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Mar’atun Jannah, Imrawati, Muzakkir Baitz,
STIFA Makassar
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Penentuan Profil Metabolit dan Uji Aktivitas Antioksidan Pada Fraksi Daun Sawo Duren (Chrysophyllum Cainito L.) Agiel, Fadillah Maryam Bau; Umar, Abd. Halim; Ulfa, Maria; Mus, Suwahyuni; Imrawati, Imrawati
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.702

Abstract

Sawo duren (Chrysophyllum cainito L.) merupakan tanaman yang banyak digunakan dalam pengobatan, diantaranya antiinflamasi, antidiabetes dan sebagai antioksidan. Daun sawo duren mengandung senyawa saponin, triterpenoid, flavonoid, fenolik, serta alkaloid dan steroid. Tujuan dari penelitian ini adalah untuk mengalisis dan membandingkan profil metabolit fraksi n-Butanol daun sawo duren berdasarkan analisis FTIR. Proses ekstraksi daun sawo duren dilakukan dengan metode maserasi menggunakan pelarut etanol kemudian difraksinasi menggunakan pelarut etanol, n-heksan dan n-butanol. tahapan selanjutnya fraksi n-butanol dipilih untuk analisis FTIR. Hasil dari analisis spektrum untuk sampel fraksi daun sawo duren memiliki O-H (Fenol), C-H (Alkana), C-O (Alkohol), C=O (Aldehida), C=C (Alkena) terdeteksi pada sampel. Berdasarkan hasil data FTIR menunjukkan adanya gugus fungsi O-H yang diprediksi merupakan senyawa fenol, saponin dan tanin; C-H alkana diprediksi senyawa terpenoid dan steroid; C-H aromatic diprediksi senyawa fenol; dan C-O diprediksi senyawa flavonoid, alkaloid dan tanin.
Fraksi Daun Andong Merah (Cordyline fruticose (L.) A. Cheval) Berpotensi sebagai Sitotoksik Metode BSLT Utami, Yuri Pratiwi; Imrawati, Imrawati; Mus, Suwahyuni; Astri, Andi Astri Sri Nurul Fardila; Mustarin, Rahmah
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 4, No 1 (2024): April 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v4i1.974

Abstract

Andong merah (Cordyline fruticosa (L.) A. Cheval) merupakan tanaman yang banyak digunakan sebagai obat tradisional. Kandungan senyawa yang ada pada tanaman andong merah berupa metabolit sekunder diantaranya polifenol, flavonoid, saponin, alkaloid, steroid dan triterpenoid sedangkan pada daun andong merah mengandung senyawa polifenol, tannin dan flavonoid. Tujuan dari penelitian ini yaitu untuk mengetahui sitotoksisitas fraksi daun andong merah (C. Fruticosa) terhadap larva udang Artemia salina Leach menggunakan metode BSLT. Ekstrak etanol 70% menghasilkan tiga fraksi yaitu fraksi n-heksan, fraksi etil asetat, dan fraksi etanol-air dengan teknik ekstraksi cair-cair (ECC) menggunakan tiga pelarut. Kemudian diuji sitotoksisitasnya dari seri konsentrasi 20 ppm, 40 ppm, 60 ppm, 80 ppm dan 100 ppm serta kontrol negatif. Hasil yang diperoleh dari penelitian ini berupa aktivitas sitotoksik fraksi dengan parameter nilai LC50 yaitu fraksi n-heksan 25,05 ppm ppm, fraksi etil aetat 85,21 ppm dan fraksi etanol-air 32,39 ppm. Kesimpulannya yakni fraksi dari daun andong merah (C. Fruticosa) termasuk dalam kategori sitotoksistas kuat. Cordyline fruticosa (L.) A. Cheval is a plant that is widely used as a traditional medicine. The compounds contained in the red oak plant are secondary metabolites including polyphenols, flavonoids, saponins, alkaloids, steroids and triterpenoids whereas in the leaves of the red andong contain compound polyphenol, tannins and flavanoids. The aim of the study was to determine the cytotoxicity of the C. fruticosa fraction to the larvae of the shrimp Artemia salina Leach using the BSLT method. The 70% ethanol extract produces three fractions namely the n-hexane fraction, the ethyl acetate fraction and the ethanole-water fraction using the liquid-liquid extraction technique (ECC) using three solvents. Then they tested their cytotoxicity from a series of concentrations of 20 ppm, 40 ppm and 60 ppm as well as negative controls. The results obtained from this study were fractional cytotoxic activity with LC50 parameters of 25.05 ppm n-hexane fraction, 85.21 ppm ethyl acetate fraction and 32.39 ppm ethanol-water fraction. The conclusion is that the fraction of the C. Fruticosa leaves belongs to the category of strong cytotoxists
Penyuluhan dan Edukasi Kosmetik yang Aman Bersama HIASKOS di SMKN 8 Makassar Jariah, Ainun; Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; AS, Indah Meilani; Wahyuddin, Nurzadrina; Yanti, Yuniar Dwi
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2025): Sahabat Sosial: Jurnal Pengabdian Masyarakat (Desember)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v4i1.967

Abstract

Cosmetics are substances or preparations used on the external parts of the human body (epidermis, hair, nails, lips, and external genital organs) primarily for cleansing, perfuming, altering appearance, or improving body odor, or for protecting or maintaining the body's health. Providing counselling and education on safe cosmetics to teenagers is not just about giving beauty tips; it's a crucial step in protecting their long-term health. Adolescents are in a phase of physical and hormonal transition that makes them very concerned about their appearance, but they often lack sufficient consumer literacy to distinguish between safe and harmful products. This counselling aims to educate students to be wiser in choosing safe cosmetics. The method used is direct socialization to students at SMKN 8 Makassar, providing counselling to assess the improvement in understanding after education, direct socialization, and socialization using leaflets. The results obtained show an increase in participants' knowledge of how to choose and use appropriate and safe daily cosmetics. The conclusion of this service activity is that the counselling on safe cosmetics is highly relevant and well-received by adolescents, and it is able to improve their understanding of safe cosmetics, so similar activities can be expanded to other locations.
Karakterisasi Minyak Atsiri Daun Patikala (Etlingera elatior (Jack) R.m Smith) Metode Destilasi Air dengan GC-MS: Characterization of Essential Oil from Patikala Leaves (Etlingera elatior (Jack) R.m Smith) by Water Distillation Method with GC-MS Utami, Yuri Pratiwi; Imrawati, Imrawati; Bone, Mahfuzun; Amody, Zahira; Mustarin, Rahmah; Mono, Mono
Jurnal Sains dan Kesehatan Vol. 8 No. 1 (2026): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v8i1.2597

Abstract

Patikala (Etlingera elatior (Jack) R.M.Smith) is one type of plant from the Zingiberaceae family. Patikala leaves contain bioactive compounds such as polyphenols, alkaloids, flavonoids, steroids, saponins, and essential oils. Patikala leaf essential oil has the potential to be an antimicrobial and antioxidant agent. This research aims to characterize the essential oil from patikala leaves. The extraction method used water distillation and was characterized using GC-MS. The research results showed that the characteristics of essential oil obtained by water distillation method included a yield of 0.03%, organoleptic examination had a characteristic odor, was clear yellow in color, and contained active compounds such as Trans-3-caren-2-ol, p-Cymene, 1,3-Cyclopentadiene, dan 2-Cyclopenten-1-one. Based on the research, monoterpenoid essential oil was obtained. Keywords:          Essential oil, Etlingera elatior (Jack) R.M.Smith, Water distillation   Abstrak Patikala (Etlingera elatior (Jack) R.M.Smith) merupakan salah satu jenis tanaman dari suku Zingiberazeae. Daun patikala mengandung senyawa bioaktif seperti polifenol, alkaloid, flavonoid, steroid, saponin dan minyak atsiri. Minyak atsiri daun patikala berpotensi sebagai agen antimokroba dan antioksidan. Penelitian ini bertujuan untuk karakterisasi   minyak atsiri daun patikala. Metode ekstraksi menggunakan  destilasi air dan dikarakterisasi menggunakan GC-MS. Hasil penelitian yang didapatkan karakteristik minyak atsiri metode destilasi air meliputi % rendamen untuk metode sebesar 0,03%, pemeriksaan organoleptik memiliki bau khas, berwarna kuning bening dengan kandungan senyawa aktif yaitu Trans-3-caren-2-ol, p-Cymene, 1,3-Cyclopentadiene, dan 2-Cyclopenten-1-one. Berdasarkan penelitian diperoleh minyak atsiri monoterpenoid. Kata Kunci:         Minyak atsiri, daun patikala, destilasi air
Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats Salampe, Mirnawati; Widiasri, Dewa Ayu Diah; Wahyuddin, Nurzadrina; Agus, Rezki Rahayu; Imrawati, Imrawati; Wahyuni, Wahyuni; Awaluddin, Akbar
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.452

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic β-cell dysfunction. Morus alba leaves contain bioactive compounds with potential antidiabetic activity. This study evaluated the hypoglycemic and β-cell protective effects of ethanolic M. alba leaf extract (EMA) in diabetic rats. The extract was obtained through maceration, yielding 12.14%. Wistar rats were divided into normal control, negative control, positive control, EMA100 (100 mg/kg BW), and EMA200 (200 mg/kg BW). Diabetes was induced using a high-fat diet, 2% sucrose solution, and low-dose streptozotocin. Fasting blood glucose (FBG) and pancreatic histopathology were analyzed. EMA significantly reduced FBG and improved pancreatic β-cell morphology, particularly at 200 mg/kg BW. These findings suggest that EMA has potential as a therapeutic candidate for T2DM by improving glycemic control and preserving pancreatic β-cell integrity. 
Co-Authors Abubakar Betan Agiel, Fadillah Maryam Bau Agus, Rezki Rahayu Ainun Jariah Arif Rachman Aripa, Lusyana AS, Indah Meilani Astri, Andi Astri Sri Nurul Fardila Astuti Amin Awaluddin, Akbar Bone, Mahfuzun Desiana Desiana, Desiana Djamaluddin, Suci F Dwi Yanti, Yuniar Fhahri Mubarak Hardianti Hardianti, Hardianti HARDIANTO - Hilal, Achmad Humang, Rezki Ihsan Irwana, Rina Khairi, Nur Mangosa, Grace Pretty Maria Ulfa Maulita Indrisari, Maulita Megawati - Mono, Mono Mus, Suwahyuni Muslimin, Lukman Mustarin, Rahmah Nurjannah Bachri, Nurjannah Nursamsiar Nursamsiar paluseri, Andi Rahmah Mustarin Rosyid, Sujud Z S, St. Mujahida Salampe, Mirnawati Sami, Fitriyanti Sari, Lely Meriaya Solly Aryza Sri Wahyuni Sukriani Kursia, Sukriani Syamsu Nur, Syamsu Umar, Abd. Halim Wahyuddin, Nurzadrina wahyuni wahyuni Widiasri, Dewa Ayu Diah Yuri Pratiwi Utami Zaenal Zaenal, Zaenal Zahira Amody