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Journal of Islamic Medicine
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : -     EISSN : 25500074     DOI : https://doi.org/10.18860/jim
Core Subject : Health,
Medicine & Pharmacology
Journal of Islamic Medicine is a medical journal published twice a year in March and September by the School of Medicine, Faculty of Medicine and Medical Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang.
Arjuna Subject : -
Articles 156 Documents
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PENGAMBANGAN SISTEM NANOSTRUCTURED LIPID CARRIER (NLC) DAUN Chrysanthemum cinerariifolium (Trev.) Vis DENGAN VARIASI KONSENTRASI LIPID Listiyana, Anik; Mutiah, Roihatul; Suyadinata, Arief; Salsabilla, Farida Rahma
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.9787

Abstract

Ethanol extract 96% of Chrysanthemum cinerariifolium (Trev.) Vis leaves are proven to have anticancer activity. However, these compounds have low solubility in water and fat. To improve the bioavailability of preparations, the development of drug design in the form of Nanostructured Lipid Carrier (NLC) is carried out.The aim this study was to determine the effect of differences in lipid concentration of Monostearin and Oleic Acid in the formulation of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves, which produced good physicochemical characteristics including organoleptic characteristics, pH, viscosity, particle size, and drug entrapment efficiency. Making is done using the High Shear Homogenization method. Organoleptic tests showed ideal results for the Nanostructured Lipid Carrier (NLC) system, the resulting pH values in formula 1 (7.0 ± 0.12), formula 2 (6.7 ± 0.17) and formula 3 (6.8 ± 0.2)), the viscosity value of formula 1 (55.66 ± 2.84 cPs), formula 2 (28.86 ± 3.91 cPs), and formula 3 (28.57 ± 16.85 cPs). Particle size of formula 1 (5530 ± 320.47 nm), formula 2 (5337 ± 671.44 nm) and formula 3 (4676 ± 2215.75 nm)). The entrapment efficiency value of formula 1 drugs (33.55%), formula 2 (38.77%), formula 3 (83.75%). Based on the characterization result, the best formula was obtained at a lipid concentration of 10%, which was used for the formula of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves for oral anticancer preparations
Pengaruh Akupunktur Jin’s 3 Needle Dalam Menurunkan Intensitas Nyeri Penderita Nyeri Punggung Bawah Di Balai Kesehatan Tradisional Sehat Harmoni Indonesia Malang Abdullah, Ikhwan; Prihatono, Amal
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.8972

Abstract

Latar Belakang Nyeri punggung bawah (Low Back Pain/ LBP) merupakan masalah kesehatan dunia dan menyebabkan pembatasan aktivitas serta ketidakhadiran kerja. Akupunktur Jin’s 3 needle digunakan untuk mengatasi LBP telah menjadi perhatian dunia. Sekitar 291 penyakit yang diteliti, LBP merupakan penyumbang terbesar kecacatan global dan sekitar 80% pekerja di Dunia pernah mengalami LBP. Setiap tahun di Indonesia 14-45% orang dewasa menderita LBP. Kasus baru LBP di Malang pada tahun 2012 terdapat 330 orang (18,7%), tahun 2013 terdapat 408 orang (20,9%). Tujuan penelitian menganalisis pengaruh akupunktur Jin’s 3 needle terhadap penurunan intensitas LBP di Balai Kesehatan Tradisional Sehat Harmoni Indonesia Malang. Metode Penelitian pre-eksperimental design dengan jenis pretest-posttest design. Populasi semua penderita LBP yang berkunjung ke Balai Kesehatan Tradisional Sehat Harmoni Indonesia Malang, sampel 15 orang, teknik total sampling, instrumen menggunakan lembar observasi skala nyeri Bourbanis, jarum akupunktur, analisis data paired sample t test menggunakan SPSS v.21. Hasil penelitian sebelum diberikan terapi akupunktur Jin’s 3 Needle diketahui intensitas nyeri dari 15 penderita nyeri punggung bawah meliputi 4 orang nyeri ringan (27%), 8 orang nyeri sedang (53%), 3 orang nyeri berat (20%), setelah diberikan terapi selama 2 bulan, frekuensi 3 kali seminggu diketahui terdapat penurunan intensitas nyeri penderita LBP meliputi tidak nyeri sebanyak 2 orang (13%), nyeri ringan sebanyak 9 orang (60%), nyeri sedang sebanyak 4 orang (27%). Hasil uji Paired t test diperoleh p=0.00 α 0.05. Kesimpulan Terapi akupunktur Jin’s 3 Needle dapat menurunkan intensitas nyeri LBP. Terapi akupunktur dapat digunakan sebagai metode alternatif non farmakologi untuk mengurangi keluhan LBPKata kunci : Akupuntur, Jin’s 3 needle, Intensitas Nyeri, Nyeri Punggung
Hubungan Asupan Bahan Makanan Sumber Vitamin D Dan Vitamin C Terhadap Penurunan Glukosa Darah Pada Responden Terindikasi Diabetes Mellitus Tipe II Kardina, Rizki Nurmalya; Nuriannisa, Farah; Andini, Ary; Anita, Anita
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11433

Abstract

Latar belakang: Diabetes Mellitus tipe 2 merupakan penyakit yang disebabkan oleh penurunan sekresi insulin dan ditandai dengan peningkatan kadar glukosa darah (hiperglikemia). Vitamin D memiliki peranan terhadap sekresi insulin, metabolisme insulin dengan mempercepat perubahan proinsulin menjadi insulin dan meningkatkan sensitifitas insulin. Vitamin C adalah golongan mikronutrien yang memiliki peran penting dalam plasma manusia sebagai antioksidan. Vitamin C mempunyai sifat larut air dan mampu melawan radikal bebas. Fungsi Vitamin C adalah sebagai donor elektron atau agen pereduksi elektron sehingga mampu berperan sebagai antioksidan. Tujuan ingin mengetahui hubungan asupan bahan makanan sumber vitamin D dan vitamin C terhadap penurunan glukosa darah pada responden yang terindikasi Diabetes Mellitus tipe II. Metode penelitian pada penelitian ini adalah eksperimental dengan pendekatan crosssectional dengan menggunakan responden di wilayah kelurahan Kutisai, Surabaya. Dalam penelitian ini menggunakan 2 kelompok yaitu kelompok perlakuan dan kelompok kontrol. Teknik pengambilan sampel yang digunakan adalah incidental sampling dengan jumlah 20 responden, yang terbagi menjadi 2 kelompok. Setiap kelompok 10 responden kelompok kontrol dan 10 responden kelompok perlakuan. Pengumpulan sampel dengan dilakukan dengan pengambilan darah hari 1 dan hari 7, wawancara FFQ–SQ. Hasil penelitian menunjukkan kedua kelompok baik kelompok kontrol dan perlakuan sama sama memiliki hasil tidak terdapat hubungan asupan bahan makanan sumber vitamin D dan vitamin C pada responden yang terindikasi diabetes mellitus tipe II . Kesimpulan Tidak ada hubungan antara asupan bahan makanan sumber vitamin D dan vitamin C terhadap penurunan kadar glukosa darah pada responden yang terindikasi Diabetes Mellitus tipe IIKata kunci : Diabetes Mellitus Glukosa, Vitamin C, Vitamin D
The Effect Of Beetroot Juice (Beta Vulgaris L) And Star Fruit (Averrhoa Carambola L) On The Reduction Of Blood Pressure In Second Trimester Pregnant Women With Gestational Hypertension Retnaningsih, Reny; Wijayanti, Tut Rayani Aksohini
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10373

Abstract

Background: Gestational hypertension is usually defined as high bloodpressure that develops after 20 weeks of gestation in the absence ofproteinuria. Beets and star fruit contain vitamins and minerals such as Bvitamins and calcium, potassium, phosphorus, and iron, which can safelylower blood pressure in pregnancy.Objective: Determine the effect ofbeetroot juice (Beta vulgaris L) and star fruit (Averrhoacarambola L) on reducing blood pressure in pregnant women in the second trimester with gestational hypertension.Method: This pre-experimental research was a one-group pretest-posttest design with 200 ml/day of beet and starfruit juiceintervention for two weeks. The samples taken were 15 second trimesterpregnant women with gestational hypertension.The data taken is bloodpressure before and after treatment—data analysis using paired t-test.Results: data onthe mean systolic blood pressure before treatment is 146.53mmHg and after treatment is 126.07 mmHg and the average diastolic blood pressure before treatment is 94.53 mmHg and after treatment is 91.13mmHg. There is an effect of beet and star fruit juice administration onsystolic and diastolic blood pressure in second-trimester pregnant womenwith gestational hypertension (p 0.05).Conclusion : pregnant women withgestational hypertension is to treat hypertension using beet and starfruit juice so that hypertension can be treated immediately.Keywords: Beetroot Juice, Beta vulgaris L , Star Fruit , Averrhoa carambola L, Gestational Hypertension
Antioxidant and Cytotoxic Effect of Water Extract of Ananas comosus in Human Breast Cancer Cell Line Widyanto, Rahma Micho; Halimah, Ririt Nafi'; Rahmi, Yosfi; Utomo, Budi; Proborini, Wahyu Diah; Yunimar, Yunimar
Journal of Islamic Medicine Vol 4, No 2 (2020): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2020
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v4i2.10109

Abstract

Background: Breast cancer is the most common type of cancer and the second leading cause of death in the world. One of the supporting therapeutic efforts to overcome cancer is through food, mainly fruits. Ananas comosus has been investigated for its potential as an anti-cancer. It is a source of antioxidants from the content of Vitamin C and flavonoids that work by capturing free radicals, resulting in inhibition of cancer cell proliferation.Objective :This study was conducted to determine the antioxidant activity and cytotoxicity of water extract of Ananas comosus on T-47D breast cancer cell lines.Method: The process of extracting pineapple flesh is done using water as a solvent, then tested its antioxidant activity using DPPH and cytotoxicity using MTT assay on T-47D.Result: IC50 value for antioxidant activity was 463.369 μg / mL and the IC50 for the cytotoxicity assay was 488.003 μg / mL.Conclusion : The water extract of Ananas comosus have very weak antioxidant activity and moderate cytotoxicity properties that have potential as chemo preventive agents in T-47D breast cancer cell lines.
The Effectivity of Murottal Al-Qur’an Exposure to Spermatogenesis of Male Mice (Mus musculus) with stress Dianti, Meilina Ratna; Mazidah, Lilik Khoiriyatul; Ari Indrawijaya, Yen Yen; Inayatilah, Fidia Rizkiah
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.9886

Abstract

Introduction: Stress is the body's reaction to pressure from stressors; one of the stressors that can trigger stress is a noise stressor. Stress can disrupt the body's homeostasis system, one of the cycles of spermatogenesis. Murottal Al-Qur'an therapy listening can produce a response of relaxation and peace of mind to increase healing. Methods: The study was conducted on 25 healthy male mice aged 8-12 weeks grouped randomly into five groups. The positive control group is the normal group. The negative control group is given a 12-hour stressor. The treatment groups are given 12 hours and 1, 2, and 4 hours therapy. The treatment for each group was carried out for 21 days. Spermatogenesis of mice was observed through the number of primary spermatocytes cells and spermatid cells. It takes place during the preparation of testicular histology with Hematoxylin Eosin staining. Primary spermatocyte and spermatid counts were examined under a 40x magnification microscope. Results: Murottal Al-Qur'an therapy can affect the amount of primary spermatocyte cells (p-value = 0.000) and spermatids (p-value = 0,000) that are very significant. Conclusion: Murottal Al-Qur'an therapy can be used to increase the spermatogenesis of mice with stress. Keywords: Stress, Noise, Spermatogenesis, Murottal Al-Qur'an.
Hubungan Stres dengan Kualitas Tidur pada Mahasiswa – Mahasiswi Tingkat Akhir Di STIKES Husada Mandiri Poso Susanti, Ni Made Dewi; Kalengkongan, Desty
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.11797

Abstract

Background: Students are people who are studying in college. Stress is defined as pressure, tension or unpleasant disturbances that come from outside oneself. Sleep is a basic physiological requirement needed by humans to optimize bodily functions.  Students are required to be more mature and able to think critically, especially for final year students. Difficulties experienced by students such as lack of interest in research, failure to find titles, and difficulties in finding literature, resulting in negative feelings in students which ultimately trigger stress which has an impact on mental health. Objective: Knowing the relationship of stress with sleep quality in the final year students at Stikes Husada Mandiri Poso. Research Methods: This research was a descriptive analytic type with a cross section approach. The population in this study were all final year students totaling 87 people, determination of the sample using the rule of thumbs formula so that a sample of 70 people is obtained and the sampling technique used is purposive sampling. Results: There was a significant correlation between stress and sleep quality in the final year students at STIKES Husada Mandiri Poso with a value (r = 0.249 p 0.05). Conclusion: Stress contributes to the quality of sleep in final-year students at Stikes Husada Mandiri Poso Keyword : Sleep quailty, Students, Stress
Hubungan Tingkat Ansietas Terhadap Quality of life Pada ODHA Daramatasia, Wira; Kurniyanti, Mizam Ari
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.11617

Abstract

Background: HIV/AIDS is one of the worst pandemics, in addition to the physical impact psikososial that make fear. Increased anxiety can affect the quality of life in ODHA. Objectif : The research aims is to understand the anxiety in the quality of life of patients odha in peer support groups JCC+. Methods : This research using analytic observational with the approach of cross sectional. Respondents were 40 taken with purposive approach based on techniques of sampling from 367 responden that include in the criteria and ekslusi who join the KDS JCC. Quality of life ODHA assessed using a questioner WHOQOLHIV BREF, anxiety levels measured by the questionnaire zung self-rating anxiety scale ( ZSAS). Data analysis using spearman test to test relation between levels of anxiety with Qol with the level of significance 5 %.. Results: The results of research related to the quality of life based on 6 ODHA, domain to have enough physical domain category of 52,5 %, psychological domain have good category of 75 %, the domain independence have quite as much as 70 %, category domain have enough social category of 52,5 %, the domain ward having good category of 52,5 % religious and spiritual domain / having good category of 70 %. The anxiety on the majority of 85 odha % is categorized as a mild anxiety .There is a significant relation exists between the level of anxiety with a domain ODHA quality of life. Conclusion : The conclusion of a significant relation exists between the level of anxiety in the quality of life of the majority of 85 odha.tingkat anxiety on odha % is categorized as a mild anxiety .There is a significant relation exists between the level of anxiety with a domain odha quality of life (r1=-0,1258 , r2=-0,1144, r3=-0,0533, r4=-0,1258, r5=-0,1398, dan r6=-0,0609) .The conclusion of a significant relation exists between the level of anxiety by odha quality of life.
Evaluasi Rasionalitas Penggunaan Antihipertensi pada Pasien Geriatri di RSUD Dr. H Bob Bazar, SKM Lampung Selatan Herawati, Nenti; Saputri, Gusti Ayu Rai; Yasir, Angga Saputra
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.13435

Abstract

Background: Hypertension is a condition characterized by an increase in blood pressure 140/90 mmHg. Hypertension is an important risk factor for causing other cardiovascular diseases. Evaluation of the use of antihypertensive drugs aims to ensure the rational use of drugs in patients with hypertension. Objective: This study aims to determine the rationality of the use of antihypertensive drug in geriatric patients at RSUD Dr. H. Bob Bazar, SKM Lampung Selatan in terms of the correct diagnosis, the right indication, the right drug, the right dose, the right way of giving, the right time interval for giving and the right patient. Methods: This study is a non-experimental type of research in the sense that it does not provide any treatment to the research subjects and used retrospective data, namely medical record sheetsof hypertension patients in 2019. Of the total 423 medical records of hypertension patients, 51 medical records were used as research samples. The data obtained were then compared using the JNC VIII literature and the Geriatric Dosage Handbook (Lexicomp Drug Reference). Results: The results showed that the rationality of the use of antihypertensives in geriatric patients in RSUD Dr. H. Bob Bazar, SKM Lampung Selatan, is 100% accurate on diagnosis, 100% right on indication, 100% right on drug, 94.12% right on dose, 100% right on route of administration, 96.08% right on time interval and 100% right on patient. Conclusion: The percentage value of rational used of antihypertensive drugs in geriatric patients is 96,8%.Keyword : Evaluation, Hypertension, Geriatric Rationality,
Hubungan Asupan Vitamin D Dan Selenium Dengan Indeks Bakteriologi Penderita Kusta Tipe MB (Multibacillary) : Systematic Literature Review Putri, Fildzah Karunia; Yusyifak, Eka Zulfiana; Kardina, Rizki Nurmalya
Journal of Islamic Medicine Vol 5, No 2 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i2.12974

Abstract

Background : As one of the infectious diseases that have a high prevalence until now, leprosy is a chronic transmission disease caused by infection with Mycobacterium Leprae. Apart from the standard MDT (Multidrug Therapy), nutritional support is a crucial component to restrict further infection severity. Vitamin D and selenium play essential roles as the primary defence against susceptibility. Methods : The systematic literature review was conducted using three international databases : PubMed, ResearchGate, and DOAJ, which were published between 2010 – 2020 using English or Indonesian. A total of 8 articles (2 articles identifying the correlation of selenium with leprosy, and 6 articles identifying the correlation of vitamin D with leprosy) using cross- sectional analytic and case-control analytic studies were included in this review. Results : The average serum levels of vitamin D and selenium in leprosy patients were lower than in healthy controls. This case was also found in Multibacillary leprosy patients compared to Paucibacillary leprosy patients. This serum levels can affect the bacteriological index, which is the higher the serum levels, the lower the bacteriological index. Disscusion : Serum vitamin D and selenium levels are affected by vitamin D and selenium intake, which can lead to a reduction in bacteriological index across all multibacillary leprosy patients. There is a negative correlation between vitamin D, selenium, and bacteriological index in patients with MB (Multibacillary) leprosy.Keywords:Leprosy, Vitamin D, Selenium, Bacteriological Index

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