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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

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Articles 271 Documents

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Evaluasi Mutu Fisik Tablet Antalgin Dengan Bahan Penghancur Amilum Kulit Pisang (Musa paradisiacal) Metode Granulasi Basah Sri Saptuti Wahyuningsih; Siwi Hastuti
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Tablets are solid preparations taken by oral. Some people consider banana peel as a waste, whereas banana peel contains amylum which can be used as additional material. This study aims to determine the ability of banana peel as a crushing material and its effect on the physical character of antalgin tablets.This research was done by making the formula using variation of banana peel concentration (5%, 10%, 15%). The research begins with granule preparation with wet granulation method, then continued compressing of tablets. Tests include physical character of granules and physical character of antalgin tablets (uniformity of size and weight, hardness, distegration test, friability) for each formula.The results showed that the difference in thickness of the tablets due to differences in pressure at the time of printing, granule quality and the number of fines on the granule. Uniformity of weight is affected granule quality including granule flow character. The increasing concentration of disintegrant causes the tablet to have a decreasing hardness and decay time, while the friability of the tablet increases. The result of ANOVA test shows that there is a significant influence between the variation of disintegrant concentration on the physical character of antalgin tablets. Conclusion. Banana peel can be used as an antalgin tablet crusher. The increased variation of banana peel concentration as a disintegrant resulted in decreased hardness and disintegration time of tablets as well as an increase in tablet friability

Antiasthma Activity Of Combination Of Decoction Of Sembung Leaves (Blumea balsamifera L. DC.), Patikan Kebo Herbs (Euphorbia hirta L.), Kemukus Seeds (Piper cubeba L.), and Teki Rhizomes (Cyperus rotundus Linn.) at Male Guinea Pig In Vitro and In Vivo Kiki Damayanti; Agung Endro Nugroho; Arief Nurrohmad
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Secara empiris, rebusan kombinasi daun sembung, herba patikan kebo, biji kemukus, dan rimpang teki telah digunakan untuk menangani asma. Secara individu keempat tanaman tersebut telah diketahui beraktivitas sebagai obat asma. Penelitian ini bertujuan untuk mengetahui aktivitas rebusan kombinasi keempat tanaman tersebut dalam beberapa perbandingan sebagai antiasma secara in vitro dan in vivo.Pengujian aktivitas antiasma secara in vitro dilakukan menggunakan otot polos trakea marmut terisolasi yang direndam dalam bufer Krebs bebas ion kalsium. CaCl2 digunakan sebagai induktor kontraksi otot polos trakea marmut. Persen kontraksi otot polos trakea marmut sebelum dan sesudah perendaman rebusan dibandingkan untuk menyatakan adanya aktivitas sebagai penghambat kontraksi akibat peningkatan kadar ion kalsium intraseluler. Aktivitas antiasma secara in vivo diketahui menggunakan marmut yang diinduksi dengan ovalbumin secara sub kutan dan nebulasi sebagai model hewan uji asma. Marmut asma diberi rebusan antiasma selama 29 hari. Otot polos trakea marmut dibuat preparat dengan pewarna hematoksilin dan eosin untuk mengetahui jumlah eosinofil dan persen udem yang terjadi.Hasil penelitian menunjukkan bahwa salah satu jenis rebusan mempunyai aktivitas dalam menghambat kontraksi otot polos trakea marmut akibat peningkatan kadar ion kalsium intraseluler pada menit ke 14 – 26. Tidak ada perbedaan jumlah eosinofil dan persen udem pada preparat trakea marmut yang diberi rebusan dibandingkan marmut yang diberi aquadest, sehingga secara in vivo rebusan tidak mempunyai efek sebagai penghambat infiltrasi eosinofil dan penghambat udem

Aktivitas Antiparkinson Ekstrak Rimpang Temulawak (Curcuma Xathorriza Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol Nofika Dwi Anitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Temulawak (Curcuma xathorriza Roxb.) Is a plant that contains curcumin. Curcumin in ethanol extracts of temulawak rhizome has been shown to penetrate the blood brain barrier and has a neuroprotective effect that can reduce the symptoms of parkinsonism caused by haloperidol. This study aims to determine the activity of ethanol extract of temulawak rhizome in reducing symptoms of Parkinson's and know the effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's.This study used 35 rats divided into 7 groups, each group consisting of 5 rats. Group 1 was given aquadestilata. Group II was given a solution of 0.5% CMC-Na p.o. Group III was given levodopa dose 27 mg/kgbb. Group IV was given vitamin E dose of 180 IU/kgbb. Groups V, VI, VII were given the temulawak extracts of 120, 240 and 480 mg/kgbb. 45 minutes later all groups except group I were given haloperidol 2 mg/kgbb i.p. The catalepsy and rota rod tests were performed on days 0, 4, 7, 11 and 14.From catalepsy test of temulawak extract dose 120, 240, 480 mg/kgbb respectively showed activity of catalepsy decrease equal to 23,25; 52,28 and 58,56 %. While in rota rod test shows the activity increase time of latency consecutively equal to 26,87; 30,34 and 34,58 %. The effective dose of temulawak rhizome extract in reducing symptoms of Parkinson's is a dose of 240 mg / kgbb

Aktivitas Antiparkinson Ekstrak Rosella (Hibiscus Sabbdariffa L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Sprague Dawley Yang Diinduksi Haloperidol Irsyad Rizky Ardhianta; Jasson Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Parkinson's disease is a disease caused by decreased dopamine levels in pars compacta substantia nigra. Dopamine is closely related to antioxidants, because antioxidants can reduce free radicals that damage dopamine-producing cells. Rosella is one plant that has antioxidant content of flavonoids, saponins, and alkaloids. The purpose of this study was to determine the effect of roselle extract on the decrease of symptoms of Parkinson's disease.This research uses Sprague dawley rodents as 35 rats, divided into 7 groups. Group I (healthy control) was given aquadestillata po, group II (negative control) was given CMC-Na 0.5% po, group III (positive control I) was given levodopa 27 mg / kgbw po, group IV (positive control II) E 180 IU / kgbw rat po Groups V, VI, and VII were given 150 consecutive doses of rosella; 300; 600 mg / kgbw p.o. The whole group was induced with haloperidol at the 45th minute after treatment except in group I (healthy control). Then tested with a catalepsy bar test, recorded the latency time expressed in the score and rota test rod, recorded time latency in seconds on days 0, 4, 7, 11, and 14.The results showed that roselle extract gave antiparkinson effect on white rat of the haloperidol-induced Sprague dawley rod. The effective dose of rosella in reducing Parkinson's symptoms is 300 mg / kgbw

DETEKSI MOLEKULER EKSON 1 GEN BETA GLOBIN PADA PASIEN TALASEMIA BETA MAYOR DI RSUD DR. SOEROTO NGAWI DENGAN METODE POLYMERASE CHAIN REACTION (PCR) Agus Supriadi; Ana Indrayati; Elfahmi Elfahmi
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Talasemia is an autosumal recessive gene mutation caused by a lack of synthesis of hemoglobin-forming globin chains of blood with anemia-like symptoms will decrease the production of red blood cells, and should be treated with regular blood transfusions.This study aims to determine the presence of mutations in exon 2 gene beta globin thalassemia patients using PCR method, where 5 samples in DNA isolation and continued PCR amplification, the amplification result of electrophoresis region 2 beta globin gene Region II is the result of amplification of primary 4 and primer primer reverse 5 with a target of 350 bp, on PCR there is amplification or doubling of the desired DNA sequence based on the primary selection for the reaction, the PCR product of each of these regions which is subsequently performed by SSCP.In the SSCP result the five samples were found in one sample showing different ribbon pattern with the sample N, there was sample 6, while the remaining four samples, there were 1,2,3,5 showed three bands. All the samples showed different from the N sample pattern. This shows that all samples indicated there were mutation

Aktivitas Antiparkinson Ekstrak Gambir (Uncaria Gambir Roxb.) Pada Tikus Putih (Rattus Norvegicus) Galur Sprague Dawley yang Diinduksi Haloperidol Lutfi Nofitasari; Jason Merari Peranginangin; Sri Rejeki Handayani
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Parkinson disease is a disease that occurs due to damage to dopaminergic nerve cells in the brain which resulted in decreased dopamine production. Gambir is a dry extract made from the leaves of Uncaria gambier Roxb plant. Gambir contains flavonoids in the form of catechins not less than 90%, alkaloids and terpenoids. This study aims to determine the activity of gambir extract that can reduce the symptoms of Parkinson's in the male rats Sprague dawley induced haloperidol.Test animals of 35 rats divided into 7 groups. Group I (healthy control) was given aquadest orally, group II (negative control) was given a 0.5% CMC-Na solution, group III (positive control I) was given levodopa 27 mg / kgbb po, group IV (positive control II ) Were given vitamin E 180 IU / kgbb po Groups V, VI, and VII were given a dose of 70 consecutive gambir extracts; 140; 280 mg / kgbb. The whole group induced haloperidol 2 mg / kgbb i.p at the 45th minute after treatment except in the healthy group. Then the group was tested with a catalepsy bar test, recorded time latency expressed in scores and rota test rods, recorded time of latency in seconds on days 0, 4, 7, 11, and 14.The result of the research using catalepsy bar test method showed a decrease of catalepsy in gambir extract dose 70; 140; 280 mg / kgbb has a successive activity of 22.53; 52.50; 57.12%. While the results with rota rod test method showed% increase in time latency extract gambir respectively of 27.69; 35.75; 39.61%.

Analisis Docking Molekuler Senyawa Derivat Phthalimide sebagai Inhibitor Non-Nukleosida HIV-1 Reverse Transcriptase Tiara Ajeng Listyani; Rina Herowati
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. Docking molekuler analysis in phthalimide derivative compounds against reverse transcriptase enzym necessary to determine the affinity and interaction patterns between the above compounds with reverse transcriptase enzym. Derived compounds phthalimide geometry optimized using VegaZZ software then performed by way of target preparation, ligand preparation, docking method validation, and analysis of docking using PyRx-Python0.8 - AutoDock vina so we get to the target ligand interactions, free energy bonding, hydrogen bonding, and interaction patterns. Interaction pattern seen in thirty-three phthalimide derivatives with reverse transcriptase enzym showed hydrogen bonding with amino acids Lys101 where the interaction is similar to the interaction of TIBO R 86183 compounds which are the original ligands of the target protein.

Pengaruh Pemberian Minyak Hati Ikan Hiu Botol (Centrophorus atromarginatus) Terhadap Kolesterol Total Darah Tikus Hiperkolesterolemia Siti Fatimah; Muhammad Radifar; Tiara Madanti
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Research has been conducted to determine the effect of bottle shark liver oil (Centrophorus atromarginatus) on total cholesterol levels of the blood of hypercholesterolemic rats fed high fat feed. This research was carried out experimentally using 25 male rats, aged 2-3 months with a weight of 150-200 g, which were divided into 5 treatment groups randomly, ie group K1 (normal control) were given standard feed, group K2 (positive control) given high fat feed for 7 days, while group P1, P2, and P3 were given bottle shark liver oil in a sonde with a dose of 54 mg / 200 mg / day, 108 mg / 200 mg / day, 216 mg / 200 g BW / day. Each treatment consisted of 5 rats which were examined 3 times the total cholesterol level by the CHOD-PAP method. Data obtained from examinations were analyzed using one-way ANOVA p <0.005 followed by post hoct test. The results of the P1, P2, and P3 groups were significantly different from K1 (p = 0,000). Groups P1, P2, and P3 were significantly different from K2 (p = 0,000). Bottle shark liver oil with a dose of 54mg / 200g BB / day, 108mg / 200g BB / day, 216mg / 200g BB / day each can reduce cholesterol levels by 23% or 43.67 mg / dl, 30% or 55, 72 mg / dl, and 38% or 70.94 mg /

Formulasi Dan Uji Aktifitas Nanoemulsi Minyak Atsiri Daun Kemangi (Ocimum basilicum L.) Terhadap Salmonella typhi Monica Kristiani; Septiana Laksmi Ramayani; Klara Yunita; Meilina Saputri
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Essential oil of basil (Ocimum basilicum L.) leaves with a concentration of 2.5% can be estimated to have a diameter of inhibition zone with an average value of 8.67 ± 0.58 mm. Essential oils have volatile characteristics, and are easily oxidized so that they can affect their activities as antibacterial. To increase stability, essential oils of basil leaves need to be packaged in a special delivery system. Nanoemulsion is made by spontaneous emulsification method. Nanoemulsion was further tested for physical characteristics including droplet size, polydispersity index, zeta potential and nanoemulsion morphology using a Transmission Electron Microscope (TEM). The preparation was then tested for its activity against Salmonella thypi. The method used is the Kirby-Bauer disk diffusion method. From the test of physical characteristics obtained the average particle size of 10.6 nm, polydispersity index 0.03 and zeta potential -36.4. The results of the observation using TEM form the particles produced are spherical. Antibacterial test results were shown by the formation of inhibition zones of basil leaf essential oil (9.3 mm), positive control (6.6 mm), negative control (7.5 mm), nanoemulsion of basil leaf essential oil (8.3 mm), Virgin Coconut Oil (7 mm). Based on the results of statistical analysis it was found that there were no significant differences in treatment between groups.

Uji Stabilitas Spironolakton Terhadap Perubahan pH dengan Menggunakan Kromatografi Cair Kinerja Tinggi (KCKT) Nelly Suryani; Yardi Supandi; Ririn Astri Sabdowati
Jurnal Farmasi Indonesia Vol 16 No 1 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Spironolactone is an aldosterone diuretic antagonist for hypertension. In practice spironolactone is sometimes combined with other drugs, and in unconscious patients the drug must use a feeding tube and be susceptible to instability. The object of this study was to see the effect of pH changes on spironolactone tablets which were crushed and suspended in water. The method of measuring spironolactone levels using High Performance Liquid Chromatography based on methods in the United State Pharmacopeia. Spironolactone suspension was made at pH 3, 5, 7, and 9 with sampling time in minutes 0, 15, 30, 45, and 60. The results showed that the level of spironolactone at pH 3 was ≤ 0%, pH 5 was 74% - 100%, at pH 7 it was in the range of 27% - 61%, and at pH 9 was 38% - 54%. This explains that percent of spironolactone at pH 3.7, and 9 at all sampling times did not match the minimum therapeutic level in the monograph. Only at pH 5 does the level of spironolactone still match the levels specified in the monograph. In this study it can be concluded that changes in pH can significantly reduce spironolactone levels in suspension.

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