Article Per Year (5 Year)
p-Index From 2021 - 2026
1.456
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Molecular and Cellular Biomedical Sciences (MCBS) Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) eJournal Kedokteran Indonesia Borneo Journal of Pharmacy
Ayeshah A Rosdah
Department Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 18 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 18 Documents
Search

 1   2 
The Relationship between Knowledge and Self-Medication Practices for Dysmenorrhea among Female Students of SMK Negeri 2 Palembang Kamalia Layal; Syarinta Adenina; Septi Purnamasari; Ayeshah Augusta Rosdah; Msy Rulan Adnindya
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.236

Abstract

Dysmenorrhea is a common occurrence in most women. The pain arising from dysmenorrhea ranges from mild to moderate and can disrupt daily activities and performance. Many women practice self-medication to alleviate this pain. This self-medication practice is influenced by several factors, one of which is the level of knowledge. This study aims to explore the relationship between the level of knowledge among female students and self-medication behavior in dysmenorrhea. This study used a cross-sectional design with a random sampling of female students from SMK Negeri 2 Palembang. The total sample involved 41 students. Data were collected and analyzed using chi-square and Mann-Whitney U tests. The majority of students experienced dysmenorrhea (87.8%) with an average Visual Analog Scale (VAS) score of 4.6. The duration of pain varied, with most experiencing pain for 2-3 days after menstruation. Almost all students (97.6%) had good or sufficient knowledge about dysmenorrhea. However, only a few students practiced self-medication (11.1%), with paracetamol being the most commonly used medication. The analysis showed a significant relationship between knowledge level and self-medication behavior (p=0.002, OR: 12.681). The level of knowledge among female students is significantly associated with self-medication behavior in dysmenorrhea. Better health education on dysmenorrhea management and the use of safe medication needs to be strengthened to reduce the risk of side effects and improve the well-being of students.
Mitochondrial Dynamics: An Attractive Therapeutic Target for Ischemia-Reperfusion Injury in the Heart Rosdah, Elisha Rosalyn; Zulissetiana, Eka Febri; Rosdah, Ayeshah Augusta
Molecular and Cellular Biomedical Sciences Vol 8, No 3 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i3.487

Abstract

Myocardial infarction is one of the leading causes of death worldwide. Current treatments do not compensate for the loss of cardiomyocytes, thus progression to heart failure is often inevitable. In myocardial infarction, the occlusion of coronary arteries and sudden restoration of blood flow give rise to ischemia-reperfusion injury, which leads to cardiomyocyte death. Mitochondria are not only involved in the bioenergetic aspect of the heart but also play a pivotal role in cell death during ischemia-reperfusion injury. Their morphology dynamically changes via fusion and fission in a balanced manner to maintain cellular health. However, ischemia-reperfusion injury triggers excessive mitochondrial fission, which is pathological to the myocardium. This review article discusses the association between myocardial ischemia-reperfusion injury and mitochondrial dynamics, serving as a rationale for a novel therapeutic strategy for myocardial infarction. Strategic modulation of mitochondrial dynamics under this pathological setting has been shown to be effective for cardioprotection. Increasing mitochondrial fusion or reducing excessive mitochondrial fission in the myocardial tissue could prevent cardiomyocyte death, thereby reducing infarct size. Proof-of-concept studies have utilized small molecules and peptides to implement this strategy into in vivo myocardial ischemia-reperfusion injury models. However, there remains a need to address the issues of specificity, bioavailability, and potency of these pharmacological agents before future application in cardiovascular therapeutics. Nevertheless, there has been growing interest in this therapeutic strategy in recent years, rendering it an attractive approach for ischemia-reperfusion injury in the heart.Keywords: mitochondria, heart, ischemia-reperfusion, cardioprotection
EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW Amanda Putri, Khairunnisa Rizqika; Lusiana, Evi; Theodorus; Rosdah, Ayeshah Augusta; Harahap, Debby Handayati; Larasati, Veny
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.453

Abstract

Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms.
THE RELATIONSHIP BETWEEN HIGH GLYCEMIC INDEX DIET AND MUSCULOSKELETAL DISORDERS Adinda, Adinda; Legiran; Arwan Bin Laeto; Ayeshah Augusta Rosdah; Eka Febri Zulissetiana; Kamalia Layal
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.552

Abstract

Musculoskeletal disorders include acute and chronic conditions affecting the muscles, bones, joints, and supporting structures in the neck, back, and limbs, posing significant challenges across all age groups. Approximately 30% of cases occur in adolescents and individuals in their productive years, not just in the elderly. These disorders lead to substantial socioeconomic and health burdens. Previous research indicates that dietary patterns play a critical role in the onset and progression of these conditions. A persistent high-glycemic index (GI) diet is associated with systemic inflammation, metabolic dysregulation, and musculoskeletal health. This study aims to provide a comprehensive review of existing literature to summarize and identify the potential relationship between high-GI diets and the prevalence of musculoskeletal disorders (MSDs). Articles were collected using search engines such as PubMed, Medscape, and ScienceDirect, focusing on publications from 2013 to 2024. The findings emphasize the importance of dietary interventions as modifiable risk factors for preventing and managing musculoskeletal disorders, particularly in at-risk populations. Further studies are needed to develop dietary strategies to reduce the global burden of musculoskeletal disorders effectively.
Evaluation of Aqueous Extract from Cosmos caudatus Leaves in Alloxan-Induced Diabetic Rats Rosdah, Ayeshah Augusta; Natasha, Amanda; Tamzil, Nia Savitri; Subandrate, Subandrate
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8652

Abstract

Kenikir (Cosmos caudatus), often consumed as a vegetable in Southeast Asia, possesses therapeutic benefits for several diseases, including diabetes mellitus. However, there has been limited investigation of the aqueous extract of C. caudatus for this disease model. This study aimed to examine the glucose-lowering effect of C. caudatus aqueous extract in an alloxan-induced diabetes model in rats. Ultrasound-assisted extraction was performed to obtain an aqueous extract of C. caudatus leaves. Qualitative phytochemical screening was carried out to identify the presence of bioactive compounds. Male Wistar rats were allocated to the following experimental groups: non-diabetic, diabetic without treatment, and diabetic treated with glibenclamide or aqueous C. caudatus extract at concentrations of 25%, 50%, or 100%. Diabetes was induced by intraperitoneal injection of 150 mg/kg alloxan. Random blood glucose and body weight were monitored before (Day 0) and after treatment (Days 3 and 7). There was a trend of weight loss in diabetic rats compared to non-diabetic rats, though the difference was not statistically significant. After 7 days of treatment, there was a comparable decrease in the blood glucose of diabetic rats treated with 50% or 100% of aqueous C. caudatus extract and those treated with glibenclamide. Qualitative phytochemical screening indicated the presence of steroid, saponin, phenol, and flavonoid compounds. The total phenolic content was 38.48 mg GAE/g and IC50 DPPH antioxidant activity was 375.64 ppm. This study demonstrated that an aqueous extract of C. caudatus exhibits a blood glucose-lowering effect in an alloxan-induced diabetic rat model.
POTENSI KOLAGEN IKAN TERHADAP PENYEMBUHAN SOKET PASCA PENCABUTAN GIGI Ricardo, Angelina Natalia; Harahap, Debby Handayati; Rosdah, Ayeshah A.
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 6 No 2 (2024): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v6i2.2577

Abstract

ABSTRAK Latar Belakang: Pencabutan gigi merupakan prosedur perawatan invasif yang merangsang proses penyembuhan luka yang terdiri dari fase hemostasis, inflamasi, proliferasi, dan remodelling. Dalam berbagai fase penyembuhan, kolagen berperan mempercepat penyembuhan luka dengan cara menghentikan perdarahan, mencegah inflamasi yang berkepanjangan, mendukung angiogenesis, pembentukan jaringan granulasi, dan kontraksi luka. Kolagen umumnya diekstraksi dari kulit atau tulang sapi atau babi, namun kontroversi agama dan risiko penularan penyakit memicu pencarian sumber kolagen alternatif, yaitu ikan. Pemanfaatan kolagen yang diekstraksi dari produk limbah ikan membantu menambah nilai ekonomi dan mengurangi masalah lingkungan. Kolagen ikan bersifat biokompatibel dan memiliki komposisi asam amino yang setara dengan kolagen sapi atau babi. Kesimpulan: Kolagen ikan berpotensi sebagai bahan terapi tambahan untuk mempercepat penyembuhan luka pasca pencabutan gigi karena bersifat biokompatibel, tidak berisiko menularkan penyakit, dan mengandung asam amino yang berperan dalam mendukung proliferasi makrofag, fibroblas, dan epitel, sintesis kolagen, angiogenesis, dan kontraksi luka. Kata kunci : Kolagen ikan, pencabutan gigi, penyembuhan luka, soket gigi ABSTRACT Background : Tooth extraction is an invasive treatment procedure that stimulates the wound healing process, consisting of the hemostasis, inflammation, proliferation, and remodelling phases. In the wound healing phases, collagen plays a role in accelerating wound healing by stopping bleeding, preventing prolonged inflammation, promoting angiogenesis, the formation of granulation tissue, and wound contraction. Generally, collagen is extracted from the skin or bone of bovine or porcine, but religious controversies and the risk of disease transmission have triggered the search for alternative sources of collagen, namely fish. Extracting collagen from fish waste products helps to increase economic value and reduce environmental problems. Fish collagen is biocompatible and have similar amino acid composition to bovine and porcine collagen. Conclusion : Fish collagen has the potential to be an additional therapeutic material to accelerate after tooth extraction healing because that collagen is biocompatible, low risk of disease transmission, and contains amino acids that play role in promoting the proliferation of macrophage, fibroblast, and epithelial cells, collagen sintesis, angiogenesis, and wound contraction. Keywords : Fish collagen, tooth extraction, tooth socket, wound healing
Edukasi swamedikasi obat herbal yang rasional pada kelompok ibu rumah tangga di Kelurahan Karya Baru Rosdah, Ayeshah Augusta; Adenina, Masayu Syarinta; Parisa, Nita; Harahap, Debby Handayati; Lusiana, Evi; Fatmawati, Fatmawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.169

Abstract

Indonesian Health Survey reported that more than half of the population in South Sumatera utilizes herbal medicine to alleviate disease symptoms. The survey also indicated that factors such as lower-middle income levels and the female gender are relatively more likely to utilize medicinal plants compared to higher-income levels and the male gender. The findings from this health survey strongly support the characteristics of the target audience for this community service, specifically the residents of Karya Baru Village represented by the women in Majelis Taklim Al-Kahfi. Initial interviews with several members of this group revealed a tendency to self-treat sick family members, particularly using herbal remedies, as they are perceived to have no side effects compared to modern medications (synthetic drugs). These findings indicate a potential irrational use of herbal medicine in self-medication practices. Self-medication refers to the efforts made by individuals to determine treatments for their disease symptoms. For self-medication practices to be safe and effective, it is essential for the community to be equipped with adequate knowledge about the rational use of herbal medicines. Therefore, a community service initiative is necessary to enhance public knowledge regarding the types of herbal medicines and promote rational behaviors on self-medication practice of herbal medicines within the community.
Insights into Acute Coronary Syndrome: A Study of Patient Characteristics in Dr. Rivai Abdullah Public Hospital Zerlinda, Zabrina; Azmar, Erwin; Rosdah, Ayeshah Augusta
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1163.1

Abstract

Acute Coronary Syndrome (ACS) remains a leading cause of morbidity and mortality worldwide, with variations in patient characteristics and risk factors across regions. In Indonesia, especially in resource-limited settings, data on the demographic and clinical features of ACS are limited. Such information is crucial for guiding management strategies. This study analyzed secondary data from medical records of 86 ACS patients admitted to Dr. Rivai Abdullah Public Hospital between January and December 2023. This cross-sectional study included new and existing patients with acute coronary syndrome who had complete demographic, clinical, and electrocardiographic data. In contrast, patients with incomplete data or congenital heart disease were excluded. The research was conducted between July and September 2024. Of these patients, 64% were male, and 51.16% were aged 41 to 60 years. Nearly half (46.51%) had only primary education, and 25.58% were farmers or housewives. Hypertension was the most common comorbidity (66.28%), followed by diabetes mellitus (25.58%), obesity (18.60%), and dyslipidemia (5.81%). Electrocardiographic findings showed that 55.81% had ST-elevation myocardial infarction (STEMI), mainly involving the anteroseptal region. Meanwhile, 44.19% had non-ST-elevation myocardial infarction (NSTEMI), with T-wave inversion present in 42.11% of these cases. These results indicate that ACS mainly affects middle-aged males with low education and informal occupations. Hypertension was the leading risk factor, and STEMI was the most common presentation. Targeted prevention and early detection are vital to improving outcomes in this population.
Co-Authors Abdulwahab Hakimi Abdurrahman Akib Adinda Adinda Adnindya, Msy Rulan Afkara Husna Agustina Septi Hijir Amanda Putri, Khairunnisa Rizqika Arwan Bin Laeto Azmar, Erwin Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Eka Febri Zulissetiana Evi Lusiana Fadhila Khairunnisa Fatmawati, Fatmawati Jayawarsa, A.A. Ketut Joko Marwoto Larasati, Veny Layal, Kamalia Legiran Legiran Mgs Irsan Saleh Muhammad Irsan Saleh Muhammad Reagan Muhammad Reagen Natasha, Amanda Nia Savitri Tamzil Nita Parisa Nita Parisa RACHMAT HIDAYAT Radiyati Umi Partan Ricardo, Angelina Natalia Rosdah, Elisha Rosalyn Salni Salni Salni Salni Septi Purnamasari Sri Nita Sri Nita Subandrate Syarinta Adenina Theodorus Tiara Fatrin Triwani Triwani Triwani Triwani Yeni Agustin Yundari, Yundari Zerlinda, Zabrina Ziske Maritska