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All Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Buletin Kedokteran dan Kesehatan Prima Jurnal Kesehatan Amanah Nusantara Scientific Medical Research Journal Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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TINGKAT PENGETAHUAN DAN SIKAP MAHASISWA FARMASI UNPRI TERHADAP PENGGUNAAN OBAT DIABETES MELITUS TIPE 2 Amelia, Ade; Ginting, Astriani Natalia Br; Meutia, Rena; Lubis, Asyrun Alkhairi
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.44811

Abstract

Diabetes melitus (DM) adalah suatu kondisi kronis yang terjadi ketika pankreas tidak dapat lagi memproduksi insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Penyakit DM diklasifikasi menjadi beberapa bagian, termasuk DM tipe 2 yang umum terjadi pada usia dewasa dan dapat dipicu oleh obesitas dan faktor keturunan serta berisiko menyebabkan komplikasi jika tidak dikendalikan. Mahasiswa farmasi berperan dalam edukasi dan pelayanan kesehatan, sehingga tingkat pengetahuan dan sikap mahasiswa farmasi terhadap penggunaan obat DM tipe 2 sangat penting. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan sikap mahasiswa farmasi UNPRI terhadap penggunaan obat DM tipe 2 guna mendukung pengelolaan penyakit secara efektif. Penelitian ini dilakukan di Universitas Prima Indonesia menggunakan desain penelitian deskriptif dengan teknik pengambilan data yaitu data primer yang dikumpulkan menggunakan kuesioner yang dibagikan kepada mahasiswa farmasi UNPRI. Data dianalisis secara univariat menggunakan aplikasi spss versi 27. Terdapat total 100 responden yang termasuk dalam penelitian ini. Didapatkan sebagian besar responden merupakan perempuan dan berusia 17-19 tahun. Berdasarkan tingkat pengetahuan mahasiswa kategori Baik 88 orang (88.0%), kategori Cukup Baik 7 orang (7.0%), dan kategori Kurang Baik 5 orang (5.0%) dan tingkat sikap mahasiswa kategori Baik berjumlah 44 orang (44.0%), kategori Cukup Baik 50 orang (50.0%), dan kategori Kurang Baik berjumlah 6 orang (6.0%). Berdasarkan hasil penelitian ini dapat disimpulkan bahwa tingkat pengetahuan dan sikap mahasiswa farmasi UNPRI tentang penggunaan obat diabetes melitus tipe 2 sebagian besar baik, namun sikap mereka cenderung cukup baik. 
Skrining Resep untuk Identifikasi Interaksi Obat pada Pasien Diabetes Melitus dan Hiperurisemia Periode Oktober 2023 hingga Maret 2024 di Rumah Sakit Advent Surbekti , Destiana Tata; Sembiring, Novitaria Br; Lubis, Asyrun Alkhairi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.894

Abstract

Background: Diabetes mellitus (DM) and hyperuricemia are frequently encountered comorbidities in clinical practice with increasing prevalence. Long-term pharmacological therapy for these conditions carries the potential for drug interactions and other drug-related problems. Prescription completeness evaluation and drug interaction identification are necessary to ensure therapeutic safety and efficacy. Objectives: This study aimed to identify medications prescribed for patients with DM and hyperuricemia, evaluate potential drug interactions, and assess prescription completeness based on administrative standards according to Indonesian Ministry of Health Regulation No. 72 of 2016. Methods: This retrospective descriptive study with a cross-sectional design analyzed 50 outpatient prescriptions at Advent Hospital Medan from October 2023 to March 2024. The analysis covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using Drugs.com with classification as major, moderate, and minor. Results: The most frequently prescribed antidiabetic drugs were metformin (82%), glimepiride (76%), and acarbose (64%), while for hyperuricemia they were allopurinol (88%) and meloxicam (72%). Ten drug interactions were identified, consisting of 8 moderate (80%), 1 major (10%), and 1 minor (10%). Administrative evaluation showed 92% completeness for mandatory components, but patient weight (48%), physician address (64%), and physician phone number (56%) were frequently omitted. Conclusion: The study revealed a significant prevalence of moderate drug interactions between antidiabetic drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Optimization of prescription screening systems and completion of patient clinical data are required to enhance therapy safety.
Pengujian Efek Proteksi Jus Tomat (Solanum Lycopersicum (L.)) Terhadap Fungsi Ginjal Tikus Yang Diinduksi Parasetamol Angelia Vega; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.763

Abstract

Excessive doses of paracetamol can cause nephrotoxicity due to accumulation of NAPQI and oxidative stress, which damages the proximal tubules of the kidney. Tomato (Solanum tomato L.) which is rich in lycopene has the potential to prevent this damage through its antioxidant activity. This experimental study used a posttest-only control group design with 25 white rats (Rattus norvegicus) divided into 5 groups: positive control, negative control, and three treatment groups. The mice were induced with toxic doses of paracetamol, while the treatment group was given tomato juice. Evaluation is carried out through measurement of plasma creatinine and renal histopathological analysis. The results showed that toxic doses of paracetamol (250 mg/kgBW) increased creatinine levels and relative kidney weight, which indicated acute kidney damage. Giving high doses of tomato juice (800 mg/kgBW) was most effective in reducing creatinine levels and protecting kidney tissue compared to lower doses. Administration of paracetamol 250 mg/kgBW caused kidney damage which was characterized by an increase in creatinine and relative kidney weight. Tomato juice at a dose of 800 mg/kgBW provided the best protective effect by reducing creatinine levels close to the positive control. These results demonstrate the potential of tomato juice as a protective agent against paracetamol-induced kidney damage.
Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dalam Penurunan Hiperurisemia pada Mencit (Mus musculus L.) Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.764

Abstract

Hyperuricemia is a degenerative condition due to increased blood uric acid levels from purine metabolism, often occurring in the elderly. Avocado seeds (Persea americana Mill.) contain flavonoids with antioxidant and anti-inflammatory properties that can inhibit xanthine oxidation. This study evaluated the effectiveness of its extract in reducing uric acid levels in potassium bromate-induced male mice. Mice were divided into six groups: negative control (Na CMC 0.5%), positive control (allopurinol 10 mg/kg BW), three treatment groups (avocado seed extract 120, 150, and 180 mg/kg BW), and normal group. Uric acid levels were measured for seven days using one-way ANOVA test and BNT test LSD method. The results showed that doses of 120-180 mg/kg BW effectively reduced uric acid levels, with the optimal dose of 150 mg/kg BW reducing hyperuricemia by 37.3% (p = 0.118).
Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Relationship Between the Level of Knowledge and Medication Adherence Level in Diabetes Mellitus Patients in Advent Medan Hospital Amazihono, Keytrin; Erida Novriani; Lubis, Asyrun Alkhairi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.102

Abstract

Hyperglycemia or elevated blood sugar levels due to decreased pancreatic insulin productin, is a sign of a metabolic disorder that leads to diabetes mellitus (DM). One crucial factor in managing diabetes mellitus is the patient’s knowledge and adherence to treatment. Patients with adequate knowledge are more likely to comply with therapy, which helps control the disease. This study aims to determine the relationship between the level of knowledge and the level of medication adherence in diabetes mellitus patients in Advent Hospital Medan. This research employed a quantitative approach with a cross-sectional design and a purposive sampling technique. The research involved 90 patients who were selected and agreed to participate as respondents. Data were collected using a validated Diabetes Knowledge Questionnaire (DKQ-24) and Medication Adherence Report Scale (MARS-5). Data analysis was conducted using a non-parametric statistical test, specifically the Chi-Square test. The study found that the majority of patients had a high level of knowledge (48,9%) but were non-adherent to medication (56,7%). The Chi-Square test showed a significance of 0.001 < 0.05, indicating a significant relationship between the level of knowledge and medication adherence among diabetes mellitus patients at Advent Medan Hospital.
Uji Efek Nefroprotektif Ekstrak Etanol Daun Sirih Hijau (Piper betle L.) pada Tikus Jantan yang Diinduksi Gentamisin. Waruwu, Tuti Putri; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47642

Abstract

Upaya nefroprotektif bertujuan untuk menjaga kesehatan ginjal dari risiko kerusakan.Tujuan dari studi ini adalah agar memahami pengaruh efek protektif terhadap ginjal serta menentukan dosis dalam jumlah yang tepat dari ekstrak etanol daun sirih hijau yang berfungsi sebagai agen pelindung ginjal.Studi melibatkan 25 ekor tikus jantan yang terbagi kedalam lima kelompok perlakuan berbeda,dimana kelompok kontrol normal tidak diberi perlakuan,Kelompok kontrol negatif yang diinduksi dengan gentamisin,serta kelompok uji yang menerima perlakuan ekstrak etanol daun sirih hijau dengan dosis brturut turut dari 100 mg/KgBB,150 mg/KgBB dan 200 mg/KgBB.Ekstrak diberikan melalui oral sekali sehari masa 8 hari,kemudian setiap hewan uji diberikan injeksi intraperitoneal gentamisin dengan dosis 80 mg/KgBB sejam setelah pemberian ekstrak,kecuali pada kelompok normal. Hasil pemeriksaan kreatinin hari 1 dan 9 mengindikasikan bahwa ekstrak etanol daun sirih hijau berpotensi sebagai agen nefroprotektif
Efek Nefroptotektif Ekstak Etanol Bawang Putih (Allium sativum L.) Pada Tikus Yang Diinduksi Rifampicin Fadira, Nurazra; Lubis , Asyrun Alkhairi; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1020

Abstract

Background: Drug-induced nephrotoxicity, particularly caused by rifampicin—a first-line antituberculosis drug is a significant contributor to acute kidney dysfunction. The search for effective and safe nephroprotective agents to mitigate this side effect is crucial, and garlic (Allium sativum L.), with its potent antioxidant content, has emerged as a promising candidate. Objective: To evaluate the nephroprotective effect of ethanol extract of garlic (EEG) in male white rats (Rattus norvegicus) induced with rifampicin, based on serum creatinine levels, relative kidney weight, and histopathological findings. Methods: An in vivo experimental study was conducted on 25 rats randomly divided into five groups: (GI) normal control (distilled water); (GII) negative control (rifampicin 100 mg/kg BW, intraperitoneal); and three treatment groups (GIII, GIV, GV) receiving rifampicin 100 mg/kg BW and EEG at doses of 50, 120, and 300 mg/kg BW orally. Treatments were administered for 10 days. The measured parameters were serum creatinine levels, relative kidney weight, and histopathological damage scores (degeneration, necrosis, inflammatory cell infiltration). Results: Rifampicin induction (GII) significantly increased serum creatinine levels (1.28 ± 0.79 mg/dL) compared to the normal control (0.57 ± 0.05 mg/dL) (p<0.001). Administration of EEG at doses of 50, 120, and 300 mg/kg BW significantly reduced creatinine levels (0.53 ± 0.05; 0.51 ± 0.18; 0.51 ± 0.04 mg/dL, respectively). The relative kidney weight was highest in GII (1.6%), whereas treatment groups showed values close to normal. Histopathological analysis revealed the highest damage score in GII (score 2; 25–50%), while treatment groups, particularly the 300 mg/kg BW dose, showed the mildest damage (score 1; 5–25%). Conclusion: Ethanol extract of garlic exerts nephroprotective effects against rifampicin-induced kidney damage in rats, as evidenced by reduced serum creatinine levels, improvement in relative kidney weight, and amelioration of histopathological structures. These protective effects were dose-dependent, with the 300 mg/kg BW dose showing the most optimal outcome.
Efek Nefroprotektif Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) Terhadap Gambaran Histopatologi Ginjal Tikus (Rattus norvegicus) Yang Diinduksi oleh Etilen Glikol Anselia , Bella; Lubis , Asyrun Alkhairi; Sembiring, Novitaria Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1021

Abstract

Background: The kidney is a vital organ susceptible to damage from exposure to nephrotoxic compounds such as ethylene glycol. Red ginger (Zingiber officinale var. rubrum) is known to contain bioactive compounds with antioxidant and anti-inflammatory potential that may protect the kidney from injury. However, its effectiveness as a nephroprotective agent needs to be scientifically validated. Objective: To evaluate the nephroprotective effect of ethanol extract of red ginger against ethylene glycol–induced kidney damage in male white rats (Rattus norvegicus), Wistar strain. Methods: An experimental study using a post-test only control group design was conducted to minimize bias by ensuring equivalent baseline conditions among groups. A total of 25 rats were divided into five groups: normal control (distilled water), negative control (0.75% ethylene glycol), and three treatment groups (ethylene glycol + red ginger extract at doses of 100, 200, and 300 mg/kgBW/day). Parameters measured included serum creatinine levels and kidney histopathology. Data were analyzed using one-way ANOVA (p < 0.05) followed by LSD post hoc test. Results: Red ginger extract significantly reduced serum creatinine levels (p < 0.05), with the greatest reduction observed at a dose of 300 mg/kgBW (0.528 ± 0.082 mg/dL). Histopathological improvement of the kidney was also evident, indicated by decreased necrosis, cellular degeneration, and inflammatory cell infiltration. The kidney damage score in the treatment groups (score 1) was lower than in the negative control group (score 2). Conclusion: Ethanol extract of red ginger exhibits a nephroprotective effect against ethylene glycol–induced kidney injury, with the optimal dose being 300 mg/kgBW/day. These findings support the potential of red ginger as an alternative therapy for kidney disorders, although further studies are needed to elucidate the molecular mechanisms and conduct clinical trials.
Co-Authors AA Sudharmawan, AA Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Angelia Vega Anselia , Bella Anzelita, Ayu Astriani Natalia Astriani Natalia Br Ginting Br Ginting, Anissa Destryana Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Farren Farren Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Jefri Naldi Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring nurasni nurasni Pricella Ginting Rahimi, Armon Reh Malem br Karo Rena Meutia Rizkya Adinda Nasution Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Siti Nurkholifah Sri Devi Alfitriani Surbekti , Destiana Tata Sylvia Winata Tiara Salsabilla Mendrofa Waruwu, Tuti Putri Yunus , Muhammad