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Jurnal Kesehatan Islam : Islamic Health Journal
Published by Universitas Islam Malang
ISSN : 2303022X     EISSN : 26158345     DOI : -
Core Subject : Health, Science, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health
Jurnal Riset Kedokteran Islam berisi informasi tentang hasil kegiatan penelitian, pemikiran konseptual dan kajian bidang ilmu kedokteran dan kedokteran. Jurnal ilmiah ini diterbitkan oleh Fakultas Kedokteran Universitas Islam Malang. Jurnal ini diterbitkan dengan frekuensi 2 kali setahun, yaitu pada bulan Maret dan bulan September.
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Articles 113 Documents
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Psoriasis Relationship with Hypertension in Psoriasis Patients at RSI Jemursari Surabaya Retna Gumilang; Meidyta Sinantryana Widyaswari; Zakiyyatur Rizkiyyah Husin
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13827

Abstract

Abstract. Background: Psoriasis is a chronic inflammatory disease of the skin that characterized by firmly bound erythema plaques covered in thick squama and caused by multiple abnormalities of genetic, biochemical, immunologic, vascular with further severed by various other factors such as psychology, drugs, smoking, and alcohol consumption. Several studies revealed that psoriasis can increase the risk of cardiovascular diseases such as hypertension, however, the underlying pathophysiological mechanism has not been confirmed yet. This mechanism is probably attributed to increased levels of angiotensin-converting enzyme produce angiotensin II that regulates vascular tonus, endothelin-1 (ET-1) has been considered an important role in that vasoconstrictor proteins are potent, and increased plasma renin activity has been reported in patients with psoriasis. Purpose: In order to figure out the relationship between psoriasis and hypertension in psoriasis patients at the Outpatient Unit -RSI Jemursari Surabaya.  Methods: This study was observational analytics with cross sectional study design in 28 psoriasis patients at Outpatient Unit-RSI Jemursari Surabaya during 2017-2019, using total sampling technique. Secondary data from medical records was collected and further analyzed with spearman correlation tests. Result: The obtained significance value is 0.000 (p < 0.05), which represent a significant relationship between hypertension and psoriasis. the correlation coefficient is 0.757, which indicates the strength of a strong relationship between two variables. Conclusion: There is a significant association between Psoriasis and Hypertension.
Komplikasi Nyeri dan Perdarahan Pasca Sirkumsisi Metode Klem Resa Budi Deskianditya; Anis Kusumawati; Yuhantoro Budi Handoyo Sakti; Naura Faisa Adiyanti; Sabrina Diva Wulandari
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13828

Abstract

Abstract: Circumcision is a minor surgery procedure that provides several benefits and is closely related to religious life.  Currently there are various methods in the action of circumcision.  The incindence of complication related to circumcision is low, but various variations of methods can affect complications.  The aim of this study is to present data on the incidence of pain and bleeding complication post clam method circumcision, as well as the factors associatd with both complications.  This study is an observa­tional analytic study with a cross-sectional method, with the research subject is medical record data at Klinik Rumah Sunatan Purwokerto for the period January 2017 – August 2020 which meets the inclusion criteria and excluded from exclusion criteria.  Data were collected and performed bivariate analysis of independent variables to complications of pain and bleeding using the Spearmen method for numerical variables and Chi square for nominal and ordinal variables, and follow up with the backward logisitic regression test.  There were 153 medical record data met the criteria, with 47.7 % pain complication and 38.6 % bleeding compllication.  Multivariate test showed a significant relationship between aged and pain (p = 0.039; B = -0.155) and bleeding complication (p = 0.003; B = -0.202), glans adhesions with pain (p = 0.007; B = 1.295) dan bleeding complication (p = 0.005; B = 1.346), and narrow prepucium and pain (p = 0.002; B = 1.294) and bleeding complication (p = 0.003; B = 1.200).  The conclusion of this study is the frequency of pain and bleeding complication were 47,7 % and 38,6 % respectively, and there was a significat relationship between age, glans adhesions, and narrow prepucium with pain and bleeding compli­cations.
Studi In silico Potensi Anti Hipertensi dan Prediksi Profil Farmakokinetika Daun Jati Belanda (Guazuma ulmifolia. Lamk) Andri Tilaqza; Merlita Herbani
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13821

Abstract

Abstract. Hypertension is a disease that is often occurred in every country, including Indonesia. Hypertension is one of the risk factors that lead to cardiovascular disease. Guazuma ulmifolia Lamk are one of the plants used empirically as antihypertensive in Indonesia, but research on the antihypertensive potential of its leaves has never been done before.The purpose of this study was to predict the potential activity and predict the pharmacokinetic of several compounds contained in Guazuma ulmifolia leaves. The Guazuma ulmifolia leaves compounds and captopril were docked to the Angiotensin-Converting Enzyme protein (PDB ID: 1O86). Mole­cular docking tests were performed using PyRx software while the visuali­zation analysis of molecular anchoring results was performed using Biovia Discovery Studio Visualizer software. Prediction of phar­macokinetic and physicochemical properties of the tested compounds was carried out using the pkCSM web page. Based on the molecular docking test, all compounds in Guazuma ulmifolia leaves have lower energy than the captopril. Kaempferitrin (-9.9 k/mol) and beta-sitosterol (-9.2 kcal/mol) had the lowest energy among other test compounds compared to captopril (-5.5 kcal/mol). Quercetin, kaempferol, and beta-caryophyllene were compounds that had similar interactions to the captopril based on the chemical interaction. All compounds had varied pharmacokinetic profiles but still had a fairly good profile.
Hubungan Tingkat Stres pada Pandemi Covid-19 terhadap Kualitas Tidur Tenaga Kesehatan RSI Unisma Tri Wahyu Sarwiyata; Pyarkatariana Putri E. P.; Mayvita Muntadiroh; Firsania Bunga W; Erfina Daniati; Erna Sulistyowati
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13829

Abstract

Abstract. Introduction: The incidence of COVID-19 continued to increase due to human-to-human transmission. To prevent the transmission of COVID-19, the government applied self-quarantine regulation. However, health workers must continue to work, especially those located in big cities, such as Malang. One of the COVID-19 referral hospitals in Malang is the Rumah Sakit Islam Malang (RSI UNISMA). The high number of patients undergoing examination tests and handling COVID-19 treatment increased the workload of health workers at RSI UNISMA. Stress due to high workload had an impact on sleep quality disturbances. This study aimed to analyze the relationship between stress levels of health workers at RSI UNISMA on sleep quality during COVID-19.Methods: This type of research was an analytic observational study with a cross-sectional approach. The sampling technique used a simple random sampling method, with as many as 74 respondents. The questionnaire instrument was in the form of a google form regarding the Covid Perceived Stress Scale (COVID PSS-10 Items) which assesses stress levels and the Pittsburgh Sleep Quality Index (PSQI) which assesses sleep quality. Data analysis used SPSS 25.0 with fisher's exact test.Results: From a total of 74 respondents, there were 58 respondents who met the inclusion criteria. Based on statistical analysis, there was no relationship between stress levels and the sleep quality of UNISMA Hospital health workers during the COVID-19 pandemic (p > 0.05).Conclusion: There was no significant relationship between stress levels and the quality of sleep for health workers at RSI UNISMA during the COVID-19 pandemic. This can be caused by various factors, one of which is thought that the health worker is accustomed to doing work with a high level of stress or a deficiency in research methods such as classifying work units.
Uji Potensi Antioksidan Kumis Kucing (Orthosiphon aristatus) dengan Pendekatan In Vitro dan In Silico Dian Novita W; Silvy Amalia Falyani
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13823

Abstract

Abstract: Orthosiphon aristatus is a potential herb as a source of antioxidants. It is known from previous research, that the active compounds O.aristatus include eupatorin, rosmarinic acid and sinensetin. The study of the potential approach of active compounds extracts O.aristatus with the in vitro methods DPPH (1,1-Difenil-2-Pikrilhidrazil) and in silico using the help of pyrex autodock vina software, with the help of visualization using biovia discovery studio and pymol. Results obtained from in vitro tests using DPPH showed the presence of antioxidant activity with yellow spotting markers against a purple background. Studies in silico show that O.aristatus extract is potentially an antioxidant compound, this is demonstrated through the presence of ligand bonds with glutathione peroksidase (GPX) receptors namely van der Waals bonds, hydrogen bonds and several other bonds.
Pengaruh Ekstrak Etanol 96% Bawang Dayak (Eleutherine Palmifolia (L.) Merr.) Terhadap Pertumbuhan Methicillin Resistant Staphylococcus Aureus (MRSA) Feriandri Utomo; Laura Nurul Alfiola
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16102

Abstract

The number of Methicillin Resistant Staphylococcus aureus (MRSA) continues to increase.The antibiotics used to treat MRSA infections is vancomycin, but the number of Staphylococcius aureus bacteria that are resistant to vancomycin has also increased. Dayak onion as a medicinal plant which has been used for a long time, has antibacterial compounds namely flavonoids, tannins, terpenoids, and quinones.The purpose of this study was to analyze the effect of 96% ethanol extract of Dayak onion with concentrations of 12.5%, 25%, 50% on the growth of MRSA compared to vancomycin, and to determine the phytochemical content of MRSA antibacterial compounds in Dayak onions.The study design used a post test only with control group by giving 0.9% NaCl to the negative control group. MRSA growth in this study was assessed from the size of the inhibition zone by the Kirby-Bauer method. Data analysis using One-Way ANOVA , then continued post hoc test. The results of this study indicated that Dayak Onion had weak anti-bacterial activity against MRSA, so it is not effective as an anti-bacterial MRSA because an average inhibition zone of <15mm is formed in all concentration groups (10.88mm at 12,5 % concentration, 12.35mm at 25 % concentration, and 14.35mm at 50% concentration). The average diameter of the inhibition zone in the treatment group of Dayak onion extract with 12,5 % concentration was significantly lower (p value <0.05) than the average diameter of the inhibition zone in the treatment group with 50 % concentration of the Dayak onion extract. The average diameter of the inhibitory zone in the treatment group of all concentrations of Dayak onion extract was significantly lower (p value <0.05) than the average diameter of the inhibition zone in the Vancomycin treatment group. The average inhibition zone formed in the vancomycin treatment group was 22.29 mm, so it was still effective as an anti-bacterial MRSA. This study also found the presence of flavonoid compounds, terpenoids, tannins, and quinones in Dayak onions. Therefore, it can be concluded that the 96% ethanol extract of Dayak onion which contains phytochemical anti-bacterial compounds has weak activity in inhibiting the growth of MRSA, so it is not effective as anti-bacterial for MRSA.
Pengaruh Kualitas Tidur dan Aktivitas Fisik pada Pasien Hipertensi di Puskesmas Ngajum, Kabupaten Malang Fitria Nugraha Aini; Dewi Martha Indria; Rizky Setia Firdaus; Ardhita Okky Riyana Dewi; Roziq Siroj Ramadhan; Cornellia Agnes Fransiska Putri
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16105

Abstract

Sleep quality affects overall health and quality of life, including blood pressure. Increased blood pressure or hypertension is one of the factors causing cardiovascular disease that is often found in primary health care. Based on Riskesdas data in 2018, 25.8% of the Indonesian population suffers from hypertension. This study aims to determine the effect of sleep quality and level of physical activity with the incidence of hypertension in patients at the Ngajum Public Health Center, Malang Regency. Method: The research design used is a case control study. This research was conducted on 60 respondents in the working area of the Ngajum Health Center, Ngajum District, Malang Regency in December 2019. Sampling was carried out using the purposive sampling method. The research instrument used a sleep quality questionnaire adopted from the Pittsburgh Sleep Quality Index (PSQI) and a physical activity questionnaire adopted from the Global Physical Activity Questionnaire (GPAQ). Results: The case group consisted of 30 hypertensive patients and the control group consisted of 30 non-hypertensive patients. In the hypertension group, 23.3% of patients had good sleep quality and 76.7% had poor sleep quality. In the group of non-hypertensive patients, 73.3% had good sleep quality and 26.7% had poor sleep quality (p≤0.05). Meanwhile, the level of physical activity in hypertensive patients was 60.0% who had high activity, 6.7% had moderate activity, and 33.3% had low activity. Then in the control group there were 70.0% who had high activity, 20.0% had moderate activity, and 10.0% had low activity (p≤0,05). Conclusion: Based on the results of the study, it can be concluded that the quality of sleep and activity had a significant effect on the incidence of hypertension in patients at the Ngajum Public Health Center, Ngajum District, Malang Regency.
Efek Ekstrak Bunga Melati (Jasminum Sambac) dengan Metode Elektrik terhadap Efek Knockdown pada Nyamuk Aedes Aegypti Stadium Dewasa Rizky Noni Amalia; Anung Putri Illahika; Aida Musyarrofah; Fathiyah Safithri
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16078

Abstract

Abstract. Dengue Hemorrhagic Fever (DHF) is caused by the Dengue virus (DENV) which is transmitted by mosquitoes. One of the factors that cause high number of dengue infections in Indonesia is due to poor vector management. Chemical-based insecticides used to control mosquitos can cause human health problems and mosquito resistance. Jasmine flower (Jasminum sambac) can be used as an alternative because it contains flavonoids, alkaloids, saponins, and tannins that can act as natural insecticides. Objective: Proving the effect of jasmine flower extract (Jasminum sambac) with the electric method has a knockdown effect on adult stage Aedes aegypti mosquitoes. Method: True Experimental Post Test Only Control Group Design. In each test group, 20 adult Aedes aegypti were used with four replications. In this study, the test group consisted of malathion as positive control, aquades as negative control, and jasmine flower extract (Jasminum sambac) at concentrations of 5%, 10%, 15%, 20%, and 25%. Data was analyzed using Kruskal Wallis test, Post Hoc Mann Whitney test, Spearman correlation test and Probit test. Results and Discussion: Kruskal Wallis test obtained a significance value (P) <0.05. Post hoc mann whitney test showed knockdown effect at concentrations of 15%, 20% and 25%. The results of the Spearman correlation test (P = 0.019 and R = 0.440) showed a sufficient correlation between the con­centration of jasmine flower extract and the knockdown effect. LC50 was obtained by probit test at a concentration of 12.839%. The results showed that the content of jasmine flower extract had an insecticidal effect with the electric method. Conclusion: Jasmine flower extract (Jasminum sambac) applied using the electric method has a knockdown effect on adult Aedes aegypti at concentrations of 15%, 20% and 25%.
Butenedioic Acid of Soursop Leaves (Annona muricata) Water Extract as Dipeptidyl-peptidase 4 (DPP4) Inhibitor Dini Sri Damayanti; Nurdiana Nurdiana; HMS. Chandra Kusuma; Djoko Wahono Soeadmadji
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16106

Abstract

The aim of the study was to prove the potential of Soursop Leaves Water Extract (SLWE) content as DPP4 inhibitor an in silico method. The extraction process of soursop leaves uses water solvent with the infusion method. Withdrawal of the active compounds using acetone solvent. Identification using the GCMS method. Molecular docking of SLWE active compounds, Linagliptin as a control and DPP4 protein target  using  Autodoc Vina application. 2D visualization using LigPlot. Validation of affinity of active compounds of Annona muricata Leaves  using the measurement results of free binding energy, the number  similarity of bond position to active site ot  the protein target, and the number of hydrogen bond compared to controls. To determine the potential effect as a drug and toxicity using the 5 rules of Lipinski and ADME. The results of molecular docking found that the active SLWE compounds that have affinity close to control is butenedioic acid. It has the ∆G of  -7 kcal / mol, binds 53% of amino acid residues of DPP4 and has one hydrogen bond. Based on 5th rules of Lipinski and ADMET, Buetenoic acid has the potential to be developed as DPP4 inhibitor drugs which is administered orally and had a non-toxic effect. The the Conclusion Butenedioic acid, the active compound found from SLWE is potential as DPP4 inhibitors.
Pengaruh Ekstrak Buah Labu Siam (Sechium edule) terhadap Ketebalan Dinding Aorta Tikus Putih (Rattus norvegicus strain wistar) Model Aterosklerosis Desy Andari; Aulia Wiraldi Putra; Meddy Setiawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16079

Abstract

Background: Atheroslerosis is a disease that formed due to cumulation of the fibrous tissues in vascular wall and gradually become thrombus. Chayote contains antioxidants such flavonoid, saponin, and ascorbic acid that could prevent the thickening of the vascular wall. Objective: To determine the effect of chayote extract on aortic vascular wall thickness in white rats with atherosclerosis model. Methods: True experimental with post-test only controlled group design. Sixteen white male rats divided into 4 groups: positive control group and 3 treatment groups that given chayote extract at different doses (20 mg/day, 40 mg/day, 80 mg/day). The H&E stained aortic preparate were observed with 400x magnification used optical microscope and vascular thickness were measured with optilab software. Data analized with one way ANOVA, post hoc, pearson and linear regression test. Result: There was significant effect of chayote extract to the aortic arch vascular wall thickness (ANOVA p=0,001) and the dose that started giving effect was 40 mg/day (Post Hoc test). There was very strong, significant, and reciprocally correlation between chayote extract and aortic wall thickness (R=-0,896). Chayote extract affected aortic wall thickness with the value of 80,4%. Conclusion: Chayote extract could prevent the thickening of aortic wall in atherosclerotic rats.

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