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All Journal JBIO: jurnal biosains (the journal of biosciences) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Wahana Pendidikan JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional JUKEJ: Jurnal Kesehatan Jompa
Pratama, Kharisma Jayak
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANTIHYPERGLYCEMIC ACTIVITY, IMPROVING ENZIMATIC ANTIOXIDANT ACTIVITY OF ETHYL ACETATE FRACTION FROM KERSEN LEAVES (Muntingia calabura) ON INDUCED STREPTOZOTOSIN-NICOTINAMIDE RAT Wicahyo, Septian Maulid; Pratama, Kharisma Jayak
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v4i1.3811

Abstract

Balance blood glucose concentration and antioxidant activity are keys to prevent Diabetes Melitus and its complications. Kersen leaves (Muntingia calabura) a plant that have empirical usage for reducing glucose blood that can do both. Purposes of this study were for observing ethyl acetate fraction from kersen leaves effects in reducing blood glucose, improving enzim antioxidant SOD and GPx activity, reducing MDA concentration and β cell regeneration. Forty two Wistar male white rats of 8 weeks with weight 150-250 g were made diabetes with streptozotosin-nicotinamide and randomly divided into 7 groups. Group I as normal rats, group II diabetic rats, group III diabetic with glibenclamid treatment, group IV and V diabetic rat treated by ethil acetate fraction 250 dan 350 mg/kg BW respectively. treatment had done orally once a day within 18 days. Blood glucose was measured on the 1st, 4th, 11th and 18th day. Ethyl acetate fractions significantly decreased blood glucose concentration, improved SOD and GPx activity, reduced MDA concentration and regenerated pancreatic β-cell also occured. In conclusion, ethyl acetate fraction have antihyperglycemic activity, ameliorates enzimatic antioxidant activity and can induce β cell regeneration.
Evaluation of Quality of Life in Breast Cancer Patients: A Cross-Sectional Comparative Study between Targeted Therapy and Conventional Chemotherapy Pratama, Kharisma Jayak; Luthfiyanti, Niken
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404453

Abstract

Breast cancer is one of the most common cancers worldwide, with treatment often involving conventional therapies such as chemotherapy. Although effective, chemotherapy is often accompanied by significant side effects and reduces patients' quality of life. Targeted therapy, which targets specific molecular mechanisms in cancer cells, offers the potential to address these issues with higher efficacy and fewer side effects. This study aims to compare the quality of life of breast cancer patients receiving targeted therapy with chemotherapy. The study design used a comparative cross-sectional design involving 60 patients (30 receiving targeted therapy, 30 receiving chemotherapy) selected via consecutive sampling at RSUD Moewardi in Surakarta (January–June 2025). Data were collected using the validated Indonesian version of the EORTC QLQ-C30 questionnaire. Statistical analysis included parametric t-tests and non-parametric Mann-Whitney U tests. The study results showed that the targeted therapy group had better role functioning (p = 0.047.95% CI=0.044-0.053) and significantly lower pain (p= 0.001.95% CI=0.000-0.002) and nausea (p = 0.019.95% CI=0.016-0.021) symptoms compared to chemotherapy. Global health status did not differ significantly (p= 0.545.95% CI=0.536-0.556). Age (p = 0.012.95% CI=0.08-0.012) and stadium (p = 0.001.95% CI=0.001-0.003) significantly influenced global QoL. Targeted therapy provided advantages in functional aspects and specific symptoms, although not in global QoL. A key study limitation is its cross-sectional design, which prevents the establishment of causal relationships between the type of therapy and quality of life outcomes.
PROFIL PENGOBATAN KANKER PAYUDARA RSUD DR. MOEWARDI SURAKARTA TAHUN 2019-2024 Ningsih, Putri Harum Satia; Pratama, Kharisma Jayak; Apriliawan, Hidayah
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.56106

Abstract

Kanker payudara adalah pertumbuhan sel yang berubah menjadi tumor ganas pada jaringan kelenjar susu, saluran kelenjar susu, dan jaringan penunjang payudara. Faktor risiko yang menyebabkan timbulnya kanker payudara di antaranya faktor keturunan dari keluarga yaitu ibu yang sebelumnya mengalami kanker payudara, riwayat terpapar radiasi berlebih guna pengobatan di area dada, menggunakan alat kontrasepsi dan terapi hormonal, usia menstruasi dan menopause yang lebih awal dari pada wanita umumnya. Penelitian ini menggunakan desain retrospektif dengan 100 sampel pasien kanker payudara. Pengumpulan data diperoleh melalui data yang diambil dari rekam medis yang didapatkan dari RSUD Dr. Moewardi Surakarta. Pengambilan sampel dilakuakan dengan  purpose sampling berdasarkan kriteria inkulsi dan eksklusi. Hasil pengukuran pasien kanker payudara paling banyak dengan grade 3 sebesar72%,  memiliki ukuran tumor 2-5cm sebesar 43% dan 6-10cm sebesar 41%. Jenis terapi paling banyak digunakan yaitu kemoterapi dengan persentase 85% dengan jenis obat kombinasi paclitaxel dan epirubicin sebesar 36%. Kemoterapi diberikan untuk memperlambat pertumbuhan dan membunuh sel kanker, selain itu grading juga akan mempengaruhi agresivitas tumor dan respon terhadap pengobatan. Dari hasil pengukuran ukuran tumor dan grading yang didominasi dengan hasil yang tinggi, maka sebagian besar pasien kanker payudara.
HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA Alifia, Neha Azziza Cherrysha; Pratama, Kharisma Jayak; Fitriawati, Anna
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2035

Abstract

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.
Co-Authors Akbar, Finica Dwi Alifia, Neha Azziza Cherrysha Andhika, Intan Fatna Anisawati, Amanda Anna Fitriawati Apriliawan, Hidayah Ardi Setyawan Artini, Kusumaningtyas Siwi Azizah, Indah Wafiq Azka, Nihlatin Cahyani, Esti Tri Danang Raharjo Hafalika, Aviv Hendra, Naufal Dhuha Indahsari, Rosi Nur Khasanah, Isna Nur Kusumaningrum, Indah Mega Listyani, Tiara Ajeng Luthfiyanti, Niken Monica Ningsih, Putri Harum Satia NOVIANA NURUL HIDAYAH Oktaviani, Rita Permata, Bangkit Riska Permatasari, Desy Ayu Irma Rahmatillah, Annie Rohmana, Vivin Marwiyati Safitri, Ayu Dwi Saputri, Dina Tika Septian Maulid Wicahyo Septiarini, Anita Dwi Sudarsih, Dyah Ayu Suwardi, Nisa Aura Rizky Wardani, Tatiana Siska Wijayanti, Sovie Nofia Yuliana, Irma