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All Journal Jambura Journal of Health Sciences and Research JURNAL FARMASIMED (JFM) PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Kedokteran dan Kesehatan Prima Nusantara Scientific Medical Research Journal Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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TINGKAT PENGETAHUAN DAN SIKAP MAHASISWA FARMASI UNPRI TERHADAP PENGGUNAAN OBAT DIABETES MELITUS TIPE 2 Amelia, Ade; Ginting, Astriani Natalia Br; Meutia, Rena; Lubis, Asyrun Alkhairi
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.44811

Abstract

Diabetes melitus (DM) adalah suatu kondisi kronis yang terjadi ketika pankreas tidak dapat lagi memproduksi insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Penyakit DM diklasifikasi menjadi beberapa bagian, termasuk DM tipe 2 yang umum terjadi pada usia dewasa dan dapat dipicu oleh obesitas dan faktor keturunan serta berisiko menyebabkan komplikasi jika tidak dikendalikan. Mahasiswa farmasi berperan dalam edukasi dan pelayanan kesehatan, sehingga tingkat pengetahuan dan sikap mahasiswa farmasi terhadap penggunaan obat DM tipe 2 sangat penting. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan sikap mahasiswa farmasi UNPRI terhadap penggunaan obat DM tipe 2 guna mendukung pengelolaan penyakit secara efektif. Penelitian ini dilakukan di Universitas Prima Indonesia menggunakan desain penelitian deskriptif dengan teknik pengambilan data yaitu data primer yang dikumpulkan menggunakan kuesioner yang dibagikan kepada mahasiswa farmasi UNPRI. Data dianalisis secara univariat menggunakan aplikasi spss versi 27. Terdapat total 100 responden yang termasuk dalam penelitian ini. Didapatkan sebagian besar responden merupakan perempuan dan berusia 17-19 tahun. Berdasarkan tingkat pengetahuan mahasiswa kategori Baik 88 orang (88.0%), kategori Cukup Baik 7 orang (7.0%), dan kategori Kurang Baik 5 orang (5.0%) dan tingkat sikap mahasiswa kategori Baik berjumlah 44 orang (44.0%), kategori Cukup Baik 50 orang (50.0%), dan kategori Kurang Baik berjumlah 6 orang (6.0%). Berdasarkan hasil penelitian ini dapat disimpulkan bahwa tingkat pengetahuan dan sikap mahasiswa farmasi UNPRI tentang penggunaan obat diabetes melitus tipe 2 sebagian besar baik, namun sikap mereka cenderung cukup baik. 
Skrining Resep untuk Identifikasi Interaksi Obat pada Pasien Diabetes Melitus dan Hiperurisemia Periode Oktober 2023 hingga Maret 2024 di Rumah Sakit Advent Surbekti , Destiana Tata; Sembiring, Novitaria Br; Lubis, Asyrun Alkhairi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.894

Abstract

Background: Diabetes mellitus (DM) and hyperuricemia are frequently encountered comorbidities in clinical practice with increasing prevalence. Long-term pharmacological therapy for these conditions carries the potential for drug interactions and other drug-related problems. Prescription completeness evaluation and drug interaction identification are necessary to ensure therapeutic safety and efficacy. Objectives: This study aimed to identify medications prescribed for patients with DM and hyperuricemia, evaluate potential drug interactions, and assess prescription completeness based on administrative standards according to Indonesian Ministry of Health Regulation No. 72 of 2016. Methods: This retrospective descriptive study with a cross-sectional design analyzed 50 outpatient prescriptions at Advent Hospital Medan from October 2023 to March 2024. The analysis covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using Drugs.com with classification as major, moderate, and minor. Results: The most frequently prescribed antidiabetic drugs were metformin (82%), glimepiride (76%), and acarbose (64%), while for hyperuricemia they were allopurinol (88%) and meloxicam (72%). Ten drug interactions were identified, consisting of 8 moderate (80%), 1 major (10%), and 1 minor (10%). Administrative evaluation showed 92% completeness for mandatory components, but patient weight (48%), physician address (64%), and physician phone number (56%) were frequently omitted. Conclusion: The study revealed a significant prevalence of moderate drug interactions between antidiabetic drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Optimization of prescription screening systems and completion of patient clinical data are required to enhance therapy safety.
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Relationship Between the Level of Knowledge and Medication Adherence Level in Diabetes Mellitus Patients in Advent Medan Hospital Amazihono, Keytrin; Erida Novriani; Lubis, Asyrun Alkhairi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.102

Abstract

Hyperglycemia or elevated blood sugar levels due to decreased pancreatic insulin productin, is a sign of a metabolic disorder that leads to diabetes mellitus (DM). One crucial factor in managing diabetes mellitus is the patient’s knowledge and adherence to treatment. Patients with adequate knowledge are more likely to comply with therapy, which helps control the disease. This study aims to determine the relationship between the level of knowledge and the level of medication adherence in diabetes mellitus patients in Advent Hospital Medan. This research employed a quantitative approach with a cross-sectional design and a purposive sampling technique. The research involved 90 patients who were selected and agreed to participate as respondents. Data were collected using a validated Diabetes Knowledge Questionnaire (DKQ-24) and Medication Adherence Report Scale (MARS-5). Data analysis was conducted using a non-parametric statistical test, specifically the Chi-Square test. The study found that the majority of patients had a high level of knowledge (48,9%) but were non-adherent to medication (56,7%). The Chi-Square test showed a significance of 0.001 < 0.05, indicating a significant relationship between the level of knowledge and medication adherence among diabetes mellitus patients at Advent Medan Hospital.
Efek Nefroptotektif Ekstak Etanol Bawang Putih (Allium sativum L.) Pada Tikus Yang Diinduksi Rifampicin Fadira, Nurazra; Lubis , Asyrun Alkhairi; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1020

Abstract

Background: Drug-induced nephrotoxicity, particularly caused by rifampicin—a first-line antituberculosis drug is a significant contributor to acute kidney dysfunction. The search for effective and safe nephroprotective agents to mitigate this side effect is crucial, and garlic (Allium sativum L.), with its potent antioxidant content, has emerged as a promising candidate. Objective: To evaluate the nephroprotective effect of ethanol extract of garlic (EEG) in male white rats (Rattus norvegicus) induced with rifampicin, based on serum creatinine levels, relative kidney weight, and histopathological findings. Methods: An in vivo experimental study was conducted on 25 rats randomly divided into five groups: (GI) normal control (distilled water); (GII) negative control (rifampicin 100 mg/kg BW, intraperitoneal); and three treatment groups (GIII, GIV, GV) receiving rifampicin 100 mg/kg BW and EEG at doses of 50, 120, and 300 mg/kg BW orally. Treatments were administered for 10 days. The measured parameters were serum creatinine levels, relative kidney weight, and histopathological damage scores (degeneration, necrosis, inflammatory cell infiltration). Results: Rifampicin induction (GII) significantly increased serum creatinine levels (1.28 ± 0.79 mg/dL) compared to the normal control (0.57 ± 0.05 mg/dL) (p<0.001). Administration of EEG at doses of 50, 120, and 300 mg/kg BW significantly reduced creatinine levels (0.53 ± 0.05; 0.51 ± 0.18; 0.51 ± 0.04 mg/dL, respectively). The relative kidney weight was highest in GII (1.6%), whereas treatment groups showed values close to normal. Histopathological analysis revealed the highest damage score in GII (score 2; 25–50%), while treatment groups, particularly the 300 mg/kg BW dose, showed the mildest damage (score 1; 5–25%). Conclusion: Ethanol extract of garlic exerts nephroprotective effects against rifampicin-induced kidney damage in rats, as evidenced by reduced serum creatinine levels, improvement in relative kidney weight, and amelioration of histopathological structures. These protective effects were dose-dependent, with the 300 mg/kg BW dose showing the most optimal outcome.
Efek Nefroprotektif Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) Terhadap Gambaran Histopatologi Ginjal Tikus (Rattus norvegicus) Yang Diinduksi oleh Etilen Glikol Anselia , Bella; Lubis , Asyrun Alkhairi; Sembiring, Novitaria Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1021

Abstract

Background: The kidney is a vital organ susceptible to damage from exposure to nephrotoxic compounds such as ethylene glycol. Red ginger (Zingiber officinale var. rubrum) is known to contain bioactive compounds with antioxidant and anti-inflammatory potential that may protect the kidney from injury. However, its effectiveness as a nephroprotective agent needs to be scientifically validated. Objective: To evaluate the nephroprotective effect of ethanol extract of red ginger against ethylene glycol–induced kidney damage in male white rats (Rattus norvegicus), Wistar strain. Methods: An experimental study using a post-test only control group design was conducted to minimize bias by ensuring equivalent baseline conditions among groups. A total of 25 rats were divided into five groups: normal control (distilled water), negative control (0.75% ethylene glycol), and three treatment groups (ethylene glycol + red ginger extract at doses of 100, 200, and 300 mg/kgBW/day). Parameters measured included serum creatinine levels and kidney histopathology. Data were analyzed using one-way ANOVA (p < 0.05) followed by LSD post hoc test. Results: Red ginger extract significantly reduced serum creatinine levels (p < 0.05), with the greatest reduction observed at a dose of 300 mg/kgBW (0.528 ± 0.082 mg/dL). Histopathological improvement of the kidney was also evident, indicated by decreased necrosis, cellular degeneration, and inflammatory cell infiltration. The kidney damage score in the treatment groups (score 1) was lower than in the negative control group (score 2). Conclusion: Ethanol extract of red ginger exhibits a nephroprotective effect against ethylene glycol–induced kidney injury, with the optimal dose being 300 mg/kgBW/day. These findings support the potential of red ginger as an alternative therapy for kidney disorders, although further studies are needed to elucidate the molecular mechanisms and conduct clinical trials.
Uji Efektivitas Ekstra Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp) Terhadap Profil Histologi Pankreas Tikus Putih Jantan (Rattus Norvegicus) Diabetes Melitus Gerhart Frengki Hardian Harefa; Erida Novriani; Asyrun Alkhairi Lubis
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3339

Abstract

ABSTRACT Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or function, which can damage organs, including the pancreas. Natural treatment alternatives are needded because conventional drugs cause side effects. Bay leaf, also known as Syzygium polyanthum (Wight) Walp, contains bioactive compounds like flavonoids, tannins, and saponins that have potential to fight diabetes and protect pancreatic tissue. The aim of this study is to determine the effect of bay leaf extract on the histology of the pancreas in diabetic rats and to identify the optimal dose to reduce pancreatic tissue damage. This study used 25 male Rattus norvegicus rats and was conducted experimentally with a pretest-posttest control group design. The rats were divided into 6 groups: normal control, negative control (NaCMC), positive control (metformin), and three treatment groups given bay leaf extract at doses of 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. For 15 days, the extract was administered orally, and blood glucose was measured; therefore, bay leaf extract can be used as an alternative to improve pancreatic damage caused by diabetes.
Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Abstract

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Skrinning Resep Interaksi Obat Pasien Hipertensi dan Gagal Ginjal Periode Oktober S.d Desember 2023 di Rumah Sakit Rasyida Medan Sri Devi Alfitriani; Novitaria Br Sembiring; Asyrun Alkhairi Lubis; Nurasni Nurasni
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6173

Abstract

Hypertension is a significant health issue in Indonesia, frequently referred to as a silent killer due to its asymptomatic nature.  Hypertension complications may result in damage to essential organs, including the heart, brain, and kidneys, potentially culminating in chronic kidney failure (CKD).  The therapy of hypertension and renal failure requires appropriate pharmacological intervention to avert complications and enhance patient quality of life.  This research seeks to identify medications often prescribed to patients with hypertension and renal failure, ascertain the prevalence of concurrent illnesses, and assess potential drug interactions in prescriptions at Rasyida Hospital Medan from October to December 2023. The research used a descriptive methodology via an analysis of patient prescriptions.  The study's findings indicated the use of diverse combinations of antihypertensive medications and renal failure treatment, along with the possibility of drug interactions in multiple patient prescriptions.  The results underscore the need of prescription screening and monitoring for drug interactions within clinical pharmacy services to mitigate the risk of medication mistakes and enhance the safety and efficacy of treatment in patients with hypertension and renal failure.
Co-Authors Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Anselia , Bella Anzelita, Ayu Astriani Natalia Bangar, Roy Indrianto Br Ginting, Anissa Destryana Cristin Natali Rouli Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Jefri Naldi Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Naibaho, Novrika Desclarita Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring nurasni nurasni Pricella Ginting Rahimi, Armon Razoki Reh Malem br Karo Rena Meutia Rizkya Adinda Nasution Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Simbolon, Cherryl A.M Siti Nurkholifah Sri Devi Alfitriani Surbekti , Destiana Tata Sylvia Winata Tiara Salsabilla Mendrofa Yunus , Muhammad