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Yanti Fitri Yasa
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Nursing

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KEMATIAN SEL TERPROGRAM (APOPTOSIS) Yanti Fitri Yasa
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1902

Abstract

Apoptosis is a programmed cell death mechanism that plays a crucial role in maintaining cellular homeostasis, tissue development, and eliminating damaged cells. Disruption of apoptosis regulation is known to contribute to various diseases, such as cancer and neurodegenerative disorders. Therefore, studying the mechanisms of apoptosis is crucial to strengthen our biological understanding and its clinical implications. This study employed a descriptive-analytical literature review approach. Data were obtained from international scientific articles published in reputable databases and analyzed qualitatively to examine the molecular mechanisms, apoptosis pathways, and the role of key regulators in programmed cell death. The results indicate that apoptosis proceeds through two main pathways: the intrinsic pathway involving mitochondria and the release of pro-apoptotic factors, and the extrinsic pathway triggered by the activation of death receptors. Both pathways culminate in the activation of caspases, the primary executors of apoptosis. Furthermore, additional regulatory mechanisms were identified that refine the classical apoptosis model. Apoptosis is a highly controlled and integrated biological process, playing a crucial role in the balance and continuity of cellular function. A comprehensive understanding of the mechanisms of apoptosis provides a crucial contribution to the development of therapeutic approaches based on the regulation of programmed cell death.
Co-Authors Abdullah, Dessy Ade Teti Vani Annisa Diva Dhiersa Aryaldy Zulkarnaini Atika Karina Asmi Debie Anggraini Dessy Abdullah Efriza Efriza Elfahmi Erdanella Setiawati Gangga Mahatma Haiga, Yuri Hansah, Rendri Bayu Irdawati Izrul Irwan Triansyah Irwan Triansyah, Irwan Jefri Henky Jenny Tri yuspitasari Khuntum Khairatul Ummah Letvi Mona Maryeti Mawarzi Melya Susanti Muhammad Alfan Syuri Asqa Muhammad Ivan Muhammad Rizki Saputra Nadia Purnama Dewi Nilas Warlem Relly Angelica Putriz Rendri Bayu Hansah Resdamia Aprilia Rifaldo Yudistira Rinita Amelia Roland Helmizar Rosmaini Rosmaini, Rosmaini Sahla Riska Nafiah Shafira Larissa Soufni Morawati Suharni Suharni Tati khairina Vani, Ade Teti