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LAPORAN KASUS: ANALISIS KOMBINASI PENGGUNAAN HEPATOPROTEKTOR PADA CEDERA HATI KARENA INFEKSI BAKTERI STREPTOCOCCUS VIRIDANS Muhammad Hasan Andryanto; Fauna Herawati; Umi Fatmawati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2179

Streptococcus viridans is one of the bacteria that can cause Community-Acquired Pneumonia (CAP). CAP disease has a higher prevalence of non-alcohol-related fatty liver disease (NAFLD). Continuous increase in fat levels in the liver triggered by pneumonia can cause inflammation in the liver, it causes a rapid decline in liver function and results in increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin. The use of hepatoprotectors in conditions of impaired liver function is essential to improve liver cell regeneration and promote liver detoxification. One of the drugs and supplements that can act as a hepatoprotector is ursodeoxycholic acid (UDCA) and Curcuma. Here we report the use of hepatoprotector drugs in cases of Community-Acquired Pneumonia (CAP) disease due to Streptococcus viridans bacteria in patients without comorbidities with the results of liver function test examinations from the beginning of hospital admission, during treatment, until the patient is discharged. The purpose of our case report is to illustrate the effect of the combined use of UDCA and Curcuma drugs on liver injury due to Streptococcus viridans bacterial infection in order to prevent complications, morbidity, mortality and improve the quality of life of patients. Based on the case reports that we present, the combined use of UDCA and Curcuma drugs as hepatoprotectors can improve liver function with reduced parameters of AST, ALT, and total bilirubin levels.

UPAYA PEMBERDAYAAN MASYARAKAT DALAM PEMANFAATAN LIMBAH ECENG GONDOK SEBAGAI SPRAY LUKA Juwita Ramadhani; Hasniah Hasniah; Dewi Rosaria; Aris Fadillah; Karina Erlianti; Muhammad Fauzi; M. Hasan Andryanto; Lia Mardiana
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 5 (2025): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i5.34501

Abstrak: Permasalahan limbah eceng gondok yang melimpah di Desa Sungai Arfat mendorong perlunya inovasi pemanfaatan agar memiliki nilai tambah ekonomi. Kegiatan pengabdian ini bertujuan meningkatkan pengetahuan dan keterampilan masyarakat dalam mengolah eceng gondok menjadi produk kesehatan bernilai jual serta memperkenalkan strategi promosi digital. Metode yang digunakan meliputi sosialisasi potensi eceng gondok, penyuluhan mengenai urgensi pengelolaan limbah, serta workshop pembuatan spray luka berbasis eceng gondok. Kegiatan diikuti oleh 29 anggota PKK Desa Sungai Arfat dengan pendampingan langsung dari tim pelatih, sedangkan evaluasi dilakukan melalui angket pemahaman. Evaluasi dilakukan melalui pretest dan postest, dengan indikator keberhasilan berupa peningkatan pengetahuan dan pemahaman peserta. Hasil menunjukkan rata-rata nilai pretest 51,03 meningkat menjadi 97,93 pada postest dengan kenaikan rata-rata 46,90 atau 149,71%. Kegiatan ini tidak hanya meningkatkan hardskill masyarakat dalam produksi, tetapi juga membuka peluang pengembangan UMKM berbasis eceng gondok yang berorientasi pada peningkatan ekonomi lokal secara berkelanjutan.Abstract: The problem of abundant water hyacinth waste in Sungai Arfat Village has prompted the need for innovative utilization to add economic value. This community service activity aims to increase the knowledge and skills of the community in processing water hyacinth into marketable health products and introducing digital promotion strategies. The methods used included socialization of the potential of water hyacinth, counseling on the urgency of waste management, and workshops on making water hyacinth-based wound sprays. The activity was attended by 29 members of the Sungai Arfat Village PKK with direct assistance from the training team, while the evaluation was conducted through a comprehension questionnaire. The evaluation was conducted through pre-tests and post-tests, with the success indicators being an increase in the participants' knowledge and understanding. The results showed that the average pretest score of 51.03 increased to 97.93 in the posttest, with an average increase of 46.90 or 149.71%. This activity not only improved the community's hard skills in production but also opened up opportunities for the development of water hyacinth-based MSMEs oriented towards sustainable local economic improvement.

ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11, No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.

PEMBERDAYAAN MASYARAKAT MELALUI PELATIHAN PEMBUATAN JAMU ANTIHIPERTENSI HALAL Karina Erlianti; Hasniah Hasniah; Aris Fadillah; Muliyani Muliyani; Juwita Ramadhani; Muhammad Hasan Andryanto
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 5 (2025): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i5.34716

Abstrak: Hipertensi adalah penyakit tidak menular yang memiliki prevalensi tinggi di Indonesia dan menjadi faktor risiko utama berbagai komplikasi serius. Masyarakat Desa tempat pelaksanaan kegiatan diketahui memiliki angka kejadian hipertensi yang cukup tinggi, namun masih memiliki tingkat pengetahuan yang rendah terkait pemanfaatan tanaman herbal sebagai terapi alternatif, terutama dalam bentuk jamu aman, berkhasiat, dan halal. Tujuan kegiatan ini adalah untuk memberdayakan masyarakat melalui peningkatan hardskill yaitu keterampilan dalam pembuatan jamu antihipertensi sesuai prinsip kehalalan. Metode kegiatan terdiri atas tahap persiapan, pelaksanaan kegiatan dengan metode ceramah dan praktik langsung, serta proses evaluasi. Edukasi dan pelatihan diberikan kepada 21 peserta yang merupakan anggota PKK setempat. Evaluasi dilakukan dengan mekanisme pre-test dan post-test, serta observasi keterampilan. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta, ditunjukkan oleh peningkatan skor rata-rata pretest sebesar 2,4 menjadi 9,5 pada posttest. Pelatihan ini menumbuhkan keterampilan masyarakat dalam pembuatan jamu serta meningkatkan kesadaran pentingnya aspek kehalalan dalam pengolahan produk herbal. Sehingga berkontribusi pada bidang kesehatan dan membuka peluang usaha jamu.Abstract: Hypertension is a leading non-communicable disease in Indonesia and a major risk factor for serious health complications. The target community demonstrated a relatively high prevalence of hypertension yet possessed limited knowledge about the use of herbal plants as alternative therapy, particularly in the form of jamu (traditional herbal medicine) that is safe, effective, and halal. This community engagement program aimed to empower local residents by enhancing both knowledge and practical skills in preparing antihypertensive jamu in accordance with Islamic principles. The program was conducted in three phases: preparation, implementation, and evaluation. A total of 21 participants, all members of the local Family Welfare Movement (PKK), took part in education and training sessions. Evaluation involved pre-test and post-test assessments, complemented by skill observations. The results showed a substantial improvement in knowledge, with mean scores rising from 2.4 to 9.5. Moreover, participants gained practical competencies in jamu preparation and increased awareness of halal considerations in herbal product processing. This initiative contributes to public health promotion while opening opportunities for small-scale jamu entrepreneurship.

PEMANFAATAN GULMA TANAMAN BUNDUNG SEBAGAI BAHAN SABUN PADA SISWA MADRASAH TSANAWIYAH Aris Fadillah; Lia Mardiana; Yuniarti Falya; Juwita Ramadhani; Muliyani Muliyani; Muhammad Fauzi; Muhammad Hasan Andryanto; Yulistia Budianti Soemarie
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 5 (2025): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i5.34556

Abstrak: Peningkatan kesadaran masyarakat terhadap pentingnya menggunakan sabun pasca COVID-19 mendorong peningkatan penggunaannya. Ekstrak daun tanaman Bundung (Scirpus grossus), yang mudah ditemukan di persawahan, terbukti efektif mempercepat penyembuhan luka dan cocok digunakan sebagai bahan aktif dalam sabun. Kegiatan ini bertujuan untuk meningkatkan kemampuan hardskill peserta dalam memahami tanaman bundung serta cara pembuatan sabun dengan memanfaatkan daun bundung. Metode yang digunakan dalam kegiatan ini meliputi ceramah, diskusi bersama, serta praktik langsung. Kegiatan diikuti oleh 30 siswa kelas IX. Evaluasi pengetahuan siswa dilakukan dengan metode pre-post test menggunakan angket. Hasil pengukuran menunjukkan peningkatan skor dengan nilai rata-rata kenaikan sebesar 15,17%. Hasil evaluasi ini mengindikasikan bahwa peserta dapat menangkap materi yang disampaikan dengan baik.Abstract: The increase of public awareness on the importance in the use of soap post-COVID-19 has led to an increase in its use. The extract of Bundung (Scirpus grossus), which is commonly found in rice fields, has been proven to be effective in promoting wound healing and suitable for use as an active ingredient in soap. This program aims to improve the participants' hard skills in understanding the Bundung plant and utilize it as the active ingredient in soap-making process. The methods used in this activity include lectures, group discussions, and direct practice. The participant in this program were 30 of ninth-grade students. The evaluation of the participants' knowledge was conducted with the pre-post test method using a questionnaire. The results showed an increase in the average score by 15.17%. These results indicated that the participants were able to comprehend the material presented properly.

ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11 No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.

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