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Research Center for Smart Molecule of Natural Genetics Resources (SMONAGENES) office: 2nd floor MIPA Building, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Jl. Veteran Malang, East Java, Indonesia – 65145
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JSMARTech : Journal of Smart Bioprospecting and Technology
Published by Universitas Brawijaya
ISSN : 26860805     EISSN : 27147894     DOI : https://doi.org/10.21776/ub.jsmartech.2020.001.02.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
JSMARTech : Journal of Smart Bioprospecting and Technology (p-ISSN: 2686-0805, e-ISSN : 2714-7894) is an Open Access Scientific Journal published by Research Center of Smart Molecule and Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Malang, East Java, Indonesia, since 2019. It is a journal covering of bioprospecting, biochemical, biotechnology, bioinformatics, natural product, pharmaceuticals, biomedical, genetics engineering, nutrigenomic, and nanotechnology. The journal publishes a manuscript written in English for original research papers, short communications, and review articles. The paper published in this journal implies that the work described has not been, and will not be published elsewhere, except in abstract, as part of a lecture, review or academic thesis.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 77 Documents
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Anticancer Potential of Cyanidin and Cyanidin-3-Glucoside Through TrkB Receptor Inhibition: Evidence From Molecular Interaction Docking Kurnianingsih, Nia; Suprapto, Ratih Paramita; Ratnawati, Retty
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.41

Abstract

Cancer remains a global health problem with persisten demand on therapeutic development to inhibit cancer cells growth without harmful effects on healthy cells. Plant bioactive compounds are intensively studied as anticancer via several signalling pathway. Anticancer therapy via inhibition of tropomyosin kinase receptor-B (TrkB) signal was previously proposed as target therapy. The role of plant metabolites cyanidin and cyanidin-3-glucoside as TrkB inhibitor is has not been investigated. This study was aimed to identify physicochemical of cyanidin and cyanidin-3-glucoside as well as determine it’s role towards TrkB receptor signalling pathway through in silico approach. Molecular docking was performed using Hex 8.0.0 software and visualizes using Discovery Studio Visualizer. The energy binding of TrkB with cyanidin and cyanidin-3-glucoside was -263,21 kcal/mol and 281,65 kcal/mol respectively. Complex of cyanidin-3-glucoside had hydrogen and hydrophobic bond more than TrkB-cyanidin complex. The hydrogen bond formed at Lys637, Arg558 and Gly 561 amino residues. Physicochemical analysis demonstrated that both ligand are potential as kinase enzyme inhibitor. Cyanidin-3-glucoside was predicted more potential as anticancer than cyanidin via TrkB receptor inhibition. Future studies are required to confirm current finding both in-vitro and in-vivo models.
Exploration of Secondary Metabolites in Black Pomegranate Peel Extract (Punica granatum L.) as Antioxidants Using DPPH Method Rofiidah, Anisatul; Innaya, Allinha Yusfin; Putri, Nela Vede Rhofa; Maulida, Hilda Jihan; Dewi, Lina Purnama; Al Shofura, Nadya Raisa; Badria, Shoimatul Umi; Faiza, Hilda Wahyu; Hidayah, Ulfa; Ramadhani, Mieta Widya; Rafsanjani, Ramizard; Januarista, Terra; Faisal, Faisal; Ramadhan, Majida
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.46

Abstract

Pomegranate (Punica granatum) is a plant that contains secondary metabolite compounds that can be used as medicinal content. Black pomegranate contains the highest secondary metabolites compared to red pomegranate and white pomegranate, the skin of the pomegranate contains flavonoids, phenols, tannins, and saponins. This study aims to determine the antioxidant activity of black pomegranate peel extract (Punica granatum L.) with the DPPH method. DPPH method is a method to determine the antioxidant activity in the sample by looking at its ability to counteract the free radical compound 2,2-diphenyl-1-picrylhydrazyl. The results of testing the antioxidant activity of black pomegranate skin (Punica granatum L.) produced an IC50 value of 47.51 ppm which can be concluded that black pomegranate skin is classified as very strong. This research is important because there has not been much research on black pomegranate, especially its skin, so there is a need for additional expansion and renewal of the species. In addition, it can be used as the main basis for the advancement of natural materials, especially in the field of health.
Antioxidant Activity Test of Tomato Extract Face Mist (Solanum lycopersium L.) Apsari, Anindya Hana; Rachma, Bashita Rizka; Yulianto, Susilo; Nugroho, Praptanti Sinung Adi
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.52

Abstract

Tomatoes contain compounds that act as natural antioxidants and are useful toward off free radicals. Tomatoes can be used as a basic ingredient in the development of facial cosmetics in the form of face mist. The purpose of this study was to determine the antioxidant activity of face mist tomato extract (Solanum lycopersicum L.). This study used quantitative methods with a descriptive research design. The organoleptic face mist has a yellow color with a distinctive oleum rosae aroma and is liquid. The homogeneity test results show all four homogeneous formulas. pH test results range from 4.71±0.005 to 5.68±0.015. The dry time test results were in the range of 2.39±0.015 – 3.12±0.015 minutes. The color test results on the face mist showed that it was positive for beta-carotene with a blue color. The IC50 value of face mist preparations at F0, F1, F2 and F3 was 208.488 ppm, 124.304 ppm, 73.683 ppm and 56.271 ppm, respectively. F0 face mist preparations are very weak antioxidants, F1 are moderate antioxidants, F2 and F3 are strong antioxidants. From this research can be concluded that the best formula to use F3.
Phylogenetic Study of Several Parasitic Plant Species Based on The atp-1 Gene Sequence Pratama, Ardo Cahya; Karuniasari, Nadaa; Rahmadini, Agnia Fadillah; Ezra, Achmad; Hose, Victor Alvianoes Guterez; Turhadi, Turhadi; Suyanto, Eko; Fatchiyah, Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 2 (2024): JSMARTech Volume 5, No. 2, 2024
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.02.57

Abstract

The distinction between parasitic and non-parasitic plants can be determined by analyzing the atp-1 gene, which plays a vital role in respiration and is known for its high mutation rate. This study analyzed the kinship of parasitic plant subclass species through the construction of a phylogenetic tree based on atp-1 gene sequences. The atp-1 gene sequences of parasitic and non-parasitic plants with a total of 29 species were obtained from NCBI. The sequences were then aligned with ClustalW and analyzed for mutation patterns. Sequences that have been aligned, phylogenetic trees were made with MEGA11 software with the Maximum Likelihood method and analyzed using the iTOL website. The sequences were analyzed for similarity and kinship with Matrix Coefficient and Haplotype Construction. The atp-1 gene proved that parasitic plants (hemiparasites) are furthermore related to non-parasitic plants compared to holoparasite parasitic plants. Besides that, the kinship of parasitic plants can be analyzed by several methods, namely matrix coefficient to measure similarity, DnaSP to analyzing haplotype, and haplotype network to find out detailed information on mutations that occur. Matrix coefficients can also be used to measure specific similarities between species. It was found that the same subclass had high similarities, for example the species Santalum album and Heisteria parvifolia with a genetic distance value of 0.00574. Meanwhile, different subclasses have low similarity, such as Cassytha filiformis and Ombrophytum with a genetic distance value of 0.07871. This study shows that the atp-1 gene is effective in analyzing the kinship between parasitic and non-parasitic plants. Hemiparasites are genetically closer to non-parasitic plants than holoparasites, with higher genetic similarity within the same subclass.
Comparative Insilico Analysis of RuBisCo Proteins of Green, Red, and Brown Seaweeds M, Thangaraj
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.04

Abstract

In this study, Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) was selected from three seaweeds such as Ulva lactuca (Green algae), Gracilaria edulis (Red algae) and Sargassum fusiforme (Brown algae) to predict the physicochemical characters, secondary and 3-D structure properties using appropriate bioinformatics tools. The result showed that, the least percentage amino acid was Cys (0.8%) occurred in G. edulis and the highest percentage of amino acid was Gly (10%) in U. lactuca. Three amino acids such as Lys, Ser and Trp were more or less in same percentage in all the three seaweeds. The maximum molecular weight (MW) was predicted as 54.11 KDa in G. edulis. As per the theoretical pI, the proteins were acidic in nature in all the three seaweeds and the values ranged from 5.62 to 5.98. The instability index (II) values for this protein was 27.05, 29.11, 37.38 in S. fusiforme, G. edulis and U. lactuca respectively which shows the protein was stable.  GRAVY value was found to be -0.110, -0.127, and -0.263 which indicated that the protein was hydrophilic and water-soluble.  The secondary structure of this protein primarily composed of α-helixes and β-sheets, revealing the stable structure. The modeling of the 3-D structure of this protein was performed by Swiss model and the model was validated by PROCHECK and QMEAN. The results of this study may provide valuable insights into fundamental characteristics of RuBisCO proteins in different seaweeds.
Phylogenetic study of Genus Scomberomorus based on cyt b gene in the north and south coast of Java, Indonesia Purba, Laurentia Henrieta Permita Sari; Sutan, Ditha Klarissa; Simanjuntak, Monayanti; Kusumaningrum, Fransisca Victory
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.11

Abstract

Indonesia possessed megabiodiversity especially in marine animals. As the highly commercial commodities, the understanding for species distribution of Spanish mackerel and seerfish (Scomberomorus spp.) plays a key role for their sustainability. Thus, the aim of this study was to map the species distribution of Scomberomorus spp. in Java surrounding waters.  We collected 10 specimens from 4 landing sites in northern and southern coast of Java. Using partial cytochrome b gene fragment (~400 bp), we characterized the gene and haplotype diversity as well as the phylogenetic relationship. Three species of mackerel and seerfish were found in Java coastal line. The genetic differences Scomberomorus sp. ranged from 0 to 14%. By this study, we provide useful data that can be utilized as biodiversity monitoring. In addition, we confirmed that cythocrome b were effective for future application in fishery management and product authentication of mackerel in Java and surrounding areas.
Considering Bali's Agricultural Policies in Implementing the Development of MDA-Path Analysis Rejeki, Sasi Wilujeng Sri; Solimun, Solimun; Nurjannah; Fernandes, Adji Achmad Rinaldo
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.52

Abstract

The agricultural sector plays a vital role in Bali’s economy, culture, and food security, particularly in rice production. However, challenges such as land conversion and fluctuating farmer incomes have led the Bali government to implement various agricultural policies. Farmers' welfare is a critical factor in ensuring national food security, as prosperous farmers can improve production and maintain food stability. This study employs Discourse Network Analysis (DNA) to identify key factors affecting farmers' welfare in Bali and integrates MDA-Path Analysis to examine the relationships between exogenous variables and farmers' economic conditions. A mixed-method approach (qualitative and quantitative) is used to explore farmers' inclusivity and validate the MDA-Path Analysis model. Data is collected through in-sample validation using surveys conducted among farmers who are members of farmer groups in Bali. The results of this study indicate that human resource quality has the most significant impact on farmers' welfare, followed by price volatility and ease of technology use. The MDA-Path Analysis model demonstrates high classification accuracy, as reflected in sensitivity values exceeding 80%, confirming its effectiveness in distinguishing between different income and welfare categories. These findings provide valuable insights for strategic policy-making, enabling data-driven decision-making to enhance farmers' welfare and economic stability in Bali.
Antimicrobial Activity and Metabolite Profiles of Begonia multangula Blume from Cibodas Botanical Garden and Gunung Halimun Salak National Park, Indonesia Niken Pertiwi, Nyoman Ayu; Dewi Jumiarni; Muhammad Efendi; Intani Quara Lailaty
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.18

Abstract

The resistance of microorganisms requires innovation in finding for alternative natural substances with antimicrobials properties. One of the plants reported to have antimicrobial potential is the plant Begonia multangula Blume. The purpose of this study was to examine the antimicrobial activity and metabolite profiles of ethanol extracts from the leaf and petiole of B. multangula originating from Cibodas Botanical Garden (KRC) and Gunung Halimun Salak National Park (TNGHS). Ethanol extracts of B. multangula leaf and petiole from KRC and TNGHS at a concentration of 100 mg/ml were tested for their antimicrobial activity against the growth of Staphylococcus aureus ATCC 25923 and Candida albicans using the disk diffusion method. Tetracycline 100 mg/ml and fluconazole 50 mg/ml were used as positive controls, and aquadest as a negative control. The metabolite profile compounds were obtained by GC-MS analysis. The results of the study showed that the highest antimicrobial activity was found in the leaf extract of B. multangula from KRC, with an average inhibition zone of 13,5 ± 1,73 mm against S. aureus and 10 ± 0,08 mm against C. albicans, which categorized as moderate. The most highly detected antimicrobial metabolites in the leaf and petiole extracts of B. multangula from KRC were Hexadecanoic acid ethyl ester. Furthermore, the major compound found in the B. multangula  from TNGHS, was Neophytadiene  and n-Hexadecanoic acid in leaf and  petiole. These findings suggest that B. multangula has the potential to be developed as a natural antimicrobial agent in the future
Plant Morphology, Paradermal Anatomy, and Leaves Metabolite Profiles of Rhododendron multicolor Miq. from Cibodas Botanic Garden, West Java, Indonesia Devy Janisca Shalihi; Neni Murniati; Rahman, Wiguna; Hutabarat, Prima Wahyu Kusuma; Intani Quarta Lailaty
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.32

Abstract

Rhododendron multicolor Miq. exhibits distinctive morphoanatomical characteristics and various bioactive compounds with medicinal and horticultural potential. Numerous studies indicated Rhododendron species are widely utilized as medicinal and ornamental plants, owing to their diverse phytochemical profiles and distinctive morphoanatomical characteristics. However, comprehensive studies of the morphoanatomy and leaves metabolite profile of R. multicolor are still limited globally, as well as its minimal utilization by local communities, highlighting a significant knowledge gap. Therefore, this study aimed to analyze the morphology, paradermal anatomy, and metabolite profile of young leaves and mature leaves of R. multicolor. Morphoanatomy characteristics were analyzed descriptively, anatomical features were analyzed using specific formulas, and metabolite profiling was analyzed using qualitative phytochemicals and gas chromatography-mass spectrometry (GC-MS). The result shows that R. multicolor is a shrubby plant characterized by funnel-shaped flowers in a vibrant red hue, along with narrowly elliptic, scaly leaves. The scales are stellate lobed irregularly with lower density than stomata; the epidermis is polygonal to irregular that has a higher density compared to stomata. The results of the qualitative phytochemical test of Rhododendron multicolor are that it contains phenols, flavonoids, Mayer alkaloids, Bouchardat alkaloids, Dragendorf alkaloids, tannins, and saponins. Based on GC-MS analysis of young leaves and mature leaves of R. multicolor, a total of 31 metabolite compounds from 21 compound groups were identified, with the major compound being squalene from the terpenoid group, which has the potential to be an antioxidant, anticancer, antibacterial, antifungal, antitumor, and cardioprotective.
Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025 M.Kes., Ph.D, Fatchiyah,
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 1 (2025): Vol. 6 No. 1 (2025): JSMARTech Volume 6, No 1, 2025
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.01.01

Abstract

Page 7 of 8 | Total Record : 77

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