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All Journal JMM (Jurnal Masyarakat Mandiri) AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Pharmacoscript Jurnal Ilmiah Farmako Bahari Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
M. Hasan Andryanto
Program Studi Farmasi, Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin, Kalimantan Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Energy Health Professions Medicine & Pharmacology Public Health Other

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ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11 No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Abstract

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.
Co-Authors Amelia Lorensia Anita Apriliana Anita Apriliana Aris Fadillah Dewi Rosaria Fauna Herawati Fauzi Rahman Ghina Adhila Hasniah Hasniah Hasniah Juwita Ramadhani Karina Erlianti Lia Mardiana Muhammad Fauzi Muliyani Muliyani Noriandani Riska Ayu Novi Milasari Riska Ayu Noriandani Rizki Rahmadi Pratama Siti Lili Rizki Sari Soedarsono Soedarsono Triswanto Sentat Triswanto Sentat Umi Fatmawati Umi Fatmawati Yulistia Budianti Soemarie Yuniarti Falya