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Majalah Biomorfologi (Biomorphology Journal)
Published by Universitas Airlangga
ISSN : 02158833     EISSN : 27160920     DOI : 10.20473/mbiom.v30i1.2020.1-7
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health
Majalah Biomorfologi publishes articles in the form of original research report, excel-literature review, communication and special case report. The scope of this journal includes Medicine and Health sciences, focusing in basic and applied Anatomy and Histology (i.e., neuroscience, medical and health education, anthropology, clinical genetics, embryology, medical education, clinical anatomy, histotechnics, and photomicroscopy) although other correlated topics are also welcomed.
Arjuna Subject : Kedokteran - Anatomi
Articles 123 Documents
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CLINICAL PROFILE OF TYPE-1 DIABETES PEDIATRIC PATIENTS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL SURABAYA: CORRELATION OF GROWTH STATUS AND METABOLIC CONTROL Grawira Drana Putra Respati; Muhammad Faizi; Agung Pranoto; Mia Ratwita Andarsini
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.7-13

Abstract

Highlights1. Diabetes mellitus type 1 (DM) is a chronic autoimmune illness characterized by insulin insufficiency and hyperglycemia as a consequence.2. Stable HbA1c levels may be indicative of improved growth rates. AbstractBackground: Type-1 diabetes mellitus (DM) is a chronic auto-immune disease characterized by insulin insufficiency and resultant hyperglycemia caused by the destruction of insulin-producing beta cells in the pancreas. Metabolic control in type-1 DM affects the metabolism of patients, one of which is growth status, which is influenced by growth hormone. Improved growth rates can indicate stable HbA1c levels. However, whether growth is affected by the degree of diabetic control is still debatable. Objective: This study was conducted to determine whether the metabolic control correlates with growth status of children with type-1 diabetes in the Endocrine Polyclinic at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Material and Method: Retrospective observational analysis with a cross-sectional method was conducted on 96 type-1 DM patients at Dr. Soetomo General Academic Hospital Surabaya, Indonesia. The analysis was carried out using Chi-Square test to determine whether there was a correlation. Result: From a total of 96 pediatric patients, the majority was male (54.1%), patients with high-risk metabolic control were 79.2%, and those with z-score normal category were 62.5%. The results indicated no significant correlation between growth status and metabolic control of pediatric patients, with Chi-Square test results showed p=0.421 (p>0.05). Conclusion: There was no significant correlation between growth status and metabolic control of type-1 diabetes pediatric patients at the Endocrine Polyclinic Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
THORACIC CT-SCAN WITH EGFR MUTATIONS IN PULMONARY ADENOCARCINOMA PATIENTS WITH PULMONARY METASTASES AT DR. MOEWARDI HOSPITAL, SURAKARTA, INDONESIA Viska Wahyu Arianti; Widiastuti Soewondo; Sulistiyani Kusumaningrum; Muhammad Lukman Hermansyah; Yusup Subagio Sutanto; Hari Wujoso
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.1-6

Abstract

Highlights The thoracic CT scan can be an alternative evaluation before administering EGFR-targeting medicine to patients. EGFR is now a therapeutic target for lung cancer.   Abstract Background: EGFR mutation is one of the molecular markers associated with prognosis and therapy in lung adenocarcinoma patients, including with lung metastases. The predominant imaging modality for assessing lung cancer is a chest CT scan, which correlates with prognosis. Objective: This study aimed to explore the association between characteristics of lung adenocarcinoma based on chest CT-Scan and EGFR mutation in lung adenocarcinoma with lung metastases. Material and Method: This study involved 65 lung adenocarcinoma patients in Dr. Moewardi Hospital, Surakarta, Indonesia, from January 2018-December 2020. Result: Chest CT-Scan and EGFR mutation were assessed in all subjects. EGFR mutation was found in 32 (49.8%) subjects. The risk of EGFR mutation was found to be higher in patients with lung adenocarcinoma who had lung metastases in a peripheral location (OR=11.56; 95%CI 3.57-37.33; p<0.001), tumor size <4 cm (OR=8.00; 95%CI 2.64-24.22; p<0.001), and semi-solid density (OR=5.21; 95%CI 1.79-15.19; p=0.002). Conclusion: EGFR mutation is associated with tumor location, size, and thickness based on chest CT-Scan in lung adenocarcinoma with lung metastases patients.
THE HDL LEVEL IN DIABETIC FOOT ULCER PATIENTS WITH AND WITHOUT AMPUTATION AT DR. SEOTOMO GENERAL ACADEMIC HOSPITAL SURABAYA Ahmed Eliaan Shaker Abuajwa; Hermina Novida; Heroe Soebroto; Yan Efrata Sembiring
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.30-37

Abstract

Highlights1. Diabetes mellitus is a category of metabolic disease characterized by uncontrolled hyperglycemia.2. This study revealed no statistically significant differences in total cholesterol, TG, LDL, HDL, or LDL/HDL ratio between amputated and non-amputated DFU patients. AbstractBackground: Diabetic foot ulcers (DFU) are microvascular and macrovascular consequences of diabetes and are associated with neuropathy, vascular disease, and immunosuppression. Increased blood glucose levels may result in the glycosylation of proteins in the nerve cells of the foot, leading to ischemia and cellular disturbances that can damage muscular, sensory, and autonomic neurons. Objective: To compare the lipid profiles of amputated and non-amputated DFU patients. Material and Method: This was a cross-sectional, analytic, retrospective research using total sample approach to analyze the medical records of all diabetes patients admitted to Dr. Soetomo General Academic Hospital between February 2018 and December 2020, with or without amputation. Result: The average age of DFU patients at Dr. Soetomo General Academic Hospital was 55.6 9.4 years, and the majority of patients were female (57%). Diabetic foot ulcers were most prevalent in the age group ≥50 years old (74%), amputated DFU patients had larger mean total cholesterol, TG, LDL, and HDL than non-amputated DFU patients, although the difference was not statistically significant. While the mean LDL/HDL ratio was greater in non-amputated DFU patients, the difference was statistically insignificant. The HDL level was low in 84% of amputated DFU patients, whereas in non-amputated DFU patients it was 81%. Conclusion: This research showed no significant variation in total cholesterol, TG, LDL, HDL, or the LDL/HDL ratio between amputated and non-amputated DFU patients. Most DFU patients with and without amputations had low HDL values.
DIFFERENTIATION OF SPINAL TUBERCULOSIS AND METASTATIC SPINAL TUMOR USING MRI FEATURE: A SYSTEMATIC REVIEW Justicia Izza Tsuroya; Muhammad Faris; Paulus Rahardjo
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.44-51

Abstract

Highlights1. Lesions that are regularly diagnosed in the spine include TB of the spine and tumors that have spread throughout the body.2. The examined papers included 35 individuals with tuberculous spondylitis and 31 patients with metastatic spinal malignancies.3. A methodology for MRI imaging and an accurate medical history will aid in establishing an accurate diagnosis. AbstractBackground: Spinal tuberculosis and metastatic tumors are commonly diagnosed lesions in the spine. Tuberculosis spondylitis, also known as Pott's Disease, is the most common extrapulmonary tuberculosis disease. MRI is the gold standard for early diagnosis because there is no significant difference in the results of clinical manifestations and histopathological examination. A biopsy will usually be used for a final exam for diagnosis. Objective: To provide information to confirm the diagnosis of TB spondylitis cases and metastatic spinal tumors. Method: A literature search was conducted via PubMed, Science Direct, and Scopus by selecting studies according to inclusion and exclusion criteria. The quality and risk of bias assessments were performed using Joanna Briggs Institute (JBI) tools. Overall, 35 spinal tuberculosis and 31 metastatic spinal tumor patients from 2 studies were reviewed. Result: Of the 35 patients with tuberculous spondylitis and 31 patients with metastatic spinal tumors from the two studies reviewed. It was found that the thorax was the most common region. The following imaging findings were of statistical significance (p<0.05): skip lesion, solitary lesion, intraspinal lesion, concentric collapse, abscess formation (paraspinal, intraosseous, and epidural lesions), and syrinx formation. Conclusion: An MRI imaging protocol and correct medical history will help establish an accurate diagnosis. Skip lesions, abscesses, and modular lesion margins are considered for diagnosis.
BODY MASS INDEX WITH SYSTOLIC AND DIASTOLIC BLOOD PRESSURE AT A PUBLIC HEALTH CENTER IN SURABAYA, INDONESIA Bella Patricia Simanjorang; Florentina Sustini; Sundari Indah Wiyasihati
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.14-19

Abstract

Highlights1. The Body Mass Index (BMI) measures how much fat the body carries.2. Obesity and overweight are characterized by an excessive buildup of fat that may be detrimental to health. AbstractBackground: Body Mass Index (BMI) is an indicator of body fat. It is classified as underweight, normal, overweight, and obese. Obesity is a risk factor for hypertension (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg). Objective: To analyze the correlation between BMI with systolic and diastolic blood pressure. Methods: This was an observational research with a cross-sectional design, and the samples consisted of 60 individuals aged 35 to 59 selected using accidental sampling. Blood pressure was the dependent variable whereas BMI was the independent variable. Data were analyzed using Pearson and Spearman correlation tests. Results: There were 44 females (73.3%) and 16 males (26.7%). The largest age groupings were between 45-49 and 50-54 years (31.7%), while the smallest was between 55-59 years (5%). Thirty-three samples (55%) were overweight (>25 kg/m2), 32 samples (53.4%) had systolic blood pressure above normal (≥120 mmHg), and 42 samples (70%) had diastolic blood pressure above normal (≥80 mmHg). The Pearson correlation test between BMI and systolic blood pressure showed a weak correlation (p=0.009 r=0.336). The Spearman correlation test between BMI and diastolic blood pressure showed a weak correlation (p=0.013 r=0.321). Conclusion: There was a weak correlation between BMI with systolic blood pressure, and there was a weak correlation between BMI with diastolic blood pressure in this study.
EFFECTIVENESS OF THE LARVACIDE ETHANOL EXTRACT OF JACKFRUIT (Artocarpus heterophyllus L.) AGAINST Aedes aegypti LARVA Selvi Marcellia; Rediyanto; Dewi Chusniasih
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.68-74

Abstract

Highlights Jackfruit leaf extraction was performed by percolation method using 96% ethanol solvent with flavonoid, saponin, tannin, alkaloid, and steroid terpenoid test. Jackfruit leaf extract was effective as a larvicide against larvae of Aedes aegypti. Abstract Background: Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus, which enters the human bloodstream through the bite of a mosquito of the Aedes genus. The DHF control program is carried out by breaking the vector chain, the Aedes aegypti larvae. The underutilized jackfruit (Artocarpus heterophyllus L.) leaves contain secondary metabolites that have the potential to be larvicides. Secondary metabolites that have the potential as larvicides are flavonoids, saponins, tannins, alkaloids, steroids, and terpenoids. Objective: This study was to determine the effectiveness of jackfruit leaf extract as a larvicide in controlling Aedes aegypti vectors and to determine the most effective concentration of jackfruit leaf extract as an Aedes aegypti larvicide. Material and Method: The study was an analytic observational study using a cross-sectional design. The study was conducted from March 2022 to April 2022. Jackfruit leaf extraction was performed by percolation method using 96% ethanol solvent with flavonoid, saponin, tannin, alkaloid, and steroid terpenoid test. The data were analyzed with SPSS Anova (parametric) and Kruskal Wallis non-parametric. Result: In the extraction of 243 gr jackfruit leaves using the percolation method, the yield was 24.3%. Jackfruit leaf extract was effective as a larvicide against Aedes aegypti larvae, even at a concentration of 0.75%. The LC50 results for the total concentration obtained were 0.331% with strong toxicity (poisonous). Jackfruit leaf extract at a concentration of 2% yielded mortality value of 91.2 at 8 hours and at a concentration of 3% it yielded mortality value of 96 at 8 hours. Conclusion: Jackfruit leaf extract was effective as a larvicide against Aedes aegypti mosquito larvae.
GLUCOSE LEVELS OF PLEURAL EFFUSION FLUID AND HER2 STATUS IN PLEURAL-METASTATIC BREAST CANCER Muhammad Dhanny Irawan; Desak Gede Agung Suprabawati; Heru Purwanto
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.75-81

Abstract

Highlights Patients with breast cancer who have distant metastases are frequently impacted by pleural effusion. HER2 status was found to be substantially correlated with glucose levels in pleural effusion fluid. Abstract Background: Patients diagnosed with breast cancer who have also been affected by distant metastases often suffer from pleural effusion. The prognosis of malignant pleural effusions worsens when glucose levels in the pleural fluid are low. Elevated levels of anaerobic glycolysis due to HER2 overexpression cause breast cancer cells to take in more glucose. Objective: This study aimed to identify any correlation between glucose levels in pleural fluid and HER2 status in breast cancer patients. Material and Method: In this research, 35 female patients with thoracocentesis pleural metastatic breast cancer participated in an analytical observational study using a cross-sectional design. Patients who had undergone thoracocentesis had their HER2 status determined based on the information included in their medical records in the Integrated Oncology Clinic (Poli Onkologi Satu Atap (POSA)) Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. After obtaining data on glucose levels in pleural fluid and HER2 status, statistical analysis was carried out to determine the relationship between the two parameters. Results: The statistical test results with a 95% significance level obtained p=0.004 (p<0.05), so it could be statistically said that there was a significant relationship between the glucose level of pleural fluid effusion with HER2 status. The obtained OR values were 10.93 and CI=95% (1.87-63.97), so that it could be interpreted that the low-glucose levels of pleural effusion fluid increase the proportion of patients with positive HER2 compared to not low-glucose levels of pleural effusion fluid. The correlation between the glucose level of pleural effusion fluid and HER2 status was moderately positive (Chi-Square Contingency Coefficient = 0.44). Conclusion: Glucose levels in pleural effusion fluid were significantly correlated with HER2 status.
TUBERCULIN SKIN TEST AND INTERFERON-γ RELEASE ASSAY ON THE DIAGNOSIS OF TUBERCULOUS SPONDYLITIS Hadid, Tsabita; Faris, Muhammad; Betty Agustina Tambunan; Caesaroy Afif Wibowo
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.92-99

Abstract

Highlights                                                                                                                                      TST and IGRA have a significant correlation with the diagnosis of patients with Tuberculous Spondylitis. Various factors may affect the results of TST and IGRA. Thus, the use of TST and IGRA can be adjusted according to the condition of the hospital, the availability of diagnostic tools, the health worker's physical examination results, and the patient's medical history. Abstract Background: Tuberculous spondylitis or Pott's disease is extrapulmonary tuberculosis that is still a concern to health workers because of the broad spectrum of its clinical symptoms. Delay in diagnosis is very common in this disease. Therefore, its diagnostic tool needs to be thoroughly reviewed to determine its effectiveness. The diagnostic tools studied in this study were Tuberculin Skin Test (TST) and Interferon-γ Release Assay (IGRA). Objective:  To analyze the role of TST and IGRA as diagnostic tools for the diagnosis of tuberculous spondylitis. Material and Method: This study used a systematic review method to analyze topic-related kinds of literature written in English and Indonesian found on PubMed, Scopus, ProQuest, and Web of Science databases. The literature screening process was carried out based on the PRISMA 2020 Guidelines. Result:  Sixteen types of literature were included for a total of 116 patients. TST was detected positive in 45 (63%) and negative in 21 (30%) of a total of 66 patients with Pott's disease. IGRA was detected positive in 51 (77%), negative in 8 (12%), and indeterminate in 2 (3%) of a total of 61 patients with Pott's disease. Conclusion:  TST and IGRA results significantly correlate with the diagnosis of tuberculous spondylitis. Both tests are still relevant for use in the diagnosis of the disease. IGRA and TST are used according to the needs of health workers and patients' health backgrounds.
EFFECT OF MODIC CHANGE ON CLINICAL OUTCOME OF CERVICAL DISC HERNIATION PATIENTS UNDERGOING ANTERIOR CERVICAL DISCECTOMY AND FUSION Wibowo, Caesaroy Afif; Sri Andreani Utomo; Muhammad Faris; Tsabita Hadid
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.100-108

Abstract

Highlights                                                                                                                                      The presence of preoperative Modic changes tends not to affect clinical outcomes after ACDF due to degenerative pathology, including disc herniation. Preoperative Modic changes are correlated with a worse preoperative picture. Abstract Background:  Modic Change (MC) is a phenomenon that can be found in Magnetic Resonance Imaging (MRI) of patients with degenerative spinal diseases and in the cervical region. The effect of Modic change on the clinical outcome of postoperative patients has not been fully established. Anterior Cervical Discectomy and Fusion (ACDF) is a procedure that has become the gold standard in treating cervical disc herniation because it is able to eliminate pathological lesions and prevent the recurrence of nerve compression. Objective:  This study aimed to determine the effect of MC on the clinical outcome of patients undergoing ACDF therapy due to degenerative disc pathology, including cervical disc herniation. Material and Method: This was a systematic review using filtered literature based on PICOs. The variables examined in this study were "modic change", "ACDF", and "clinical outcome". Data were collected from three databases, which were then screened based on eligibility criteria, assessed for study quality, and reviewed using a qualitative descriptive method. Result:  A total of six articles published between 2017 and 2021 were included in this study. This study was an observational study with a retrospective cohort method. Preoperative Modic changes tend not to affect clinical outcomes after ACDF. Conclusion:  The presence of preoperative Modic changes tends not to affect clinical outcomes after ACDF due to degenerative disc pathology, including disc herniation, but remains a risk factor for postoperative disability and provides a worse preoperative picture.
MEDICATION ADHERENCE IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CORONARY HEART DISEASE Shafiero Muhammad Elsya Putera; Sony Wibisono; Andrianto; Hermina Novida
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.109-117

Abstract

Highlights                                                                                                                                      Type 2 diabetes mellitus (T2DM) that is not appropriately handled can result in macro- or micro-complications. Medication adherence is one of the most important efforts to do to prevent complications in chronic diseases such as T2DM. Abstract Background:  Diabetes medication non-adherence can aggravate the patient's condition and raise the chance of acquiring diabetes complications such as coronary heart disease. Medication adherence can help prevent micro- and macrovascular problems. Objective: This study aimed to investigate the medication adherence of type 2 diabetic patients with coronary heart disease. Material and Method: This research used a systematic literature review for the research design, with a PRISMA chart as a guideline. Researchers searched 3 databases using predefined keywords: PubMed, Google Scholar, and ScienceDirect. Result:  The search yielded 3.373 pieces of literature, and six pieces that fit the requirements were chosen. The total number of people who responded was 9.950. More men over 60 years old who have had diabetes for more than 5 years, who are taking oral medication, insulin, or combination treatment, and who are ex-smokers were shown to have characteristics of people with type 2 diabetes mellitus and coronary heart disease. Results from a systematic literature review revealed five kinds of literature with low medication adherence levels and one literature with a high medication adherence rate. Conclusion:  Medication adherence differs among type 2 diabetic patients with coronary heart disease. More research, however, has revealed that the level of medication adherence in type 2 diabetic patients with coronary heart disease remains low.

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