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Development of Ethnosciene Reels of Ketapang Malay Tribe as Supplementary Learning Resources on Hydrocarbon Compounds Laila Fitri; Raudhatul Fadhillah; Dini Hadiarti
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8596

Abstract

The habit of the Malay community in using natural materials as fuel can be integrated into chemistry teaching materials in schools. The aim of this research is to assess the validity and practicality of reels as a learning resource and to develop reels based on the ethnoscience of the Ketapang Malay tribe. The research development model used is the Three Stages Research and Development (TSRD) model, which consists of three steps: planning, development, and dissemination. Data collection techniques involve indirect communication using validation sheets and response instruments. The subjects of the research are students from SMA N 1 Sungai Laur. The results of the study indicate that the ethnoscience-based reels of the Malay tribe are valid and practical, with validity and practicality scores of 96.3% and 90.30%, respectively. The reels can be used as an independent, practical, and engaging learning resource that is relevant to students. Therefore, the validity and practicality results of the development of ethnoscience-based reels are expected to serve as an innovative and contextual alternative media for chemistry education in schools.
Implementation of FTIR-Based Fingerprinting, Antioxidant Compounds Profiling by UHPLC-Q-Orbitrap HRMS, and Docking Study COVID-19 Inhibitor of Buas-Buas (Premna serratifolia) Leaf Extract from Pontianak Indonesia Dini Hadiarti; Mahwar Qurbaniah; Ely Setiawan; Taufan Hari Sugara
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 1 (2025): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.1.92020.149-161

Abstract

This research aims to profile the active antioxidant compounds from leaf extracts of Buas-buas (Premna serratifolia) growing in Pontianak of West Kalimantan (Indonesia) through a metabolomics approach and their activity as anti-COVID-19 candidates by molecular docking. In this study, P. serratifolia leaves were macerated and fractionated using solvents with different polarities. The extracts were then tested for antioxidant activity using the DPPH method, determined the total phenolic content (TPC), flavonoids (TFC), and steroids (TSC), and analyzed antioxidant the functional groups and compounds by Fourier Transform Infrared spectroscopy (FTIR) and Ultra High-Performance Chromatography UHPLC-Q-Orbitrap HRMS. The functional groups on antioxidant activity were determined by Principal Component Analysis (PCA) and Partial Least Square (PLS) regression. Based on a metabolomics approach, the PCA and PLS analysis shows that hydroxyl was the most active antioxidant from P. serratifolia leaves. UHPLC-Q-Orbitrap HRMS analysis showed the presence of scopoletin, esculetin, 7-hydroxycoumarine, matairesinol, hymecromone, and hexylresorcinol in the water fraction of P. serratifolia leaves. Molecular docking with 4YE6, 1OG5, and 3NRZ shows that matairesinol had the most potential as an antioxidant. Mataresinol and hexyresorcinol are phenolic compounds that have great potential as a COVID-19 inhibitor based on molecular docking with 5R81, 7CMD, and 6M2N.