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All Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Buletin Kedokteran dan Kesehatan Prima Jurnal Kesehatan Amanah Nusantara Scientific Medical Research Journal Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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THE EFFECT OF DRUG COUNSELING ON PATIENT COMPLIANCE AT ADAM MALIK CENTRAL GENERAL HOSPITAL USING THE PILL COUNT METHOD Elfia Neswita; Melnihati Laia; Henny Yolanda Ardilla; Siti Nurkholifah; Adinda Silvani Ginting; Asyrun Alkhairi Lubis; Muhammad Yunus
Jambura Journal of Health Sciences and Research Vol 5, No 1 (2023): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v5i1.17428

Abstract

Masih rendahnya kepatuhan pasien terhadap pengobatan pada pasien asma, stroke, rematik dan TBC menjadikan penyakit kronis ini menjadi masalah di Negara maju dan berkembang. Kebaruan penelitian ini adalah meneliti pengaruh konseling obat terhadap kepatuhan pasien pada beberapa jenis penyakit seperti asma, stroke, rematik dan TBC dengan menggunakan metode pill count. Tujuan dari penelitian ini untuk melihat perbedaan kepatuhan pasien sebelum dan sesudah diberi konseling obat (dengan materi konseling bersumber dari buku Pharmacotherapy Handbook Joseph T Dipiro edisi 9 untuk asma, stroke dan rematik; dan Farmaseutical Care untuk penyakit tuberculosis dimana membandingkan pill count sebelum dan sesudah konseling obat. Penelitian ini bersifat deskriptif dengan desain cross sectional pada pasien asma sebanyak 15 orang, pasien stroke 10 orang, pasien rematik 10 orang dan pasien TBC 30 orang yang memenuhi kriteria inklusi dan ekslusi dan hasil perhitungan dengan menghitung manual berdasarkan catatan sebelum dan sesudah konseling obat terhadap jumlah sisa obat (metode pill count). Hasil penelitian didapatkan adanya pengaruh konseling obat pada pasien asma, stroke, rematik dan TBC, dengan tingkat kepatuhan sebelum diberi konseling obat yang diukur menggunakan metode pill-count pada pasien asma, stroke, rematik dan TBC secara berturut-turut sebesar 6,66%, 40%, 30% dan 26,66 %. Sedangkan tingkat kepatuhan setelah diberi konseling obat yang diukur menggunakan pill-count pada pasien asma, stroke, rematik dan TBC secara berturut-turut sebesar 86,66%, 90%, 80% dan 83,33%. Kesimpulan terdapat perbedaan kepatuhan pasien sebelum dan setelah diberi konseling obat,  dimana kepatuhan pasien semakin meningkat setelah diberi konseling obat pada pasien Asma, Stroke, Rematik dan TBC.Kata kunci: Kepatuhan; Konseling Obat; Pill Count.AbstractThe low adherence of patients to treatment in patients with asthma, stroke, rheumatism, and tuberculosis makes this chronic disease a problem in developed and developing countries. The novelty of this study is to examine the effect of drug counseling on patient adherence to several types of diseases, such as asthma, stroke, rheumatism, and tuberculosis, using the pill count method. The purpose of this study was to look at differences in patient adherence before and after being given drug counseling (with counseling material sourced from Joseph T Dipiro's 9th edition of the Pharmacotherapy Handbook for asthma, stroke, and rheumatism; and Pharmaceutical Care for tuberculosis disease where comparing pill count before and after drug counseling. This study is descriptive with a cross-sectional design in 15 asthma patients, 10 stroke patients, 10 rheumatic patients, and 30 TB patients who meet the inclusion and exclusion criteria and the calculation results by calculating manually based on records before and after drug counseling on the amount of drug residue (pill count method). The results of the study found the influence of drug counseling on asthma, stroke, rheumatism, and tuberculosis patients, with the level of adherence before being given drug counseling as measured using the pill-count method in asthma, stroke, rheumatism and tuberculosis patients respectively by 6.66%, 40%, 30%, and 26.66%. Meanwhile, the compliance rate after being given drug counseling measured using pill count in asthma, stroke, rheumatism, and tuberculosis patients was 86.66%, 90%, 80%, and 83.33%, respectively. Conclusion there are differences in patient adherence before and after being given drug counseling, where patient adherence increases after being given drug counseling in patients with Asthma, Stroke, Rheumatism, and Tuberculosis.
Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat Asyrun Alkhairi Lubis; Muhammad Yunus; Jefri Naldi; Muhammad Andry; Pricella Ginting; Fira Safitri; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.209

Abstract

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Abstract

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Pengaruh Ekstrak Daun Kunyit (Curcuma Longa Linn.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Pada Luka Diabetes Metode Difusi Cakram Br Ginting, Anissa Destryana; Nasution, Ali Napiah; Lubis, Asyrun Alkhairi
Jurnal Mahasiswa Ilmu Kesehatan Vol. 2 No. 3 (2024): Juli: Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v2i3.1490

Abstract

Daun kunyit memiliki kandungan bahan aktif, seperti flavonoid, tanin dan senyawa fenolik. Zat-zat ini memiliki beragam manfaat bagi kesehatan. Daun kunyit juga mempunyai kandungan berupa minyak atsiri yang diketahui memiliki efek positif terhadap kesehatan tubuh. Studi ini mempunyai tujuan guna mengetahui adanya pengaruh ekstrak daun kunyit (Curcuma Longa Linn.) dalam menghambat pertumbuhan bakteri Staphylococcus aureus pada luka diabetes. Ekstraksi dengan cara maserasi menggunakan pelarut etanol 96%. Ekstrak daun kunyit diuji dalam perlakuan dengan konsentrasi bertingkat (20%, 40%, 60%, dan 80%) serta kontrol positif menggunakan Kloramphenikol dan kontrol negatif menggunakan DMSO (Dimethyl sulfoxide). Hasil analisis fitokimia menunjukkan keberadaan zat aktif seperti steroid, saponin, tanin, flavonoid, dan alkanoid dalam daun kunyit. Studi ini mengungkapkan ekstra daun kunyit mempunyai potensi untuk menghambat pertumbuhan bakteri Staphylococcus aureus, yang terbukti dengan pembentukan zona hambat yang signifikan. Hasil percobaan menunjukkan bahwa konsentrasi ekstrak 80% menunjukkan efek penghambatan yang paling efektif terhadap pertumbuhan bakteri Staphylococcus aureus, dengan ukuran zona hambat mencapai 5,52 mm.
Pengaruh Ekstrak Biji Alpukat (Persea Americana Mill.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Pada Luka Diabetes Metode Difusi Cakram Nabilah Khairunnisa; Ali Napiah Nasution; Asyrun Alkhairi Lubis
Jurnal Mahasiswa Ilmu Kesehatan Vol. 2 No. 3 (2024): Juli: Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v2i3.1527

Abstract

. Avocado seeds are one of the plants used as a medicine for diabetes mellitus with the Latin name (Persea americana Mill.). Avocado seeds contain compounds such as alkaloids, flavonoids, saponins, tannins and triterpenoids which are beneficial for health. This study aims to determine the effect of avocado seed extract (Persea americana Mill.) on the growth of Staphylococcus aureus bacteria in diabetic wounds using the disc diffusion method. The extraction process is by maceration using 96% ethanol. The treatment was repeated 4 times with extract concentrations of 25%, 50%, 75%, 100%, as a positive control Ciprofloxacin and DMSO (Dimetyl Sulfoxide) as a negative control. The results of phytochemical screening show that avocado seeds contain alkaloids, flavonoids, saponins, tannins and triterpenoids. Based on the results of research conducted, avocado seed extract can inhibit the growth of Staphylococcus aureus bacteria as an inhibition zone is formed. The most effective concentration in inhibiting the growth of Staphylococcus aureus bacteria is at 100% concentration of 10.14 mm.
Pengaruh Pemberian Ekstrak Etanol Daun Kunyit (Curcuma Domestica Val) Terhadap Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Jantan Yang Di Induksi Akmalul Habib Damanik; Asyrun Alkhairi Lubis; Ermi Girsang
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1682

Abstract

Indonesia is the largest archipelago in the world (17,504 islands). In addition, Indonesia has abundant natural resources and fertile soil that allows a wide variety of plants to live. Curcuma domestica val, known as turmeric, is one of Indonesia's medicinal plants. A number of active ingredients found in turmeric have been shown in studies to have potential health benefits, including anti-diabetic anti-inflammatory, anti-cancer, cough medicine, liver medicine, and Alzheimer's disease. Based on the results of phytochemical research, flavonoids, alkaloids, tannins, triterpenoids, steroids, saponins, and glycosides are present in the ethyl ethanol extract of turmeric leaves (Curcuma domestica Val). Diabetes mellitus is a metabolic condition characterised by increased blood glucose levels caused by disruption of the insulin hormone which functions to lower blood glucose levels to maintain body homeostasis. Because of the close relationship between diabetes mellitus and lifestyle, diet, sleep, work, daily routine activities and others must be balanced. This study was conducted in the laboratory and was experimental in nature using male white rats as research subjects. Rats were induced using Alloxan at a dose of 100 mg/kgBB. Rats were divided into 6 groups, each consisting of 5 rats. Group 1 is a normal group, Group 2 is a negative group only given aquadest and induced with Alloxan.
Efek Pemberian Ekstrak Daun Gelagah (Saccharum spontaneum L.) terhadap Diabetes Induksi Aloksan pada Tikus Putih (Rattus Norvegicus) Tiara Salsabilla Mendrofa; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.05

Abstract

Saccharum spontaneum L. (Family: Poaceae) is a tall perennial grass with deep roots and rhizomes, capable of growing up to 3-4 meters in height, and is commonly found along water bodies or roadsides. This plant is widely distributed throughout the tropical regions of Asia, Africa, America, and Australia. Saccharum spontaneum L. is a tall, erect, perennial grass with feathery inflorescences, often growing in swampy areas. Its leaves and stems contain lignin, carbohydrates, proteins, and amino acids, while its roots and lower stems contain starch and polyphenolic compounds. This study aims to evaluate the effect of Saccharum spontaneum L. leaves extract on blood glucose levels in male white rats (Rattus norvegicus) induced with alloxan. The leaves extract was obtained through maceration using 96% ethanol solvent. Phytochemical screening results indicated that the leaves of Saccharum spontaneum L. contain alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The antidiabetic test was conducted using male Wistar rats. In this study, the Saccharum spontaneum L. leaves extract was administered in three different doses: group 4 received a dose of 100 mg/KgBW, group 5 received a dose of 200 mg/KgBW, and group 6 received a dose of 400 mg/KgBW. Additionally, there were control groups consisting of group 1 (normal), group 2 (negative control), and group 3 (positive control) which were given the drug glibenclamide 5 mg/60 kg. All doses were administered orally. Diabetes induction in the rats was performed using alloxan monohydrate at a dose of 100 mg/KgBW administered intraperitoneally. The results of the study showed that the greatest reduction in blood glucose levels occurred in group 6 with a dose of 400 mg/KgBW, which decreased blood glucose levels by 71.78% at the 180th minute. Group 5 showed a reduction of 55.80% and group 4 showed a reduction of 51.91% at the 180th minute. Group 3, which was given glibenclamide, showed a reduction in blood glucose levels of 71.14% at the 180th minute. These results indicate that the highest dose of Saccharum spontaneum L. leaves extract (400 mg/KgBW) had the most significant effect in lowering blood glucose levels in male Wistar rats induced with alloxan monohydrate
Uji Efek Nefroprotektif Ekstrak Daun Kemangi (Ocimum Bacilicum L.) Terhadap Tikus Wistar Jantan Yang Diinduksi Aspirin Rizkya Adinda Nasution; Asyrun Alkhairi Lubis; Novitaria Br Sembiring
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2537

Abstract

The kidneys serve a vital function in maintaining homeostasis by filtering blood, excreting metabolic waste, and eliminating exogenous substances, including drugs and environmental toxins. However, prolonged or excessive exposure to certain chemicals, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, can result in nephrotoxicity and lead to significant renal damage. In the pursuit of alternative therapeutic agents with fewer side effects, natural compounds with antioxidant properties have gained increasing interest. Ocimum basilicum L., commonly known as sweet basil, is a medicinal plant traditionally used for various therapeutic purposes. Its leaves are rich in antioxidant compounds that are hypothesized to possess nephroprotective activity. This study aimed to investigate the protective effects of Ocimum basilicum leaf extract against aspirin-induced renal injury in experimental rats. The study involved dividing the rats into multiple groups: a control group, a group treated with aspirin only, and groups treated with aspirin followed by Ocimum basilicum leaf extract at different dosages (400, 600, and 800 mg/kg BW). Renal function was assessed via serum creatinine levels and histopathological analysis of kidney tissues. The results revealed that aspirin administration significantly increased serum creatinine levels and caused observable damage to kidney tissue, confirming nephrotoxicity. However, post-treatment with Ocimum basilicum extract, particularly at the highest dose of 800 mg/kg BW, markedly reduced serum creatinine levels and improved renal histological architecture. These findings indicate that Ocimum basilicum leaf extract has potential as a nephroprotective agent, capable of mitigating aspirin-induced kidney damage, likely through its antioxidant activity. Further research is warranted to explore its mechanism of action and potential clinical applications.
Efek Protektif Ekstrak Jinten Hitam (Nigella sativa L.) terhadap Gambaran Histopatologi Ginjal Tikus Putih (Rattus norvegicus) yang Diinduksi Tetrasiklin Anzelita, Ayu; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 2 (2025): July
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i2.3975

Abstract

Penggunaan tetrasiklin sebagai antibiotik spektrum luas dapat menyebabkan efek samping nefrotoksisitas yang berisiko merusak ginjal. Jinten hitam (Nigella sativa L.) diketahui memiliki aktivitas antioksidan yang berpotensi melindungi ginjal dari kerusakan akibat stres oksidatif. Penelitian ini bertujuan untuk mengetahui efek protektif dari jinten hitam (Nigella Sativa L.) terhadap gambaran histopatologi ginjal tikus putih (Rattus novergicus) yang diinduksi tetrasiklin. Penelitian ini menggunakan 25 ekor tikus yang dibagi menjadi lima kelompok perlakuan, yaitu kelompok kontrol positif (K+), kelompok kontrol negatif (K-) diberi tetrasiklin 200 mg/kgBB, kelompok perlakuan diinduksi tetrasiklin 200 mg/kgBB dan ekstrak jinten hitam sebagai terapi (P1)  200 mg/kgBB, (P2) 400 mg/kgBB, dan (P3) 800 mg/kgBB. Penelitian dilakukan selama 14 hari.  Hasil penelitian menunjukkan bahwa kadar ekstrak jinten hitam (Nigella sativa L.) dapat menurunkan kadar kreatinin dan memperbaiki histopatologi ginjal pada tikus. Dilihat berdasarkan hasil yang diperoleh ekstrak jinten hitam (Nigella sativa L.) memiliki efek protektif terhadap gambaran histopatologi ginjal tikus yang diinduksi tetrasiklin.
Co-Authors AA Sudharmawan, AA Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Angelia Vega Anselia , Bella Anzelita, Ayu Astriani Natalia Astriani Natalia Br Ginting Br Ginting, Anissa Destryana Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Farren Farren Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Jefri Naldi Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring nurasni nurasni Pricella Ginting Rahimi, Armon Reh Malem br Karo Rena Meutia Rizkya Adinda Nasution Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Siti Nurkholifah Sri Devi Alfitriani Surbekti , Destiana Tata Sylvia Winata Tiara Salsabilla Mendrofa Waruwu, Tuti Putri Yunus , Muhammad