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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Formulasi Gel Peel Off Pewarna Kuku yang Mengandung Ekstrak Daun Pacar Air (Impatiens balsamina L.) dan Sodium Carboxy Methyl Cellulose Teti Indrawati; Titih Ayunda Larasati; Anggun Nia Mulyani; Desy Muliana Wenas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.816

Abstract

Leaves of Pacar air or Impatiens balsamina L. (IB) are directly pounded and then placed on the surface of the nail to color the nails traditionally. It’s preferred by Moslem because wudu water can penetrate to the nail. The traditional way of using the leaves is unpleasant and these leaves should be used in the fresh form. The IB leaves contain fl avonoids, quinones and tannins that provide a natural orange color. A formulation of a nail polish containing the leaf’s extract is needed so it’s easy to use and stable during storage. The aim of this research is to make nail color gel peel off from IB extract which is easy to use and stable. Nail color gel peel off is made using Sodium Carboxy Methyl Cellulose (Na-CMC) as a gel base. This research was carried out by making six formula of gel peel off using swelling and mixing methods at various IB extract concentrations of 5%, 10% and 15% using 1% and 3 % of Na-CMC as the base respectively and the prepared product was evaluated. The IB leaves can be made into cosmetic preparations that have a good quality. All preparations have a yellow to orange red, odorous and homogeneous, pH 4.7-5.4, viscosities 630-3600 cps, has a pseudo plastic thixotropic fl ow properties. When nail color gel peel off used in nails, the base can remove from nail and only the coloring agent attached to the nail.
Uji Banding Metode Isolasi DNA Sampel FTA Card menggunakan Kit Wizard® Genomic DNA Purification, PureLink® Genomic DNA, dan Chelex-100 Dyah Aryani Perwitasari; Imaniar Noor Faridah; Yeni Alfiana Ratnasari; Kania Agustina; Ikrimah Nisa Utami; Rita Maliza
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.838

Abstract

FTA Cards are an easy way to collect blood samples, deliveries, and stores. The totalvolume of blood samples is less is needed when compared to the blood samples taken through a vein(venipuncture). The purpose of this research is a method that can be applied to isolate DNA samplesfrom FTA Cards using the Wizard® Genomic DNA Purifi cation Kit (Promega), PureLink® GenomicDNA Kits, and Chelex-100. This research was a type of experimental research, and data analysis wasshowed in qualitative and quantitative descriptively. The samples used were 16 samples of human bloodtaken using a lancet and then placed on the FTA Card, sampling was done by accidental samplingtechnique. The variations of the PureLink® Genomic DNA kits method with the addition of SDS 10%showed thin and smear DNA bands on agarose gels. Furthermore, the Chelex-100 method showed aclear DNA band. The purity data obtained varied between 1 to 1.1 and concentrations between 190 to950 ng/μl. The conclusion of this study is DNA kits method with the addition of 10% SDS and theChelex-100 method still have impurities, with the purity value of DNA was less than 1.8 and a lowconcentration to be used as a DNA template for further molecular analysis.
Penapisan Fitokimia dan Uji Aktivitas Antimikroba Ekstrak Etanol Daun Jeruk Nipis (Citrus Aurantifolia) Safira Nafisa; Greesty Finotory Swandiny; Erlindha Gangga; Yulianita Ariefiyanty Zaenudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1095

Abstract

Jeruk nipis (Citrus aurantifolia S.) merupakan salah satu tanaman obat tradisional yang digunakan secara luas untuk berbagai penyakit termasuk infeksi. Penelitian ini bertujuan untuk menguji aktivitas ekstrak etanol 70% dan 96% daun Citrus aurantifolia terhadap mikroba penyebab infeksi pada manusia, antara lain Staphylococcus aureus, Salmonella typhi, Escherichia coli, dan Candida albicans secara in vitro. Penapisan fitokimia dilakukan untuk memprediksi metabolit sekunder yang berperan dalam aktivitas antimikroba daun Citrus aurantifolia. Aktivitas antimikroba ditentukan menCitrus aurantifolia S. is a traditional medicinal plant that is widely used for various diseases including infections. This study aims to test the in vitro antimicrobial activity of 70% and 96% ethanolic extract of Citrus aurantifolia leaves to microbes that cause infection in humans, including Staphylococcus aureus, Salmonella typhi, Escherichia coli, and Candida albicans. Phytochemical screening was carried out to predict secondary metabolites that play a role in the antimicrobial activity of Citrus aurantifolia leaves. The antimicrobial activity was determined using agar diffusion method with disc paper and well diffusion method. Phytochemical screening showed that simplicia powder, 70% ethanol extract, and 96% ethanol extract from Citrus aurantifolia leaves contained flavonoids, coumarin, saponins, tannins, steroids / triterpenoids, and essential oils. This study showed that 70% and 96% ethanol extract of Citrus aurantifolia leaves can inhibit the growth of Staphylococcus aureus, Salmonella typhi, and Escherichia coli bacteria. It can be concluded that the ethanol extract of Citrus aurantifolia leaves is potential to be developed as an antibacterial product.ggunakan metode difusi agar dengan kertas cakram dan metode difusi sumuran. Penapisan fitokimia menunjukkan bahwa baik serbuk simplisia, ekstrak etanol 70%, dan ekstrak etanol 96% dari daun Citrus aurantifolia mengandung metabolit sekunder flavonoid, kumarin, saponin, tanin, steroid/triterpenoid, dan minyak atsiri. Ekstrak etanol 70% dan 96% daun Citrus aurantifolia dapat menghambat pertumbuhan bakteri Staphylococcus aureus, Salmonella typhi, dan Escherichia coli. Dengan demikian dapat disimpulkan ekstrak etanol daun Citrus aurantifolia berpotensi dikembangkan sebagai produk antibakteri.
Formulasi Dan Uji Aktivitas Anti-Aging Gel Lendir Lidah Buaya (Aloe vera Linn.) Benni Iskandar; Anita Lukman; Okla Elfitri; Safri Safri; Meircurius Dwi Condro Surboyo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.907

Abstract

Aging is one of the problems that occurs in the skin. The factors cause aging are either free radicals. The use of antioxidants can prevent aging. Mucous Aloe vera known to have an antioxidant effect. The purpose of this study is to get aloe vera gel that stable and has anti-aging effects. This research was conducted by making a gel of aloe vera preparations in three formulas, each with aloe vera mucous of 5% (F1), 15% (F2) and blank (F0). Evaluation of gel preparations includes organoleptic, pH, Stability checks at room and cold temperatures, Scatter test, Adhesion, homogenity, irritation and anti-aging test on the skin of the backs of volunteers using skin analyzer with measured parameters including moisture, evenness, large pores, spot, and wrinkles. Gel was used twice a day for 30 days and was carried out every week. Statistical data were analyzed using the two-way ANOVA and continued with the Tukey test. The results showed that the stable a gel of aloe vera formula was F2 with a aloe vera concentration of 15%. Anti-aging activity test results showed that aloe vera gel preparations 15% (F2) faster recovery in increasing moisture, skin smoothness, shrinking pore size, reducing spot and wrinkles.
Pengaruh Disintegran dan Cara Pencampuran Terhadap Sifat Fisika Kimia Telmisartan Hestiary Ratih; Fikri Alatas; Jessie Sofia Pamudji; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1013

Abstract

Telmisartan (TMS) has a compact structure and is interlocked between crystal units. As a result, the substance has a high electrostatic force, which causes TMS to sintering when compressed into tablets. One method of overcoming sintering on TMS tablets is to add a disintegrant to the compressed tablet. The disintegrants used are derived from starch groups: Starch 1500® (S1500) and sodium starch glycolate (SSG), as well as microcrystalline cellulose (MCC) and croscarmellose sodium (CCS) groups. The purpose of this study was to examine the effects of several disintegrants on the dissolution and physicochemical properties of TMS with various treatments. TMS was varied with each disintegrant at a ratio of 1:9 % b/b. The treatment of TMS binary mixtures with various disintegrants includes physical mixtures, milled mixtures, compressed mixtures, and crushed compressed mixtures. Characterization and evaluation include PXRD and SEM testing as well as dissolution test. The characterization of PXRD and SEM in various treatments showed the effect of physicochemical properties on the TMS binary mixture with various disintegrants. The combination of TMS:CCS with a ratio of (1:9) resulted in the highest dissolution rate in all treatments.The treatment of the milled mixture produced the highest dissolution with DP60 minutes, which was around 55.86±2.47%. The addition of disintegrants to TMS with various treatments may reduce sintering but is not sufficient to meet the requirements for TMS dissolution, which dissolves within 30 minutes in phosphate buffer medium pH 7.5 with Q>75%.
Analisis Dampak Program Pengelolaan Penyakit Kronis (Prolanis) Dalam Meningkatkan Outcome Klinis Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta, Indonesia Reise Manninda; Yusi Anggriani; Astrid Kartika Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1107

Abstract

Prolanis is a Chronic Disease Management Program under the Indonesian National Health Insurance for promoting and preventing chronic disease. Main activities of Prolanis program are disease control and counseling, scheduled education, scheduled exercise, participant’s remainder, and home visit. The aim of this study was to evaluate the impact of prolanis on the clinical outcome in type 2 Diabetes Mellitus (DM) patients. An observational retrospective study was evaluated for 12 months. Data was collected from medical record. 426 patients from five primary health care center in Jakarta was selected by simple random sampling and divided into prolanis and non-prolanis groups. The indicators were the difference of clinical outcome between prolanis and non-prolanis patients was analyzed using Mann-Whitney test; the correlation of adherence with clinical outcome was analyzed using Chi-Square test.The results showed that prolanis patients had a significant improvement in Fasting Blood Glucose (FBG) compared with non-prolanis patients (P<0.05). The adherence of prolanis patients showed a significant improvement on FBG (124 patients-58.2%). Patients with nonadherence had lower improvement on FBG, the improvement was observed only at 16 patients (7.5%) and 60 patients (28.17%) was poor FBG. Prolanis is an effective program to improve the clinical outcome of DM patients.
Uji Efek Anti-Inflamasi dan Analgesik dari Rebusan Daun Bambu Kuning (Bambusa vulgaris Schard) Sondang Khairani; Lestari Rahayu; Ni Made Sandhiutami; Rika Sari Dewi; Ita Rahmawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.875

Abstract

Bamboo Kuning (Bambusa vulgaris Shard) leaves its efficacy as antioxidant, anti-inflammation, antidiabetic and antiulcer. The study aims to know volume edema decrease of rats foot as anti-inflammatory effect and the amount of strectching mice an analgesic effect the decoction of Bamboo Kuning. Anti-inflammatory test used Winter methods. Rats were be diveded into 5 groups: negative control be given aquadest, positive control be given sodium diclofenac 4,367 mg/200g BB, the test groups were given the decoction of Bamboo Kuning leaves 2,8 mL/200g BB with a concentration of 10%, 20% and 40%. Analgesic testing used methods Sigmund. Mice were divided into 5 groups: negative control be given aquadest, positive control were given sodium diclofenak 0,26 mg/20g BB, the test group was given the boiled of bamboo kuning leaves 0,4 mL/20g BB with concentration 10%, 20% and 40%. Statistic result decoction of leaves Bamboo Kuning dose 2,8 mL/200g BB with concentration 10%, 20% and 40% have anti-inflammatory and analgesic effect. Decoction of Bamboo Kuning leaves dose 2,8 mL/200g BB with concentration of 10%, 20% and 40% have anti-inflammatory and analgesic effect are lower than sodium diclofenac. Increased dose boiled of Bamboo Kuning leaves no provide increased effect as an anti-inflammatory and analgesic.
Pengaruh Pemberian Patient Information Leaflet (PIL) dan SMS Motivasi Terhadap Pengetahuan, Persepsi, dan Kepatuhan Pasien Hamil di Pelayanan Primer Susan Fitria Candradewi; Ginanjar Zukhruf Saputri; Adnan Adnan; Dyah Purmi Ta Arum; Herlanisa Yuliana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.937

Abstract

Based on data from WHO (World Health Organization), it is estimated that 41.8% of anemia occurs in pregnant women, with the highest prevalence rate of 61.3% in Africa and 52.5% in Asia. Pharmacist interventions have shown a positive effect in improving therapeutic adherence to hypertensive patients, as well as diabetes mellitus who routinely taking the drugs. The aim of the study was to know effect of giving patient information leaflet (PIL) along with motivational SMS on knowledge, perception, and compliance of pregnant patients in primary care. This study used a quasi-experimental method with pre-post design for two groups, the control group who received the Patient Information leaflet (PIL) and the intervention group who received the Patient Information leaflet (PIL) and motivational SMS from the researcher. Statistical analysis using SPSS with paired t test was used to determine differences in knowledge, perceptions and patient compliance before and after the intervention. Respondents who met the inclusion and exclusion criteria in this study were 74 patients. In the control group the mean score showed a significant difference was the knowledge of iron supplementation with p value= 0.001. Whereas in the treatment group, the mean score showed a significantly different were knowledge of iron supplementation and patient compliance with p values ​​were 0.002 and 0.001.
Formulasi Granul Sereal Daun Kelor dengan Variasi Jenis Pengikat dan Konsentrasi Xanthan Gum Karina Citra Rani; Nani Parfati; Endang Wahyu Fitriani; Dina Novita Sari; Hilmiyatul Islamia; Tiara Yuni Wulansari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1000

Abstract

Moringa leaves contain macronutrients and micronutrients, potential to be developed into cereal products in the form of granules using the wet granulation method. The type of binder and the concentration of the suspending agent are the main factors that affect the physical characteristics and proximate content of cereals. In this research, 6 formulas of cereal granules were optimized with various types of binders (arrowroot flour, sorghum flour, cornstarch) and variations in the concentration of xanthan gum (0.5% and 1.0%). This study aims to obtain a granule formula of Moringa leaf cereal that meets the requirements of physical, chemical, proximate, and heavy metal characteristics. The results of the evaluation of the granule characteristics showed that all Moringa leaf cereal formulas had good flow characteristics. The results of the evaluation of cereal characteristics after reconstitution showed that cereal granules dispersed quickly (12.58–16.45 seconds), viscosity 73.75 -245 cps, pseudoplastic flow characteristics, and met the pH requirements of food products (5.00-6.00). The results of proximate analysis and metal content showed that all cereal formulas met the SNI requirements for cereal milk (SNI 01-4270-1996) in terms of protein, carbohydrate, ash, lead (Pb), and copper (Cu) content parameters. The most optimal cereal formula is formula 2 because it shows physical characteristics, fat content, carbohydrates, protein, and heavy metals that meet the requirements, as well as crude fiber content (0.76%) which is closest to the requirements (0.7%).
Pengaruh Pemberian Antibiotika Profilaksis Golongan Penisilin dengan Golongan Sefalosporin terhadap Tanda Klinis IDO Superfisial dan LOS ada Pasien SC di Rumah Sakit “X” Teulis Sumiartini; Dian Ratih Laksmitawati; Hesti Utami Ramadaniati; Ranald Irwanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1059

Abstract

A hospital "X" in Jakarta has priority obstetrics services with a high birth rate. Sectio caesarea (SC) at the hospital uses prophylactic antibiotics penicillin and cephalosporins to reducing superficial Surgical Site Infection (IDO). Complication of infection can increase prolongs stay patient (length of stay - LOS). The aim of this study is to look the influence administration of penicillin prophylactic antibiotics with cephalosporins towards the clinical signs of superficial IDO and LOS to SC patients in hospital "X". The test sample calculated using a formula of two proportions difference with retrospective data tracing from medical records which are analyzed using the Chi-Square method with the help of Microsoft Excel to determine the influence administration of penicillin prophylactic antibiotics with cephalosporins towards the clinical signs of superficial IDO and LOS. The results showed that the chi-square calculated value in bivariate analysis of prophylactic antibiotics with LOS and clinical signs of IDO are smaller than the Chi-Square table value (Chi-Square table value at degree of freedom (DF) 1 and significance of 0.05 = 3.8415) with a p value greater than 0.05. In conclusion, there is no statistically significant difference in influence between the group receiving penicillin prophylactic antibiotics with the group receiving cephalosporin prophylactic antibiotics towards the clinical signs of superficial IDO and LOS to SC patients in hospital "X".

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