5% and 13.38±4%, respectively. These percentages notably surpassed that of the negative control group (p=0.005). However, the TGF-β and VEGF serum levels in the MOLE-treated groups did not differ significantly from the negative control (p=0.081 and p=0.149, respectively). Thus, the study concludes that while MOLE expedites wound closure, it does so without the systemic involvement of TGF-β and VEGF in vivo.
Co-Authors Ahmad Kurniawan Aida Riyanti Alia, Fenty Alif Bagus Rakhimullah Alkaustariyah Lubis Alkaustariyah Lubis Alkaustariyah Lubis Alvin Yusuf Anisah Dahlan Arief Boediono Ariefqi, Muhammad Naufal Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Deru Indika Deru R Indika Dinar F. Agustin Djunaedi, Diah Dhianawaty Dwi Cipto Budinuryanto Dwi Wahyudha Wira Edhyana Sahiratmadja Erick Khristian Fauziah, Nisa Gita Widya Pradini Grace Angelica Hanna Goenawan Henhen Heryaman Husneni Mukhtar Irma M. Puspitasari Irma Melyani Puspitasari Isa Mahendra Iwan Setiawan Jaqueline Sudiman Jaya, Fidi Bhawana Jeri Nobia Purnama Julia Windi Gunadi Julius Pangayoman Kikin Winangun Kikin Winangun Lubis, Alkaustariyah Madeline Priscilla Maratul Mahdiyyah Masahiko Kurabayasi Mohammad Ghozali Mohammad Ghozali, Mohammad Muhammad Nurhalim Shahib Muhammad Rosyid Ridhlo Neni Anggraeni Nia Kania Norisca A. Putriana Norisca Aliza Putriana Nova Sylviana Ramdan Panigoro Rangga Setiawan Rangga Setiawan Ratu Safitri Ratu Safitri Ridhlo, Muhammad Rosyid Rikho Melga Shalim Rini Widyastuti Ronny Lesmana Roro Wahyudianingsih Rosdianto, Aziiz Mardanarian Sigit Prastowo Sigit PRASTOWO Sony Heru Sumarsono Sony Heru Sumarsono SONY HERU SUMARSONO Sony Heru Sumarsono Sudiman, Jaqueline Sulistiyorini, Ifa Syah Putra, Heru TAKDIR SAILI Tatsuya Iso Tyagita Hartady Tyagita Tyagita Unang Supratman Uni Gamayani Winangun, Kikin Yulin Prisdiany Yuni Susanti Pratiwi Yusuf, Alvin