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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Jurnal Surya Masyarakat Indonesian Journal for Health Sciences (IJHS) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Dinamika Journal : Pengabdian Masyarakat KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Jurnal Surya Masyarakat Prosiding Seminar Nasional Program Pengabdian Masyarakat Journal Of Human And Education (JAHE) SWARNA SWARNA: Jurnal Pengabdian Kepada Masyarakat Biosaintifika: Journal of Biology & Biology Education Prosiding International Conference on Sustainable Innovation (ICoSI)
Astuti, Yoni
Universitas Muhammadiyah Yogyakarta
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Alteration Level of VEGF of Colon Cancer Cell After Induction with Mandarin Orange (Citrus Reticulata) Peel Ethanol Extract Astuti, Yoni; Zuliana Utami, Anisa; Suharto, Agus; Yano, Yoshihiko; Aristyaning Putri, Wahyu
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 2 (2024): August 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i2.3401

Abstract

The natural ingredient-based therapy extracted from various plants is assumed more tolerable to cancer patients’ bodies than synthetic drugs. To tell successful novel cancer therapy, an indicator is needed to confirm the result. VEGF is a pro-angiogenic factor that leads the cancer cells’ invasion to another organ and is associated with high mortality in patients. Hence, the VEGF level is widely used as one of the successful cancer therapy indicators. Purposed of research elucidated the effect of Mandarin orange peel ethanol extract (EEKJM) to improve the reduction of VEGF levels in colon cancer in vitro. This study was an experimental posttest and control group design to analyze different level of VEGF on cancer cells at end of the study.  Research began with the preparation of EEKJM followed by a cytotoxic extract test using the MTT assay method. Furthermore, the measurement of VEGF levels by the VEGF ELISA kit protocol. One Way ANOVA was performed to analyze data.Results showed the cytotoxic test of the EEKJM and doxorubicin against WiDr cells was 240 g/ml and 1.59 µg/ml. VEGF levels showed decreasing after being induced with EEKJM and doxorubicin with doses ½ IC50 and ¼ IC50. Conclusion: EEKJM was able to reduce VEGF levels and viability of WiDr colon cancer cells. The advantages are as much as initial evidence of the ability of the orange to treat cancer even though further animal studies or evidence of a pathway of decrease of the VEGF or other signals are required.
Apoptosis Effect of Ethanol Extract Soursop Leaves On WiDr Cancer Cell Line Yoni Astuti; Wahyu Joko Priambodo; Sabtanti Harimukti; Agus Suharto
Proceedings International Conference on Sustainable Innovation (ICoSI) Vol. 1 No. 1 (2021): Maximizing Opportunities and Research for a Better Life
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/icosi.v3i1.32

Abstract

Apoptosis is a critical physiological process responsible for the homeostatic mechanism and maintenance of cell populations in tissues. Due to the close correlation between the mechanism of apoptosis and the effect of anticancer agents, extensive research has been done on this mode of cell death. Annona muricata has a significant antiproliferative effect on some cancer cells. This research carried out to explore the apoptosis effect of ethanol extract soursop leaves from Tawangmangu on WiDr cancer cell line. Methods To gain the ethanol extract of soursop leaves use maserasi method. To calculate the death cell used colouring Tryphan blue. The result showed that the average of death cell at dose IC 50 in 24 hrs was (6.35±2.05) 104 in 48 hours were (11.1±1.27) 104. meanwhile that the average of death cell at dose ½ IC in 24 hours were (6.15±0.64)104 and (10.25±1.59) 104. The Increasing of death cell at dose IC 50 during 24 hours were 1,71 times and at dose ½ IC 50 were 1,67 times. Conclusion: Ethanol extract Annona muricata from Tawangmangu able to increase death cell around 1,71 times per hours in IC50 and 1,67 in 1/2IC50 on WiDr cell line.
The Correlation between Total Urine Protein Levels and The Frequency of Hemodialysis in Chronic Kidney Failure Patients Yusuf, Carla Shafira Angelina; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol. 25 No. 1 (2025): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v25i1.24138

Abstract

Chronic Kidney Failure (CKF) is a global health problem with a high prevalence, including in Indonesia. Renal replacement therapy, such as hemodialysis, is used to maintain the life of patients with CKF. The study aims to analyze the correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital from January to September 2023. The research is quantitative and descriptive, using cross-sectional survey methods and secondary data from patient medical records. Statistical analysis uses the Spearman test to test the correlation between variables. Total of HD frequency 1x/week = 6, 2x/week = 58, 3x/week= 1. In order, the trace of protein + 1 = 6, +2 = 58 , +3 = 1. The result of the analysis showed that the total urine protein rate with a frequency of hemodialysis was negatively correlated (r= 0,026; p= 0,84), also did not correlate with gender (r= -0,039; p= 0,756), comorbid (r= -0,038; p= 0,766), and age (r= 0,174; p= 0,166). The conclusion is that there is no correlation between total urine protein levels and the frequency of hemodialysis in patients with chronic kidney failure at PKU Muhammadiyah Gamping Hospital.
Pemberdayaan Masyarakat melalui Pemanfaatan Botol Bekas untuk Pengendalian Hama Lalat Buah Syuhada, Ammar Fatwa; Santosa, Mohammad Rizky Nur; Ramadhan, Andhika Putra; Agraini, Fitria Kusuma; Carera, Silviana Chandra; Abdillah, Annisa Jasminna; Fayyidillah, Bagas Adi; Pramudya, Bramanta Eka; Rielies, Noer Fadilla Sapoetri; Astuti, Yoni
Prosiding Seminar Nasional Program Pengabdian Masyarakat Vol. 8 No. 1 (2025): Rekonstruksi Pendidikan di Indonesia
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/ppm.81.1323

Abstract

This community service program was carried out by the team of Muhammadiyah University of Yogyakarta (UMY) with the aim of helping the people of Padukuhan Dukuhsari, Wonokerto Sub-district, Turi District, Sleman Regency, in overcoming the problem of fruit fly pests that threaten salak plants. This problem originated from the high level of salak fruit damage caused by the fruit fly pest Bactrocera dorsalis. This pest attacks plants by laying eggs inside the fruit, which then hatch into larvae and damage the fruit from the inside. This condition has a significant impact on reducing the yield of salak farmers in the region.Overcoming this problem, the UMY team initiated an environmentally friendly innovation-based community empowerment program by utilizing used bottles as fruit fly traps. This program involves three main stages, namely socialization, training, and evaluation. At the socialization stage, the community gained an understanding of the characteristics of fruit fly pests, their impact on salak plants, and how to effectively control them. The training was followed by the practice of making traps using key materials such as used bottles, petrogenol as an attractant, insecticide, and insecticidal adhesive as a binding agent. The traps were designed to be installed at various strategic points in the salak orchard.The evaluation was conducted by monitoring the number of fruit flies trapped for six days in five different locations. The results showed that the location with the highest number of trapped fruit flies was Kebun Salak Belakang Pendopo more than 41%, which is thought to have many alternative host plants for the pest. Weather factors and food availability also affected the number of flies captured. The program received a positive response from the community, who enthusiastically participated in the socialization activities and trap-making practices. With this innovation, it is hoped that the community can reduce dependence on excessive chemical pesticides, increase salak yields, and utilize plastic waste effectively to support sustainable agriculture
Co-Authors Abdillah, Annisa Jasminna Agi Rinaldi Agraini, Fitria Kusuma Agus Suharto Agus Suharto, Agus Alfaina Wahyuni Ambar Relawati Ambar Relawati Anggoro, Dedy Sukmo Anggoro, Dedy Sukmo Anna Monita Aristyaning Putri, Wahyu Arswendy Ainurridho Aulia Primasari Carera, Silviana Chandra Dedy Irawan Dewi, Lisa La Rosma Ekorini Listyowati Eni Kaharti Ervina Ratna Ningsih Fayyidillah, Bagas Adi Fitnaningsih Endang C Fitriana, Selly Fitriana, Selly Gatot Supangkat Giand Elmadahlia Tusara Hayati, Nur Ika Dyah Kurniati Ikhlas Muhammad Jenie Inayati Inayati Indrayanti, Indrayanti Irawan, Dedy Kelvin Kumiawan Sahputra Lilis Suryani Lilis Suryani Mauladina Yuni Pratiwi Muhammad Iqbal Fauzi Mutiara Nur Cahyaningrum Nisa Kartika Hasanah Noor, Zulkhah Nunuk Siti Rahayu Nur Chayati Nur Shani Meida Nurul Aisyah Nurul Qomariah Oryzati Hilman Pramudya, Bramanta Eka Pretty Nur Syilvia Ramadhan, Andhika Putra Retno Wulandari Rielies, Noer Fadilla Sapoetri Rifki Hulalata Rini Handayani Rini Handayani Rum Wijayanti Sabtanti Harimukti Sabtanti Harimurti Santosa, Mohammad Rizky Nur Sri Andayani Suryanto Syuhada, Ammar Fatwa Tiny Mafdalena Tri Wulandari Kesetyaningsih Tusara, Giand Elmadahlia Wahyu Joko Priambodo Wahyu Joko Priambodo YOSHIHIKO YANO Yusiriwayatul Afsoh Yusuf, Carla Shafira Angelina Zuliana Utami, Anisa