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Jurnal Farmasi Higea

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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 347 Documents

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Penentuan Pengaruh Jenis Pelarut Pengekstrak Terhadap Perolehan Kadar Senyawa Fenolat Dan Aktifitas Antioksidan Dari Daun Jambu Biji (Psidium guajava L.) Harrizul Rivai; Rizky Yulion Putra; Krisyanella Krisyanella
Jurnal Farmasi Higea Vol 4, No 1 (2012)
Publisher : STIFARM Padang

Influence of type of extracting solvent on determination of phenolic compound level and antioxidant activities of Guava Leaf (Psidium Guajava, L.) have been done. The determination of phenolic compound by using Folin-Ciocalteau method and Antioxidant activities by using DPPH method that Gallic Acid was used as reference and determination of phenolic compound and antioxidant activities by using UV-Visible spectrophotometry. The content of phenolic compound from methanol:water extract; ethanol:water extract; aceton:water extract are 82.2699; 81.4762 and 80.9206 mg/g respectively. The finding showed that methanol: water solvent is the best solvent for Phenolat extract compare with ethanol:water and aceton:water. Antioxidant activities from methanol:water extract: ethanol:water ; aceton:water are IC50 3.694; 8.249 and 4.968 mg/mL respectively. From the data can get conclusion that methanol:water is the best solvent for extracting Guava Leaf (Psidium Guajava, L.).

Analisis Kualitatif Vitamin B1 Pada Kacang Hijau (Phaseolus radiates L.) Menggunakan Metode Konvensional dan KLTKT Silika Gel 60 F254 Ridho Asra; Boy Chandra; Zulharmita Zulharmita; Elsa Febrianti
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Efek Diuretik dan Daya Melarutkan Batu Ginjal Dari Ekstrak Herba Pecut Kuda (Stachytarpheta jamaicensis (L)Vahl) Helmi Arifin; Masitah Masitah; Elisma Elisma
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

The herbal extract of pecut kuda’s potencies on dissolving kidney stones and it’s diuretic effect has been studied. Test dissolve kidney stones performed in vitro by dissolving the crystals or stones are usually found in the kidney. Test were carried out at 4 treatment groups, control (no extract), 0.1%; 1% and and 2% groups. In the control group, the levels of dissolved kidney stones at 52.116 ppm, while the group of 0.5%, 1% and 2% at 56.140 ppm, 61.592 ppm and 76.602 ppm respectively. One-way ANOVA test result and test advanced non-parametric Kruskal-wallis test showed that of the three consentrations of the extract has a difference in dissolving kidney stones. Diuretic effect tested on 15 white male rats were divided into 5 groups, where in the extract is administered orally. The test group was divided into a positive group (furosemide), 1 negative group (given Na-CMC) and the 3 treatment groups (125; 250 and 500 mg/kg BW). Volume of rat urine into variable observations. Based on the results of two-way ANOVA test and test advanced non-parametric Friedman test show that all three doses of the test has diuretic effect. So that the conclutions of this study are horse whip herbal extracts can dissolve kidney stones and has a diuretic effect on test animals.

Identifikasi Zat Warna Rhodamin B Pada Lipstik Berwarna Merah yang Beredar Di Pasar Raya Padang Helmice Helmice; Nila Wise Utari
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

The purpose of this study was to determine whether the red lipstick sold in the market Pasar Raya Padang containing rhodamine B. The samples were randomly taken from the market with five (5) red lipsticks samples with notification number (NA) and the other five (5) red lipsticks samples without notification number (NA). The identification of Rhodamine B in the sample by using thin layer chromatography method and the type of this research is qualitative research. The results of samples identification with thin layer chromatography method is as follow: a). Five samples of red lipstick rthat does not have notification number (NA) showed one lipstick sample (code A) containing Rhodamine B as the standard distance of Rhodamine B is equal or parallel with the difference of sample’s Rf and raw Rf less than or equal 0.2. Meanwhile the other four lipstick samples (code B, C, D, E) does not contain Rhodamine B b). Five samples of red lipstick with notification number (code F, G, H, I, and J) showed not contain Rhodamine B as Rhodamine B standard distance of and raw is not equal or not parallel with the difference between the sample’s Rf and raw Rf is more than 0.2.

Pengaruh Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium. Merr) Terhadap Fungsi Hati Dan Kadar Kreatinin Urin Mencit Putih Jantan Helmi Arifin; Rahmi Yulia Nesia; Elisma Elisma
Jurnal Farmasi Higea Vol 3, No 2 (2011)
Publisher : STIFARM Padang

The effect of ethanolic extract of Nothopanax scutellarium. Merr on liver function and urine creatinine level of male white mices had been done. The extract was administered orally with variation of dose at 150, 300, 600 mg/kg BB one times a day for 15, 30, 45 days. As a control group was used male white mices that administered only Na CMC 0,5% solution. The result showed that administered of ethanolic extract Nothopanax scutellarium. Merr at variation of dose did not influence on liver function and urine creatinine level (p>0,05).

UJI TOKSISITAS AKUT EKSTRAK DAUN WARU (Hibiscus tiliaceus L.) PADA MENCIT PUTIH JANTAN Sri Oktavia; Ifora Ifora; Adelina Damayanti Putri
Jurnal Farmasi Higea Vol 10, No 1 (2018)
Publisher : STIFARM Padang

Daun waru (Hibiscus tiliaceus L.) banyak digunakan sebagai obat tradisional. Pembuktian secara ilmiah mengenai keamanannya penting untuk diketahui, salah satunya melalui uji toksisitas akut. Penelitian ini bertujuan untuk mengetahui nilai LD50 dan toksisitas tertunda dengan pemberian ekstrak daun waru terhadap mencit putih jantan. Toksisitas tertunda diamati selama 14 hari meliputi perubahan berat badan, volume konsumsi air minum, dan berat relatif organ seperti paru-paru, jantung, hati, ginjal, dan lambung. Pemberian ekstrak daun waru secara oral hingga dosis 16 g/kgBB menunjukkan bahwa ekstrak daun waru termasuk kategori praktis tidak toksik (LD50>15 g/kgBB). Efek toksisitas tertunda terlihat pada perubahan berat badan dan volume konsumsi air minum. Hasil statistik menggunakan ANOVA dua arah, untuk perubahan berat badan dan volume konsumsi air minum terdapat perbedaan signifikan (P<0,05). Kemudian dilakukan uji lanjut Duncan, dimana semua dosis yang diberikan menunjukkan perubahan berat badan, sedangkan pada volume konsumsi air minum dosis yang mempengaruhi adalah dosis 8 g/kgBB dan 16 g/kgBB. Pada berat relatif organ menggunakan ANOVA satu arah menunjukkan tidak terdapat perbedaan signifikan (P>0,05).

Pengaruh Hasil Fraksinasi Ekstrak Daun Kemangi (Ocimum sanctum L.) Terhadap Aktivitas Susunan Saraf Pusat Pada Mencit Putih Jantan Rahimatul Uthia; Helmi Arifin; Feni Efrianti
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Study about activity of the central nervous system stimulant of breadfruit’s leaf the water fraction Ocimum santum L. Using experimental animals male white mice (Mus musculus, L) has been done. Breadfruit’s leaf the water fraction at a dose of 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW given to mice orally 15 days. Stimulant activity was tested on day -5, -10 and -15. As a comparison used caffeine 13 mg/kg BW while luminal 50 mg/kg BW is used to test a long sleep induction and sleep in mice. Parameters used stimulant activity is endurance test with Rotary road equipment, test sensor activity and test motor activity wiht a Automotic hole board and sleep induction test and a long sleep. From the research that has been done, it is know that kemangi leaf the water fraction at a 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW have a central nervous system stimulan activity by increasing endurance, sensor activity and motor activity as well as increase the time to accelerate the induction of sleep and long sleep in mice sigficantly (P>0,05).

Profil Disolusi Parasetamol Mukoadhesif Menggunakan Kombinasi Polimer Hydroxy Propyl Metyl Celluloce (HPMC) dan Natrium Alginat Maria Dona Octavia; Novi Rini Novita; Auzal Halim
Jurnal Farmasi Higea Vol 2, No 2 (2010)
Publisher : STIFARM Padang

Research on the dissolution profile of paracetamol by using a combination of polymer mucoadhesive hydroxypropyl methylcelulloce (HPMC) and sodium alginate has been done. This study aimed to see the effect of the combination of polymer HPMC and Sodium Alginate on the dissolution profile of paracetamol mucoadhesive. in this study were made four formula granule containing 100 grams of acetaminophen as an active ingredient and combination of HPMC with sodium alginate with various concentrations: 50 grams of sodium alginate (F1), 40 grams of sodium alginate and 10 grams of HPMC (F2), 30 grams of sodium alginate and 20 grams of HPMC (F3) and 50 grams of HPMC (F4), where Avicel PH 102 is used as a filler. The resulting granules are evaluated which include : content level, dissolution profile and test bioadhesif granules. Dissolution profiles performed by the method of rowing in the 900 mL medium of pH 5.8 buffer fosphat, 37±0.5°C and a speed of 50 rotation/min. The measurement results at minute 60 shows that the average granule dissolution F1, F2, F3 and F4 are 8.8341%, 9.2838%, 12.9828% and 17.2589% respectively. The Conclusion is the combination of paracetamol mucoadhesive polymers HPMC with sodium alginate showed an influence on the dissolution profile of paracetamol, where F1 formula shows the best dissolution profiles among the other four formulas.

Penetapan Kadar Zink Pada Sediaan Farmasi Dengan Metode Kompleksometri dan Spektrofotometri Serapan Atom Dwi Dinni Aulia Bakhtra; Zulharmita Zulharmita; Valeria Pramudita
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Research on the determination of zinc in pharmaceutical preparations have been carried out by complexometry and atomic absorption spectrophotometry. This research aims to determine and compare the levels of zinc in pharmaceutical preparations by complexometry method and atomic absorption spectrophotometry. Samples used zinc tablets were Zinkid® (PT. Indofarma), Zincare® (PT. Kalbe Farma) and Zinc generic tablets (PT. Kimia Farma). Zinc calibration curve at wavelength 213.9 nm used standard solution ZnSO4.7 H2O have correlation coefficient 0.9937 and linear regression equation y = 0.1124 + 0.4403x. Standard deviation 0.088. Detection limit 0.5996 mg/kg and quantitation limit 1.9986 mg/kg. The assay of zinc by complexometry method trademarks Zinkid® obtained zinc content 3.57 %, Zincare® 6.12 % and Zinc generic 3.68 %. While the method of atomic absorption spectrophotometry Zinkid® obtained zinc content 3.64 %, Zincare® 6.19 % and Zinc generic 3.72 %. Result of statistical analysis using t-test, it could be concluded that the method complexometry and atomic absorption spectrophotometry for the determination of zinc in pharmaceutical preparations dosage levels were not significantly different (sig.>0.05).

Uji Efek Teratogen Ekstrak Etanol Daun Patikan Kebo (Euphorbia Hirta L.) Terhadap Fetus Mencit Putih Suhatri Suhatri; Agusdi Firdaus; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

Has done research about the teratogenic effects ethanol of extract test patikan Kebo leaves (Euphorbia hirta L.) concerning to fetal white mice. Animal experiments were grouped into 4 groups consisting of group I as negative control given only 0.5% suspension of Na CMC, group II, group III and group IV was given the ethanol extract of patikan kebo leaves with variations dose of 25 mg / kg BW, 50 mg / kg BW, and 100 mg / kg BW once a day from day 6 to day 15 of pregnancy. 18th day of pregnancy mice dilaparaktomi. Dose of 25 mg / kg BW, dose of 50 mg / kg BW did not cause teratogenic effects. Teratogenic effect was found at dose of 100 mg/kg BW there was the discovery of defects cleft palate. The results showed the ethanol extract of patikan kebo leaves not affected weight gain parent mice were significantly (p> 0.05) when compared to the negative control. Amount of fetuses were significantly reduced (p <0.05) when compared to the negative control. Fetal weight showed no significant effect (p> 0.05) if compared with negative controls.

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