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All Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Kedokteran dan Kesehatan Prima Nusantara Scientific Medical Research Journal Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Skrining Resep untuk Identifikasi Interaksi Obat pada Pasien Diabetes Melitus dan Hiperurisemia Periode Oktober 2023 hingga Maret 2024 di Rumah Sakit Advent Surbekti , Destiana Tata; Sembiring, Novitaria Br; Lubis, Asyrun Alkhairi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.894

Abstract

Background: Diabetes mellitus (DM) and hyperuricemia are frequently encountered comorbidities in clinical practice with increasing prevalence. Long-term pharmacological therapy for these conditions carries the potential for drug interactions and other drug-related problems. Prescription completeness evaluation and drug interaction identification are necessary to ensure therapeutic safety and efficacy. Objectives: This study aimed to identify medications prescribed for patients with DM and hyperuricemia, evaluate potential drug interactions, and assess prescription completeness based on administrative standards according to Indonesian Ministry of Health Regulation No. 72 of 2016. Methods: This retrospective descriptive study with a cross-sectional design analyzed 50 outpatient prescriptions at Advent Hospital Medan from October 2023 to March 2024. The analysis covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using Drugs.com with classification as major, moderate, and minor. Results: The most frequently prescribed antidiabetic drugs were metformin (82%), glimepiride (76%), and acarbose (64%), while for hyperuricemia they were allopurinol (88%) and meloxicam (72%). Ten drug interactions were identified, consisting of 8 moderate (80%), 1 major (10%), and 1 minor (10%). Administrative evaluation showed 92% completeness for mandatory components, but patient weight (48%), physician address (64%), and physician phone number (56%) were frequently omitted. Conclusion: The study revealed a significant prevalence of moderate drug interactions between antidiabetic drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Optimization of prescription screening systems and completion of patient clinical data are required to enhance therapy safety.
Relationship Between the Level of Knowledge and Medication Adherence Level in Diabetes Mellitus Patients in Advent Medan Hospital Amazihono, Keytrin; Erida Novriani; Lubis, Asyrun Alkhairi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.102

Abstract

Hyperglycemia or elevated blood sugar levels due to decreased pancreatic insulin productin, is a sign of a metabolic disorder that leads to diabetes mellitus (DM). One crucial factor in managing diabetes mellitus is the patient’s knowledge and adherence to treatment. Patients with adequate knowledge are more likely to comply with therapy, which helps control the disease. This study aims to determine the relationship between the level of knowledge and the level of medication adherence in diabetes mellitus patients in Advent Hospital Medan. This research employed a quantitative approach with a cross-sectional design and a purposive sampling technique. The research involved 90 patients who were selected and agreed to participate as respondents. Data were collected using a validated Diabetes Knowledge Questionnaire (DKQ-24) and Medication Adherence Report Scale (MARS-5). Data analysis was conducted using a non-parametric statistical test, specifically the Chi-Square test. The study found that the majority of patients had a high level of knowledge (48,9%) but were non-adherent to medication (56,7%). The Chi-Square test showed a significance of 0.001 < 0.05, indicating a significant relationship between the level of knowledge and medication adherence among diabetes mellitus patients at Advent Medan Hospital.
Efek Nefroptotektif Ekstak Etanol Bawang Putih (Allium sativum L.) Pada Tikus Yang Diinduksi Rifampicin Fadira, Nurazra; Lubis , Asyrun Alkhairi; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1020

Abstract

Background: Drug-induced nephrotoxicity, particularly caused by rifampicin—a first-line antituberculosis drug is a significant contributor to acute kidney dysfunction. The search for effective and safe nephroprotective agents to mitigate this side effect is crucial, and garlic (Allium sativum L.), with its potent antioxidant content, has emerged as a promising candidate. Objective: To evaluate the nephroprotective effect of ethanol extract of garlic (EEG) in male white rats (Rattus norvegicus) induced with rifampicin, based on serum creatinine levels, relative kidney weight, and histopathological findings. Methods: An in vivo experimental study was conducted on 25 rats randomly divided into five groups: (GI) normal control (distilled water); (GII) negative control (rifampicin 100 mg/kg BW, intraperitoneal); and three treatment groups (GIII, GIV, GV) receiving rifampicin 100 mg/kg BW and EEG at doses of 50, 120, and 300 mg/kg BW orally. Treatments were administered for 10 days. The measured parameters were serum creatinine levels, relative kidney weight, and histopathological damage scores (degeneration, necrosis, inflammatory cell infiltration). Results: Rifampicin induction (GII) significantly increased serum creatinine levels (1.28 ± 0.79 mg/dL) compared to the normal control (0.57 ± 0.05 mg/dL) (p<0.001). Administration of EEG at doses of 50, 120, and 300 mg/kg BW significantly reduced creatinine levels (0.53 ± 0.05; 0.51 ± 0.18; 0.51 ± 0.04 mg/dL, respectively). The relative kidney weight was highest in GII (1.6%), whereas treatment groups showed values close to normal. Histopathological analysis revealed the highest damage score in GII (score 2; 25–50%), while treatment groups, particularly the 300 mg/kg BW dose, showed the mildest damage (score 1; 5–25%). Conclusion: Ethanol extract of garlic exerts nephroprotective effects against rifampicin-induced kidney damage in rats, as evidenced by reduced serum creatinine levels, improvement in relative kidney weight, and amelioration of histopathological structures. These protective effects were dose-dependent, with the 300 mg/kg BW dose showing the most optimal outcome.
Efek Nefroprotektif Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) Terhadap Gambaran Histopatologi Ginjal Tikus (Rattus norvegicus) Yang Diinduksi oleh Etilen Glikol Anselia , Bella; Lubis , Asyrun Alkhairi; Sembiring, Novitaria Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1021

Abstract

Background: The kidney is a vital organ susceptible to damage from exposure to nephrotoxic compounds such as ethylene glycol. Red ginger (Zingiber officinale var. rubrum) is known to contain bioactive compounds with antioxidant and anti-inflammatory potential that may protect the kidney from injury. However, its effectiveness as a nephroprotective agent needs to be scientifically validated. Objective: To evaluate the nephroprotective effect of ethanol extract of red ginger against ethylene glycol–induced kidney damage in male white rats (Rattus norvegicus), Wistar strain. Methods: An experimental study using a post-test only control group design was conducted to minimize bias by ensuring equivalent baseline conditions among groups. A total of 25 rats were divided into five groups: normal control (distilled water), negative control (0.75% ethylene glycol), and three treatment groups (ethylene glycol + red ginger extract at doses of 100, 200, and 300 mg/kgBW/day). Parameters measured included serum creatinine levels and kidney histopathology. Data were analyzed using one-way ANOVA (p < 0.05) followed by LSD post hoc test. Results: Red ginger extract significantly reduced serum creatinine levels (p < 0.05), with the greatest reduction observed at a dose of 300 mg/kgBW (0.528 ± 0.082 mg/dL). Histopathological improvement of the kidney was also evident, indicated by decreased necrosis, cellular degeneration, and inflammatory cell infiltration. The kidney damage score in the treatment groups (score 1) was lower than in the negative control group (score 2). Conclusion: Ethanol extract of red ginger exhibits a nephroprotective effect against ethylene glycol–induced kidney injury, with the optimal dose being 300 mg/kgBW/day. These findings support the potential of red ginger as an alternative therapy for kidney disorders, although further studies are needed to elucidate the molecular mechanisms and conduct clinical trials.
Uji Efektivitas Ekstra Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp) Terhadap Profil Histologi Pankreas Tikus Putih Jantan (Rattus Norvegicus) Diabetes Melitus Gerhart Frengki Hardian Harefa; Erida Novriani; Asyrun Alkhairi Lubis
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3339

Abstract

ABSTRACT Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or function, which can damage organs, including the pancreas. Natural treatment alternatives are needded because conventional drugs cause side effects. Bay leaf, also known as Syzygium polyanthum (Wight) Walp, contains bioactive compounds like flavonoids, tannins, and saponins that have potential to fight diabetes and protect pancreatic tissue. The aim of this study is to determine the effect of bay leaf extract on the histology of the pancreas in diabetic rats and to identify the optimal dose to reduce pancreatic tissue damage. This study used 25 male Rattus norvegicus rats and was conducted experimentally with a pretest-posttest control group design. The rats were divided into 6 groups: normal control, negative control (NaCMC), positive control (metformin), and three treatment groups given bay leaf extract at doses of 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. For 15 days, the extract was administered orally, and blood glucose was measured; therefore, bay leaf extract can be used as an alternative to improve pancreatic damage caused by diabetes.
Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Abstract

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Effectiveness test of avocado seeds on the renal histopathology of white rats induced by isoniazid Lubis, Khairunnisya; Lubis, Asyrun Alkhairi; Sembiring, Novitaria Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7692

Abstract

The kidneys are a pair of organs within the urinary system, located in the upper retroperitoneal cavity, functioning in blood filtration, reabsorption, and secretion through diffusion processes involved in blood purification and urine formation. The kidneys are highly susceptible to damage from exposure to nephrotoxic drugs, one of which is isoniazid. Avocado seeds (Persea americana Mill.) are known to contain antioxidant compounds with potential protective effects against renal tissue damage. This study aimed to examine the effect of avocado seed extract on the histopathological changes in the kidneys of white rats induced with isoniazid. The research employed an experimental design using 25 male rats divided into five groups: positive control (K+), negative control (K–), and three treatment groups receiving avocado seed extract at doses of 100 mg/kg body weight (P1), 200 mg/kg body weight (P2), and 400 mg/kg body weight (P3). Isoniazid induction was administered to all groups except the positive control. After a 14-day treatment period, kidney samples were collected for histopathological analysis using hematoxylin-eosin (HE) staining. The observations indicated that avocado seed extract effectively improved renal histological structure in white rats (Rattus norvegicus) induced with isoniazid. In the treatment group III, renal histological improvement was observed, with only 5–25% structural damage or a score of 1, compared to groups I and II, which showed 25–50% damage or a score of 2.
Uji Efek Nefroprotektif Ekstrak Buah Kersen (Muntingia calabura) terhadap Kadar Blood Urea Nitrogen (BUN), Albumin, dan Ureum pada Tikus Putih yang Diinduksi Gentamisin Juliana Hasan; Asyrun Alkhairi Lubis; Edy Fachrial
Jurnal Ilmu Kesehatan dan Gizi Vol. 4 No. 3 (2026): Juli: Jurnal Ilmu Kesehatan dan Gizi
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jig.v4i3.9341

Abstract

The antibiotic gentamicin has the potential to harm the kidneys by raising levels of oxidative stress, which in turn affects serum albumin and Blood Urea Nitrogen (BUN). Some of the antioxidant and nephroprotective properties found in cherry fruit (Muntingia calabura L.) include flavonoids, phenols, saponins, alkaloids, and triterpenoids. In this research, the purpose was to examine the impact of an ethanolic cherry fruit extract on the levels of albumin and BUN in male Wistar rats that had been treated with gentamicin. Thirty white rats were split into five groups for this experimental investigation. For 8 days, the normal group did not receive any therapy, the induction group took 100 mg/kgBW of gentamicin, and the treatment groups took 100, 200, or 400 mg/kgBW of cherry fruit extract orally in addition to the gentamicin induction. We used enzymatic techniques with UV-Vis spectrophotometry to assess the levels of BUN and albumin. A decrease in kidney function, as shown by changes in albumin and BUN levels, was seen after gentamicin therapy. When compared to the gentamicin group, the kidney function of the cherry fruit extract group was shown to be somewhat improved at dosages of 100, 200, and 400 mg/kgBW. There were no statistically significant changes in albumin or BUN levels brought about by the extract, according to the study.  Finally, although cherry fruit (Muntingia calabura L.) ethanolic extract showed promise in describing its effects on kidney function maintenance, it has failed to establish statistically significant efficacy as a nephroprotective drug.
Co-Authors Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Anselia , Bella Anzelita, Ayu Astriani Natalia Br Ginting Br Ginting, Anissa Destryana Br Pinem, Elys Dayanty Edy Fachrial Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Indhira Justine Ginting Jefri Naldi Juliana Hasan Kristina Agatah Sidabutar Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring Pricella Ginting Rahimi, Armon Reh Malem br Karo Rien Sapitri Br Sihaloho Rizkya Adinda Nasution Roy Indrianto Bangar S Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Siti Nurkholifah Surbekti , Destiana Tata Tiara Salsabila Tiara Salsabilla Mendrofa Yunus , Muhammad