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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Standardisasi dan Uji Aktivitas Antioksidan Ekstrak Bahan Alam Propolis untuk Terapi Infeksi SARS-CoV2 Diah Kartika Pratami; Yesi Desmiaty; Evita Maria Simorangkir; Deby Faradhila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1062

Abstract

Natural ingredients with immunomodulatory, anti-inflammatory, and antioxidant activities can be used as supportive therapy for SARS-CoV2 infection. The aims were standardized the quality and safety of propolis and determined the antioxidant activity of propolis. There are two types of propolis powder samples: microencapsulated propolis powder containing wax (SMPW) and non-waxed (SMP). Standardization includes specific and non-specific parameters. Antioxidant activity test using FRAP and ABTS methods. The total flavonoids of SMPW and SMP were 0.31% and 1.59%. The total phenolic of SMPW and SMP were 83.9082 and 98.0821 mg GAE/g. The losses on drying of SMPW and SMP were 3.65% and 3.88%. The water content of SMPW and SMP were 5.12% and 5.11%. The total ash content of SMPW and SMP were 0.80% and 0.65%. Heavy metal propolis powder negative. ALT and AKK values < 10 CFU/g, microbiology contamination was negative. Antioxidant activity of SMPW with IC50 ABTS 2.4177 ppm and EC50 FRAP 26.41 g/mL. Meanwhile, the antioxidant activity of SMP with IC50 ABTS 2.213 ppm and EC50 FRAP 32.10 g/mL. It was concluded that the extract of propolis met the requirements of the standard for extracts of natural ingredients and had strong antioxidant activity. Propolis powder can be developed for supportive therapy for SARS-CoV2 infection.
Optimasi Perolehan DNA Mikrobioma yang Diekstraksi dari Mekonium dan Feses Neonatus Prematur untuk diaplikasikan pada Next-Gen Sequencing 16S rRNA Larashintya Rulita; Amarila Malik; Radhian Amandito; Rinawati Rohsiswatmo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1112

Abstract

The composition of the intestinal microbiome of neonates can be identified from meconium and feces by Next-Generation Sequencing (NGS) technology. However, the yield of microbiome DNA of meconium and feces has its own challenges due to the consistency and the high content of PCR inhibitors in these samples. This study aims to optimize the yield of microbiome DNA from meconium sample and feces of pre-term neonates. The DNA yield was obtained by applying certain optimized parameters, i.e., considering the replication and condition of the sample, using a particular kit for DNA extraction, and modifying the DNA elution of the column purification. The genomic DNA obtained was quantified and confirmed using Polymerase Chain Reaction. Results showed that the best DNA yield was achieved by replicating the number of samples twice in the pre-extraction stage, working on fresh meconium and feces samples instead, and suspended the sample in ddH2O prior to extraction process as observed on agarose gel visualization with UV trans-illuminator, as well as in quantitative measurement by a nano spectrophotometer. The best extraction process was using MP Biomedical FastDNA Spin Kit for Soil, in addition to the use of an elution buffer in a smaller volume, resulting in a higher concentration and purity of DNA. In conclusion, we were able to obtain an optimized yet reliable DNA yields, especially from meconium, which fulfilled the quality and quantity requirement for further sequencing process of microbiome.
Formulasi Gel Antijerawat Dengan 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-On (EHP) Sebagai Bahan Antibakteri Esti Mulatsari; Esti Mumpuni; Agus Purwanggana; Siti Marsha Dyah Kusumaningtyas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1085

Abstract

Acne is a skin disease that causes non-inflammatory follicular papules, nodules, pustules and inflammatory papules. There are various oral and topical anti-acne preparations on the market. Gels are topical preparations that have better absorption than cream preparations. The anti-acne gel is formulated with antibacterial active compounds. The compound 1,5-bis(3’-ethoxy-4’-hydroxyphenyl)-1,4-pentadien-3-one (EHP) is one of the curcumin analogue compounds that have been successfully synthesized by Mumpuni et al, 2010. EHP has the potential to inhibit growth of pathogenic microbes such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Salmonella typhi, and has anti-inflammatory activity. This study aims to make an anti-acne gel formula with the active ingredient EHP as an antimicrobial agent. The formula was tested for physical and chemical stability including organoleptic, spreadability, homogeneity, viscosity, flow properties, microbiological activity and skin irritation ability. EHP is formulated in gel preparations in various concentrations. Stability test of gel preparations was carried out at a temperature of 40 °C; RH ± 75% for 4 weeks.The results showed that EHP can be formulated into gel preparations that meet the physical and chemical quality requirements. Gel preparations with the active ingredient EHP 0.1%; tretionine 0.01%; carbopol 940 1.0%; triethanolamine 1.0%; propylenglycol 15%; ethanol (96%) 10%; can inhibit the Propionibacterium acnes bacteria with a diameter of 19.6 mm in the inhibition area, the skin irritation test of rabbits does not cause irritation, thus the gel preparation with the active ingredient EHP is suitable to be developed as an anti-acne gel product.
Penyesuaian Dosis Digoxin pada Pasien Gagal Jantung di RSUD Margono Soekardjo Purwokerto Masita Wulandari Suryoputri; Laksmi Maharani; Ika Mustikaningtias
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.778

Abstract

Due to the high prevalence of heart failure in Indonesia causes the use of digoxin is increasing. The drug level in blood needs to be monitored because digoxin is a narrow therapeutic index drug. It is necessary to adjust the dose in the patient, so that clinical outcomes are achieve and toxic effects can be avoided if the estimated drug levels in the blood do not match the therapeutic range. The maintenance dose of oral digoxin is 0.0625 - 0.125 mg / day for heart failure patients and it is expected that the therapeutic range of digoxin in the blood range from 0.5 to 0.9 ng / ml. The purpose of this study was to determine the estimation of digoxin levels in blood in patients with heart failure and the calculation of dosage adjustments using a pharmacokinetic approach so that blood levels of drugs ware in the therapeutic range. This research employs a quantitative observational method conducted prospectively by using a total sampling technique. The results showed that the digoxin level of 4 patients (13,33%) were in the range of therapeutic range (0,50 – 0,90 ng/ml) and 26 patients (86,67%) exceed the therapeutic range (>1,00 ng/ml). Digoxin dose adjustment was made in 26 patients (86,67%) individually with an interval of every 24 hours in order to achieve Css according to the therapeutic range. Based on the results it can be concluded that in heart failure patients who have blood digoxin levels exceed the therapeutic range need dose adjustments to improve clinical outcomes and prevent toxicity in patients.
Conten - -
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1184

Abstract

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Efektifitas Rebusan Daun Babadotan dan Kombinasinya dengan Pregabalin sebagai Anti Nyeri Neuropatik serta Uji Toksisitas Akutnya Yedy Purwandi Sukmawan; Hendy Suhendy; Maritsa Nurfatwa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1057

Abstract

Neuropathic pain is a condition that is difficult to treated and impaired quality of life. The objective of the study was to determine the anti-neuropathic pain effectivity of Ageratum conyzoides aqueous extract and the acute toxicity study. We had 7 groups (normal, negative, pregabalin, ageratum. conyzoides-I (AC-I) 50mg/kg BW, A. conyzoides-II (AC-II) 100mg/kg BW, combination of pregabalin and AC-II), combination of AC-II and naloxone). Each group contain 5 animals (mice). All groups was induced with pyridoxine 400 mg/kg BW i.p for 14 days to cause neuropathy and followed by hyperalgesia, allodynia, and wire-hang test. In the acute toxicity study, we had 1 group and contain 5 animals (rats). The results of the hyperalgesia and allodynia study showed the effect of AC-II was better than AC-I. The combination of pregabalin and AC-II was better than AC-II as monotherapy (p<0.05). However, AC II activity was abolished when combined with naloxone. In wire hang test demonstrated no difference between falling score (p: 0.053) and reaching score (0.903), that showed AC-II wasn’t impaired the motoric system. No death or toxicity symptoms were observed for 14 days in the acute toxicity study. A. conyzoides aqueous extract is potential for anti-neuropathic pain..
Profil Fitokimia Simplisia dan Ekstrak Etanol Daun Kedondong Pagar (Lannea coromandelica (Houtt.) Merr.) sebagai Tanaman Obat Safriana Safriana; Andilala Andilala; Cut Fatimah; Samrani Samrani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.936

Abstract

Lannea coromandelica (Houtt.) Merr., or known as Kedongdong Pagar in Indonesia, family Anacardiaceae, Kedongdong Pagar leaves that has been proved by some villagers of Samakurok, Tanah Jambo Aye district, Northen Aceh, NAD, who consume boiled water of kedongdong pagar leaves to lower blood glucose levels. This study was to determine the class of chemical compounds contained in simplicia and ethanol extracts of the kedongdong pagar leaves from phytochemical screening results. The results of phytochemical screening showed that chemical compounds contained in simplicia and extracts of kedongdong pagar leaves were flavonoids, saponins, glycosides, tannins and steroids/triterpenoids. Based on the studies that have been carried out, Kedongdong Pagar leaves have great potential to be researched and further developed to become one of the sources of medicinal plants in Indonesia.
Uji Potensi Antijerawat Secara In Vitro dan Ex Vivo dari Ekstrak Etanol Herba Alfalfa (Medicago sativa L.) Erika Indah Safitri; Risha Fillah Fithria; Eko Wahyu Saputro; Danang Yogo Wijaya
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1027

Abstract

Propionibacterium acnes is one of the bacteria that causes acne. Acne problems can be controlled with herbal plants, namely alfalfa herbs. The content of flavonoids in alfalfa herb is efficacious as an antiacne. This study aimed to determine the total flavonoid content and to test the potency of alfalfa herb ethanol extract (AHEE) as an antiacne in vitro and ex vivo induced by Propionibacterium acnes. Determination of total flavonoid levels using the spectrophotometer method with quercetin comparison. Test of alfalfa herbs ethanol extract by in vitro using disk diffusion method in concentration series 40%, 50%, 60%, 70%, and 80%. Meanwhile, test of extract by ex vivo using rabbits induced Propionibacterium acnes bacteria intradermally in 3 optimal concentration from in vitro test (50%, 60%, dan 70%). The parameter of test in the form of zone inhibition and percentage reduction in erythema diameter. Ethanol extract of alfalfa herbs contains total flavonoids of 2,323 mgQE/g. All ethanol extract of alfalfa herbs test concentrations had antibacterial activity against P. acnes with an average diameter of the respective iradic inhibitory area 14,60 mm; 14,89 mm; 15,56 mm; 16,52 mm; and 18,59 mm. The average percentage reduction in erythema diameter by ex vivo on ethanol extract of alfalfa herbs (50%, 60%, and 70%) were 48.70%, 48.26%, and 54.09%, respectively.
Aktivitas Ekstrak dan Tablet Nanopartikel Buah Okra (Abelmoschus esculentus (L) Moench.) Sebagai Anti- Dislipidemia Pada Tikus Yang Diberi High Fat Diet Sarah Zaidan; Deni Rahmat; Ratna Djamil; Nadya Vresya Saputri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1097

Abstract

Dyslipidemia is a condition caused by disruption of lipid metabolism due to the interaction of genetic factors and environmental factors. There is strong evidence of an association between LDL cholesterol and cardiovascular events based on clinical outcome studies, so LDL cholesterol is the main target in the management of dyslipidemia. In addition to using synthetic drugs, dyslipidemia can be treated by consuming natural ingredients, one of which is okra (Abelmoschus esculentus (L) Moench). The form of nanoparticles and nanoparticle tablets of okra fruit extract is an effort to increase antidyslipidemic activity and to make it easier to use. This study aims to obtain nanoparticle extracts and nanoparticle tablets of okra fruit extract which have antidyslipidemic activity in vivo against mice given the High Fat Diet (HFD). The research used 24 rats divided into 6 treatment groups, namely group I as normal control, group II as positive control using simvastatin as the control control, group III as a negative control, group IV as a control treatment of ethanol extract 70% okra fruit, group V as a control treatment of okra fruit extract nanoparticles, and group VI as a treatment of okra fruit extract nanoparticles tablets. All test substances are given for 14 days. Blood sampling was carried out on days 0, 14, and 28, with the parameters measured were lipid profiles including total cholesterol (KT), LDL, Triglycerides (TG) and HDL. 70% ethanol extract, extract nanoparticles, and okra fruit extract nanoparticle tablets can decrease KT levels by 33.14%, 46.31%, 45.42%, decrease TG levels by 39.46%, 43.56%, 41, 62%, decrease LDL levels by 45.22%, 68.76%, 59.94%, and can increase HDL levels by 103.80%, 119.20%, 114.39%. Based on the lipid profile of mice given HFD, 70% ethanol extract, nanoparticles, and okra fruit extract nanoparticle tablets had antidyslipidemic activity.
Uji Stabilitas Protein Salep Kombinasi Ikan Gabus (Channa striata) dan Ekstrak Etanol Daun Sirih (Piper betle L.) Menggunakan Metode Kjeldahl Mohamad Andrie; Wintari Taurina; Maya Widya Astuti Wulandari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.799

Abstract

The endemic snakehead fish (Channa striata) supposed to speed up wound healing. Antibacterial properties of green betel leaf (Piper betle L.) are well known. Wound healing necessitates moist circumstances and prolonged medication contact. Such the fact that ointment fat-based preparation that can moisturize skin or wound area due to extended contact with the skin, increasing absorbance and effectiveness. Fish protein concentrate high-protein concentrate obtained by eliminating fat and water from fish. One way that can used is freeze drying. Using Kjeldahl method, this study intends investigate protein stability of combination freeze dry ointment extract of snakehead fish (Channa striata) and ethanol extract green betel leaf (Piper betle L.). The data was analyzed using the SPSS version 25 app. On day 28, average protein content of freeze dry ointment and a combination of freeze dry ointment in aqueous phase and ethanol extract of green betel leaf was 6.321 % and 6.630 %, respectively, indicating substantial difference in protein content. As result, the freeze dry ointment including aqueous phase and ethanol extract of green betel leaf more stable and has larger protein content than the freeze dry ointment containing snakehead fish extract.

Page 52 of 73 | Total Record : 721

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