Jurnal Farmasi Sains dan Komunitas
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
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<![CDATA[Molecular Dynamics Simulations of Ethyl-4-[(α-L-rhamnosyloxy)-benzyl]carbamate from Moringa oleifera Lam. as a Dipeptidyl Peptidase-4 Inhibitor ]]>
<![CDATA[Dewi, I Gusti Ayu Intan Puspita]]>;
<![CDATA[Istyastono, Enade Perdana]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.009791
<![CDATA[Diabetes mellitus is a global health problem that requires innovative solutions. Ethyl-4-[(α-L-rhamnosyloxy)-benzyl]carbamate (ERBC) compound contained in Moringa oleifera Lam. showed potential as a potent dipeptidyl peptidase-4 (DPP4) inhibitor, with an IC50 value of 0.798 µM. Molecular dynamics simulations indicated that ERBC interacts specifically with the active site of DPP4, providing a mechanistic basis for its inhibitory activity. The research utilized the latest technique developed by previously published plug-ins. The molecular docking simulations were performed 100 times. Then, the poses were clustered to sample the probable poses which were then subjected as the inputs in molecular dynamics simulations. Molecular dynamics simulations have shown that the ERBC compound interacts with the DPP4 protein at two possible poses. PyPLIF HIPPOS analysis demonstrated that ERBC, during its second replication, interacts with Glu205 and Glu206, two key amino acids involved in DPP4 activity.]]>
<![CDATA[The Analysis of Medicine-taking Compliance Towards Therapy Outcome in Hypertension Patients at Community Health Centers in Yogyakarta Municipality ]]>
<![CDATA[Fortinasari, Rimanita]]>;
<![CDATA[Virginia, Dita Maria]]>;
<![CDATA[Hendra, Phebe]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.008656
<![CDATA[Compliance to medication has a significant role in regulating the blood pressure and the risk for Atherosclerosis Vascular Disease (ASCVD) in Diabetes Mellitus Type 2 (DMT2) patients with hypertension as comorbidity. This study (n=523) aimed to analyzed this relationship at community health centers Yogyakarta municipality. We conducted an observational study with a cross-sectional design to analyze the medical record data collected during January-December 2023 among patients categorized under the inclusion criteria. Compliance was measured using the Medication Possession Ratio (MPR) then descriptively and correlatively with Chi-square analyses. No significant relationship is showed between the compliance of antihypertensive therapy to blood pressure (p=0.8670.05) and ASCVD risk (p=0.0800.05; OR=0.662; 95%CI:0.416-1.052). Age (p=0.001), gender (p=0.001) and BMI (p=0.0014) had a highly significant relationship with ASCVD risk, but only BMI (p=0.0070.005; OR 1.812) showed significant relationship with controlled blood pressure. The research findings reveal that compliance to antihypertensive therapy does not have a significant relationship with blood pressure control or ASCVD risk in patients with DMT2 and hypertension as comorbidities in Yogyakarta municipality. Highlighting the need for further investigation, it is vital to include other factors into blood pressure management.]]>
<![CDATA[Combining Beers and STOPP Criteria to Identify Inappropriate Medication Use in Elderly Patients with Chronic Diseases and Polypharmacy ]]>
<![CDATA[Mursyid, Abdillah]]>;
<![CDATA[Chairani, Farahdina]]>;
<![CDATA[Yusransyah, Yusransyah]]>;
<![CDATA[Pujiati, Devi]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.007965
<![CDATA[Elderly individuals often suffer from multiple chronic conditions thatrequire the prescription of various medications. This can increase therisk of being prescribed Potentially Inappropriate Medications (PIMs).The research objective was to evaluate the effectiveness of Beers 2019and STOPP version 2 2016 criteria in detecting PIMs and theircorrelation with adverse drug events among geriatric patients whowere admitted to the Hospital. The researchers conducted aretrospective analysis of the 100 patients' medical records admitted tothe hospital in 2022. Beers 2019 criteria were more effective inidentifying PIMs than STOPP version 2 2016 criteria. Using Beers 2019criteria, 31 cases of PIMs were identified among the 100 patients whomet the inclusion criteria, while only 25 cases were identified usingSTOPP version 2 2016 criteria. Alprazolam was the most frequentlyprescribed medication (19.54%) in the first criteria of Beers 2019,followed by ranitidine in category two and spironolactone in category5, each named for seven cases (22.58%). The most commonly foundPIMs, according to STOPP version 2 2016 criteria, were domperidone(40.00%) and spironolactone (28.00%). The study recommends thatclinicians and pharmacists work together to develop critical supportivedata to enhance the identification of potentially inappropriatemedications.]]>
<![CDATA[Relationship Between Knowledge and Fasting Plasma Glucose Values of Patients with Type 2 Diabetes Mellitus at Sleman Public Health Center ]]>
<![CDATA[Linawati, Yunita]]>;
<![CDATA[Kaka, Damianus Andrian Putra Lere]]>;
<![CDATA[Pandey, Monica Vini Hildegadris]]>;
<![CDATA[Chandra, Angelica]]>;
<![CDATA[Tukunang, Helen Angelique Julia]]>;
<![CDATA[Nathaly, Angel Pricillia]]>;
<![CDATA[Fitriana, Dhea Pricillia]]>;
<![CDATA[Timur, Imelda Maharani Eka]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.0013216
<![CDATA[Diabetes Mellitus (DM) is a chronic disease caused by unstable blood sugar (glucose) levels, characterized by the body's inability to metabolize carbohydrates and fats. Unstable or uncontrolled blood sugar levels can be influenced by a lack of knowledge, which impacts the attitudes and behavior of people with DM. Controlling blood sugar levels in patients with DM is very important to avoid complications, both macrovascular and microvascular. The purpose of this study is to examine the connection between type 2 DM patients’ fasting plasma glucose (FPG) values and their degree of knowledge. This study was conducted at Mlati 2, Ngaglik 2, and Ngemplak 2 Health Centers of Sleman Regency Yogyakarta. This cross-sectional study used an analytical observational strategy. Purposive sampling was used to choose the 227 patients who participated in this study as respondents. The Diabetes Knowledge Questionnaire (DKQ-24) was the tool utilized in this study to gauge respondents’ knowledge levels and the outcomes of the FPG levels taken from medical records. The Spearman-rank test was used for data analysis with significance set as p0.05. The majority of patients, 99 (43.61%) had a moderate degree of knowledge and 207 (91.19%) had uncontrollable FPG levels. Based on bivariate analysis, there was no significant relationship between knowledge level and FPG values (p = 0.926), while the strength of the relationship was classified as a very low category (r = 0.006).]]>
<![CDATA[Optimization and Physical Characterization of Kojic Acid Nanoemulsion Formula As A Whitening Agent ]]>
<![CDATA[Guanse, Yovi]]>;
<![CDATA[Dwiastuti, Rini]]>;
<![CDATA[Jenita Gandi, Brigita Tuelvin]]>;
<![CDATA[Chabib, Lutfi]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.009968
<![CDATA[Kojic acid (KA) as a topical formulation prevents hyperpigmentation through the inhibition of tyrosinase activity. However, KA has higher solubility in nonpolar solvents. Nanoparticle technology can be a novel innovation to enhance KA absorption into the skin. This study aims to improve the delivery of topically applied KA by enhancing absorption into the stratum corneum by optimizing the concentration of surfactant Tween 80 and co-surfactant Span 80. The nanoemulsion uses KA as an active ingredient and virgin coconut oil as the oil phase. The optimum area was analyzed using Design-Expert® 13 software, with a pure experimental design based on a 2x2 factorial design. The results indicate that all formulas are within the optimal region. Therefore, the determination of the optimal point can be grounded on the smallest composition within the optimal region with the objective of maximizing material efficiency, which is a formula with a concentration of Tween 80 and Span 80 of 10 grams and 3 grams, respectively. The particles are a spherical smooth shape and demonstrate an efficacy of 94.117% in inhibiting tyrosinase activity.]]>
<![CDATA[Cost Analysis of Inpatient Heart Failure Treatment at PKU Muhammadiyah Hospital of Yogyakarta Based on INA-CBG’s Tariffs in 2023 ]]>
<![CDATA[Hadning, Ingenida]]>;
<![CDATA[Wari, Lidya Prames]]>;
<![CDATA[Lestari, Nina Dwi]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.008765
<![CDATA[The prevalence of heart failure in Indonesia has reached 1.5% of the entire population. Catastrophic heart failure requires long treatment, thus necessitating large costs. The Indonesian government regulates payments to advanced health facilities through INA-CBG tariffs. This study evaluated the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023 for the treatment of inpatient heart failure. This study aims to determine the difference in the average actual costs of heart failure patients compared to the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023. This research was conducted as an observational study with a cross-sectional design at PKU Muhammadiyah Hospital of Yogyakarta. Data on heart failure inpatients were gathered using a retrospective method from January to September 2023. Data were analyzed using descriptive analysis and a one sample t-test. The analysis found some average actual costs were higher than INA-CBG tariffs, with an insignificant difference. Real costs that the Social Security Agency (BPJS) on Health could not cover caused the hospital to suffer losses.The prevalence of heart failure in Indonesia has reached 1.5% of the entire population. Catastrophic heart failure requires long treatment, thus necessitating large costs. The Indonesian government regulates payments to advanced health facilities through INA-CBG tariffs. This study evaluated the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023 for the treatment of inpatient heart failure. This study aims to determine the difference in the average actual costs of heart failure patients compared to the INA-CBG tariffs based on the Ministry of Health Regulation No. 3 of 2023. This research was conducted as an observational study with a cross-sectional design at PKU Muhammadiyah Hospital of Yogyakarta. Data on heart failure inpatients were gathered using a retrospective method from January to September 2023. Data were analyzed using descriptive analysis and a one sample t-test. The analysis found some average actual costs were higher than INA-CBG tariffs, with an insignificant difference. Real costs that the Social Security Agency (BPJS) on Health could not cover caused the hospital to suffer losses.]]>
<![CDATA[Cost Utility of Adjuvant and Neo-Adjuvant Treatment for Breast Cancer: A Systematic Review of Observational Economic Evaluations Study ]]>
<![CDATA[Larasanty, Luh Putu Febryana]]>;
<![CDATA[Setyawan, Irfanianta Arif]]>;
<![CDATA[Nurlita, Diah]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.007988
<![CDATA[This study aimed to perform a systematic review of an observational cost-utility analysis of adjuvant and neo-adjuvant agents in breast cancer patients. The PRISMA flowchart was used to conduct the literature search and study selection. Through the use of two databases, PubMed and Scopus, a literature search was done. The eligible study was determined based on the established inclusion criteria. To evaluate the quality of the study, Drummond's checklist was used. Data extraction was conducted to assess characteristics, study perspective, cost and outcome measurement, the cost-utility ratio in ICER value, threshold, sensitivity or probability analysis, and the conclusion of the cost-utility study. There was a total of 7 studies included for review. Four studies compared chemotherapy regimens as adjuvant or neoadjuvant and three studies included hormone therapy or targeted therapy as an intervention that compared. Observational characteristic includes the use of cohort methods, and a large number of participants, the comparison is mostly for adjuvant therapy purposes and direct medical cost measured from a payer perspective. Anthracycline-based chemotherapy like the FAC regimen showed potential cost-effectiveness results. The use of targeted therapy (pertuzumab, trastuzumab) and hormonal therapy (goserelin) is associated with better utility outcomes and an increase in cost burden from intervention. Based to the reviewed studies, anthracycline-containing regimens such as FAC may have pharmacoeconomic properties as adjuvant or neo-adjuvant therapy. While the use of the most recent pharmacological drug has the potential to improve utility outcomes, but is associated with an increase in the intervention's cost burden.]]>
<![CDATA[Meropenem Determination in Human Plasma by LC-MS/MS and Evaluation for Therapeutic Drug Monitoring in ICU Patients ]]>
<![CDATA[Amalia, Dita]]>;
<![CDATA[Lukitaningsih, Endang]]>;
<![CDATA[Nugroho, Akhmad Kharis]]>;
<![CDATA[Puspitasari, Ika]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.0011827
<![CDATA[Meropenem is a broad-spectrum beta-lactam antibiotic widely used in intensive care units (ICUs) for severe bacterial infections. Therapeutic drug monitoring (TDM) is essential to optimize its dosing, ensuring effective bacterial eradication while minimizing toxicity and resistance.This study aimed to determine meropenem concentrations in human plasma using LC-MS/MS and evaluate its application in TDM for ICU patients. Meropenem concentrations in plasma samples from ICU patients were analysed using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The study included 40 plasma samples from 20 patients receiving meropenem continuous infusion. Validation followed ICH M10 (2022) guidelines, assessing specificity, accuracy, precision, stability, and dilution integrity. The developed LC-MS/MS method demonstrated high selectivity, sensitivity, and linearity (r = 0.9930.996) over the 102000 ng/mL range. Accuracy and precision met ICH M10 acceptance criteria, with %CV 15%. All ICU patients maintained %fTMinimum Inhibitory Concentration (MIC) 40%, ensuring adequate bacterial eradication. Notably, patients with renal impairment required dose adjustments, while those with high creatinine clearance needed increased dosing. The validated LC-MS/MS method is suitable for meropenem TDM in ICU patients, allowing individualized dosing adjustments to optimize therapy.]]>
<![CDATA[Evaluation of Drug Interactions in Polypharmacy: A Case Study of Patients with Heart Failure Hospitalized at Tangerang District Hospital ]]>
<![CDATA[Khairani, Sondang]]>;
<![CDATA[Manninda, Reise Reise Manninda]]>;
<![CDATA[Ariani, Lusiana]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.0010033
<![CDATA[Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's metabolic needs. It is a clinical syndrome with signs and symptoms caused by abnormalities in the structure and/or function of the heart. Heart failure occurs when the heart can't pump enough blood to meet the body's needs. It is caused by problems with the structure or function of the heart. This can lead to polypharmacy, where several medications are often taken by patients with heart failure to manage their condition. This study aims to identify patient characteristics, treatment accuracy based on Indonesian Heart Association (PERKI) 2023 guidelines, and the relationship between drug interactions and polypharmacy in adult patients diagnosed with heart failure with or without comorbidities at Tangerang Regency Hospital in 2023. The research was conducted descriptively using a cross-sectional study design. A total of 78 samples specimens met the inclusion criteria, with a male majority of 37 (52.86%) patients. The most common age group was 56-65 years old with 25 (35.71%) patients. The most common length of stay was 1-5 days with 48 (68.57%) patients. Evaluation of the treatment accuracy showed that the appropriate drug class was achieved in 78 (100%) patients, the appropriate dose in 55 (70.51%) patients and the appropriate frequency in 45 (57.69%) patients. Statistical tests showed a correlation between polypharmacy and drug-drug interactions with p-value 0.05. Accordingly, it is important to enhance monitoring and assessment of drug interactions in heart failure patients to optimize treatment management and prevent the risk of complications]]>
<![CDATA[Development of Chemometric Methods for Determining Caffeine Content in Robusta Coffee as Alternative Standardization Techniques ]]>
<![CDATA[Handoyo, Theodorus Rexa]]>;
<![CDATA[Primaharinastiti, Riesta]]>;
<![CDATA[Yuwono, Mochammad]]>
<![CDATA[ Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025) ]]>
Publisher : <![CDATA[Sanata Dharma University ]]>
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DOI: 10.24071/jpsc.009242
<![CDATA[There is a necessity for standardization to uphold coffee quality due to its frequent production and consumption. High-performance liquid chromatography (HPLC) serves as the benchmark for caffeine analysis in coffee in Indonesia. However, its high cost has prompted the exploration of alternative methods. This study aims to obtain a suitable alternative method for determining the caffeine content in robusta coffee as an effort toward standardization. Employing statistical and mathematical techniques in chemistry, chemometrics emerges as a promising alternative in analyzing caffeine in coffee. The approach was integrated with an ultraviolet (UV) spectrophotometer capable of analyzing substances across wavelengths from 200 to 400 nm. From the five replications, the HPLC method showed a caffeine content of 1.435 ± 0.011% (w/w), while the spectrophotometer showed a content of 1.723 ± 0.003% (w/w). Through the partial least squares regression (PLSR) and principal component regression (PCR) methods in RStudio, the results obtained were 1.432 ± 0.003% and 1.430 ± 0.002% (w/w), respectively. These results indicate good REP values of 0.022% for PLSR and 0.155% for PCR. With these findings, it is hoped that chemometrics can become an alternative method for analyzing caffeine in coffee.]]>
