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All Journal Jurnal Analis Farmasi Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Duta Pharma Journal Jurnal Kesehatan Amanah Proceeding of International Conference Health, Science And Technology (ICOHETECH) Indonesian Research Journal on Education Eduvest - Journal of Universal Studies Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Akademik Pengabdian Masyarakat Journal of Innovative and Creativity Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Padamu Negeri Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bagas Ardiyantoro
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Journal : International Journal of Health, Engineering and Technology

 1 
Effectiveness Of Cucumber Extract (Cucumis Sativus) In Reducing Cholesterol Levels In Mice (Mus Musculus) Induced By Hypercholesterolemia Haikal Zanki; Bagas Ardiyantoro; Tatiana Siska Wardani
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Hypercholesterolemia is a global health problem and a major cause of cardiovascular disease. This study aims to explore the potential, determine the optimal dose, and identify the active compounds of cucumber (Cucumis sativus) ethanol extract as a cholesterol-lowering agent. Using a quantitative approach with a pure experimental method, a pre-test and post-test control group research design was applied in vivo to 25 mice (Mus musculus) divided into five treatment groups. The main instruments used included the Easy Touch cholesterol checker, and the data were analyzed using the One-Way ANOVA test. The results showed that cucumber extract had a significant effect in lowering cholesterol levels, with the effect increasing with dose. A dose of 700 mg/kgBW resulted in an average reduction of 49.51%, which was close to the effectiveness of simvastatin (54.05%). In conclusion, cucumber ethanol extract is a potential natural cholesterol-lowering agent, with a dose of 700 mg/kgBW being the most optimal dose that provides an effect almost comparable to that of standard drugs.
Comparison Of Flavonoid Content And Α-Amylase Inhibition Activity Of Ethanol Extracts From Compound Garlic (Allium Sativum L), Black Garlic, And Single Garlic Dwi Nurul Khotimah; Danang Raharjo; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin metabolism, and it remains one of the leading global health problems. One promising therapeutic strategy for diabetes management is the inhibition of digestive enzymes such as α-amylase, which plays a role in carbohydrate breakdown. Flavonoids, as natural bioactive compounds found in plants, have been reported to act as effective enzyme inhibitors. This study aims to compare the flavonoid content and α-amylase enzyme inhibitory activity of ethanol extracts from compound garlic (Allium sativum L.), black garlic, and single garlic. The extraction process was carried out using maceration with 96% ethanol solvent, followed by flavonoid content determination using UV-Vis spectrophotometry, while α-amylase inhibitory activity was tested using the Fuwa method. The results demonstrated that black garlic extract contained the highest flavonoid concentration, reaching 48.874 mg QE/g, compared to single garlic (40.561 mg QE/g) and compound garlic (35.943 mg QE/g). In addition, black garlic exhibited the strongest α-amylase inhibitory activity with the lowest IC₅₀ value of 32.390 ppm, indicating a higher potency compared to the other garlic extracts. These findings suggest that the fermentation process in black garlic enhances its flavonoid profile and bioactivity. Therefore, black garlic has significant potential as a natural antidiabetic agent and could be further explored as a functional food ingredient or herbal therapy for diabetes prevention and management.
Testing the Tonic Effect of Gotu Kola (Centella asiatica) Extract on Male White Mice (Mus musculus) Using the Rotarod Method Wiwin Novitasari; Anita Dwi Septiarini; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

A tonic is a substance or mixture of substances that can strengthen the body or increase a person's energy. The tonic effect is caused by stimulation of the central nervous system (CNS). The herb gotu kola (Centella Asiatica) is a natural substance that contains bioactive compounds such as terpenoids, which play a role in producing the tonic effect. This study aims to analyze the ability of gotu kola herb extract (Centella asiatica) to provide a tonic effect on male white mice (Mus Musculus) and to determine the optimal dose of gotu kola herb extract (Centella Asiatica) to provide an optimal tonic effect. This study used the Rotarod test with treatment groups, each consisting of 5 test animals given Na-CMC 0.5% as a negative control, caffeine 100mg/kgBW as a positive control, and Centella asiatica herb extract suspension at varying doses, namely 50mg/kgBW as a low dose treatment, 100 mg/kgBW as a medium dose treatment, and 150 mg/kgBW as a high dose treatment. Statistical test results showed a significant increase in the time mice remained on the rotarod in all dose treatments compared to the negative control and no treatment. The 150 mg/kgBW dose provided a tonic effect closest to that of caffeine. Phytochemical testing showed that gotu kola herb contains terpenoids, which are thought to play a role in its tonic activity. Thus, gotu kola herb extract has the potential to be developed as a natural tonic alternative.
Comparison of Antioxidant Activity Tests Using the DPPH, ABTS, and FRAP Methods on Ethanol Extracts of Cherry Leaves (Muntingia calabura L.) and Total Flavonoids Alya Atla Lidya; Anna Fitriawati; Bagas Ardiyantoro
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

This study investigates the antioxidant activity of ethanol extracts of Muntingia calabura L. leaves using DPPH, ABTS, and FRAP methods. The background emphasizes increasing environmental pollution and free radical-induced oxidative stress, which contribute to degenerative diseases and aging. The research aims to compare the sensitivity and effectiveness of these three assays in evaluating the antioxidant potential of cherry leaves and to quantify their total flavonoid content. The study employs a comparative descriptive design with samples collected from Sukoharjo, Indonesia. Instruments used include spectrophotometers, rotary evaporators, and standard reagents. Data analysis involves IC50 calculation and statistical comparison of the methods. Results show that the ethanol extract exhibited high antioxidant activity with IC50 values below 50 μg/mL across all methods, with the highest sensitivity observed in the FRAP assay. The total flavonoid content was approximately 47.2 mgQE/g. The conclusion indicates that Muntingia calabura leaves possess potent antioxidant activity and high phenolic compounds, supporting their potential as natural antioxidant sources. Future research should explore different extraction techniques and in vivo assessments.
Memory Activity Test Of Ethanol Extract Of Oil Palm Leaves (Elaeis Guineensis Jacq.) On White Mice (Mus Musculus) With Radial Arm Maze Method Nadia; Bagas Ardiyantoro; Septian Maulid Wicahyo
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.607

Abstract

Memory loss is a cognitive disorder in which oxidative stress is one of the main contributing factors. Palm leaves oil (Elaeis guineensis Jacq.) contains flavonoids and antioxidants that are believed to improve memory. This study aims to determine whether oil palm leaf extract can improve memory activity in mice and determine the most effective dosage. This study was a pure experimental study with 25 mice divided into five groups, namely negative control (CMC Na 1%), positive control (Ginkgo biloba), and treatment groups with ethanol extracts of oil palm leaves at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. The mice were induced with 10% alcohol and then given treatment for 7 days. Memory activity was tested using the Radial Arm Maze method, with parameters measured including latency time and error rate. The data obtained were then analyzed using SPSS, including normality and homogeneity tests, Anova, and followed by the Tukey test. The results showed that doses of palm leaf extract (Elaeis guineensis jacq.) of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW had an effect on the memory of mice. The effective dose for improving memory in the T1-T2 latency time difference was 200 mg/kgBW and 300 mg/kgBW with a P value > 0.05, which was not significantly different from the positive control, and the T1-T2 error rate difference was 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW, with a P value > 0.05, showing no significant difference from the positive controls. This proves that oil palm leaf extract can enhance memory activity in mice.
Co-Authors Abdul Wahab Sabrina, Azimah Alya Atla Lidya Anita Dwi Septiarini Anita dwi setiarini Anna Fitriawati apriliyanti, laela intan arniwati mat daud, Noor Danang Raharjo Dwi Nurul Khotimah Dwi S, Anita Fachry Abda El Rahman Fadila, Vera Nurhidayatul Fika Riyanti Fitriana, Mona Haikal Zanki Hery Widijanto Intan Oktaviani Iqbal Sirajudin Maulidinawan Jayak Pratama, Kharisma Karim Karim, Karim Listyani, Tiara Ajeng Lutfiyanti, Niken Luthfiyanti, Niken Merari P, Ason Meyliawati, Ika Muhamad Farid Nurohman Krisnadi Nadia Nafiah, Azidatun Netty Dea Sosiantini Ningrum, Della Puspita Permata, Bangkit Riska Putri, Anisa Fadilah Kumala Putri, Fera Adila Rahmad Adji, Alenda Rahmat Hidayat Rahmat Hidayat Rahmatillah, Annie Retno Kurnia Dewi Rohmana, Vivin Marwiyati Salsabila Khoerunniyssa Sari, Silvia Mega Kusuma Septian Maulid Wicahyo Siwi Hastuti Sugeng Santoso Suharjaya, Feby Nuranawati Tasya Aurelia Thoha Irfan Darojat Triana Triana uswatun hasanah, alfiana Wali Jati, Ilham Wardani, Tatiana Siska Wiwin Novitasari