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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat Indonesian Journal for Health Sciences (IJHS) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Dinamika Journal : Pengabdian Masyarakat KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Jurnal Surya Masyarakat Prosiding Seminar Nasional Program Pengabdian Masyarakat Journal Of Human And Education (JAHE) International Journal of Health and Pharmaceutical (IJHP) SWARNA SWARNA: Jurnal Pengabdian Kepada Masyarakat Biosaintifika: Journal of Biology & Biology Education Prosiding International Conference on Sustainable Innovation (ICoSI)
Astuti, Yoni
Universitas Muhammadiyah Yogyakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Apoptosis Effect of Ethanol Extract Soursop Leaves On WiDr Cancer Cell Line Yoni Astuti; Wahyu Joko Priambodo; Sabtanti Harimukti; Agus Suharto
Proceedings International Conference on Sustainable Innovation (ICoSI) Vol. 1 No. 1 (2021): Maximizing Opportunities and Research for a Better Life
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/icosi.v3i1.32

Abstract

Apoptosis is a critical physiological process responsible for the homeostatic mechanism and maintenance of cell populations in tissues. Due to the close correlation between the mechanism of apoptosis and the effect of anticancer agents, extensive research has been done on this mode of cell death. Annona muricata has a significant antiproliferative effect on some cancer cells. This research carried out to explore the apoptosis effect of ethanol extract soursop leaves from Tawangmangu on WiDr cancer cell line. Methods To gain the ethanol extract of soursop leaves use maserasi method. To calculate the death cell used colouring Tryphan blue. The result showed that the average of death cell at dose IC 50 in 24 hrs was (6.35±2.05) 104 in 48 hours were (11.1±1.27) 104. meanwhile that the average of death cell at dose ½ IC in 24 hours were (6.15±0.64)104 and (10.25±1.59) 104. The Increasing of death cell at dose IC 50 during 24 hours were 1,71 times and at dose ½ IC 50 were 1,67 times. Conclusion: Ethanol extract Annona muricata from Tawangmangu able to increase death cell around 1,71 times per hours in IC50 and 1,67 in 1/2IC50 on WiDr cell line.
The Correlation between Total Urine Protein Levels and The Frequency of Hemodialysis in Chronic Kidney Failure Patients Yusuf, Carla Shafira Angelina; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol. 25 No. 1 (2025): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v25i1.24138

Abstract

Chronic Kidney Failure (CKF) is a global health problem with a high prevalence, including in Indonesia. Renal replacement therapy, such as hemodialysis, is used to maintain the life of patients with CKF. The study aims to analyze the correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital from January to September 2023. The research is quantitative and descriptive, using cross-sectional survey methods and secondary data from patient medical records. Statistical analysis uses the Spearman test to test the correlation between variables. Total of HD frequency 1x/week = 6, 2x/week = 58, 3x/week= 1. In order, the trace of protein + 1 = 6, +2 = 58 , +3 = 1. The result of the analysis showed that the total urine protein rate with a frequency of hemodialysis was negatively correlated (r= 0,026; p= 0,84), also did not correlate with gender (r= -0,039; p= 0,756), comorbid (r= -0,038; p= 0,766), and age (r= 0,174; p= 0,166). The conclusion is that there is no correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital.
Pemberdayaan Masyarakat melalui Pemanfaatan Botol Bekas untuk Pengendalian Hama Lalat Buah Syuhada, Ammar Fatwa; Santosa, Mohammad Rizky Nur; Ramadhan, Andhika Putra; Agraini, Fitria Kusuma; Carera, Silviana Chandra; Abdillah, Annisa Jasminna; Fayyidillah, Bagas Adi; Pramudya, Bramanta Eka; Rielies, Noer Fadilla Sapoetri; Astuti, Yoni
Prosiding Seminar Nasional Program Pengabdian Masyarakat Vol. 8 No. 1 (2025): Rekonstruksi Pendidikan di Indonesia
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/ppm.81.1323

Abstract

This community service program was carried out by the team of Muhammadiyah University of Yogyakarta (UMY) with the aim of helping the people of Padukuhan Dukuhsari, Wonokerto Sub-district, Turi District, Sleman Regency, in overcoming the problem of fruit fly pests that threaten salak plants. This problem originated from the high level of salak fruit damage caused by the fruit fly pest Bactrocera dorsalis. This pest attacks plants by laying eggs inside the fruit, which then hatch into larvae and damage the fruit from the inside. This condition has a significant impact on reducing the yield of salak farmers in the region.Overcoming this problem, the UMY team initiated an environmentally friendly innovation-based community empowerment program by utilizing used bottles as fruit fly traps. This program involves three main stages, namely socialization, training, and evaluation. At the socialization stage, the community gained an understanding of the characteristics of fruit fly pests, their impact on salak plants, and how to effectively control them. The training was followed by the practice of making traps using key materials such as used bottles, petrogenol as an attractant, insecticide, and insecticidal adhesive as a binding agent. The traps were designed to be installed at various strategic points in the salak orchard.The evaluation was conducted by monitoring the number of fruit flies trapped for six days in five different locations. The results showed that the location with the highest number of trapped fruit flies was Kebun Salak Belakang Pendopo more than 41%, which is thought to have many alternative host plants for the pest. Weather factors and food availability also affected the number of flies captured. The program received a positive response from the community, who enthusiastically participated in the socialization activities and trap-making practices. With this innovation, it is hoped that the community can reduce dependence on excessive chemical pesticides, increase salak yields, and utilize plastic waste effectively to support sustainable agriculture
Ethanolic Extract of Citrus reticulata Peel Inhibits the Migration of WiDr Colon Cancer Cells Astuti, Yoni; Primasari, Aulia
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp60-66

Abstract

Colorectal cancer is third rank on the cancer cases in Indonesia. To cure the cancer needs big cost and lot of effort. On the other side, the side effect of medicine or chemotherapy on patient need to reduce. Cancer cell spread to other tissue based on its migration and invasion ability. Citrus reticulata peel contains flavonoid such as Tangeretin and Nobiletin, both of this compounds have anticancer activity. The aims of this study is to reveals the potency of ethanol extract of Citrus reticulata peel on the inhibition of migration on WiDr colon cancer cells. The toxicity of ethanol extract of Citurs reticulata peel on WiDr colon cancer line was measured using 3-(4,5-dimethyltiazol-2-il)-2,5-diphenyltrazolium bromide (MTT) assay and investigate the cell migration was using scratch wound healing assay. The ethanol extract of Citrus reticulata peel showed the value of inhibitory concentration 50 (IC50) was 184.5 μg/mL, this result categorize as moderate cytotoxic. Meanwhile the migration assay showed that the deceleration of migration occurred on 0.5 IC50, 0.33 IC50 and 0.25 IC50 during 24 h and 36 h incubation, event thought there were not significant different (p>0.05). The ethanol extract of Citrus reticulata peel has a potential migration inhibition on WiDr cell line.Keywords: Citrus reticulata, WiDr cell line, migration
OPTIMALISASI POJOK BACA MELALUI PEMBEKALAN GURU TK ABA DAN ORANGTUA DALAM MENDAMPINGI ANAK MENDONGENG (BERKISAH) Aisyah, Nurul; Astuti, Yoni
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 10 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i10.3746-3750

Abstract

Agenda bercerita menjadi sangat menarik dan perlu, bilamana dalam rangkaian dongeng/ kisah termuat pesan moral yang dapat diambil oleh anak sebagai pendidikan akhlaq. Itu semua juga ditunjang dari segi fasilitas yang memadai di rumah maupun di Sekolah. Atas dasar ini maka penting untuk melakukanrevitalisasi dengan pengadaankembali fasilitas ruang belajar sebagai ruang berkisah berdongeng. Selain itujuga pengadaan buku-buku penunjang juga diperlukan. Revitalisasi sarana belajar dalamhal ini pojokbelajar (Pojok baca) maka sangat di perlukan bagi anak dan sekolah. Karena budaya literasi harus ditanamkan sejak usia dini bahkan kalau bisa sejak didalam kandungan sudah dibiasakan orangtua untukmembaca. Rutinitas membaca dari orangtua akan ditiru oleh anak. Dengan adanya ProgrampengabdianPKM ini akan mengajak sekolah dan kolaborator untuk merevitalisai pojok belajar dan ditambah kegiatanbelajar anak dan Parental Lecturing tentang budaya literasi yang harus ditanamkan dari lingkungankeluarga melalui peningkatan skill orangtua dalam mendongeng, begitupun kemampuan guru juga perludiasah kembali. Pelaksanannya: 1. Anak dan guru belajar bersama di pojok belajar; mendongeng danberkisah. 2. Pengadaan buku-buku usia anak TK membaca dan menulis Al-Qur’an, buku kisah para nabi, buku dongen fabel, buku menggambar, buku keterampilan otak kiri, kisah-kisah para nabi, sejarah nabi Muhammad dan praktek sholat. 3. Dengan pojok belajar yang nyaman proses belajar juga akan kondusif 4. Parental Lecturing tentang keahlian orangtua dan guru dalam menjadi story teller bagi anak usia TK.
Dietary Protein, Vitamin C, and Iron Intake As Predictors of Hemoglobin Levels in Children With Special Needs” Astuti, Yoni; Sunarti, Sunarti; Puspita, Gina; Permana, Iman
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 1 (2026): February 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i1.622

Abstract

Hemoglobin (Hb) is a key indicator of oxygen transport and overall child health, particularly during periods of rapid growth and cognitive development. Anemia remains a significant global public health problem, often driven by nutritional deficiencies, especially iron. Vitamin C enhances iron absorption, while protein supports hemoglobin synthesis, indicating a synergistic role of these nutrients. Children with special needs are at higher risk of nutritional inadequacies due to feeding challenges and restricted diets. However, evidence on how dietary intake influences hemoglobin levels in this population is still limited. Aims:This study aimed to analyze the role of dietary protein, vitamin C, and iron intake as predictors of hemoglobin levels in children with special needs. Methods:A cross-sectional observational study was conducted among 34 students at SLB Kutoarjo between January and May 2024. Dietary intake data were collected using a 3-day food record completed by caregivers and analyzed with NutriSurvey software. Hemoglobin data were obtained from school health records. Statistical analysis included correlation and multiple regression tests to assess the relationship between nutrient intake and hemoglobin levels. Results:The findings revealed that the average intake of protein, iron, vitamin C, and total energy was below recommended levels. Despite this, the mean hemoglobin level (13.38 ± 1.33 g/dL) was within the normal range. Regression analysis showed that the combined intake of protein, iron, vitamin C, and folate explained 25% of the variation in hemoglobin levels (R² = 0.25), but the adjusted R² was low (0.036), indicating weak explanatory power. No individual nutrient showed a statistically significant association with hemoglobin levels (p > 0.05). Conclusions:Dietary protein, vitamin C, and iron intake were not significant predictors of hemoglobin levels in children with special needs. These findings highlight that hemoglobin status is influenced by complex interactions beyond dietary intake alone. Further research with larger samples and additional biomarkers is needed to better understand anemia risk in this population.
Age and Gender Differences in Urea and Creatinine Levels among Diabetic Patients: A Retrospective Observational Study From a Tertiary Hospital in Yogyakarta, Indonesia Astuti, Yoni
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 1 (2026): February 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i1.623

Abstract

Diabetes mellitus is a major global health problem associated with progressive renal complications, including diabetic nephropathy. Serum urea and creatinine are widely used biomarkers to assess renal function, yet their interpretation may be influenced by age and gender differences.This study aimed to analyze differences in urea and creatinine levels among diabetic patients based on age and gender and to evaluate their statistical significance.A retrospective observational study was conducted using medical record data from PKU Muhammadiyah Hospital, Yogyakarta, Indonesia, from Januari to December2025. Patients with complete data on age, gender, urea, and creatinine were included, while incomplete records were excluded. Subjects were stratified into three age groups: ≤50, 51–60, and ≥61 years. Independent sample t-tests were used to compare biomarker levels between males and females within each age group (p < 0.05 considered significant).Mean urea levels increased progressively with age in both genders. Male patients showed a consistent increase in both urea and creatinine levels across age groups, whereas females demonstrated less consistent creatinine trends. Significant gender differences were observed in the ≤50 years group for urea (p = 0.004) and creatinine (p = 0.042), while no significant differences were found in older groups. High variability in biomarker levels was observed, particularly among elderly patients.Age significantly influences urea levels in diabetic patients, while gender differences are more pronounced in younger individuals. These findings highlight the importance of age- and gender-specific interpretation of renal biomarkers in diabetes management.
Co-Authors Abda Abda Abdillah, Annisa Jasminna Agi Rinaldi Agraini, Fitria Kusuma Agus Suharto Agus Suharto, Agus Alfaina Wahyuni Ambar Relawati Ambar Relawati Anggoro, Dedy Sukmo Anggoro, Dedy Sukmo Anna Monita Aristyaning Putri, Wahyu Arswendy Ainurridho Cahyani, Fitnaningsih Endang Carera, Silviana Chandra Dedy Irawan Dewi, Lisa La Rosma Ekorini Listyowati Eni Kaharti Ervina Ratna Ningsih Fayyidillah, Bagas Adi Fitriana, Selly Fitriana, Selly Gatot Supangkat Giand Elmadahlia Tusara Hayati, Nur Ika Dyah Kurniati Ikhlas Muhammad Jenie Iman Permana, Iman Inayati Inayati Indrayanti, Indrayanti Kelvin Kumiawan Sahputra Lilis Suryani Lilis Suryani Mauladina Yuni Pratiwi Muhammad Iqbal Fauzi Mutiara Nur Cahyaningrum Nisa Kartika Hasanah Noor, Zulkhah Nunuk Siti Rahayu Nur Chayati Nur Shani Meida Nurul Aisyah Nurul Aisyah Nurul Qomariah Oryzati Hilman Pramudya, Bramanta Eka Pretty Nur Syilvia Primasari, Aulia Puspita, Gina Ramadhan, Andhika Putra Retno Wulandari Rielies, Noer Fadilla Sapoetri Rifki Hulalata Rini Handayani Rini Handayani Rum Wijayanti Sabtanti Harimukti Sabtanti Harimurti Santosa, Mohammad Rizky Nur Sri Andayani Sunarti Suryanto Syuhada, Ammar Fatwa Tiny Mafdalena Tri Wulandari Kesetyaningsih Tusara, Giand Elmadahlia Wahyu Joko Priambodo Wahyu Joko Priambodo YOSHIHIKO YANO Yusiriwayatul Afsoh Yusuf, Carla Shafira Angelina Zuliana Utami, Anisa