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Rizqullah, Rifqi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

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PENGEMBANGAN VAKSIN HIV BERBASIS TANAMAN: PENDEKATAN BIOTEKNOLOGI DALAM PRODUKSI DAN TANTANGANNYA Fitri, Laili; Rayes, Norina Shaumy Putri; Syahputri, Acyuta Pramesthi Asmara Sayyidina; Nurulfaaidzah, Nurulfaaidzah; Rizqullah, Rifqi
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.44763

Abstract

Permasalahan utama dalam pengembangan vaksin HIV adalah belum tersedianya vaksin yang efektif meskipun penelitian telah berlangsung selama lebih dari tiga dekade. Tantangan utama produksi vaksin konvensional antara lain biaya tinggi, risiko kontaminasi patogen, serta keterbatasan dalam skala produksi. Oleh karena itu, pendekatan bioteknologi berbasis tanaman menjadi alternatif inovatif yang menawarkan biaya produksi lebih rendah dan keamanan yang lebih baik. Penelitian ini bertujuan untuk meninjau perkembangan vaksin HIV berbasis tanaman, keunggulan, tantangan, serta potensi aplikasinya. Metode yang digunakan adalah studi literatur deskriptif kualitatif dengan pengumpulan data dari berbagai database elektronik seperti Google Scholar, PubMed, Scopus, dan Scispace pada periode Januari hingga April 2023. Hasil penelitian menunjukkan bahwa beberapa spesies tanaman seperti Nicotiana benthamiana, Nicotiana tabacum, Physcomitrella patens, dan Arabidopsis thaliana telah berhasil direkayasa untuk mengekspresikan antigen atau antibodi HIV, seperti gp120, gp41, dan p24, melalui metode ekspresi transient, transformasi genetik kloroplas, dan rekayasa genetika. Vaksin yang dihasilkan mampu menginduksi respons imun humoral dan seluler pada hewan uji. Namun, tantangan yang dihadapi meliputi stabilitas antigen, keragaman genetik HIV, regulasi, dan penerimaan masyarakat. Vaksin HIV berbasis tanaman memiliki potensi besar sebagai solusi inovatif, namun masih memerlukan penelitian lanjutan untuk mengatasi tantangan teknis dan regulasi sebelum dapat diimplementasikan secara luas.
Profile of Gram-Negative Bacteria Extended Spectrum Beta Lactamase Esbl in The Caecum of Broiler Chickens Indratama, I Nyoman Yudayana; Rosyunita, Rosyunita; Hasbi, Nurmi; Octora, Metta; Rizqullah, Rifqi
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10027

Abstract

Antimicrobial Resistance (AMR) is a global problem that causes increased morbidity, mortality, and healthcare costs. AMR arises from the irrational use of antibiotics in medicine and agriculture. This study aims to determine the profile of Gram-negative ESBL bacteria living in the cecum of broiler chickens. This study is a descriptive exploratory study using 5 chicken cecum samples taken from the Pagesangan market in Mataram city. The obtained bacteria were calculated by placing them on Macconkey agar media to count bacterial colonies. The results of this study showed that 20.1% of bacteria in the chicken cecum could grow on Macconkey media mixed with cefotaxime. Meanwhile, on Macconkey media without cefotaxime, 79.9% were obtained. Based on macroscopic, microscopic, and biochemical characteristics, it was found that the gram-negative bacteria obtained were Escherichia coli. In sensitivity tests, it was found that the bacteria were resistant to tetracycline (100%) and ampicillin (100%), and 25% were resistant to chloramphenicol. The conclusion is that gram-negative bacteria found in the cecum of broiler chickens, such as Escherichia coli, are resistant to several antibiotics. These bacteria are resistant to cefotaxime (20.1%), chloramphenicol (25%), tetracycline (100%), and ampicillin (100%).
REVIEW ARTIKEL : ANALISIS VALIDASI METODE PENETAPAN KADAR IBUPROFEN MENGGUNAKAN BERBAGAI INSTRUMEN Zaneta, Nabila Destia; Sasvania, Anisa; Putri, Fawwaz Aqila; Ali, Baiq Aulia; Rizqullah, Rifqi; Permatasari, Lina
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.38251

Abstract

Ibuprofen termasuk kedalam golongan (NSAIDs) yang memiliki efek analgesik dengan menghambat secara langsung dan selektif enzim-enzim pada sistem saraf pusat yang mengkatalis biosintesis prostaglandin seperti enzim siklooksigenase. Untuk menunjukkan bahwa teknik analisis yang digunakan valid, maka perlu dilakukan evaluasi terhadap parameter uji untuk menjadi dasar validasi. Validasi metode analisis adalah suatu tindakan penilaian terhadap parameter tertentu, untuk membuktikan bahwa parameter tersebut telah memenuhi persyaratan untuk penggunaannya. Kajian ini bertujuan untuk mengetahui validasi metode analisis untuk menentukan instrumen paling baik yang dapat digunakan untuk menentukan kadar ibuprofen dalam sampel obat. Metode yang digunakan dalam kajian ini adalah Design Systematic Review dengan mengumpulkan berbagai sumber yang valid. Database yang digunakan yaitu Google Scholar dan Pubmed. Literatur yang digunakan terdiri dari fua bahasa, yaitu bahasa inggris dan bahasa indonesia yang disaring berdasarkan kriteria inklusi dan eksklusi. Setelah sumber artikel terkumpul, dilakukan pengkajian ulang sumber artikel yang sudah diterbitkan untuk menghasilkan sebuah analisis baru yang selanjutnya akan diidentifikasi analisis validasi metode penetapan kadar ibuprofen menggunakan berbagai instrumen. Berdasarkan hasil data literatur, dapat disimpulkan bahwa instrumen High Performance Liquid Chromatography (HPLC) merupakan instrumen yang paling baik.
Identification of Antibiotic-Resistant Gram Positive Bacteria from Broiler Caecum in The Slaughterhouse of Mataram City Rizqullah, Rifqi; Wardoyo, Eustachius Hagni; Rahim, Adelia Riezka; Rosyunita, Rosyunita; Hasbi, Nurmi; Indratama, I Nyoman Yudayana
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8466

Abstract

The subtherapeutic use of antibiotics as Antimicrobial Growth Promoters (AGPs) in broilers has accelerated Antimicrobial Drug Resistance (AMR) in gut microbiota, posing a global threat. This study aimed to analyze the population, morphology, catalase test results, and antibiotic sensitivity of erythromycin and vancomycin to cefotaxime-resistant Gram-positive bacteria in the caecum of broilers from Mataram City slaughterhouses. Using exploratory descriptive method, five caecum samples were analyzed by Total Plate Count (TPC) on Man Rogosa Sharpe Agar (MRSA) media with and without cefotaxime, and incubated on Mannitol Salt Agar (MSA). Results revealed uniform bacterial morphology on MRSA (small, round, convex, entire edge, white, Gram-positive colonies) but varied morphologies on MSA. Catalase tests were negative on MRSA but mixed on MSA. Resistance to erythromycin and vancomycin was 80% on MRSA, while on MSA, erythromycin resistance reached 62.5% with variable vancomycin inhibition zones. The prevalence of cefotaxime-resistant bacteria was 5.24%. This study highlights diverse morphological, catalase, and antibiotic sensitivity profiles in cefotaxime-resistant bacteria, particularly on MSA. These findings underscore the need for stricter antibiotic use regulations and further research to mitigate AMR spread in poultry production.
Cerebral Palsy: Risk Factors, Pathophysiology, Clinical Manifestations, Diagnosis, and Management Damayanti, Ida Ayu Andara; Prawira, I Nyoman Dio Yudha; Andini, Syabila; Hanifah, Hanum Retno; Wiguna, I Made Danuarta; Wulandari, Baiq Nurhandini; Sabrina, Khansa Aulia; Khotimah, Andi Husnul; Wardana, Shira Putri; Rizqullah, Rifqi; Haikal, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10564

Abstract

Cerebral palsy is a non-progressive neuromotor disorder and the leading cause of motor disability in children worldwide, particularly in low- and middle-income countries. This study aims to examine the risk factors, pathophysiology, clinical manifestations, diagnosis, and management of cerebral palsy based on recent scientific literature. This article includes a systematic literature review using the PRISMA method and selected 15 articles that met the inclusion and exclusion criteria. The results of the systematic literature review were obtained risk factors for cerebral palsy include intrauterine infection, preeclampsia, premature birth, asphyxia, and hypoxic-ischemic encephalopathy and hyperbilirubinemia. These risk factors can disrupt neurogenesis and brain maturation, leading to structural and functional damage to the central nervous system. Clinical manifestations of cerebral palsy include impaired muscle tone, abnormal reflexes, and postural deformities, classified as spastic, dyskinetic, and ataxic, and assessed using the Gross Motor Function Classification System (GMFCS). The diagnosis of cerebral palsy is established through evaluation of the clinical history, neurological/motor examination, neuroimaging, and genetic testing. Cerebral palsy management aims to improve functionality, ability, and health in movement, cognition, social interaction, and independence. Non-pharmacological management focuses on physiotherapy and occupational therapy to improve motor skills, reduce spasticity, and support independence. The mainstay of pharmacotherapy in cerebral palsy management uses systemic medications that are symptom-based and directed at specific movement disorders.
Pengendalian Perilaku Tidak Aman dengan Behaviour Based Safety dan 5W1H pada Industri Manufaktur Rizqullah, Rifqi; Ikhwana, Andri; Sa’duddin Taptajani, Dedi
Jurnal Kalibrasi Vol 23 No 2 (2025): Jurnal Kalibrasi
Publisher : Institut Teknologi Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33364/kalibrasi/v.23-2.2404

Abstract

Workplace accidents still frequently occur in the industrial world, especially in the manufacturing industry, particularly on manufacturing production lines. Based on observations, most accidents are caused by unsafe behavior on the part of workers, such as rushing, carelessness, and non-compliance with work procedures. This study aims to identify and analyze the causes of unsafe behavior and provide solutions through a Behavior Based Safety (BBS) approach combined with the 5W1H method. Data was collected through direct observation, interviews, and documentation of workplace accidents. The analysis was conducted using the ABC (Antecedents–Behavior–Consequences) tool, which maps the triggers of behavior (antecedents), the behavior displayed (behavior), and the consequences (consequences). The results of the study show that the application of BBS is effective in increasing workers' awareness of work safety. Routine observations and direct feedback have been proven to reduce the risk of workplace accidents. The findings from the ABC analysis can be used as a basis for formulating more targeted strategies for improvement and accident prevention.
Co-Authors Ali, Baiq Aulia Andini, Syabila Andri Ikhwana Damayanti, Ida Ayu Andara Eustachius Hagni Wardoyo fitri, laili Hanifah, Hanum Retno Hasbi, Nurmi - Indratama, I Nyoman Yudayana Khotimah, Andi Husnul Metta Octora Muhammad Haikal Nurulfaaidzah, Nurulfaaidzah Permatasari, Lina Prawira, I Nyoman Dio Yudha Putri, Fawwaz Aqila Rahim, Adelia Riezka Rayes, Norina Shaumy Putri Rosyunita, Rosyunita Sabrina, Khansa Aulia Sasvania, Anisa Sa’duddin Taptajani, Dedi Syahputri, Acyuta Pramesthi Asmara Sayyidina Wardana, Shira Putri Wiguna, I Made Danuarta Wulandari, Baiq Nurhandini Zaneta, Nabila Destia