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All Journal Abdimasku : Jurnal Pengabdian Masyarakat Journal Pharmasci (Journal of Pharmacy and Science) Sasambo Journal of Pharmacy Open Access Health Scientific Journal Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Riset Informasi Kesehatan PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Community Engagement in Health Strada Jurnal Ilmiah Kesehatan (SJIK) Strada Journal of Pharmacy APMa Jurnal Pengabdian Masyarakat
Luluk Aniqoh Meliana Putri
Universitas STRADA Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effectiveness and Physical Quality Test of Ashitaba Leaf Extract Exfoliating Toner against Staphylococcus epidermidis and Propionibacterium acnes Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Open Access Health Scientific Journal Vol. 7 No. 1 (2026): February 2026
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v7i1.134

Abstract

Background: Acne (acne vulgaris) is a chronic inflammatory skin disease with a complex pathogenesis, involving the sebaceous glands and excessive colonization of acne-causing bacteria. In the modern era, the trend of using natural cosmetics is gaining momentum, not only in Indonesia but also globally. An example of a plant with great potential is Ashitaba. Ashitaba leaves have antibacterial. This study aimed to observe the physical quality test and antibacterial test of ashitaba leaf extract toner against Staphylococcus epidermidis and Propionibacterium acnes bacteria.Methods: The design in this study is an experimental method, physical quality tests include, Organoleptic tests are carried out visually, the components evaluated are the smell, shape, color and texture of the preparation, pH test and viscosity test.  analysis of data from the physical quality test of the Ashitaba leaf extract facial toner, the physical characteristics of the preparation, including organoleptic, homogeneity, viscosity, and pH, of all three formulas met the parameters.Results: The toner tested against Staphylococcus epidermidis and Propionibacterium acnes bacteria had the largest inhibition zone, namely with an extract concentration of 20%.Conclusion: The toner tested against Staphylococcus epidermidis bacteria with a 20% extract had the largest inhibition zone of 27.6 mm, while Propionibacterium acnes bacteria with a 20% extract had the largest inhibition zone of 27.9 mm
Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Musdalifah Qadariah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Abstract

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).
Improving Health-Related Knowledge Among Older Adults Through Herbal Education and Functional Beverage Training in Mangunrejo Village Devita Riafinola; Sri Rahayu Dwi Purnaningtyas; Luluk Aniqoh Meliana Putri; Bilal Subchan Agus Santoso; Juvita Herdianti; Ivan Junius Mesak; Chintia Devientasari; Selly Septi Fandinata; Dini Berliana; Adi Wibisono; Maulana Firdaus; Imam Fathurrahman; Anggi Restyawati
Journal of Community Engagement in Health Vol. 9 No. 2 (2026): September
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jceh.v9i2.842

Abstract

Older adults are at increased risk of noncommunicable diseases, including diabetes mellitus (DM) and hypertension, highlighting the need for accessible and practical health education. This community service activity aimed to improve health-related knowledge among older adults regarding DM, hypertension, herbal plants, bioactive compounds, and the appropriate use of natural ingredients through health education and functional beverage training. The activity was conducted as a community service program with quantitative evaluation using a one-group pretest–post-test design among 20 older adults in Mangunrejo Village. The activities included education on DM, hypertension, herbal plants, bioactive compounds, and the appropriate use of herbal ingredients, followed by training in the preparation of infused water using lemon, cucumber, and cinnamon. Participants’ knowledge was assessed using a 20-item true/false questionnaire before and after the activity. Data were analyzed using the Wilcoxon signed-rank test at α = 0.05. The mean knowledge score increased from 9.85 ± 1.23 (49.25%) in the pretest to 16.15 ± 1.46 (80.75%) in the post-test representing an absolute improvement of 6.30 points or 31.50 percentage points (p < 0.001). All participants showed increased post-test scores. These findings indicate an improvement in health-related knowledge following the community service activity. However, the one-group design, limited number of participants, and immediate post-test assessment limit the ability to establish causal effects or determine changes in health-related behavior and long-term outcomes.
In silico study of potential alkaloid compounds in Kratom Leaves (Mitragyna speciosa) as CNS stimulant Anggi Nur Prasetio; Sentot Purwandi; Sri Rahayu Dwi Purnaningtyas; Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Sasambo Journal of Pharmacy Vol. 7 No. 2 (2026): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i2.685

Abstract

Dysfunction of Central Nervous System (CNS) is often associated with various neurological and psychiatric disorders. The use of stimulant can improve CNS function. Kratom leaves (Mitragyna speciosa) are predicted to have potential as CNS stimulant candidate through the inhibition of dopamine transporter (DAT) receptor. The objective of this study is to determine potential of alkaloid compounds contained in kratom leaves as CNS stimulant using in silico approach. This study was conducted in silico through the prediction of physicochemical properties (SwissADME), pharmacokinetic profiles (pkCSM), and molecular docking. The target protein used for DAT receptor was SLC6A3 with PDB ID: 8Y2C and 9EO4. The results showed that five test compounds met Lipinski’s Rule of Five. Pharmacokinetic predictions show that five test compounds have good pharmacokinetic profiles, with favorable absorption and distribution, although some compounds have potential to cause drug interactions and certain toxicities. Mitragynine, Paynantheine, Speciogynine, and Speciociliatine, have potential as CNS stimulants by inhibiting the DAT receptor, with binding energies ranging from -6,2 to -8,3 kcal/mol. Four of the five alkaloids in kratom leaves are predicted to have potential as CNS stimulants by inhibiting DAT receptors in silico.
Physical Quality Stability Test and Antibacterial Activity Test of Face Toner Roll On Formulation of Centella Asiatica (L.) Urb. Leaf Extract Againts Propionibacterus acnes Elpi Lutpiani; Luluk Aniqoh Meliana Putri
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 1 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i1.585

Abstract

Acne affects all ages, from teenagers to adults, and is generally caused by bacteria. One of the main causes is Propionibacterium acnes, a gram-positive bacterium that lives in the skin and sebaceous follicles. Therefore, a natural solution for treating acne is gotu kola leaves, which are blended into a liquid roll-on face toner. Its flavonoids, tannins, saponins, and alkaloids act as antibacterial agents against Propionibacterium acnes. This study used a laboratory experiment. The results showed that the physical stability test of gotu kola leaf extract roll-on face toner (Centella asiatica (L.) urb) in formulation 1 (7.5%), formulation 2 (10%), and formulation 3 (12.5%) successfully withstood the test, maintained stable pH and viscosity, and exhibited no significant changes in color and odor upon storage. The gotu kola leaf extract roll-on face toner demonstrated very strong antibacterial activity against Propionibacterium acnes. Formula F3 (12.5%) had the largest inhibition zone diameter of 46.27 mm. However, based on ANOVA and post hoc tests, there was no significant difference between F2 (10%) and F3 (12.5%) compared to the positive control (sig > 0.05), so both formulas had comparable antibacterial effectiveness to the positive control.), so that both formulas had antibacterial effectiveness comparable to the positive control.
Analysis of the Effectiveness of Oral Antidiabetic Therapy on HbA1c Control in Type 2 Diabetes Mellitus Patients: Analisis Efektivitas Terapi Antidiabetes Oral terhadap Pengendalian Kadar HbA1c pada Pasien Diabetes Mellitus Tipe 2 Chinthia Devientasari; Selly Septi Fandinata; Dini Berliana; Anggi Restyana; Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 2 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i2.595

Abstract

Effective glycemic control is crucial for preventing chronic complications in patients with type 2 diabetes mellitus (T2DM). HbA1c levels are one of the best indicators that can be used to evaluate the success of pharmacological therapy in the long term. The purpose of this study was to analyze the effectiveness of oral antidiabetic use in reducing HbA1c levels in T2DM patients. This study used an observational quasi-experimental design with a one-group pre-post test approach conducted on 100 respondents. Statistical analysis used a paired sample t-test with a significance level of 95% (? = 0.05). The data used included demographic profiles and HbA1c levels before and after oral antidiabetic therapy intervention. The results showed that the average HbA1c level before therapy was 6.85 ± 1.54%, while after therapy it became 6.40 ± 1.22%. There was a decrease in the average HbA1c by 0.45%. The results of the Paired Sample t-Test showed a p value = 0.002 (p < 0.05), indicating a significant difference between HbA1c levels before and after therapy. In addition, the proportion of patients with poorly controlled HbA1c decreased from 15% to 5% after therapy. The conclusion of this study is that a significant decrease in HbA1c levels indicates that oral antidiabetic therapy can help achieve glycemic control targets and potentially reduce the risk of long-term diabetes complications.
Co-Authors Adi Wibisono Adjie Wahyu Pradana Amalia Eka Putri Anggi Nur Prasetio Anggi Restyana Anggi Restyawati Ardhi Broto Sumanto Ardhi Broto Sumanto Ardhi Broto Sumanto Arif Wijayanto Arif Wijayanto Bilal Subchan Agus Santoso Chinthia Devientasari Chinthia Devientasari Chintia Devientasari Dabyt Faizin Firzatullah Devientasari, Chinthia Devita Riafinola Devita Riafinola Dini Berliana Dini Berliana Elpi Lutpiani Imam Fathurrahman Ismi Rahmawati Ivan Junius Mesak Ivan Junius Mesak Ivan Junius Mesak Ivan Junius Mesak Juvita Herdianti Juvita Herdianty Juvita Herdianty Juvita Herdianty Lambertini, Imelda Lutpiani, Elpi Maulana Firdaus Musdalifah Qadariah Opstaria saptarini Purnaningtyas, Sri Rahayu Dwi Qadariah, Musdalifah Restyana, Anggi Saifullah Al Fahmi Selly Septi Fandinata Sentot Purwandi Septi Fandinata, Selly Sri Rahayu Dwi Purnaningtyas Varel Tsania Faza Yahya Febrianto