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All Journal Jambura Journal of Health Sciences and Research PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Kedokteran dan Kesehatan Prima Nusantara Scientific Medical Research Journal Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Jurnal Mahasiswa Ilmu Kesehatan Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Sciences and Clinical Pharmacy Research Journal Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Asyrun Alkhairi Lubis
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Isolasi dan Karakterisasi Bakteri Asam Laktat pada Food Replacement ‘X’ dan Fermentasi Akar Teratai Br Pinem, Elys Dayanty; Bangar, Roy Indrianto; Lubis, Asyrun Alkhairi
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 2 (2026): Mei: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i2.6681

Abstract

Functional foods provide additional health benefits beyond their nutritional value. One approach in the development of functional foods is through fermentation involving lactic acid bacteria (LAB). This study aims to isolate and characterize lactic acid bacteria produced from the fermentation of lotus root and food replacement X as alternative food ingredients. The study was conducted experimentally through a five-day fermentation process at 37°C. The results show that LAB was successfully isolated from the fermentation of lotus root with a colony count of 1.88 × 10⁵ CFU/mL at a 10⁻² dilution, while no LAB growth was found in food replacement X. Four pure isolates were obtained with colony characteristics of round shape, milky white color, non-motile, and catalase-negative. Two isolates were Gram-positive, while the other two were Gram-negative. All isolates showed the ability to survive in acidic pH conditions (pH 3), with isolate EDP 1 having the highest resistance. The results indicate that lotus root fermentation has the potential to be a source of LAB for functional food applications. 
Uji Aktivitas Anti Diabetes Ekstrak Umbi Bawang Dayak (Eleutherine Bulbosa) pada Tikus Putih (Rattus Noverginus ) yang Diinduksi Aloksan Tiara Salsabila; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5142

Abstract

This study aims to examine the antidiabetic activity of ethanol extract of Dayak onion (Eleutherine bulbosa) bulbs in white rats (Rattus norvegicus) induced by alloxan. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. This condition can lead to various serious complications, such as kidney damage, cardiovascular disorders, neuropathy, and impaired wound healing. As the prevalence of diabetes increases globally, the search for safer and more affordable alternative therapies has become a crucial need, especially in developing countries. In recent years, the use of medicinal plants as alternative therapies for diabetes mellitus has received increasing research. Dayak onion is a herbal plant that has long been traditionally used by the people of Kalimantan to treat various diseases, including diabetes. The content of secondary metabolites in Dayak onion bulbs, such as flavonoids, alkaloids, tannins, saponins, and glycosides, is believed to act as a hypoglycemic agent. Flavonoids, for example, are known to have antioxidant activity that can protect pancreatic beta cells from oxidative damage, while saponins can inhibit glucose absorption in the intestine. This study used an experimental method with a post-test only control group design approach. Rats were induced with a certain dose of alloxan to create hyperglycemic conditions, then divided into several groups, including a negative control group, a positive control group (given standard drugs such as metformin), and a treatment group that received ethanol extract of Dayak onion bulbs at varying doses. Blood glucose levels were measured on days 0, 7, and 14 after treatment. It is hoped that the results of this study can provide strong scientific data regarding the potential of Dayak onion extract as an effective and relatively safe antidiabetic agent, as well as become the basis for the development of phytopharmaceutical drugs based on local Indonesian plants.
Efektivitas Ekstrak Etanol Bunga Telang (Clitoria Ternatea L ) sebagai Nefroprotektor terhadap Tikus Putih Jantan (Rattus Norvegicus) yang Diinduksi Gentamisin Rien Sapitri Br Sihaloho; Asyrun Alkhairi Lubis; Novitaria Br Sembiring
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5147

Abstract

Nephrotoxicity is a disorder of kidney function that can occur due to exposure to drugs, environmental chemicals, or other toxic substances. One aminoglycoside antibiotic known to have nephrotoxic effects is gentamicin, which is often used in the treatment of bacterial infections, but can cause kidney damage if used in high doses or for long periods. Therefore, it is important to find agents that can protect the kidneys from the side effects of this drug. Butterfly Pea Flower (Clitoria ternatea L.) is a plant known to contain secondary metabolites with antioxidant activity that have the potential to act as nephroprotective agents. These compounds can help combat oxidative stress that occurs in the kidneys due to exposure to toxic substances. This study aims to determine the optimal dose of Butterfly Pea Flower ethanol extract in protecting the kidneys of white rats from gentamicin-induced damage. A total of 25 male white mice were divided into five treatment groups: a normal control group (given distilled water), a negative control group (given only gentamicin 100 mg/kgBW), and three test groups given Butterfly Pea Flower extract at doses of 100, 200, and 400 mg/kgBW. Evaluation was carried out by measuring serum creatinine levels as an indicator of kidney function and histopathological analysis of kidney tissue to assess structural damage to the rats' kidneys. The results showed that administration of gentamicin caused a significant increase in serum creatinine levels and relative kidney weight, indicating acute kidney damage. Conversely, administration of Butterfly Pea Flower extract, especially at a dose of 400 mg/kgBW, provided the most effective protection against kidney damage. This was indicated by a decrease in creatinine levels approaching normal control values and improvement in histological damage to kidney tissue, such as repair of the structure of kidney tubules damaged by the effects of gentamicin.
Uji Efek Nefroprotektif Ekstrak Kulit Buah Mangga Arumanis (Mangifera Indica L. ) terhadap Fungsi Ginjal Tikus Putih Jantan yang Diinduksi Rifampisin Kristina Agatah Sidabutar; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5149

Abstract

This study aimed to evaluate the nephroprotective effect of mango peel extract (Mangifera indica L.) on the kidney function of male white rats (Rattus norvegicus) induced by rifampicin. Rifampicin is a first-line antibiotic used to treat tuberculosis, but its repeated use can cause side effects, including nephrotoxicity. This nephrotoxic effect can damage kidney function and disrupt the body's balance. Therefore, the search for agents that can protect the kidneys from damage caused by rifampicin is important. One potential natural nephroprotective agent is mango peel extract, which is known to contain bioactive compounds with antioxidant and anti-inflammatory activities, such as flavonoids, tannins, and saponins. This study was conducted experimentally with five treatment groups. The normal control group was given distilled water, the negative control group was given rifampicin, and three treatment groups were given mango peel extract at doses of 100, 200, and 400 mg/kgBW. The parameters observed included serum creatinine levels in rats before and after treatment, as well as histopathological features of kidney tissue to assess the presence of structural damage to the kidneys. The results showed that rifampicin administration increased serum creatinine levels, indicating impaired kidney function, and caused structural damage to kidney tissue. However, administration of arumanis mango peel extract, especially at a dose of 400 mg/kgBW, significantly reduced serum creatinine levels, approaching normal control values, and improved kidney histological structure. The damage score in kidney tissue in the group given arumanis mango extract also showed significant improvement compared to the negative control group. This nephroprotective effect is thought to be related to the content of bioactive compounds in arumanis mango extract, which have antioxidant and anti-inflammatory activities, which can reduce oxidative stress and inflammation in the kidneys.
Uji Efek Nefroprotektor Ekstrak Etanol Kulit Manggis (Garcinia Mangostana L.) terhadap Kerusakan Histologis Sel Ginjal Tikus Putih yang Diinduksi Gentamicin Indhira Justine Ginting; Asyrun Alkhairi Lubis; Muhammad Yunus
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5209

Abstract

Gentamicin is an antibiotic widely used in medicine to treat serious bacterial infections, particularly urinary tract, respiratory tract, skin, and soft tissue infections. This drug belongs to the aminoglycoside class, which works by inhibiting bacterial protein synthesis, preventing bacterial survival. Despite its high efficacy, gentamicin has significant side effects, particularly on the kidneys. Long-term or high-dose use of gentamicin can cause nephrotoxicity, which is damage to kidney tissue characterized by decreased filtration function, impaired glomerular and tubular structure, and increased blood creatinine and urea levels. This occurs because gentamicin tends to accumulate in the proximal tubules of the kidneys, triggering oxidative stress and inflammation. To reduce the toxic effects of gentamicin on the kidneys, nephroprotective agents are needed. One potential natural ingredient is mangosteen rind extract (Garcinia mangostana). Mangosteen rind is known to contain active compounds such as xanthones, which have antioxidant, anti-inflammatory, and antimicrobial properties. This compound is capable of neutralizing free radicals and suppressing the inflammatory response, which is one of the causes of kidney tissue damage. This study aimed to determine the effect of mangosteen peel extract on the histological appearance of the kidneys of rats treated with gentamicin. Histological analysis was performed to observe changes in kidney structure, such as tubular cell degeneration, necrosis, or inflammatory cell infiltration. It is estimated that administering mangosteen peel extract can minimize or prevent kidney tissue damage, making it an alternative complementary therapy to gentamicin. This research also marks the first step in the development of safe and effective herbal-based phytopharmaceuticals to support kidney health.
Efek Pemberian Ekstrak Daun Gelagah (Saccharum spontaneum L.) terhadap Diabetes Induksi Aloksan pada Tikus Putih (Rattus Norvegicus) Tiara Salsabilla Mendrofa; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.05

Abstract

Saccharum spontaneum L. (Family: Poaceae) is a tall perennial grass with deep roots and rhizomes, capable of growing up to 3-4 meters in height, and is commonly found along water bodies or roadsides. This plant is widely distributed throughout the tropical regions of Asia, Africa, America, and Australia. Saccharum spontaneum L. is a tall, erect, perennial grass with feathery inflorescences, often growing in swampy areas. Its leaves and stems contain lignin, carbohydrates, proteins, and amino acids, while its roots and lower stems contain starch and polyphenolic compounds. This study aims to evaluate the effect of Saccharum spontaneum L. leaves extract on blood glucose levels in male white rats (Rattus norvegicus) induced with alloxan. The leaves extract was obtained through maceration using 96% ethanol solvent. Phytochemical screening results indicated that the leaves of Saccharum spontaneum L. contain alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The antidiabetic test was conducted using male Wistar rats. In this study, the Saccharum spontaneum L. leaves extract was administered in three different doses: group 4 received a dose of 100 mg/KgBW, group 5 received a dose of 200 mg/KgBW, and group 6 received a dose of 400 mg/KgBW. Additionally, there were control groups consisting of group 1 (normal), group 2 (negative control), and group 3 (positive control) which were given the drug glibenclamide 5 mg/60 kg. All doses were administered orally. Diabetes induction in the rats was performed using alloxan monohydrate at a dose of 100 mg/KgBW administered intraperitoneally. The results of the study showed that the greatest reduction in blood glucose levels occurred in group 6 with a dose of 400 mg/KgBW, which decreased blood glucose levels by 71.78% at the 180th minute. Group 5 showed a reduction of 55.80% and group 4 showed a reduction of 51.91% at the 180th minute. Group 3, which was given glibenclamide, showed a reduction in blood glucose levels of 71.14% at the 180th minute. These results indicate that the highest dose of Saccharum spontaneum L. leaves extract (400 mg/KgBW) had the most significant effect in lowering blood glucose levels in male Wistar rats induced with alloxan monohydrate
Co-Authors Adinda Silvani Ginting Akmalul Habib Damanik Amazihono, Keytrin Amelia, Ade Andri Hidayat, Andri Anselia , Bella Anzelita, Ayu Astriani Natalia Br Ginting Br Ginting, Anissa Destryana Br Pinem, Elys Dayanty Edy Fachrial Elfia Neswita Erida Novriani Ermi Girsang Fadira, Nurazra Fioni, Fioni Fira Safitri Gerhart Frengki Hardian Harefa Ginting, Astriani Natalia Br Henny Yolanda Ardilla Indhira Justine Ginting Jefri Naldi Juliana Hasan Kristina Agatah Sidabutar Lubis, Khairunnisya Lumbantobing, Christina JRE Melnihati Laia Meutia, Rena Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Muhammad Yunus Muhammad Yunus Nabilah Khairunnisa Nasution, Ali Napiah Neswita, Elfia Novitaria Br Sembiring Pricella Ginting Rahimi, Armon Reh Malem br Karo Rien Sapitri Br Sihaloho Rizkya Adinda Nasution Roy Indrianto Bangar S Sembiring, Novitaria Br Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Simatupang, Veronica Triwindari Siti Nurkholifah Surbekti , Destiana Tata Tiara Salsabila Tiara Salsabilla Mendrofa Yunus , Muhammad