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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Sains dan Teknologi Buletin Kedokteran dan Kesehatan Prima Jurnal Rumpun Ilmu Kesehatan Jurnal Kesehatan Amanah PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Jurnal Sains Farmasi dan Kesehatan Jurnal Indah Sains dan Klinis
Ginting, Astriani Natalia Br
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Gambaran Penggunaan Obat Antibiotik dan Analgetik pada Resep Pasien Poli Gigi di RSUD Muyang Kute Razoki Razoki; Elvi Sasmi; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.02

Abstract

Background: Dental and oral diseases often lead to infections and pain, thus requiring treatment with antibiotics and analgesics. These conditions, if not treated properly, can significantly impact patients' quality of life and may result in further complications. Objective: This study aims to provide an overview of the use of antibiotics and analgesics in prescriptions for dental clinic patients at RSUD Muyang Kute. Method: A descriptive retrospective study was conducted on 80 prescriptions from patients at the Dental Clinic in September 2024. The sampling technique used was random sampling. Results: The majority of patients were female (60%) and within the age range of 26–45 years (37.5%). The most frequently prescribed antibiotic was amoxicillin (92.5%), followed by a combination of amoxicillin and metronidazole (3.75%), lincomycin (2.5%), and cefadroxil (1.25%). The most commonly used analgesic was a combination of paracetamol and dexamethasone (97.5%), followed by mefenamic acid and dexamethasone (2.5%). Conclusion: Amoxicillin and the combination of paracetamol-dexamethasone were the preferred drugs due to their high effectiveness, safety, and relatively affordable cost.
Profil Pelayanan Resep dengan Obat Glibenklamid di RSUD Muyang kute Bener Meriah Masriani; Razoki Razoki; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.03

Abstract

Background: Optimal pharmaceutical services are essential in chronic disease management, particularly in diabetes mellitus, where glibenclamide is frequently prescribed. Inadequate dispensing practices and lack of patient information can compromise treatment outcomes. Objective: This study aimed to evaluate the profile of prescription services involving glibenclamide at RSUD Muyang Kute Bener Meriah, focusing on drug availability, patient information gathering, medication counseling, and labeling practices. Methods: A descriptive observational design was applied using the simulated patient method. Researchers visited the pharmacy unit with a standardized prescription scenario involving glibenclamide. Data were collected using an observation checklist immediately after each interaction. Results:The majority of pharmacy staff did not actively collect essential patient information. Counseling was limited to usage instructions, with no mention of adverse effects or drug interactions. Labels were incomplete, often missing key components such as patient name, drug name, or preparation date. However, the availability of glibenclamide remained consistent during the observation period. Conclusion: Prescription services for glibenclamide at RSUD Muyang Kute are still below optimal standards. Improvements in patient assessment, communication, and labeling practices are necessary to enhance medication safety and treatment effectiveness
Formulasi Krim yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora L.) dan Tantangannya dalam Menghambat Staphylococcus aureus: Studi Potensi Terapi Luka pada Penderita Diabetes Putri Andari; Novitaria Br Sembiring; Astriani Natalia Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1425

Abstract

Diabetes mellitus is a chronic metabolic disorder that can cause wounds that are difficult to heal and susceptible to bacterial infection, especially Staphylococcus aureus. This study aims to formulate an antibacterial cream preparation containing robust coffee bean extract (Coffea canephora L.) and evaluate its activity against Staphylococcus aureus. The extract was obtained through maceration with 96% ethanol with a crude yield of 30% and an extract yield of 14.05%. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, phenols, saponins, and terpenoids. Antibacterial testing of the extract showed inhibitory activity against Staphylococcus aureus at concentrations of 30% (7.73–8.44 mm) and 50% (8.52–13.16 mm). The extract was then formulated into creams with varying concentrations of 0%, 30%, and 50%. All formulations met the physical parameters, except for the cream that did not contain the extract, which showed a pH higher than the ideal range for topical application and showed a decrease in spreadability with increasing extract concentration. However, testing the antibacterial activity of the cream preparations using the disk diffusion method did not produce an inhibition zone in any of the formulations tested. The results of this study indicate that although Robusta coffee bean extract shows activity in vitro, it has not been successfully applied in cream formulations with the existing bases and testing methods. These findings highlight the major challenges in developing natural topical preparations, particularly regarding the selection of formulation bases and appropriate evaluation methods for semisolid preparations.
Co-Authors Amelia, Ade Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Bengimiate, Nuriza Chrismis Novalinda Ginting Daimah W. S. Harahap Damanik, Dedech M. Sari DAMERIA DAMERIA Elvi Sasmi Farren Farren Gusbakti Rusip Hartopo, Haqi Hikmad Elsi Enoni Harefa Hotvera Merianis, Hotvera Ketaren, Nessya Try Natasya Br Linda Chiuman Lubis, Asyrun Alkhari Masriani Merianis, Hotvera Meutia, Rena Milka Rositi Sianipar Muhammad Yunus Nerly Juli Pranita Simanjuntak Novitaria Br Sembiring Paulina, Roslina Purba, Helprida GM Putri Andari Razoki Razoki Razoki, Razoki Rena Meutia Rena Meutia Roy Indrianto Bangar S Sembiring, Ernesta Br. Siburian , Friska Lasro Yanti Sihombing, Tabita Ronauli Simanjuntak, Mafe Robbi Siregar, Nur Aini Sitanggang, Titin Krisdayanti Situngkir, Luwis Sosa Ester Kristiani Lase Suci, Tri Tiara Fortuna A.R Vera Estefania Kaban