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Jurnal Prima Medika Sains
Published by Universitas Prima Indonesia
ISSN : 26863502     EISSN : 27146707     DOI : https://doi.org/10.34012/jpms
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Prima Medika Sains adalah jurnal ilmiah di bidang kesehatan dan kedokteran yang terbit dua kali dalam setahun yaitu pada bulan Juni dan Desember. Diterbitkan oleh Universitas Prima Indonesia yang secara teknis dikelola Program Studi Magister Kesehatan Masyarakat Fakultas Kedokteran Universitas Prima Indonesia. Berisi tulisan hasil penelitian lapangan atau laboratorium maupun studi pustaka di bidang kesehatan dan kedokteran.
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 24 Documents
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Search results for , issue "Vol. 6 No. 2 (2024): December" : 24 Documents clear
Antioxidant test of crude extract of secondary metabolites from Fusarium sp. isolate of rizosphere of cat’s whisker Piska, Finna; Zega, Sati Angriani; Hutauruk, Rico Halim; Septia, Evianti Dwi; Meutia, Rena
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5344

Abstract

Antioxidants are compounds needed in the prevention and therapy of diseases such as diabetes mellitus, cancer and premature aging. Over time, secondary metabolite compounds as antioxidants can be obtained from microbes, namely those originating from the endophyte and rhizosphere of plants. Based on previous research, secondary metabolites that act as antioxidants are flavonoids and phenolics, with phenolic compounds and flavonoids can bind free radicals through hydroxyl groups present in their aromatic rings. Microbes that live on medicinal plants will have similarities in producing secondary metabolites which can also be used as medicine. Fusarium sp. Laboratorium Basic Science UNPRI (LBSU) isolate is an isolate isolated from the rhizosphere of the cat's whisker plant (Orthosiphon stamineus). The cat's whisker plant is known to be an antioxidant. This study aims to test the antioxidant crude extract of secondary metabolites from Fusarium sp. LBSU. The method for isolating secondary metabolites is by liquid fermentation, then extracted using ethyl acetate and tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The antioxidant test results were obtained from the DPPH radical inhibition value by Ethyl acetate Extract of Fusarium sp. LBSU (EEF) is 44%, while Vitamin C is 88%. Thus, the ability to capture DPPH free radicals by EEF is 44%, weaker than Vitamin C.
Antibacterial test of secondary metabolites of Rhizosphere bacterial isolates of cat whisker against Escherichia coli and Staphylococcus aureus Septia, Evianti Dwi; Hutauruk, Rico Halim; Razoki, Razoki; Piska, Finna
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5544

Abstract

The rhizosphere is the zone between the root surface and soil. Rhizosphere bacteria can produce metabolites that are antibacterial because they produce phytotherapeutic compounds that have the same properties as those produced by the plant. The purpose of this study was to isolate secondary metabolite compounds from the rhizosphere bacteria of cats’ whisker plants (Orthosiphon stamineus) as antibacterial agents against Escherichia coli and Staphylococcus aureus. This study began with the isolation of rhizosphere bacteria, purification, bacterial characterization, bacterial fermentation, and antibacterial tests. The results of the isolation of Orthosiphon stamineus rhizosphere bacteria obtained as many as six isolates, with each isolate coded as RKK-1, RKK-2, RKK-3, RKK-4, RKK-5, and RKK-6. The results showed that RKK-5 had an inhibition zone against Escherichia coli with a diameter of 8.5 mm. Based on these results, it can be concluded that RKK-5 has a moderate response to Escherichia coli.
Analysis of the potential of memelong leaves (Philodendron giganteum) as an antioxidant and antimicrobial Silitonga, Martha; Sitompul, Mutiara Rolika Putri; Gulo, Agnes; Anggeria, Elis
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5552

Abstract

Ornamental plants are plants whose main function is to decorate. Many ornamental plants have benefits, one of which is the Philodendron plant. It is important to know the benefits of antioxidants and antimicrobials that ornamental plants have and can be used to improve health. The research aimed to determine the potential of Memelong (Philodendron giganteum) as an antioxidant and antimicrobial. The research carried out was empirical research at the FKKGIK UNPRI Laboratory for 1 month. The samples used were all Memelong leaves. Memelong leaf extract is made by maceration. Next, carry out phytochemical tests including alkaloid testing, flavonoid content testing, saponin testing, testing for the presence of tannins, and testing for triterpenoids and steroids. The antioxidant activity test was carried out using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The antimicrobial activity test was carried out using the paper disc diffusion method. Data analysis using univariate presented in the form of tables and graphs descriptively. The results of this study have potential as antioxidants based on antioxidant tests using the DPPH method with sample concentrations of 400 ppm 14%, 600 ppm 16%, 800 ppm 19%, and 1000 ppm 27%, but the results are still smaller when compared to the vitamin C test results. However, in the antibacterial activity test on Memelong leaf extract, there was no inhibition zone in the 25% formulation, an average of 0.50%, an average of 0.75%, an average of 0, the K(+) was found to be an average of 18,85 diameter of inhibition zone. The research conclusion is that the leaves of Memelong are proven to contain antioxidants.
Urgent release of constriction band syndrome of the leg with single-stage Z-plasty procedure in neonates: A case series Winanto, Iman Dwi; Sofyan, Jefryan; Muchtar, Muhammad Arafat; Guci, Ricovially Davya
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5597

Abstract

The congenital constriction band syndrome (CCBS) is a group of fetal abnormalities with myriad of clinical presentation that is characterized by the presence of a fibrous band that encircles fetal tissues in utero. It is a rare disease with a reported incidence of 1/15,000 live births. The disease is treated with release of the constricting band with Z-plasty, where it is classically done as a two-stage procedure. Single stage z-plasty is a relatively new approach that still needs more reports regarding to its result. Our cases described successful release with a single stage Z-plasty reconstruction in the setting of an urgent surgery in neonates aged less than 48 hours.
Radiological imaging of pulmonary cavitations in adult multidrug-resistance and extensively drug-resistance tuberculosis patients Ginting, Justin; Dominika, Katharina Ellen; Sanjaya, Ardo; Gunadi, Julia Windi
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5639

Abstract

Mycobacterium tuberculosis is a pathogen that causes the infectious disease tuberculosis. Based on its resistance, tuberculosis can be divided into Drug-susceptible Tuberculosis (DS-TB) and Drug-resistant Tuberculosis (DR-TB). MDR-TB is one type of DR-TB when M. tuberculosis complex strains unresponsive to rifampicin and isoniazid. Another type of DR-TB is XDR-TB, A strain of M. tuberculosis that was unresponsive to rifampicin, isoniazid, fluoroquinolones, and at least 1 drug from group A. Research on the comparison of lung cavities in DS-TB, MDR-TB, and XDR-TB is still limited, this literature review is intended to explore comparative studies of lung cavity radiography in adult MDR-TB and XDR-TB patients. This literature review uses secondary data from literature searches through PubMed and Google Scholar by searching for keywords such as "Pulmonary Cavity", "Multidrug Resistance Tuberculosis", "Extensively Drug Resistance". Articles were included in the inclusion criteria if published in national or international journals with topics that match the research objectives within the last ten years. We found 7 studies that compared the radiologic features of lung cavities in individuals who have been diagnosed with DS-TB, MDR-TB, and XDR-TB. The literature review results showed that the radiologic features of cavities from DR-TB appear to be more massive than those in DS-TB. Similarly, in XDR-TB, the radiological picture of cavities appears more massive than in MDR-TB. The conclusion that can be drawn is that cavitation can be seen in DS-TB and DR-TB, and more cavitation in XDR-TB than in MDR-TB and DS-TB.
Recurrent anterior dislocation of radial head treated with ulnar distraction osteotomy and reconstruction of annular ligament using palmaris longus tendon with bioabsorbable screw anchoring: A case report Winanto, Iman Dwi; Siregar, Alamsyah Faritz; Nugraha, Tesar Akbar
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5663

Abstract

Introduction: Radial head dislocation in children may be either congenital, an isolated injury or more commonly part of a complex injury to the elbow. Isolated traumatic radial head dislocation in children is a rare and easily missed condition.The reported case shows various treatment and intervention with ulnar osteotomy and annular ligament reconstruction in order to reach the definitive reduction of recurrent dislocation of radial head. Case Presentation: Male 9 years old with anterior dislocation of the radial head, came with difficulty on flexing his elbow due to bony prominence on his anterior elbow. He had recurrent radial head dislocation with redundant annular ligament. From the physical examination there was a prominent radial head on anterior region of elbow. From x-ray examination we found anterior dislocation of ulnar head without any fracture or deformity of ulna. Patient underwent ulnar distraction osteotomy to achieve radial traction and allow stable reduction of radial head. After 5 months he had reconstruction of annular ligament with palmaris longus tendon graft and anchoring with bioabsorbable screw in order to reduce and stabilize the radial head. Conclusion: In this case we found ulnar osteotomy may gave improvement for the reduction of the radial head. But additional annular ligament reconstruction give stability of the radial head which will held in place with full range of motion of the elbow. So this combined procedures hopefully can gave best achievement and satisfactory results of the children and last a lifetime.
Surgical hip dislocation for posterior hip dislocation with femoral head fracture pipkin classification type II: A case report Siregar, Chairiandi; Rambe, Syahrul Ramadan; Renaldi, Rizal
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5664

Abstract

Introduction: Surgical hip dislocation is a powerful and safe approach. It allows for simultaneous treatment of intra-articular pathologies, either preexisting or as a result of trauma, and improves long-term results. It can be used to treat a wide variety of intra-articular pathologies that would be extremely challenging or impossible arthroscopically or with other common open approaches to the hip. Surgical hip dislocation has been used in the trauma setting for open reduction and internal fixation of femoral head fractures and posterior wall acetabular fractures that do not extend into the posterior column. Case Report: A 28-year-old male with a posterior hip dislocation had difficulty flexing and extending his hip, internal rotation, and shortening his leg. During physical examination, we found a prominent head left femur on the posterior gluteus. During an X-ray examination, we found a posterior dislocation of the femoral head with a fracture. Treatment: Open reduction is preferable whenever there is a nonconcentric hip reduction. This reduces the risk of additional trauma, thus avoiding abrasion to the articular cartilage and bone contusion at the head of the femur. The surgeon who performs open reduction must be fully familiar with the surgical anatomy of the hip and must be aware of the fixation techniques used on fractures in this region. The fragment can be fixed both with 2.0-mm Herbert screws or mini fragment screws, taking care of the head of the implant into the articular cartilage. The joint capsule should always be repaired. When femoral head impaction is present, and the patient is an adult, the goal is to save the femoral head. In this situation, it is preferable to use the Watson-Jones or anterolateral approach with greater trochanteric osteotomy to perform the controlled dislocation of the hip.
Identifying risk factors for stunting among toddlers at PPA Helefanika, Gunungsitoli City Purba, Eva Marlina; Damanik, Hosiana Rodearni; Harefa, Edward; Halawa, Alfrin
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5692

Abstract

Stunting exerts detrimental effects on health, growth and development, and economic outcomes. These adverse impacts encompass elevated risks of morbidity and mortality, cognitive and language delays, and increased healthcare expenditures. Given these significant consequences, stunting has become a global health priority. This cross-sectional study investigates the influence of maternal height and exclusive breastfeeding practices on the incidence of stunting among children under five years of age in Gunungsitoli City. Conducted from February to April 2024, the study initially included 375 children aged 12–59 months. Due to specific inclusion criteria, the final sample comprised 63 participants selected through purposive sampling. The independent variables analyzed were maternal height and exclusive breastfeeding, with stunting incidence serving as the dependent variable. Data collection employed five questionnaires, and maternal height was measured using a stadiometer. Statistical analyses, including univariate analysis and chi-square tests, were performed using SPSS version 25.0 to explore associations between the variables. The results revealed that most mothers had an elementary school education (34.85%), exhibited normal height (63.64%), and the majority of children were exclusively breastfed (60.61%). Statistical analysis demonstrated a significant association between maternal height and stunting incidence (p=0.026), indicating that children born to shorter mothers were at higher risk of stunting. Furthermore, a significant association was found between exclusive breastfeeding practices and stunting incidence (p=0.003), with children who were not exclusively breastfed having a 3.94 times greater odds of experiencing stunting. This study concludes that maternal height and exclusive breastfeeding practices are crucial factors influencing the incidence of stunting in children.
Effect of gotu kola leaf extract cream on collagenization and histopathological picture of rat skin exposed to Ultraviolet B light Al Hamid, Muhammad; Novita, Cut Elvira; Wijaya, Johanna Fransiska; Djamin, Djamin
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5743

Abstract

Changes due to genetic conditions (internal and chronological aging) overlap with aging symptoms triggered by environmental conditions (extrinsic aging). Until recently, exposure to the sun's ultraviolet (UV) radiation was considered the leading cause of extrinsic skin aging; both UVB (290-320 nm) and UVA (320-400 nm) caused photoaging, and due to their physical properties, UVB radiation was especially harmful to the skin condition. This study aims to analyze and test the effect of administering gotu kola leaf extract cream (Ceentella asiatica) on collagenization in Wistar rats (Rattus norvegicus) exposed to ultraviolet-B light. This study uses a posttest-only control group design, where only observations are made to the control group and treatment after the treatment is given. The research results show that gotu kola leaf extract contains phytochemicals that can be used as an antioxidant and anti-inflammatory ingredient because they contain flavonoids, saponins, tannins, and phenolic compounds. This research concludes that pegagan leaf extract contains phytochemicals that can be used as medicinal ingredients because it contains high antioxidant and anti-inflammatory compounds. The average percentage of collagen growth in the control group compared to treatment groups P1, P2, and P3 after exposure to UVB light was very high, and the group control of collagen growth was not significant and tended to be stable.
The effectiveness of butterfly pea flower extract cream on collagen synthesis in post-dermapen wound healing Fatimah, Aulia Nurul; Hutabarat, Bartimeus Nicomama; Chairul, Muhammad
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5744

Abstract

Skin wounds, whether acute or chronic, disrupt the integrity of the largest organ in the human body. The healing process involves intricate stages, with collagen playing a crucial role. Microneedling therapies, such as dermapen, stimulate collagen production and improve skin texture. This study investigated the effect of butterfly pea flower (Clitoria ternatea) extract cream on collagen production during the healing of dermapen-induced wounds in obese Wistar rats. Dermapen treatment, a minimally invasive cosmetic procedure, induces controlled skin punctures to stimulate collagen production. However, obesity can impair wound healing. This study aimed to determine if butterfly pea extract, rich in antioxidants, could enhance collagen synthesis and accelerate wound closure in obese rats. The results demonstrated that all treatment groups with butterfly pea extract cream exhibited significantly faster wound healing compared to the control group. Histopathological analysis revealed denser collagen deposition in the treatment groups, particularly those treated with 7% and 10% extract cream. These findings suggest that butterfly pea extract cream may have therapeutic potential in promoting efficient wound healing, particularly in obese individuals, by enhancing collagen production and accelerating the recovery process.

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