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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 150 Documents
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Aktivitas Antiinflamasi Ekstrak Etanol Dan Fraksi Etil Asetat Daun Karet Kebo (Ficus elastica) Dengan Menggunakan Metode Spektrofometri UV-Vis Suhaenah, Asriani; Nuryanti, Siska; Abidin, Zainal; Evatiara, Nur
Jurnal Fitofarmaka Indonesia Vol 11, No 2 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i2.1288

Abstract

Ficus is a species that is rich in polyphenolic compounds, such as flavonoids. These compounds are strong antioxidants that can aid in the prevention and treatment of various diseases caused by oxidative stress. They also protect cell structures, have anti-inflammatory properties, and can act as antibiotics. The aim of this study was to evaluate the anti-inflammatory properties of the ethanol extract and ethyl acetate fraction of rubber kebo (Ficus elastica) leaves using the Bovine Serum Albumin (BSA) protein denaturation method. The measurements were taken on a Uv-Vis spectrophotometer at a wavelength of 660 nm.  The study consisted of four experimental groups: a negative control, a positive control of diclofenac sodium, and test groups of ethanol extract and ethyl acetate fraction. The study revealed that the positive control (IC50) had an anti-inflammatory value of 9.2 μg/mL. Additionally, the ethanol extracts and ethyl acetate fractions of rubber kebo leaves (Ficus elastica) demonstrated anti-inflammatory activity with IC50 values of 31.24 μg/mL and 37.89 μg/mL, respectively. These findings suggest that the ethanol extracts and ethyl acetate fractions of rubber kebo leaves possess anti-inflammatory properties.
Uji Ketahanan Air Sediaan Breathable Nail Polish Ekstrak Ubi Jalar Ungu Dengan Variasi Eudragit® ® RL-100 Wulandari, Asri; Fatmi, Mindya; Noerlaela, Ella; Sofiani, Alvina
Jurnal Fitofarmaka Indonesia Vol 11, No 2 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i2.1282

Abstract

AbstractThe use of nail polish on Muslim women is only allowed during menstruation and postpartum, because nail polish can block water from entering the nails, making ablution and prayer invalid. Conventional nail polish cannot penetrate water and air. Purple sweet potato peel extract contains anthocyanin as a colouring agent. The main composition in the manufacture of nail polish is a polymer that acts as a film forming material on the nails. Eudragit® RL-100 polymer used as a film-forming material that is permeable, can penetrate water, and air so that it can be used as a film forming material in breathable nail polish preparations. This study aims to formulate breathable nail polish preparations with variations of Eudragit® RL-100 as a polymer that can penetrate water and air based on the water resistance test. The formula was made in 3 variations with concentrations of Eudragit® RL-100 F1 (5%), F1 (10%), F2 (15%). The results showed that formula 2 is the best formula that meets the water absorption test using a 4.6% glass plate, absorption using a tissue 34 seconds, water penetration using effervescent tablets 11 seconds, and water absorption using simulated hand washing colour fading. Keywords: Eudragit® ® RL-10; breathable nail polish; polymer; water resistance; purple sweet potato skin extract. 
Kajian Kandungan Fitokimia Dan Efek Antioksidan Ekstrak Istoma longiflora Dan Clitornia ternatea Sebagai Agen Terapi Oftalmotonus Awaluddin, Annisa Maharani; Hujjatusnaini, Noor; Nirmalasari, Ridha
Jurnal Fitofarmaka Indonesia Vol 11, No 2 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i2.1283

Abstract

Oftalmotonus terjadi peningkatan tekanan intraokular (TIO) yang dapat menyebabkan kerusakan saraf optik hingga kebutaan. Penelitian ini mengkaji efek kombinasi 1:2 ekstrak Istoma longiflora dan Clitornia ternatea terhadap TIO pada oftalmotonus akibat infeksi Staphylococcus aureus. Metode eksperimental laboratorium dengan pendekatan post-test only control group design digunakan, melibatkan pengukuran TIO mencit sebelum dan sesudah infeksi, serta setelah terapi. Uji fitokimia menunjukkan adanya flavonoid, tanin, alkaloid, saponin, dan steroid/triterpenoid dengan sifat antibakteri, antiinflamasi, dan antioksidan. Hasil menunjukkan penurunan TIO mencit dari 25,97–34,67 mmHg (setelah infeksi) menjadi 7,45–19,42 mmHg (setelah terapi) dengan tingkat signifikansi p = 0,000. Analisis ANOVA dan uji Duncan menunjukkan perbedaan signifikan antar kelompok perlakuan. Kombinasi ekstrak pada dosis 50%–60% memberikan efek optimal. Kesimpulannya, kombinasi ekstrak Istoma longiflora dan Clitornia ternatea berpotensi sebagai terapi alami efektif untuk oftalmotonus akibat infeksi. Penelitian lanjutan diperlukan untuk menguji toksisitas dan efektivitasnya pada manusia.
Uji Oligosakarida Ekstrak Tepung Buah Semu Jambu Mete (Anacardium occidentale L.) Terhadap Pertumbuhan Baketri Lactobacillus casei Sebagai Altenatif Prebiotik Rasydy, La Ode Akbar; Elsa, Restia; Nuraini, Nuraini; Hamidu, La
Jurnal Fitofarmaka Indonesia Vol 11, No 2 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i2.1223

Abstract

Cashew pseudo-fruit (Anacardium occidentale L.) is rich in carbohydrates. Carbohydrates can be chemically hydrolyzed into simple monomers such as oligosaccharides. This study aims to ensure the effectiveness of cashew pseudo-fruit flour oligosaccharide extract as an alternative to prebiotics that are able to stimulate the growth of lactic acid bacteria such as Lactobacillus casei. The test was carried out on the growth of Lactobacillus casei bacteria using a 4% concentration cashew pseudo-fruit flour oligosaccharide solution with a dilution of 10-10 using the pour plate method and incubated at a temperature of 37°C for 48 hours to determine the ALT value. The results of the prebiotic parameter test showed the growth of the number of eligible bacterial colonies, namely 25-250 colonies found in dilution 10-4 - 10-8 with an ALT result of 7.3 x 10-6 so it can be concluded that The oligosaccharides extracted from the cashew pseudo-fruit have met the characteristics and criteria as an alternative prebiotic.
Antioxidant Activity of Bioproduced Endophytic Fusarium Sp. HSFP-3 from Sijangkang Plant (Hornstedtia scyphifera Var. fusiformis) Koraag, Alfa Michael Gabriel; Farida, Yunahara; Tarigan, Elsera Br.; Efendy, Oscar; Agusta, Andria; Simanjuntak, Partomuan
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.1252

Abstract

Endophytic mold Fusarium sp. HSFP-3 is one of the endophytic molds isolated from Sijangkang plants (Hornstedtia scyphyfera var. fusiformis). The purpose of this study is to conduct bioproduction, and test the antioxidant activity of bioproduced extracts and identify active fractions that have antioxidant activity. The research method started from the cultivation of endophytic mold HSFP-3 on PDB media for 21 days, the bioproduction results were extracted using ethyl acetate and acetone solvents. Antioxidant activity of HSFP-3 extract was determined by IC50 and AAI values, using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Isolation of antioxidant active fraction was carried out by column chromatography method using sephadex LH-20 stationary phase and silica. Isolation of antioxidant active compounds of HSFP-3 extract using bioautography guided assay approach with TLC-DPPH Bioautography method. The antioxidant test results of HSFP-3 extract has moderate activity with IC50 value 74,64 and AAI 0,844. Fraction 2.4 is an active fraction that has spot compounds with higher yellow color intensity compared to other fractions. Spot with Rf 0.35 in fraction 2.4 has a dark zone under UV 254 light. has a sea blue color under UV 366 light and a dark purple color after with Vanillin-Sulfate reagent
The In-vivo Safety and Efficacy Test of Antiaging Serum Containing Gold Nanoparticle Synthesized Using Sida rhombifolia Extract Waluyo, Dyah Ayuwati; Sutriyo, Sutriyo Sutriyo; Vardhani, Afifah K.; Wardana, Mutia Sari
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.1212

Abstract

Advance glycation end products (AGEs) are the basic root cause of endogenous aging. AGEs causing fragmentations and crosslinked collagen which damaging the skin integrity and mechanical properties resulting in reduced skin elasticity. Gold nanoparticles (AuNP) has been synthetized using Sida rhombifolia (Sidaguri) extract. This study aimed to determine the efficacy of antiaging serum containing AuNP synthetized using Sidaguri extract. AuNP was produced by reducing HAuCl4 solution using Sidaguri extract. 10% of AuNP colloid was formulated into the serum. 19 woman applied patch containing serum and base placebo to perform irritation test followed by provocative test if there is any reddish reaction found. 16 women showed no signs of irritation and 3 women showed a reddish reaction, the provocative test showed no signs of irritation. Then efficacy test performed to 18 women by applying 1 drop of the serum at one side of the forearm and base placebo serum at the other side, after passing patch test. The antiaging serum had the ability to increase skin collagen (64.72 ± 27.11%) and skin elasticity (64.11 ± 11.67%) after 8 weeks of use, twice a day. There was a significant increase in skin collagen and elasticity index (P-value < 0.0001).
The Extract Standardization Test and Physical Properties Evaluation of Uncaria gambier Roxb Extract Catechine Capsules Oktavilantika, Dina Melia; Suzana, Dona; Himawati, Ditiya; Putra, Hendri Dwi
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.1048

Abstract

Society does not really know that the catechin extract contained in uncaria gambir roxb can be used as an anti-inflammatory and antioxidant. The catechins in gambier plant are very complex. They are composed of extracts of catechins (C), epicatechins (EC), epicatechin gallate (ECG), epigalocatechin (EGC), epigalocatechin gallate (EGCG), and galocatechin (GC). Thus, the use of this medicinal plants with anti-inflammatory and antioxidant properties needs to be developed as an alternative treatment. In addition, this species of plant has also important effectiveness and relatively smaller side effects. In an effort to increase efficiency and maximize the therapeutic effects of gambier as an anti-inflammatory and antioxidant, the authors need to develop an innovate pharmaceutical product from this plant. One of the selected pharmaceutical preparations is the capsule since it can conceal the taste and the unpleasant smell; besides, it is also easy to consume. The maceration method was carried out in the catechin extraction process. After obtaining pure catechin extracts, the authors tested catechin levels using the HPLC method and antioxidant levels using the DPPH method. Next, the authors performed extract standardization tests, and evaluated the physical properties of the capsule preparations. The test results showed catechin levels of 98.697% and IC50 antioxidant levels of 8.54 µg/dl. The results of the standardized extract and capsule evaluation tests indicated that they met the applicable requirements.
GC-MS Analysis of Ginger Rhizome with Various Extraction Methods Syarif, Rezki Amriati; Faradiba, Faradiba; Alyanti, Tifani Kursya; Savitri, Triana Aulia
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1105

Abstract

Ginger (Zingiber officinale) is a rhizome plant well-known as a spice and medicinal material. Either one of the bioactive components is an essential oil, which is efficacious in preventing and treating various diseases. This research aims to determine the percentage yield of extracts and GC-MS analysis of the percentage of the chemical content of essential oils of ginger with various extraction methods. Firstly, compounds from ginger rhizomes were extracted using maceration, ultrasonic, and distillation techniques, and the extracts were analyzed using GC-MS Spectrophotometer. The highest percentage extract yield from ultrasonic extraction was 21.29%, then maceration extraction was 6.26%, and distillation extraction was 5.00%. The GC-MS results showed that the secondary metabolite compounds from maceration, ultrasonics, and distillation contained zingiberol, zingiberin, shogaol, borneol, linalool, citral, geraniol, and E-citral. The zingiberol group of compounds was obtained with the highest percentage from ultrasonic extraction at 1.07%, then maceration extraction at 1.03%, and distillation extraction at 0.27%.
Burn Wound Healing Activity of Ethanol Extract of Jackfruit Leaves (Artocarpus heterophyllus Lmk.) in Sprague Dawley Male Rats Solihah, Indah; Herlina, Herlina; Mareta, Fauzia
Jurnal Fitofarmaka Indonesia Vol 11, No 3 (2024): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i3.978

Abstract

Burn wounds have the potential to become infection, dehydration, and serious complications if not treated properly. Jackfruit leaves (Artocarpus heterophyllus Lmk.) contain secondary metabolites such as flavonoids, tannins, saponins, and steroids which has big potential to accelerate of burn wound's healing. The purpose of this study is to learn more about the effect of jackfruit leaves ethanol extract application on the burn wound healing. The experimental animals were 25 Sprague Dawley rats separated into five groups: negative control group, positive control group, and test groups G1 (94 mg/Kg BW), G2 (188 mg/Kg BW), and G3 (376 mg/Kg BW). The wound area, wound recovery (%), and wound healing time were all measured. To determine the difference on a given day of observation, wound area data were evaluated using a one-way ANOVA test. The ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lmk.) was found to have an effect on burn healing. On the 14th day, the percent recovery values for burns in the positive control, negative control, G1, G2, and G3 groups were 89.9%, 76.5%, 88.8%, 87.2%, and 100%, respectively. Treatment group 3 had the quickest burn healing time and the highest percentage of recovery.
In vitro, efek antidiabetes dan antikolestrol kopasanda (Chromolaena odorata L.) Rahmawati, Rahmawati; Baits, Muzakkir; Putri, Hemalia; Nurhikmah, Nurhikmah
Jurnal Fitofarmaka Indonesia Vol 12, No 1 (2025): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v12i1.1330

Abstract

The leaves of the kopasanda plant (Chromolaena odorata L.) contain alkaloids, flavonoids, saponins, terpenoids and tannins which have the potential to be anti-diabetic and anti-cholesterol. In vitro research has been carried out on the ethanol extract of kopasanda leaves (Chromolaena odorata L.) to determine the potential of α-glucosidase enzyme inhibitor compounds as antidiabetic by determining the IC50 value and the potential to reduce cholesterol levels as an anticholesterol by determining the EC50 value. Testing for the inhibitory activity of the α-glucosidase enzyme used the spectrophotometer method with a microplate reader at a wavelength of 405 nm, with acarbose as a comparison. The results showed that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) as an inhibitor of the α-glucosidase enzyme obtained an IC50 value of 444.019 µg/mL in the very weak category. In testing the anti-cholesterol potential using a UV-Vis spectrophotometer with measurements at a wavelength of 672 nm, the calculation results obtained an EC50 value of 1,017.118 µg/L. This shows that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) has the potential to inhibit cholesterol.

Page 15 of 15 | Total Record : 150

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