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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) EMBRIO : Jurnal Kebidanan Medical and Health Journal Media Penelitian dan Pengembangan Kesehatan
Aziz, Muhammad Alamsyah
Department Of Obstetrics And Gynecology Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Medicine & Pharmacology Public Health

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Journal : Althea Medical Journal

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Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Abstract

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM. 
Co-Authors Adhi Pribadi Aditya Wibowo Akhmad Yogi Pramatirta, Akhmad Yogi Alifa, Dhara Almira, Nadia Larastri Ana Mariana, Ana Anabela, Lisa Milena Andi Kurniadi, Andi Aqilah, Nurjihan Syarifah ASTRI ASTUTI Avivi, Safiya Fathina Benny Hasan Purwara Budi Handono Budi Setiabudiawan Cool, Charlotte Johanna Damayani, Ayi Diah Devina, Velika Dewanto, Wenardy Dewi Marhaeni Diah Herawati Dewi Retno Wulandari Dida Akhmad Gurnida Dwi Prasetyo Elga Caecaria Grahardika Andani Elly Yana, Elly Fakih, Mohamad Fauzi, Ali Amali Gusasih, Bahar Sangkur Harsono, Ali Budi Insi Farisa Desy Arya Johanes C Mose Jusuf Sulaeman Effendi Katharina Hiria Daundy Kharismawati, Nuniek Kurnia Wahyudi, Kurnia Lillah, Alfarisi Syukron Madjid, Tita Husnitawati Nadia Larastri Almira Nugrahani, Annisa Dewi Pramudyo, Miftah Prihatni, Delita Putra, Ridwan Abdullah Ritonga, Mulyanusa Amarullah Ritonga, Mulyanusa Amrullah Sembiring, Gaipyana Setyorini Irianti Shely Karma Astuti Siti Salima Sofie R. Krisnadi Sumawan, Herman Susiarno, Hadi Sutjighassani, Tjut Syahbana, Chandra Garnida Tjut Sutjighassani Windi Nurdiawan Zulvayanti Zulvayanti