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All Journal Jambura Journal of Health Sciences and Research JURNAL FARMASIMED (JFM) PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Kedokteran dan Kesehatan Prima Nusantara Scientific Medical Research Journal Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Effectiveness test of avocado seeds on the renal histopathology of white rats induced by isoniazid Lubis, Khairunnisya; Lubis, Asyrun Alkhairi; Sembiring, Novitaria Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7692

Abstract

The kidneys are a pair of organs within the urinary system, located in the upper retroperitoneal cavity, functioning in blood filtration, reabsorption, and secretion through diffusion processes involved in blood purification and urine formation. The kidneys are highly susceptible to damage from exposure to nephrotoxic drugs, one of which is isoniazid. Avocado seeds (Persea americana Mill.) are known to contain antioxidant compounds with potential protective effects against renal tissue damage. This study aimed to examine the effect of avocado seed extract on the histopathological changes in the kidneys of white rats induced with isoniazid. The research employed an experimental design using 25 male rats divided into five groups: positive control (K+), negative control (K–), and three treatment groups receiving avocado seed extract at doses of 100 mg/kg body weight (P1), 200 mg/kg body weight (P2), and 400 mg/kg body weight (P3). Isoniazid induction was administered to all groups except the positive control. After a 14-day treatment period, kidney samples were collected for histopathological analysis using hematoxylin-eosin (HE) staining. The observations indicated that avocado seed extract effectively improved renal histological structure in white rats (Rattus norvegicus) induced with isoniazid. In the treatment group III, renal histological improvement was observed, with only 5–25% structural damage or a score of 1, compared to groups I and II, which showed 25–50% damage or a score of 2.
Formulasi dan Evaluasi Sediaan Tablet Effervescent dari Ekstrak daun Andaliman (Zanthoxylum acanthophodium Dc.) dengan Variasi Asam dan Basa Naibaho, Novrika Desclarita; Bangar, Roy Indrianto; Lubis, Asyrun Alkhairi
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.206

Abstract

Andaliman leaves (Zanthoxylum acanthopodium) are a plant that has the potential to be used as a natural ingredient in the development of herbal preparations. Andaliman leaves are known to contain secondary metabolite compounds, including flavonoids, terpenoids, alkaloids, and tannins. This potential encourages the processing of Andaliman leaves into extracts which are then formulated in the form of effervescent tablets to increase practicality of use. This study aims to produce effervescent tablets of Andaliman leaf extract with good physical quality by making three formulas with varying concentrations of acid-base components. Extraction was carried out using 70% ethanol solvent, then an evaluation of the properties of the resulting granules and tablets was carried out. The test results showed that all formulas met the requirements for organoleptic tests, water content, flow time, and compressibility, but in the angle of repose test only F2 met the criteria. Tablet evaluation showed that all formulas met the organoleptic tests, hardness, friability, and dissolution time, while the uniformity and weight tests still showed discrepancies in some formulas. Overall, formula F2 is the best formula because it meets most of the evaluation parameters for granules and tablets, so it has the greatest potential to be developed as an effervescent tablet preparation from andaliman leaf extract.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Sirsak (Annona Muricata L.) terhadap Bakteri Pseudomonas Aeruginosa Cristin Natali Rouli; Muhammad Yunus; Asyrun Alkhairi Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2090

Abstract

Soursop leaves (Annona muricata L.) are known to contain secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and polyphenols, which have antibacterial potential. This study aimed to formulate soursop leaf extract into a gel dosage form and to evaluate its antibacterial activity against Pseudomonas aeruginosa. This research was conducted as an experimental laboratory study. Soursop leaf extract was obtained using the maceration method with 96% ethanol as the solvent and then formulated into gel preparations with extract concentrations of 5%, 10%, and 15%. Physical evaluation of the gel preparations included organoleptic test, homogeneity, pH, spreadability, and viscosity. Antibacterial activity was evaluated using the well diffusion method on Nutrient Agar medium. The results showed that all gel formulations met the physical requirements for topical preparations. The antibacterial activity test demonstrated that the soursop leaf extract gel inhibited the growth of Pseudomonas aeruginosa, with the 15% concentration producing the largest inhibition zone of 10 mm compared to other concentrations. In conclusion, soursop leaf extract gel has potential to be developed as a topical antibacterial agent against Pseudomonas aeruginosa.
Pharmacoeconomic Analysis of Cost Comparison Between Calcium Channel Blocker (CCB) and Angiotensin II Receptor Blocker (ARB) Antihypertensive Drugs in Hospitalized Hypertensive Patients at RSU Royal Prima Simbolon, Cherryl A.M; Razoki; Asyrun Alkhairi Lubis
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/y2fhvc35

Abstract

Hypertension is a global health problem that contributes substantially to morbidity and mortality, thus requiring therapeutic management that is both clinically effective and economically efficient. In clinical practice, Calcium Channel Blockers (CCB) and Angiotensin II Receptor Blockers (ARB) are commonly used, either as monotherapy or in combination, but they differ in terms of cost and effectiveness. This study aimed to conduct a pharmacoeconomic analysis by comparing the costs and effectiveness of antihypertensive therapy using CCB and ARB in hospitalized hypertensive patients at RSU Royal Prima Medan. The study employed a retrospective design with a pharmacoeconomic analysis approach. Data were obtained from the medical records of hospitalized hypertensive patients during the period October–December 2024 using a total sampling technique, resulting in 52 patients who received CCB therapy, ARB therapy, or a combination of CCB + ARB. The analysis included patient characteristics, treatment costs, therapeutic effectiveness based on achievement of target blood pressure <140/90 mmHg, and calculation of the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results showed that the combination therapy of CCB + ARB had the highest total treatment cost, while the lowest average cost per patient was found in the ARB monotherapy group. In terms of effectiveness, CCB monotherapy demonstrated the highest effectiveness (75.0%). ACER analysis indicated that CCB monotherapy was the most cost-effective therapy, and ICER analysis confirmed that CCB dominated both ARB and the CCB + ARB combination. In conclusion, CCB monotherapy is the most cost-effective antihypertensive treatment option for hospitalized hypertensive patients at RSU Royal Prima Medan.
Co-Authors Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Anselia , Bella Anzelita, Ayu Astriani Natalia Bangar, Roy Indrianto Br Ginting, Anissa Destryana Cristin Natali Rouli Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Jefri Naldi Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Naibaho, Novrika Desclarita Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring nurasni nurasni Pricella Ginting Rahimi, Armon Razoki Reh Malem br Karo Rena Meutia Rizkya Adinda Nasution Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Simbolon, Cherryl A.M Siti Nurkholifah Sri Devi Alfitriani Surbekti , Destiana Tata Sylvia Winata Tiara Salsabilla Mendrofa Yunus , Muhammad