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All Journal HAYATI Journal of Biosciences Jurnal Sain Veteriner Biota Biology, Medicine, & Natural Product Chemistry Journal of Tropical Biodiversity and Biotechnology JMM (Jurnal Masyarakat Mandiri) Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Biota Aquacultura Indonesiana Biological Environment and Pollution
Septriani, Nur Indah
Gadjah Mada University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Congenital Malformations in Chicken Embryos After Oxybenzone Exposure Saragih, Hendry T.S.; Empra, Desi Eka Putri; Rahmadian, Desti; Shalihah, Fianicha; Primahesa, Alfian; Oktaviana, Shintia; Allimi, Hayu Swari; Septriani, Nur Indah; Nuriliani, Ardaning
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.589-598

Abstract

Topical use of oxybenzone, commonly found in sunscreens, can be absorbed by the skin, and long-term use may cause endocrine disruption, cancer, and teratogenic effects. However, its potential teratogenic effects on embryonic development have not been well-studied. This study aims to determine the impact of oxybenzone exposure on the early stage of embryonic development. Chicken embryos aged 72 hours (20 Hamburger-Hamilton/HH stage) were exposed to a pure oxybenzone for 24 hours at varying concentrations (0, 1, 5, 10, and 20 ppm), each group consisting of 3 embryos. Embryo preparations were made using the wholemount method. Morphological abnormalities were observed with a stereo microscope, and descriptively morphometric measurements were analyzed using ImageJ software. Statistical analysis used One-way ANOVA and Tukey’s test for normally distributed data, while Kruskal-Wallis H and Mann-Whitney U test for non-normally distributed data. This study found that oxybenzone significantly enlarged the embryo, telencephalon, and eye. Several abnormalities were observed in the embryos exposed to oxybenzone, including incomplete closure of the anterior neuropore, concavity in the anterior and lateral of the mesencephalon, and depressions in the tail bud. This study concludes that oxybenzone acts as a teratogen, causing abnormalities in embryonic development, particularly in the central nervous system.
Co-Authors Aeniah, Siti Allimi, Hayu Swari Anisya, Alifia Anita Restu Puji Raharjeng Aprilia Sufi Subiastuti Apriliyani, Tia Ardaning Nuriliani Ariel Hananya Ariesti, Wiwin Asifa Bella Ilmy Firdaus Bambang Retnoaji Dwi Eny Djoko Setyono Dwi Sendi Priyono Empra, Desi Eka Putri Fajar Sofyantoro Frida Prasetyo Utami Frida Prasetyo Utami Gizela Aulia Agustin Halim, Shuha Ma’muriyah Hendry Saragih Hendry Tri Sakti Saragih Karlina, Ina Khoiruddin Anshori Maria Nur Hasanah Muhammad Ardillah Rusydan Nareta Defiani Nastiti Wijayanti Nata Dwi Annisa Nizma Nisrina Salsabila Nizma, Nata Dwi Annisa Oktaviana, Shintia Pradnya Paramita Primahesa, Alfian Pusparini, Nur Ainun Oktavia Rahmadian, Desti Rohmah, Zuliyati Ruchianasari Delia Putri Rustadi Rustadi Saeed, Faisal Saragih, Hendry T.S. Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Senny Helmiati Setyo, Agnessia Asian Budi Shalihah, Fianicha Simanungkalit, Eben Ezer Slamet Widiyanto Sukirno Sukirno Supraitno, Murtiadi Erlan Wahyu Aristyaning Putri Wahyu Aristyaning Putri Zusrina, Laili Mufli