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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Indonesian Journal of Pharmaceutical Science and Technology Prosiding Seminar Biologi INDONESIAN JOURNAL OF PHARMACY Journal of Medicine and Health Journal of Dentomaxillofacial Science Argipa (Arsip gizi dan Pangan) ARSHI Veterinary Letters Jurnal Ilmu dan Teknologi Kayu Tropis Pharmacoscript JURNAL KAJIAN VETERINER Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Journal of Medicine and Health
Vetnizah Juniantito
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

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Journal : Pharmacoscript

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IN SILICO STUDY OF APIGENIN AND ITS DERIVATIVES AS POTENTIAL INHIBITORS OF TNF-Α AND MMP-9 FOR BURN WOUND HEALING Baharun, Rasyid; Rini Madyastuti, Purwono; Bayu Febram, Prasetyo; Vetnizah, Juniantito
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.2062

Abstract

The prevalence of burns ranks fourth in trauma after traffic accidents, falls, and violence. The prevalence of burns ranks fourth in trauma after traffic accidents, falls, and violence. The healing of burn wounds results from a complex inflammatory response where pro-inflammatory cytokines, for instance, TNF-α and MMP-9, play a pivotal role. Flavonoids with strong anti-inflammatory activity are apigenin, this compound comes from plants. In this study, we evaluated apigenin and its derivatives to determine their effectiveness as burn wound healing agents using molecular docking modeling techniques. To evaluate the molecular docking of these compounds with their target proteins, we used computer-aided drug design tools such as AutoDock Vina, PyMOL, and Discovery Studio. The data showed that apigenin compounds have better affinity than natural ligands to inhibit MMP-9 which can increase the rate of the inflammatory phase of burn wound healing. These findings indicate that apigenin and its derivatives have good potential to be candidates in the development of new therapeutic interventions for burn wound healing.
Co-Authors . Jumari Abdullah Baharun Agatha Grace Agus Setiyono Agus Setyono Aisyah Aisyah Akhmad Endang Zainal Hasan Alfina Zalfa Suryono Ali Khomsan Andrea Laurentius Annisa Rahmi Antonius Anre Sianturi Armando Balses Ishimora Azizah, Hanifah Nur Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Cesilia M Dwiriani D R Agungpriyono Deded Sarip Nawawi Dewi R Agungpriyono Dondhin Sajuthi Dondin Sajuthi Dwi Rofifah Putri Jania Endang Syamsudin Eva Harlina Evy Ayu Arida Evy Damayanthi Fajar Rezandaru Femmi Dwinda Agustini Fivi Melva Diana, Fivi Melva Gregorius Bhaskara Wikanendra I Nyoman Jaya Wistara IETJE WIENTARSIH Iis Ismawati Indra Hadikrishna Itje Wintarsih Kusmardi Kusmardi L N Sutardi Madyastuti, Rini Makhroja, Lalu Faris Naufal Miranti Fardesiana Putri Mohamad Sadikin Mokhamad Fahrudin Monica Septiani Nafrialdi Nafrialdi Ni Wayan Kurniani Karja Nina Herlina Nopen Meisaroh Nugraha, Arifin Budiman Nur Indrawaty Lipoeto Putri Ramadhanty Rafida Nisa Maghfiroh Rahayu WoroWiranti Ranady Perwira Nuruzzaman Rimbawan , Rita Kartika Sari Safitri, Debby Endayani Sajuthi, Dondhin Sharon Aurellia Silmi Hanifah Siti Magfiroh Soni Siswanto Sri Estuningsih Sri Wahyuni Salam Sri Widia A Jusman Subangkit, Mawar Sugeng, Santoso Syahruddin Said Titta Novianti Tsulatsy Puspitasari Purnamiharja Umi Cahyaningsih Vici Eko Handayani Wahono Esthi Prasetyaningtyas Wawaimuli Arozal Wawaimuli Arozal Wawaimuli Arozal Yenny Rakhmawati