cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
respirasi@journal.unair.ac.id
Editorial Address
Jl. Mayjen Prof. Dr. Moestopo 6-8 Surabaya 60286 Indonesia
Location
Kota surabaya,
Jawa timur
INDONESIA
Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
Arjuna Subject : -
Articles 321 Documents
 26   27   28   29   30 
Neutrophil-Lymphocyte Ratio (NLR) as a Prognostic Marker in Advanced Lung Cancer Patients Undergoing First-Line Treatment Dewi, Dinda Ary Miranda; Setyawan, Ungky Agus; Karliasari, Liana
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.209-213

Abstract

Introduction: Neutrophil-lymphocyte ratio (NLR) is one of the systemic inflammatory markers that play a role in detecting the degree of sepsis in the cancer microenvironment. A high NLR, with a dominant predominance of neutrophil cells, can release cytokines and chemokines that induce cancer cell proliferation and metastasis. Conversely, a low NLR, predominately of lymphocyte cells, can activate the immune system to handle chronic inflammation. From its mechanism of action, NLR is often used to predict the future prognosis and survival rate of cancer patients. This study aimed to analyze the effect of first-line therapy in lung cancer patients with an alternative prognostic indicator in the form of changes in NLR values confirmed by the response evaluation criteria in solid tumors (RECIST). Methods: This study used an analytical observational method with a cross-sectional approach and was conducted using secondary data samples from the medical records of lung cancer patients treated at Dr. Saiful Anwar General Hospital, Malang. Results: Spearman’s correlation analysis between NLR and RECIST revealed a relationship (p = 0.001). Determining the NLR cut-off point using the receiver operating characteristic (ROC) curve yielded a value of 3.55, with NLR sensitivity and specificity at 69.44% and 69.76%, respectively. The therapy administration to lung cancer patients significantly decreased NLR (p = 0.032). Conclusion: NLR is a valuable tool for routinely monitoring therapy outcomes in lung cancer patients and can be considered an alternative prognostic marker due to its promising results.
Vitamin C Intake and Anti-Tuberculosis Drugs-Induced Hepatitis in Pulmonary Tuberculosis Patients Rabbani, Hadiati; Nurwidya, Fariz; Andayani, Diyah Eka; Agustin, Heidy; Syam, Shaogi
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.214-221

Abstract

Introduction: Drug-induced hepatitis (DIH) is one of the serious side effects of anti-tuberculosis drugs (ATD) that can reduce patient compliance with tuberculosis (TB) treatment, increase the risk of treatment failure, or develop drug resistance. Vitamin C is a potential antioxidant known to have a protective effect against DIH. This study examined the relationship between vitamin C intake and the incidence of ATD-induced hepatitis (ATDIH) in pulmonary TB patients at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: This was a cross-sectional study of 108 patients with drug-sensitive pulmonary TB. Data was collected using a sociodemographic questionnaire, anthropometric measurements, semi-quantitative food frequency questionnaire (SQ FFQ), and data on the subject's liver function laboratory results in the last 1 month. Fisher exact test was utilized to analyze the association between adequacy of vitamin C intake and DIH. Results: The proportion of DIH in pulmonary TB patients in this study was 6.5%. Most subjects were males (54.6%) with a median age of 41. The median vitamin C intake was 66.65 mg/day, with 63.0% of patients having an intake below the recommendation. Fisher's exact test showed that vitamin C intake was not statistically significantly associated with the incidence of ATDIH (OR 3.77 95% CI 0.44-32.55, p-value 0.256). No factors also influenced the incidence of ATDIH in this study. Conclusion: No association was found between vitamin C intake and other factors related to the incidence of ATDIH. This is the first study in Indonesia to link vitamin C and E intake with the incidence of DIH in drug-sensitive pulmonary TB patients, providing information for future studies.
Volatile Organic Compounds (VOC) and Serum Leukotriene B4 between COPD Patients and COPD with Lung Cancer Patients Djajalaksana, Susanthy; Listyoko, Aditya Sri; Prasetyo, Kevin Wahyudy; Wardoyo, Arinto Yudi Ponco
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.222-227

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is estimated to become the third leading cause of death worldwide in 2030. COPD can affect the lungs and cause chronic systemic inflammation. Leukotriene B4 (LTB4) is involved in COPD and lung cancer pathogenesis. There has been the development of non-invasive methods for detecting lung disease in the last few decades, such as the examination of volatile organic compounds (VOC). This study aimed to analyze the serum LTB4 and the difference of VOCs in exhaled breath of stable COPD patients and COPD with lung cancer patients. Methods: This case-control study recruited 20 stable COPD patients and 20 patients with COPD and lung cancer. An exhaled breath sample was collected in Tedlar bags and analyzed using an arrayed sensor breath analyzer to check the concentration of VOCs. Meanwhile, a venous blood sample was collected to examine the level of LTB4 using an ELISA kit. Independent t-test and Mann-Whitney test were used to analyze the data. Results: The carbon dioxide (CO2), nitrogen dioxide (NO2), carbon monoxide (CO), benzene (C6H6), and propane (C3H8) levels were significantly different (p <0.05) in COPD-only patients compared to COPD with lung cancer patients. Serum LTB4 increased in both groups. Conclusion: CO2, CO, and C3H8 levels increased, but the NO2 level decreased in COPD patients with lung cancer compared to COPD-only patients. Serum LTB4 increased in COPD with lung cancer patients.
Assessment of Quality of Life in Advanced-Stage Lung Cancer Patients Using EORTC QLQ-C30 Questionnaire Ariantika, Ariantika; Lubis, Rahayu; Asfriyati, Asfriyati; Ashar, Taufik; Nurmaini, Nurmaini; Soeroso, Noni Novisari; Siregar, Kamal Basri; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.228-235

Abstract

Introduction: Quality of life (QoL) is a multidomain concept that assesses a person through health status, functional status, and symptoms. The patient's QoL is greatly reduced due to the course of disease, severity of symptoms, and side effects of chemotherapy treatment. This study aimed to assess the QoL in advanced lung cancer patients using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30). Methods: This descriptive and observational study was conducted at the Pulmonary Polyclinic, Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (USU) Hospital from February to July 2024, with a cross-sectional design using patient medical records and EORTC QLQ-C30 questionnaire. The EORTC QLQ-C30 questionnaire was analyzed with a score formula and categorized as good, moderate, and bad. The sample was 100 lung cancer patients using a purposive sampling technique according to the criteria. Results: The results showed that almost all QoL was in the moderate category (80%). The general health status was mostly in the moderate category (61.66%), the functional status was mostly in the good category (75.35%), and the symptoms were in the moderate category (35.65%). In the functional scale, the role domain had the lowest mean, 69.99 ± 29.43. In the symptoms scale, the pain domain had the highest mean, 52.66 ± 29.43. Conclusion: The overall QoL of lung cancer patients was in the moderate category, lower than the healthy population. It needs to be improved, especially in the role domain, by providing supportive-expressive group therapy.
Front Matter Vol 10 No 3, 2024 Matter, Front
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Back Matter Vol 10 No 1, 2024 Matter, Back
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Deterioration of Respiratory Symptoms in Uncontrolled CPFE: A Case Report Raffael, Frans; Tarigan, Amira Permatasari
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.54-61

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) has a global impact on health and increases healthcare costs. Combined pulmonary fibrosis and emphysema (CPFE) combines interstitial lung disease (ILD) and emphysema. Excessive short-acting β2-agonist (SABA) usage escalates exacerbation risk, affecting prognosis. Case: A 44-year-old former smoker presented with worsening shortness of breath, cough, and weight loss. Examination showed respiratory distress, including wheezing. Initially, he was diagnosed with tuberculosis (TB) and COPD exacerbation. He regularly used jet nebulizers without medical supervision, and during the initial treatment, he developed acute respiratory failure, leading to acidosis. Treatment involved SABA and short-acting muscarinic-antagonist (SAMA), steroids, and oxygen therapy. In November 2023, his condition worsened, requiring emergency treatment. Radiological findings indicated CPFE. Management included nebulized medications, intravenous steroids, and antibiotics. Despite challenges, he rarely attended follow-up appointments after showing improvement, missing scheduled rehabilitation therapy, inhaler monitoring, comorbid therapy, and home oxygen monitoring. Conclusion: Combined pulmonary fibrosis and emphysema combines ILD and emphysema, causing severe respiratory impairment. Management mirrors that of COPD, involving inhalers, corticosteroids, and oxygen therapy.
Determining Chronic Cough Using the Methacholine Bronchial Provocation Test Aksu, Esra Arslan; Uzun, Oğuz
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.1-5

Abstract

Introduction: Chronic cough is a common symptom in pulmonology outpatient clinics, often associated with lung conditions, though extrapulmonary causes can also be responsible. This study aimed to detect bronchial hyperreactivity (BHR) and cough-variant asthma using a methacholine bronchial provocation test (BPT) in patients with chronic cough for whom standard diagnostic procedures could not identify a cause. Methods: This prospective study evaluated patients admitted to the clinic who presented with chronic coughs over one year. A BPT was performed on patients for whom standard diagnostic procedures failed to identify a cause, and this selected group was included in this study. Results: This study included a total of 40 patients who were examined for chronic cough symptoms without an identifiable etiology. The BPT was negative (PD20 >16 mg/mL) in 30 patients (75%) and positive in 10 patients (25%). Among the patients with negative BPT results, 13 (43.3%) had no identifiable cause for their cough. Conclusion: This study differs from others by focusing on a selected group of patients with chronic coughs for whom the etiology could not be determined through standard diagnostic procedures. The BPT was performed alongside typical diagnostic tests, and no diagnoses were made in the included patients. Tests identified BHR and cough-variant asthma in 25% of these patients, suggesting that BPT is a valuable tool in diagnosing chronic cough when conventional methods fail.
The Effects of Inspiratory Muscle Training in Lung Cancer Patients: A Scoping Review Kadir, Yolanda; Sabirin, Rahmaningsih Mara; Hasyim, Ammar Abdurrahman; Iqbal, Roihan Mohamad; Siswanto, Siswanto
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.75-82

Abstract

Introduction: Lung cancer is the leading cause of cancer worldwide, with a high mortality rate. Chronic dyspnea promotes a pathologic cycle of decreased activity, which has been shown to limit exercise tolerance and deteriorate quality of life (QoL). Inspiratory muscle training (IMT) is a resistance-based exercise regimen that aims to improve the strength and endurance of the inspiratory muscles, thereby reducing respiratory symptoms. This study aimed to comprehensively review the possible beneficial effects of IMT on various aspects of lung cancer patients. Methods:  The PubMed, Embase, and Cochrane databases were searched from inception to 20 May 2024. All clinical trials examining the impact of IMT on lung cancer patients, utilizing either quantitative or qualitative approaches, were included. The extracted data were then descriptively presented, focusing on the main themes to provide a comprehensive literature review. Results: This scoping review identified 9 unique studies comprising eight randomized-controlled trials and one retrospective cohort study with 460 lung cancer patients. An IMT regimen was proven to reduce sedentary behavior and significantly improve physical activity and health-related quality of life (HRQL). Furthermore, the IMT program reduced dyspnea, improving maximum inspiratory pressure (PImax) and 6-minute walking test (6MWT). It also provided the benefits of shorter postoperative stay and reduced patient distress concerning dyspnea. Conclusion: Inspiratory muscle training provides several benefits, including improvements in dyspnea indexes, exercise tolerance, and overall HRQL. Further studies are required to determine the optimal IMT regimen for this special population.
Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient Hanafi, Christi Giovani Anggasta; Nurwidya, Fariz; Lestari, Wiji; Agustin, Heidy; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.6-14

Abstract

Introduction: As one of the leading causes of death worldwide, pulmonary tuberculosis (PTB) is an infectious disease that continues to pose a serious threat to public health. The presence of cavities in radiological imaging of patients with PTB is associated with malnutrition, age, gender, and other comorbidities, including diabetes mellitus. This study aimed to find the association between nutritional status and lung cavity in PTB patients. Methods: This was an analytical observational study with a cross-sectional design that involved 134 adult patients who were diagnosed with PTB at Persahabatan National Respiratory Referral Hospital, Jakarta. All patients were interviewed using a questionnaire for sociodemographic and anthropometric data, the nutritional status was assessed using the subjective global assessment (SGA), and the lung cavity was determined using a chest X-ray interpreted by radiologists. The Chi-square test was performed using the Statistical Package for the Social Sciences (SPSS) version 25 for Windows. Results: Of 134 PTB patients, 61.9% were males, and 92.5% were from the 18-59 years old age group. Based on the SGA score, 77 (57.5%) were grouped as mild-moderate malnutrition/SGA B and 22 (16.4%) as severe malnutrition/SGA C. Lung cavity was found in 42 (31.3%) patients. The analysis showed that malnutrition was statistically significantly associated with lung cavity with OR=6.933 (95%CI 1.986-24.205; p=0.002) and the adjusted OR were 7.303 (95%CI 2.060-25.890; p=0.002) after controlling for age, sex, smoking, education, and comorbidities. Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.

Page 28 of 33 | Total Record : 321

 26   27   28   29   30 

Filter by Year

2015 2025


Reset
Filter By Issues
All Issue Vol. 11 No. 3 (2025): September 2025 Vol. 11 No. 2 (2025): May 2025 Vol. 11 No. 1 (2025): January 2025 Vol. 10 No. 3 (2024): September 2024 Vol. 10 No. 2 (2024): May 2024 Vol. 10 No. 1 (2024): January 2024 Vol. 9 No. 3 (2023): September 2023 Vol. 9 No. 2 (2023): May 2023 Vol. 9 No. 1 (2023): January 2023 Vol. 8 No. 3 (2022): September 2022 Vol. 8 No. 2 (2022): May 2022 Vol. 8 No. 1 (2022): January 2022 Vol. 7 No. 3 (2021): September 2021 Vol. 7 No. 2 (2021): May 2021 Vol. 7 No. 1 (2021): January 2021 Vol. 6 No. 3 (2020): September 2020 Vol. 6 No. 2 (2020): May 2020 Vol. 6 No. 1 (2020): January 2020 Vol. 5 No. 3 (2019): September 2019 Vol. 5 No. 2 (2019): Mei 2019 Vol. 5 No. 1 (2019): Januari 2019 Vol. 4 No. 3 (2018): September 2018 Vol. 4 No. 2 (2018): Mei 2018 Vol. 4 No. 1 (2018): Januari 2018 Vol. 3 No. 3 (2017): September 2017 Vol. 3 No. 2 (2017): Mei 2017 Vol. 3 No. 1 (2017): Januari 2017 Vol. 2 No. 3 (2016): September 2016 Vol. 2 No. 2 (2016): Mei 2016 Vol. 2 No. 1 (2016): Januari 2016 Vol. 1 No. 3 (2015): September 2015 Vol. 1 No. 2 (2015): Mei 2015 Vol. 1 No. 1 (2015): Januari 2015 More Issue