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Journal of Islamic Medicine
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : -     EISSN : 25500074     DOI : https://doi.org/10.18860/jim
Core Subject : Health,
Medicine & Pharmacology
Journal of Islamic Medicine is a medical journal published twice a year in March and September by the School of Medicine, Faculty of Medicine and Medical Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang.
Arjuna Subject : -
Articles 156 Documents
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Integrasi KeIslaman Dalam Kurikulum Clinical Skills PSPD Uin Maulana Malik Ibrahim Malang Riskiyah, Riskiyah; Susanti, Nur Laili
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.20677

Abstract

Background: A medical education curriculum that integrates Islamic content is necessary for Muslim doctors. Implementing Islamic integration in medical science must be reflected in curriculum development and learning. Objective: This research aims to determine how Islamic integration is implemented in the CSL curriculum in the Medical Education Study Program at UIN Maulana Malik Ibrahim Malang. Method: This research used a qualitative phenomenological with purposive sampling. In-depth interviews were conducted with 16 people, namely ten students and six lecturers, at the UIN Malang Medical Education Study Program. Results: The results of the research found six themes, including Islamic integration was still lacking in the CSL curriculum; Islamic values material that needed to be integrated into the CSL curriculum; Forms of activities that incorporate Islamic values into the CSL curriculum; Needed to include Islamic integration in the assessment OSCE; There needed to be a guidebook in the form of a CSL module that contains the theory and practice of Islamic integration; Prepared lecturers as role models for doctors who apply Islamic values in the CSL curriculum. Conclusion: The integration of Islam in the CSL curriculum still has many shortcomings that need to be improved.
Patofisiologi dan Manajemen Defisiensi Zat Besi pada Gagal Jantung: Sebuah Tinjauan Literatur Laksono, Sidhi; Hertanto, Yoseph Jeffry
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.21513

Abstract

The human body needs iron to function. Deficiency of iron causes inefficient use of oxygen and decreased oxygen availability. Iron deficiency is diagnosed when serum ferritin concentration is less than 100 ng/ml or concentration of ferritin is 100-299 ng/mL with transferrin saturation less than 20% in patients with heart failure. Several possible mechanisms are proposed as a cause for iron deficiency, such as; decreased food intake, increase hepcidin secretion that causes poor iron absorption, inflammation of reticuloendothelial system that causes iron leakage and loss of blood from gastrointestinal tract. Management of iron deficiency in heart failure is focused on iron supplementation, either orally or intravenously. Oral iron supplementation is generally considered less effective and may cause severe gastrointestinal side effects. Current guidelines also support use of IV therapy. Currently, several novel therapies in development focus on iron metabolism.
Potensi Daun Genitri (Elaeoarpus Ganitrus) terhadap Profil Leukosit dan Histopatologi Lien Tikus Wistar Induksi Virus Influenza Primiani, Cicilia Novi; Pujiati, Pujiati; Bhagawan, Weka Sidha
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.22708

Abstract

Background: Genitri (Elaeocarpus ganitrus) is a local plant, growing well in tropical forests. Genitri seeds are used as jewelry. Utilization of genitri in the health sector is still lacking. Objectif: To analyze the potential of genitri leaves on the leukocyte profile and splenic histopathology of Wistar rats. Methods: Experimental true approach, using experimental male wistar rats aged 5-6 months, weighing 280-360 grams, totaling 24 rats. Experimental animals were placed in group cages at 27oC, 12 hours of light, fed and watered ad libitum. Acclimatization was carried out 7 days before treatment. Treatment P0 (negative control), P1 induced influenza virus (Vaxigrip trivalent) 0.5 ml (positive control), P2 induced influenza virus 0.5 ml and 1 gram of genitri leaves. Induction of virus from intramuscular vaccine. Induction was carried out on day 0 and day 14. Genitri leaves were administered using the oral gavage method on the 3rd day for 29 days. On the 33rd day, blood sampling was carried out through the heart and surgery and spleen retrieval. Total leukocyte count using a hemocytometer. Histopathologically examined using hematoxylin and eosin (HE) staining. Results: The total leukocyte count on the 19th day, P0 4263.82 cells/mm3, P1 6314.46 cells/mm3, P2 8443.72 cells/mm3. Total leukocytes on day 33, P0 4241.66 cells/mm3, P1 4983.33 cells/mm3, P2 7520.83 cells/mm3. Diameter of germinal center spleen on day 19, P0 231 nm, P1 186 nm, P2 202 nm. Germinal center diameter on day 33, P0 239 nm, P1 191 nm, P2 242 nm. Tissue structure of the P1 spleen was congested and haemorrhagic, the structure of the spleen P2 had leukocyte infiltration, the marginal zone and germinal center were thickened. Conclusion: genitri leaves can increase the number of leukocytes and the diameter of the splenic germinal center of Wistar rats .
Pengaruh Konsumsi Minuman Khusus Ibu Pengaruh Konsumsi Minuman Khusus Ibu Hamil terhadap Kecukupan Zat Gizi Makro Ibu HamilHamil terhadap Kecukupan Zat Gizi Makro Ibu Hamil Irgananda, Anisa Ilhami; Sartika, Ratu Ayu Dewi; Nuryandari, Primasti
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.23210

Abstract

Background: Macronutrients are needed in greater amounts by pregnant women to meet their own nutritional needs as well as for fetal growth and development. Commercial milk formula formulated with special nutritional content for pregnant women are widely circulated in the community, so it is necessary to study the adequacy of macronutrients from the consumption of these products and their compliance with the requirements and information on the product label. Objective: To determine the relationship between consumption of commercial milk formula-pregnant and nutritional status, to compare macronutrient intakes between pregnant women who consume commercial milk formulapregnant and those who do not, and to provide an overview of the contribution of macronutrient intakes derived from that product to the values set as product standards. Methods: Cross-sectional study in Sawangan Subdistrict, Depok City on 225 pregnant women selected by total sampling. Data were analyzed univariately and bivariately using chi-squared to assess the influence between the independent variable and the dependent variable, and independent t-test to compare the nutritional intake of the group who consumed commercial milk formula-pregnant with those who did not. Results: The habit of consuming commercial milk formula-pregnant was significantly associated with energy, fat and protein deficiencies (p≤0.05). Macronutrient intakes were higher among mothers consuming commercial milk formula-pregnant than among nonconsumers, with average macronutrient intakes from prenatal beverages being in accordance with the nutrient requirements and RDAs listed in nutrition facts on the product label. Conclusion: The study results can be used as a reference for evaluating standard regulations and product monitoring as well as public health recommendations, especially for pregnant women's nutrition.
The Benefits of Intermittent Fasting as an Alternative to Medical Therapy to Improve Health Status Amiruddin, Muhammad; Oktavia, Reza Putri; Hidayat, Hakmi
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.20591

Abstract

Background: Health is a fundamental human need to be cared for. In order to maintain health of the body, there is one alternative medicine growing around the community, a therapy performed by the prophet Muhammad SAW or commonly known as thibbun nabawi. The example of the prophet’s teaching and actions included in pillars of islam is fasting. Fasting in addition to increase faith and taqwa, can also benefit from the fasting. Objectif: The purpose of this research was for communities to understand fasting and health relationships for the next time being practiced in live. Methods : The research method used was literature review. As for the nature of this studt is a descriptive analysis, which is a regular break from fasting to health, then an explanation is given for the reader to read well. Results: The study result in that fast devoted to disease are called Intermittent fasting. The detoxification process will occur naturally in the human body that regularly performs intermittent fasting, eventually improving its resistance. Conclusion :  The conclusion is that intermittent fasting can improve health status, either improving body immunity and or disease treatment. It must also be offset by implementing a healthy lifestyle. 
The Role Of Magnetic Resonance Spectroscopy To Improve The Accuracy Of Brain Tumor Diagnosis Arisetijono, Eko; Pradhana, Satwika; Yueniwati, Yuyun
Journal of Islamic Medicine Vol 8, No 1 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i1.25512

Abstract

Background: In Indonesia, primary brain tumor incidence reaches 7 per 100,000, with a mortality rate of 4.25 per 100,000 people per year. Histopathology is the gold standard for determining tumor type and degree of aggressiveness. Non-invasive approaches and precision in determining brain tumor grading are essential for management, avoiding less necessary surgical procedures and challenging cases, one of which is MR Spectroscopy. Purpose: To analyze the relationship between Cho/Cr and Cho/NAA's suitability ratio in MRS and the degree of malignancy in histopathology and investigate the influence of differences in Cho/Cr, Cho/NAA ratio, and lactate lipid peaks in MRS on the degree of malignancy in histopathology in primary brain tumors. Methods: We retrospectively reviewed 17 patients with high and low-grade brain tumors using an observational study with a cross-sectional study design. We measured the Cho/Cr and Cho/NAA ratios and identified the Lipid Lactate peak on the homogenous contrast enhancement area with the highest Cho area. We conducted data analysis using McNemar's test and independent t- test. Result: Statistical analysis showed no significant difference in the ratio of Cho/Cr, Cho/NAA, and lactate lipids (p > 0.05), and this study obtained the suitability of the MRS indicator with histopathological results in Cho/NAA with p = 0.219 (p > 0.05) with an accuracy of 65%. Conclusion: The Cho/NAA ratio's conformity in determining the degree of brain tumor compared to histopathological results with an accuracy of 65%. Further research with a larger sample is necessary for the results to be more optimal
In Silico Analysis of Phytoestrogens' Neuroprotective Effect on N-methyl-D-aspartate (NMDA) Receptors Muslikh, Faisal Akhmal; Pratama, Rizki Rahmadi; Ma'arif, Burhan; Gondokesumo, Marisca Evalina
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.21381

Abstract

cause of death and disability globally. One of the causes is associated with cell signaling disorders, neuronal apoptosis, inflammation, and the deposition of aggregate proteins. The N-methyl-D-aspartate (NMDA) receptor is a glutamate receptor that, when activated, causes synaptic dysfunction and leads to neuronal death. Phytoestrogen compounds are able to replace the role of estrogen in maintaining body homeostasis, including in the CNS.  Objectif: This study aims to determine the role of phytoestrogen compounds in inhibiting NMDA activation (1PBQ), which causes neurodegenerative diseases. Methods: The method used is molecular docking with the AutoDockTools 1.5.6 program. The prediction of pharmacokinetic and pharmacodynamic properties used SwissADME, while the toxicity used pkCSM and ProTox II. Results:  The results of docking using the 1PBQ protein showed that the compounds α-amyrin, β-amyrin and eudesmin had the best binding potential compared to 17β-estradiol which was the positive control. Pharmacokinetic and pharmacodynamic tests showed that the three compounds had good permeability and strong lipophilicity, so they could penetrate cell membranes, and were not toxic, except for eudesmin, which was included in class IV in the toxicity test using ProTox II. Conclusion :   α-amyrin and β-amyrin compounds have the potential to treat neurodegenerative diseases against NMDA receptors (1PBQ).
GIVING HOMEMADE MPASI ON BODY WEIGHT OF BABIES AGED 6-12 MONTHS AT PMB YUNI ERMAWATI PAGELARAN MALANG REGENCY Purwanti, Anik Sri
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.22417

Abstract

Background: Growth is an indicator to see the nutritional status and health of children. Nutrition is needed by every living thing in the process of growth and development, especially during the first 1000 days of life. If the nutrition received is bad, it will have a big impact on life. The prevalence of stunting cases in Malang Regency in 2019 was 25.4%, there is a decrease to 23.8% in 2020. To prevent stunting, adequate nutritional intake can be given. Providing nutrition to infants aged over 6 months by providing solids. Provision of Homemade MPASI according to WHO recommendations, namely a balanced menu. Objective: to determine the effect of giving Homemade MPASI on the weight of infants aged 6-12 months. Methods: Pre-experimental research design with one group pretest posttest design. Sampling technique with purposive sampling the number of respondents 30 infants aged 6-12 months. Results: The baby's weight was measured before and after being given Homemade MPASI with a span of 1 month. The results tested using the Wilcoxon Test showed an increase of 0.547 points (between 0.478 to 0.616) statistically it was stated that there was a significant difference (sig/p = 0.000 0.05). Conclusion: Homemade MPASI can significantly increase baby's weight. Therefore it is recommended for mothers who have babies and toddlers to provide Homemade MPASI as an effort to prevent stunting.
Systematic Review : Kajian Fitokimia Dan Potensi Farmakologi Jeruk Pamelo (Citrus Maxima) Mutiah, M.Kes, Roihatul; Qonita, Kesimira; Luthfi, Fitrati Hasanah
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.15444

Abstract

Background: The Citrus maxima plant is native to the Malay islands and East India. This plant grows widely in the tropics and has been widely used as medicine. Objectif: The purpose of this study was to study Citrus maxima from the aspect of phytochemical and pharmacological activity. Methods: The method used in this research is PRISMA systematic review. Sources of data obtained from electronic databases PubMed, Science Direct, and Google Scholar. Results: The results of a systematic review showed that the Citrus maxima plant contains naringin, hesperidin, hesperetin, rutin, nobiletin, tangeretin, vitamin C, limonene, lycopene, bergapten, umbelliferone and auraptene compounds. . Conclusion: These compounds have pharmacological activities as antioxidants, anticancer, antibacterial, anti-inflammatory, and antidiabetic
In Silico Study of Curcuminoid Compounds in Turmeric ( Curcuma longa) Plants as Halal Anticoagulant Active Ingredients Dewi, Tanaya Jati Dharma; Sya'bana, Mohammad Mohammad Ihda Faiz; Wafi, Abdul; Ma’arif, Burhan; Muchlasi, Luthfi Ahmad
Journal of Islamic Medicine Vol 7, No 2 (2023): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2023
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v7i2.24568

Abstract

Background:  Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.Background:  Thrombosis is a condition when there is a reduction in the flow of blood fluid in the blood vessels that occurs due to the process of forming blood clots. One of the drugs most often used as an anticoagulant is enoxaparin. Enoxaparin itself is obtained by depolymerizing the base of heparin benzyl ester which is derived directly from the intestinal mucosa of pigs so that its use triggers a lot of controversy by Muslims. The mechanism of action of enoxaparin is to act as an antithrombin III catalyst which functions to inhibit the formation of blood clots by factor X. The curcumin compound in turmeric is known to have the ability as an anticoagulant drug by inhibiting the formation of factor Xa by factor X. Objectif :This study aims to predict physicochemical properties, predict toxicity, and predict the antiviral activity of 8 curcumin-derived compounds in turmeric against antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF). Methods :Prediction of physicochemical properties is carried out using the SwissADME application and referring to Lipinski's five laws . Furthermore, the toxicity class was carried out using the pkCSM Online Tool and Protox Online Tool applications. Prediction of the antiviral activity of compounds was carried out using the Molegro Virtual Docker (MVD) application.Results:The results of the LD50 value and the classification of toxicity classes were classified according to GHS. 8 compounds derived from curcumin belong to toxicity classes 4 and 5. Antithrombin III receptors (GDP ID: 1R1L) and factor X (GDP ID: 5VOF were said to be valid because they had RMSD values below 2 Å. Conclusion :The results showed that cyclocurcumin compounds were predicted to have good potential anticoagulant activity.

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