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All Journal Jurnal Sumberdaya Hayati Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Meditory : The Journal of Medical Laboratory PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal SAGO Gizi dan Kesehatan Jurnal Pengabdian Masyarakat Nusantara Journal of Experimental and Clinical Pharmacy (JECP) Pengabdian Kampus: Jurnal Informasi Kegiatan Pengabdian Pada Masyarakat Kontribusi: Jurnal Penelitian dan Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia Barigas: Jurnal Riset Mahasiswa
Turnip, Oktaviani Naulita
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pengaruh konsentrasi ekstrak daun pare (momordica charantia l.) terhadap kematian larva aedes aegypti Halim, Rahmawati; Toemon, Agnes Immanuela; Ysrafil, Ysrafil; Fatmaria, Fatmaria; Turnip, Oktaviani Naulita
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 2 (2025): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i2.2320

Abstract

Background: Dengue Hemorrhagic Fever (DHF) is a health problem in Indonesia, transmitted by the Aedes aegypti mosquito. Bitter melon leaves contain active compounds such as saponins, alkaloids, and flavonoids belived to be effective as larvacides and are expected to serve as a more environmentally friendly alternative for mosquito control in preventing the spread of DHF.Objective: To determine the potential of natural biolarvacide from bitter melon leaf extract (Momordica charantia L.) against Aedes aegypti larvae.Methods: An experimental study was conducted at the Public Health Laboratory of Tanah Bumbu in July 2024. This experimental research used 375 Aedes aegypti larvae with five treatments and three repetitions, observing the number of larvae that died after 24 hours. The data were analyzed using the Shapiro-Wilk test, Levene's test, Kruskal-Wallis test, Mann-Whitney test, and probit analysis.Results: Bitter melon leaf extract at concentrations of 0,3% and 0,6% did not cause larval death, so it was not effective in inhibiting the growth of Aedes aegypti. While at concentrations of 0,9% showed a significant effect in inhibiting larval growth. The results of the Kruskal-Wallis test on the death of larvae treated with bitter melon leaf extract obtained a significance value of 0,008 (p <0,05). The results of the Mann-Whitney test showed that there was a significant difference between the concentration of 0,9% bitter melon leaf extract and the positive control abate, as well as between the negative control aquadest and the concentration of 0,9% bitter melon leaf extract. The results of the probit analysis test obtained an LC50 value of 1,202%.Conclusion: The 0.9% concentration of bitter melon leaf extract can inhibit the growth of Aedes aegypti larvae. However, it is not yet suitable as an alternative bio-larvicide.
Overview of The Rationality of Medication Use In Covid-19 Patients at The Inpatition Installation of The Bhayangkara Hospital, Palangka Raya Prillyanisa , Pasca; Alexandra, Francsisca Diana; Hanasia; Frethernety, Agnes; Turnip, Oktaviani Naulita
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 2 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i2.11910

Abstract

Bhayangkara Palangka Raya Hospital is one of the government's referral hospitals for treating COVID-19 patients. COVID-19 patients need good service and treatment because there is no appropriate drug formulary for treating COVID-19 at Bhayangkara Hospital. Currently, the standard for COVID-19 treatment is based on the third edition of the COVID-19 management guidebook. This research aims to understand the rationale for using COVID-19 drugs in patients treated at the Bhayangkara Palangka Raya Hospital Outpatient Installation.The type of research used is descriptive qualitative. This research uses the method Total Sampling. The samples in this study were patients who received COVID-19 drug therapy and were hospitalized at Bhayangkara Palangka Raya Hospital who met the inclusion criteria for the July-August 2021 period. There are 6 indicators of rationality for drug use, namely correct indication, correct drug, correct dose, correct duration and method. administration, and be aware of side effects. In this study, a sample of 41 patients was taken. Based on the results of research evaluating the rationality of using COVID-19 drugs in the Bhayangkara Hospital Palangka RayaInpatient Installation for the period July-August 2021 based on the COVID-19 management guidebook, 3rd edition of 2020, in terms of 6 indicators of rationality, it was concluded that the analysis results were correct indications (100% ), the right drug (100%), the right patient (100%), the right dose (100%), the right duration and method of administration (100%), and being aware of side effects (100%) are completely rational. Judging from the 6 indicators of rationality including the right indication, the right drug, the right patient, the right dose, the right duration and method of administration, being alert to side effects is declared completely rational
Correlation Between Personal Hygiene of Handlers With The Presence of Escherichia Coli In Meatball at Palangka Raya University Silalahi, Angelina Brigitta Darawulan; Martani, Natalia Sri; Jabal, Arif Rahman; Turnip, Oktaviani Naulita; Teresa, Astrid
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 2 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i2.18656

Abstract

Food handlers have the opportunity to transmit disease. Meatballs are one of the most popular foods, however if the sanitary hygiene facilities of the place, the hygiene of meatball processing, and the personal hygiene of the handler are poor, it is vulnerable to bacterial contamination, one of which is Escherichia coli. This study aims to determine the relationship between personal hygiene of the handler with the presence of Escherichia coli in meatballs at Palangka Raya University. This study used a correlation study design with a cross-sectional approach and the sampling technique was carried out with a total sampling technique involving 14 meatball sellers as research samples. The instruments used in this study were observation sheets and laboratory tests. Data analysis used chi-square test. The results showed that 12 respondents did not fulfill Kepmenkes RI No.492/MENKES/SK/VII/2003 and based on laboratory tests, 4 meatball samples were positive for Escherichia coli bacteria. Based on the results of statistical tests, the results of this study prove that there is no relationship between personal hygiene of the handler with the presence of Escherichia coli bacteria in meatballs
Efektivitas Antibakteri Krim Ekstrak Daun Sirih Merah (Piper crocatum) Terhadap Beberapa Bakteri Renaldy, Renaldy; Trinovita, Elsa; Furtuna, Dewi Klarita; Fatmaria, Fatmaria; Turnip, Oktaviani Naulita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.264

Abstract

The prevalence of infectious diseases is increasing in developing countries such as Indonesia, and they have become a health problem. One infectious disease caused by Staphylococcus aureus and Escherichia coli bacteria is necrotizing fasciitis. The subcutaneous tissues and fascia necrosis characterize necrotizing fasciitis. Antibiotic therapy is one way to prevent the growth and development of bacteria, but continuous use can cause resistance to bacteria. This research aimed to determine the antibacterial effectiveness of red betel leaf extract in cream preparations against the growth activity of Staphylococcus aureus and Escherichia coli bacteria using the ditch plate method. Red betel leaves were extracted using the UAE method (temperature 600 C for 15 minutes), then made into a cream dosage form with a formulation of 20% extract concentration (F1), 40% extract concentration (F2), and 80% extract concentration (F3) then tested evaluation of cream preparations and antibacterial activity test using the ditch plate method. The extraction of red betel leaves used the UAE method in concentrations of 20%(F1), concentrations of 40%(F2), and concentrations of 80% (F3) in cream preparation form. The cream was evaluated, and antibacterial activity was tested using the ditch plate method. The red betel leaf extract cream inhibits Staphylococcus aureus growth by the ditch plate method but does not have antibacterial activity on Escherichia coli.
ISOLATION AND IDENTIFICATION OF LACTIC ACID BACTERIA FROM GAMBUT TAPE Hanasia, Hanasia; Martani, Natalia Sri; Turnip, Oktaviani Naulita; Putri Welmart, Devina Vania; Puspita Sari, Dewi Marta
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4040

Abstract

Background: Lactic acid bacteria (LAB) are Gram-positive bacteria with probiotic properties, contributing to digestive health by balancing gut microflora. These bacteria are commonly found in fermented products, including gambut tape, a traditional Indonesian fermented food from Kalimantan. Gambut tape is known for its distinctive green color derived from katuk and pandan leaves.Objective:  This study aims to isolate and identify LAB from the gambut tape. Methods: LAB were isolated using Man, Rogosa, and Sharpe (MRS) agar and incubated at 37°C for 24 hours. Identification was performed through biochemical tests, including Gram staining, catalase, citrate, H2S, motility, indole, carbohydrate fermentation, methyl red, and Voges-Proskauer tests.Results:  Three isolates were obtained, exhibiting similar morphological features: milky white color, round shape, intact edges, convex elevation, and smooth surface. Biochemical results suggested that the isolates are identical to Lactococcus lactis, Lactobacillus plantarum, and Lactobacillus fermentum.Conclusions: The LAB isolated from the gambut tape shows potential as an antibacterial agent for disease prevention. Further research is needed to evaluate their antibacterial activity and characterize bacteriocins produced by these LAB.
Edukasi Bahaya Hepatitis Akut Di Unit Pelaksana Teknis Daerah Puskesmas Panarung Kota Palangka Raya Turnip, Oktaviani Naulita; Nawan; Hanasia; Praja, Rian Ka; Martani, Natalia Sri; Furtuna, Dewi Klarita
Jurnal Pengabdian Kampus Vol 10 No 2 (2023): Jurnal Pengabdian Kampus
Publisher : LPPM Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/jpmupr.v10i2.10875

Abstract

Hepatitis is a type of acute disease caused by a virus. Hepatitis virus itself is divided into several types, namely Hepatitis A, B, C, D, and E. The global prevalence of hepatitis is reported to be 2 billion patients in the world, 240 million people with chronic hepatitis B, followed by hepatitis C with 170 million patients. Every year, 1.5 million people die from hepatitis. Indonesia has the highest hepatitis B endemicity, making WHO set a global level evaluation of hepatitis control every two years. In early 2022, a case of hepatitis was found that was claimed to be acute hepatitis. The first case of acute hepatitis was reported in the United Kingdom and was designated as an Extraordinary Event in 2022. Cases of acute hepatitis spread to various countries in the world, including Indonesia. A total of 18 suspected cases of hepatitis were reported in North Sumatra, West Sumatra, Bangka Belitung Islands, DKI Jakarta, West Java, East Java, East Kalimantan, and DKI Jakarta. The main transmission of acute hepatitis is thought to be through body fluids, so the Ministry of Health has initiated procedures to prevent the transmission of acute hepatitis among the community, especially children. The low public understanding of the dangers of acute hepatitis makes us the UPR FK Microbiology team to provide understanding and education to the public regarding the dangers of hepatitis, handling, prevention and management of acute hepatitis if it occurs in the community.
Activity of Kelakai Leaf Extract (Stenochlaena palustris) as an Antioxidant and Antidiabetic: An In Vitro and In Silico Study Komara, Nisa Kartika; Hanasia; Turnip, Oktaviani Naulita; Ahmad, Farah Fauziyah Radhiyatulqalbi; Muhammad Irmawan; Ysrafil; Toemon, Angeline Novia; Muhammad Alif Sayyidinoor
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 12 No. 1 (2026): (March 2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2026.v12.i1.17494

Abstract

Background: Indonesia is the only country in Southeast Asia with the highest number of diabetics worldwide. In 2021, diabetes in Indonesia reached 10.6%, and it is predicted that this number will continue to increase, reaching 578 million by 2030 and 700 million by 2045. The way to overcome diabetes mellitus is by using drugs that can increase antioxidants and inhibit the activity of α-glucosidase; however, this method can have side effects, particularly on the digestive tract. Therefore, another alternative treatment is needed to reduce blood glucose levels in patients with diabetes mellitus, which is achieved by using natural ingredients. One of the natural ingredients predicted to have antioxidant and antidiabetic activity is kelakai leaves (Stenochlaena palustris). Methods: The content of your abstract must include background, aims of the study, used method, brief result and conclusion. Results: In this study, kelakai leaf extract showed potential as a source of bioactive compounds, particularly in terms of antioxidant activity and potential inhibition of α-glucosidase. This is indicated by the very strong IC50 value of 9,384 ppm. The best results were found in the nictoflorin compound, with a bond energy value almost close to the native ligand value (-7.7 kcal/mol) and interacting with the same amino acids as α-glucosidase, including Asp 542, Phe 575, Tyr 299, Trp 406, His 600, and Met 444. Conclusions: The potential of kelakai leaf extract as an antidiabetic is indicated by the interaction between α-glucosidase and all test compounds, as seen from the bond energy reflecting the level of affinity.
Co-Authors Agustira, Dewanti Alexandra, Francisca Diana Angeline Novia Toemon, Angeline Novia Arif Rahman Jabal Austin Bertilova Carmelita, Austin Bertilova Ayu Rahayu Desimaria Panjaitan Efendy, Dennisya Azzahra Elsa Trinovita Elvina Damayanti Fatmaria, Fatmaria Francisca Diana Alexandra Frethernety, Agnes Furtuna, Dewi Klarita Hanasia Hanasia, Hanasia Handayani, Septi Indria Augustina Komara, Nisa Kartika Malik, Handayani Mudatama, Yusuf Muhammad Alif Sayyidinoor Muhammad Irmawan Natalia Sri Martani Nawan Nawan, Nawan Ni Nyoman Sri Yuliani Palupi, Didin Retno Endah Prillyanisa , Pasca Puspita Sari, Dewi Marta Putri Welmart, Devina Vania Rahmawati Halim Rakhman, Farizky Ratna Widayati Rejeki, Fransiska Caesaria Silvi Renaldy, Renaldy Rian Ka Praja Rovik, Anwar Sadek, Yitro Tuah HR Safitri, Andini Sayyidinoor, Muhammad Alif Silalahi, Angelina Brigitta Darawulan Teresa, Astrid Toemon, Agnes Immanuela Upel, Dean Antoni Ysrafil Ysrafil, Ysrafil