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INDONESIA
Fullerene Journal of Chemistry
ISSN : 25981269     EISSN : 25985868     DOI : -
Core Subject : Science,
Fullerene Journal Of Chemistry is an chemistry indonesian journal presented by chemistry department, State University of Manado.
Arjuna Subject : -
Articles 160 Documents
Bioprospecting and Chemical Potential of Bioactive Compounds of Medicinal Plants of the Baduy Tribe of Banten Province saefurohman, Asep saefurohman; Arfi, Angger; Ais, Ais; Fahrizal, Fahrizal
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.740

Abstract

Bioprospecting is the exploration, collection, research, and utilization of genetic and biological resources to obtain chemical compounds, genes, organisms, and other natural products. Bioprospection of medicinal plants is an exploration activity to have added value from both a scientific and an economic perspective. Indonesia is one of the archipelago countries that has the potential for cultivating various plants. The objective of this research was to find bioactive compounds from plants in Baduy and the chemical potential of bioactive compounds as drugs. White Ginger (Curcuma zedoria Rosc) is included in the family of medicinal plants (TOGA) is a plant in the family Zingiberaceae. This plant is widely found in Baduy. The method used in this research is descriptive qualitative, by describing the quality of bioactive compounds contained in traditional medicinal plants in the Baduy tribe. The research results showed that the yields obtained from the extraction using 70% ethanol solvent, water, and steeping water of white rhizome powder were 24.51%, 9.65%, and 12.22%, respectively. 70% ethanol medicinal plant extract and hot water at a concentration of 300 ppm did not have an inhibitory power on the activity of the enzyme tyrosine kinase, while the crude extract of 300 ppm aquadest had an inhibitory power of 7.23%. At a higher extract concentration, which is 700 ppm, 70% ethanol extract has the highest inhibitory power of 27.77%. The inhibition power of 700 ppm aqueous extract is 26.13% and 700 ppm hot water extract is 24.50%.
Molecular Docking and Molecular Dynamics Analysis of Phytochemical Compounds from Nutmeg Fruit (Myristica fragrans Houtt.) on Androgen Receptor (4K7A) as Anti-Alopecia Therapy Yasir, Angga Saputra; Sari, Indah Puspita
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.737

Abstract

Androgenetic alopecia (AGA) represents the most prevalent hair loss form, necessitating natural treatment alternatives. This study investigated nutmeg (Myristica fragrans Houtt.) phytochemicals as anti-alopecia agents through molecular docking and dynamics simulations. Thirty-four compounds, including native ligands (minoxidil, finasteride) and 32 nutmeg-derived compounds, were evaluated against androgen receptor (PDB: 4K7A) using AutoDock4.0 and GROMACS 2024.2. Molecular docking validation achieved successful minoxidil redocking with 2.25 Å RMSD, confirming method reliability. Geranylgeraniol (ID: 33) demonstrated optimal results with -7.00 kcal/mol binding energy, nearly equivalent to finasteride (-7.19 kcal/mol) and superior to minoxidil (-4.85 kcal/mol). Geranylgeraniol formed strong hydrogen bonds with GLU793 at 1.77 Å distance, with nearby residues LEU862, TYR857, ARG854, LYS861, and LEU797. Twenty-five nanosecond molecular dynamics revealed stable complex formation with 0.23-0.25 nm RMSD values, indicating acceptable binding stability. RMSF analysis showed geranylgeraniol induced higher structural flexibility in specific regions, potentially enhancing biological activity. SASA analysis demonstrated lower surface area values (112.5 nm²), indicating improved stability versus minoxidil. These findings suggest geranylgeraniol possesses significant anti-alopecia potential with comparable finasteride efficacy and superior minoxidil performance.
Zn–Catharanthus roseus and Cu–Catharanthus roseus Complexes as Green Organometallic Photosensitizers for DSSC Applications Qoriati, Yani; Al-Bari, Akhmad; Februyani, Nawafila; Faricha, Nely Alfiana Faricha Alfiana; Kamal, Ahmad Abil
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.752

Abstract

The global energy crisis and climate change issues have driven the development of environmentally friendly renewable energy sources, one of which is the dye-sensitized solar cell (DSSC) utilizing natural pigment-based photosensitizers. Catharanthus roseus (tapak dara) was selected due to its abundance of secondary metabolites and its potential to be modified into Zn and Cu nanoparticles to enhance stability and efficiency. In this study, tapak dara leaf extract was obtained using ethanol through ultrasonic extraction, then synthesized into Zn and Cu nanoparticles with Zn:Cu ratios of 0:4, 1:3, 2:2, 3:1, and 4:0 via green synthesis. The resulting nanoparticles were deposited onto TiO₂ electrodes, with Pt used as the counter electrode in the DSSC. The cells were tested under 9 mW halogen light. The results revealed that the Zn:Cu ratio influenced crystallite size, morphology, and solar cell efficiency. XRD characterization confirmed the formation of ZnO and Cu phases with crystallite sizes ranging from 9 to 40 nm, while SEM analysis showed nanometer-sized particles with a tendency to agglomerate. The highest efficiency was achieved at a 3:1 ratio, reaching 120 × 10⁻⁴ %, indicating that Zn/Cu–tapak dara nanoparticles hold strong potential as effective photosensitizers.
Optimization of Biogas Production from Pineapple Peel Waste (Ananas comosus) through Anaerobic Fermentation with Thermal Pretreatment Mandasari, Weni -; Prawiranti, Yulizar
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.755

Abstract

The increasing global energy demand and depletion of fossil fuel reserves have prompted the search for sustainable energy alternatives. Biogas, produced through anaerobic digestion of organic waste, presents a viable solution. Pineapple peel (Ananas comosus), a major byproduct of Indonesia's fruit processing industry, remains underutilized despite its high lignocellulosic content, which includes cellulose, hemicellulose, and fermentable carbohydrates. This study investigates the potential of pineapple peel as a biogas substrate through a series of pretreatment and anaerobic digestion processes. The peel was thermally pretreated (60–100°C for 25–60 minutes) to enhance biodegradability, then digested with cow manure in a 1:1 ratio under mesophilic conditions (30–37°C) for 30–35 days. Parameters such as TS, VS, BOD, COD, methane yield, pH, and temperature were monitored. Results showed significant reductions in TS, VS, BOD, and COD, indicating efficient organic matter degradation. Methane concentration reached 67.27%, with a biogas yield of 357.19 mL/g VS. FTIR and SEM-EDX analyses confirmed structural breakdown of lignocellulosic bonds, particularly hemicellulose and lignin, enhancing substrate accessibility. The findings demonstrate that pineapple peel, with appropriate pretreatment and co-digestion, is a promising feedstock for sustainable biogas production, offering both environmental and economic benefits in tropical agricultural regions.
The Adsorption of Heavy Metal Mercury (Hg) Using Meranti Wood as Activated Carbon Pereiz, Zimon; Chuchita, Chuchita; Oksal, Efriyana; Jaya Prastiti, Arini Eka; Berlisnora Dasilva, Caroline; Anatasya, Violina; Prisnanda, Risky; Hairiah, Rusliananur
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.712

Abstract

The objective of this research is to assess the adsorption capacity of activated carbon derived from meranti wood (Shore spp) for mercury (Hg) removal from liquid waste. To establish the relationship between concentration and absorbance, the method employed involves calibrating mercury concentration using calibration curves. Additionally, the effects of pH and exposure time on adsorption capacity were examined. The results indicate that activated carbon from meranti wood can significantly adsorb mercury, achieving an efficiency level of 97.610% at pH 3, with adsorption stability reached within 80 minutes at an adsorption rate of 94.30%. The conclusions drawn from this study suggest that activated carbon from meranti wood is a sustainable and effective solution for addressing mercury contamination in wastewater. It also highlights the importance of regulating pH and exposure time. This research contributes significantly to the development of environmentally friendly methods for water purification.
Analysis of Lipid Yield from Chaetoceros calcitrans Microalgae Extract Using Gas Chromatography Stepanus, Jamius Bin; Likumahwa, Fervin Mayos; Kesauliyaa, Olivia Marie Caesaria; Angrianto, Novaldi Laudi; Sumarna, Sabir; Islam, Muh. Fajar
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.724

Abstract

Renewable energy (RE) is a solution to the threat of the upcoming energy crisis. The increasingly massive energy transition is expected to significantly reduce the use of fossil fuels. Microalgae are one of the potential sources of RE for bioenergy (biodiesel) production due to their lipid content. This research was conducted to determine the percentage of lipid components; free fatty acids (FFA), monoglycerides (MAG), diglycerides (DAG), and triglycerides (TAG) in Chaetoceros calcitrans microalgae and to compare lipid yields using two extraction methods: Bligh-Dyer (wet samples) and Soxhlet extraction (dry samples).The results for C. calcitrans extracted using the Bligh-Dyer method showed that the percentage of lipid components (FFA, MAG, DAG, and TAG) ranged from 5.44% to 17.10%, with a total of 47.92%, and the lipid yield from 6 g of wet sample was 5.07%.Meanwhile, for the C. calcitrans extract using Soxhlet method, it was found that the percentage of lipid components (FFA, MAG, DAG and TAG) ranged from 6.79 to 18.01% with a total of 63.08% and the lipid yield from 20 g of dry samples was 0. 44%.
Immobilization of Humic Acid on Chitosan and Its Application as an Adsorbent for Mercury (Hg²⁺) Ions in Freshwater Media Uktolseya, Lady Diana; Male, Yusthinus T; Tehubijuluw, Hellna
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.750

Abstract

Mercury (Hg²⁺) contamination in freshwater is a serious global environmental issue, posing toxic effects on both human health and aquatic ecosystems. This study aims to immobilize humic acid onto chitosan and evaluate its effectiveness as an adsorbent for mercury ions (Hg²⁺) in a freshwater medium. Humic acid was isolated from peat soil and characterized using Fourier Transform Infrared (FTIR) Spectroscopy. Commercial chitosan was used as the supporting matrix. The immobilization process was carried out by mixing humic acid and chitosan solutions under controlled pH conditions. The resulting humic acid–chitosan adsorbent was then tested for its adsorption capacity toward mercury ions at various initial concentrations. FTIR characterization results confirmed the successful immobilization of humic acid onto chitosan, as indicated by the appearance of characteristic absorption bands corresponding to functional groups from both components. Adsorption tests showed that the humic acid–chitosan adsorbent exhibited a significant ability to remove mercury ions from freshwater, with optimum adsorption observed at a concentration of 100 ppm. The maximum adsorption capacities of humic acid, chitosan, and humic acid–chitosan were 99.83 mg/g, 99.90 mg/g, and 99.89 mg/g, respectively. This study provides important scientific insights into the potential of humic acid immobilized on chitosan as an alternative material for reducing heavy metal pollution in aquatic environments
Characterization of Clay from Merauke Regency and Its Utilization as an Adsorbent of Free Fatty Acids in the Purification of Waste Cooking Oil Maulana, Muhammad Rasyiid; Parlindungan, John Yoro; Rettob, Abraham Laurens; Siregar, Lamtiar Ferawaty; Hitijahubessy, Hendro
Jurnal Kimia Fullerene Vol 10 No 2 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i2.747

Abstract

This study investigates the characterization and application of natural clay from Merauke as an adsorbent for the purification of waste cooking oil. The clay was characterized using X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) before and after acid activation. XRD analysis revealed quartz as the dominant mineral, while acid activation caused partial dissolution of layered silicates, leading to structural modifications without affecting quartz stability. SEM images confirmed morphological changes from compact aggregates with limited pores to rougher surfaces with larger and more interconnected pores, indicating increased surface area and porosity. Adsorption experiments demonstrated that both natural and acid-activated clays reduced free fatty acids (FFA) in waste cooking oil, with the acid-activated clay consistently showing higher efficiency. Prolonged stirring times (1, 3, and 5 hours) further enhanced adsorption, though the reduction rate decreased over time as adsorption sites approached saturation. In addition to lowering FFA levels, the treatment improved the visual quality of the oil by reducing discoloration. These findings highlight that acid-activated clay from Merauke possesses promising potential as a low-cost and effective adsorbent for oil purification and broader environmental remediation applications.
Isolation and Characterization of Dryland Microfungi From Northern Insana as Potential Sources of Antibacterial Agents mere, janrigo klaumegio; Edi, Eduardus; Nomi, Anastasia Grandivoriana
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.762

Abstract

Microfungi are one of the most extensively studied groups of microorganisms due to their remarkable ability to produce a diverse range of unique bioactive compounds. This study aimed to explore and characterize microfungi isolated from the drylands of North Insana as potential sources of sustainable antibacterial agents. The research methods included the isolation of microfungi, morphological identification, and evaluation of antibacterial activity using the disc diffusion method. Based on morphological characterization, microfungi isolated from the North Insana dry soil showed similarities to three genera, namely Mucor, Penicillium/Aspergillus, and Aspergillus. Antibacterial assays revealed that all three isolates exhibited varying degrees of activity, ranging from moderate to strong, against Staphylococcus aureus. Isolate 1 produced an inhibition zone of 7.6 ± 0.20 mm (moderate activity), isolate 2 produced 10.17 ± 0.06 mm (strong activity), and isolate 3 produced 10.77 ± 0.06 mm (strong activity). According to the Tukey test (p < 0.05), isolate 3 showed no significant difference from the standard antibiotic chloramphenicol (11.23 ± 0.15 mm), indicating a comparable antibacterial effectiveness. These results suggest that dryland-endemic microfungi possess adaptive biosynthetic capacities, enabling them to produce antibacterial secondary metabolites in response to extreme environmental stress. This potential reinforces the role of dryland microfungi as promising new sources of natural antibacterial compounds for sustainable biotechnological and health applications
Analysis Of Nutrient Content And Organoleptic Test Of Fish Waste POC With The Addition Of Ecoenzyme Papriani, Nada Pertiwi; Mishbach, Imam; Gea, Liyatin; Jannah, Miftahul; Yusriadi, Yusriadi; Ramadan, Rafsanjany
Jurnal Kimia Fullerene Vol 11 No 1: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i1.726

Abstract

Nutrients in fish waste can cause pollution (eutrophication) when directly discharged into waters. Efforts to minimize this can be done by processing fish waste into POC. Making POC from fish waste can be done by adding ecoenzymes. The purpose of this study was to observe the organoleptic, pH and nutrient content of POC from fish waste with and without the addition of ecoenzymes. The stages of the study were ecoenzyme production, POC products, organileptic tests, pH observations, and analysis of nitrogen (N), phosphorus (P), and potassium (K) content. Based on the results of the study on the observation of organoleptic odor tests before fermentation, Bucket 1 without the addition of ecoenzyme has a slightly rotten and fishy odor, reddish brown in color, pH 6, after fermentation it has a sour and fishy odor, brown in color pH 5. Bucket 2 With the addition of ecoenzyme has a slightly rotten and fishy odor, reddish brown in color, pH 5, after fermentation it has a slightly sour and fishy odor, brown in color, pH 4. The NPK content in bucket 1 without the addition of ecoenzyme is 0.35%, 0.19%, 0.09%, in bucket 2 with the addition of ecoenzyme is 0.57%, 0.32%, 0.12%.