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Helmina Wati
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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Uji Toksisitas Akut Ekstrak Etanol Daun Salam (Syzygium polyanthum) pada Mencit Jantan (Mus musculus) Safira Prasita Dewanti; Iswandi Iswandi; Nur Anggreini Dwi Sasangka
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.470

Abstract

The use of bay leaves in traditional medicine basically cannot be separated from the safety aspect. The purpose of this study was to determine the safe limit for using bay leaf extract as well as the qualitative and quantitative indicators of the safe limit for LD50. Thirty animals test were divided into 5 treatment groups, each containing 6 mice at a dose of 0.5% CMC and 800% ethanol extract; 1600; 3200; and 6400. The results obtained with the LD50 based on the decrease in the weight of the test animals at 800 mg decreased to 15.33 grams, 1600 mg decreased to 9.16 grams, 3200 mg decreased to 8.83 grams, and 6400 mg decreased to 8.16 grams. Toxic symptoms in the form of anxiety were the highest in the 800 mg group, the highest decrease in movement activity in the 3200 mg group, the highest weight loss in the 3200 mg and 6400 mg groups, and the highest death in the 6400 mg group. Doses of 800 mg occur in 20% of deaths, doses of 1600 mg and 3200 mg occur in 30% of deaths, and doses of 6400 mg occur in 50% of deaths. The r value obtained is 1,2,2,3 with an f value of 0.50 so that the LD50 value obtained is 2262.03 which is included in the mild toxic category.
Efektivitas Salep Ekstrak Bambu Tali (Gigantochloa Apus) untuk Mengatasi Infeksi Sarcoptes Scabiei Silvi Fatika Wulandari; Agus Darwanto; Dwi Setya Ningrum
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 1 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i1.472

Abstract

Tali bamboo (Gigantochloa apus) is a source of flavonoids which are useful for health, including reducing the mite Sarcoptes scabiei in scabies pathogens. The aim of this study was to make an ointment from tali bamboo leaf extract with a white vaseline and salicylic acid base to treat scabies. The data collection method used experiments with the prevalence method using a sample of rabbits (Oryctolagus cuniculus) that had been infected with scabies. Data analysis used descriptive comparative analysis. Tali bamboo leaf extract ointment is made by combining tali bamboo leaf extract, vaseline, salicylic acid, and 0.05 ml of glycerin. Tali bamboo leaf extraction process was carried out using 96% ethanol solvent. The ointment has a cream form, brown color, scented with bamboo leaf extract with a pH of 6.5. The spreading power of the ointment was 3.5 cm and the adhesion was 3.66 seconds. The content of flavonoids in the ointment was 0.1633% w/w QE and phenolics 0.371% w/w GAE. The content of antioxidant compounds in 10 ppm of ointment is 10.09%. The content of antioxidant compounds in 10 ppm of ointment is 10.09%. Ointment has inhibitory power against gram positive bacteria 9 mm, 10 mm and 11 mm. The trial results showed that the use of tali bamboo leaf extract ointment was more effective in treating scabies in rabbits compared to wormectin, ivomec, gusanex, and cooking oil. At 72 hours and 168 hours after treatment with the use of tali bamboo leaf ointment, a significant decrease in the width of the wound was obtained with indicators of changes in the wound shrinking and drying. Meanwhile, at 240 hours, all samples were declared cured of scabies infection. Thus, tali bamboo leaf extract ointment is more effective in treating scabies infection in rabbits than wormectin, ivomec, gusanex and cooking oil.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Penyakit Scabies di Pondok Pesantren Modern X Kabupaten Mailatul Ilal Haq; Like Efriani; Idmanurrahman Hadi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 1 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i1.475

Abstract

Scabies is a skin disease that is often overlooked (neglected disease). Scabies disease is still common and the prevalence rate is still high in Islamic boarding schools. Self-medication is carried out to treat mild to moderate illnesses without doctor's advice. Good self-medication requires good knowledge too. This research was conducted to determine the relationship between the level of knowledge and the self-medication behavior of scabies at Modern X Islamic Boarding School, Cirebon Regency. This study uses an observational method with a cross-sectional approach, the sampling technique uses random sampling. The research instrument was a questionnaire on the level of knowledge and self-medication behavior that had been tested for validity and reliability. The results showed that the level of self-medication knowledge of students was in the good category with a percentage of 52% (41 people) and the self-medication behavior for scabies was also included in the good category with a percentage of 76% (75 people). There is a relationship between the level of knowledge of scabies self-medication behavior with a correlation value of 0.701 and a significance of 0.00.
Perbandingan Skrining Fitokimia Esktrak Etanol Rimpang Bangle (Zingiber purpureum) Metode Maserasi dan Refluks Edhita Putri Daryanti; Faizah Bunga Alfiah; Desrika Ayunda Melatiara
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.479

Abstract

Bangle (Zingiber purpureum Roxb.) is a family of Zingiberaceae that has the advantage of being a medicinal ingredient of economic value. The rhizome part is more widely used because it contains quite complex secondary metabolites. The content of secondary metabolites in rhizomes can be a candidate as a medicinal compound. The resulting secondary metabolite compounds are strongly influenced by the extraction method and solvent used. This study aims to determine the differences in phytochemical screening results on bangle rhizomes using maceration and refluks extraction methods. The research is descriptive qualitative which is carried out using several reagents, adapted to the phytochemical group (alkaloids, phenolics, flavonoids, saponins, tannins, steroids & triterpenoids). The research stages include sample preparation, the extraction process of maceration and refluks methods with 70% ethanol solvent, and phytochemical screening. The results of phytochemical screening on bangle rhizomes showed that the maceration and refluks extraction processes contain alkaloid compounds, phenolics, flavonoids, tannins & triterpenoids. The differences found in alkaloid compounds and flavonoids from refluks show more intensity compared to maceration. The conclusions of this study show that the extract of bangle rhizomes with the refluks method produces a higher intensity of alkaloid and flavonoid compounds compared to maceration.
Uji Aktivitas Antibakteri Ekstrak Metanol Daun Ramania (Bouea. macrophylla Griffith) Terhadap Bakteri Escherichia coli hairunnisa nisa; Fitriyanti Fitriyanti; Putri Kartika Sari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.463

Abstract

Ramania (B. macrophylla Griffith) can beused as an antibacterial in the gastrointestinal tractOne of the bacteria in the digestive tract is Escherichia coli. The purpose of this study was to determine the group of compounds contained in ramania leaf methanol extract (B. macrophylla Griffith) and the activity of ramania leaf methanol extract (B. macrophylla Griffith) in inhibiting the growth of E. coli bacteria. Using the maceration method with methanol solvent and extract amendment of 8.6019%. Ramania leaf methanol extract (B. macrophylla Griffith) contains secondary metabolite compounds namely alkaloids, flavonoids, saponins, tannins, and steroids. Antibacterial activity test was carried out by the welling method with a concentration of methanol extract of ramania leaves (B. macrophylla Griffith) which is 1,024 mg / ml; 2,048 mg/ml; 4,096 mg/ml; 8.192 mg/ml; 16,384 mg/ml; 32,760 mg/ml; positive control of ciprofloxacin 5μg/disk, and negative control of Na-CMC 0.5%. The results of the antibacterial activity test of ramania leaf methanol extract (B. macrophylla Griffith) showed that the concentration of 2.048 mg / ml included the inhibition zone of the weak category, namely 3.33 mm;, while the concentration of 32,760 mg / ml included the moderate inhibition zone, namely mm; 8.48 mm and the positive control of ciprofloxacin 5μg / disk was included in the category of very strong inhibition zone, namely 22.8 mm. Based on the spss results using the Man-Whitney test the positive control and control had no difference due to the sig value (<0.05). It can be concluded that ramania leaf methanol extract (B. macrophylla Griffith) has antibacterial activity against E. coli bacteria and has secondary metabolite compounds found in ramania leaves (B. macrophylla Griffith) are Alkaloids, Flavonoids, Tannins, Saponins and Steroids.
Aktivitas Antioksidan Ekstrak Metanol Daun Tandui (Mangifera rufocostata K.)Menggunakan Metode DPPH Eka Fitri Susiani; Revita Saputri; Helmina Wati; Fitria Mahmudah; Vebruati Vebruati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.477

Abstract

Free radicals are highly reactive compounds because they have unpaired electrons so that they can interact with body cell molecules, this can cause various diseases. Antioxidants are compounds that can ward off free radicals. Plants of the genus Mangifera are known to have antioxidant activity, one of which is Mangifera rufocostata Kosterm, a typical plant of South Kalimantan known as tandui. The purpose of this study was to determine the antioxidant activity of the methanol extract of the leaves of tandui (Mangifera rufocostata Kosterm.) using the DPPH test method. Phytochemical screening and antioxidant activity tests were performed using a UV-Vis spectrophotometer. The compounds contained in the methanol extract of tandui leaves (Mangifera rufocostata Kosterm.) are phenols, flavonoids, and tannins. The IC50 value of quercetin obtained was 2.39 ppm and the IC50 value of the tandui leaf methanol extract (Mangifera rufocostata Kosterm.) which was obtained was 8.222 ppm. Tandui leaf methanol extract has very strong antioxidant activity.
Verifikasi Metode Analisis Larutan Quercetin Menggunakan Spektrofotometer UV-Vis (T60) Muhammad Andi Chandra
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.484

Abstract

Quercetin has many health benefits including: antidiabetic, antiobesity, antioxidant, antiviral, anti-inflammatory, anticancer. The use of quercetin is due to quercetin is a flavonoid compound that is found in almost higher plants, and has strong antioxidant activity. Method Validation is also the main regulatory requirement in pharmaceutical analysis with compliance as per the guidelines or chapter any pharmacopeia of the same scope. Verification of analytical methods aims to ensure that analysts can apply analytical methods properly and guarantee the quality of test results. Verification of the analytical method of quercetin in phosphate buffer pH 7.4 using a UV-vis spectrophotometer (T60) it can be concluded that the linearity parameters, detection limit (LOD), quantification limit (LOQ), accuracy and precision have met the requirements with the following sequential results. ; 0.9995;1.427;4,326;102;0.273. The results of the verification of this analytical method are expected to be applied in the analytical method properly and ensure the quality of the test results.
Uji Aktivitas Antioksidan Ekstrak Etanol 96% Daun Karamunting (Melastoma malabathricum L.) dengan Metode CUPRAC Nabila Saputri; Rahmi Muthia; Muhammad Hidayatullah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.486

Abstract

Free radicals are compounds that can damage cellular structures in the body, including DNA, lipids and proteins. Antioxidants are compounds that can inhibit the oxidation process. Karamunting leaves (Melastoma malabathricum L.) a plant that can be used as a natural antioxidant source. The purpose of this study was to determine the content of secondary metabolites contained in 96% ethanol extract of caramunting leaves and to determine the EC50 value obtained from the antioxidant activity test of caramunting leaf extract tested quantitatively using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method. Karamunting leaves (Melastoma malabathricum L.) were extracted using maceration method with 96% ethanol solvent. Testing the antioxidant activity of caramunting leaves using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method with a UV-Vis spectrophotometer with quercetin as a comparison. The quercetin test for comparison is with a concentration of 1; 2; 3; 4; 5; ppm and extract samples with a concentration of 25; 50; 75; 100; 125; ppm. In the phytochemical screening test, positive results were obtained for containing antioxidants in the test for alkaloids, phenols, flavonoids, saponins, steroids, tannins. The results of the study showed that the EC50 with quercetin was 3.8059 ppm and the EC50 value of 96% ethanol extract of caramunting leaves (Melastoma malabathricum L.) was 61.6185 ppm. In conclusion, 96% ethanol extract of karamunting leaves is classified as a strong antioxidant activity.
Hubungan Tepat Pasien Terhadap Tepat Dosis Antibiotik ISPA pada Balita di Puskesmas Banjarbaru Utara Periode Tahun 2022 Baiq Nurdiana Ulfa; Karunita Ika Astuti; Helmina Wati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.487

Abstract

Acute Respiratory Infection (ARI) is a pathological condition characterized by the invasion of microorganisms, namely bacteria and viruses, into the respiratory tract of human individuals. The misuse of antibiotics can result in the development of antibiotic resistance. The objective of this study is to assess the appropriate patient selection and dosage determination as well as investigate the correlation between patient selection and dosage of ARI antibiotics in toddlers attending the North Banjarbaru Health Center. The present study is a retrospective, non‐experimental investigation that examined patient medical records from January to April 2023. The sample consisted of 184 individuals who satisfied the predetermined inclusion and exclusion criteria. According to the findings of the research, the utilization of ARI antibiotics was characterized by the prevalence of Cotrimoxazol 85 (46.19%), followed by Amoxicillin 67 (36.41%), and Cefadroxil 32 (17.40%). The patients were evaluated accurately in 184 cases, representing 100% of the total. The correct dosage was administered in 155 instances, accounting for 84.2% of the total, while an incorrect dosage was administered in 29 cases, representing 15.8% of the total. The statistical analysis using the Mann‐Whitney test indicated that there was no significant relationship between the appropriate patient selection and the correct dosage administration, as evidenced by a p‐value greater than 0.05 (p = 1.000). The study findings indicated a lack of correlation between the appropriate patient selection and the correct dosage of ARI antibiotics administered to toddlers at the North Banjarbaru Health Center.
Uji Aktivitas Antioksidan Ekstrak Etil Asetat Daun Tigaron (Crateva Religiosa) Menggunakan Metode DPPH Rosya Rizky Maulidya; Revita Saputri; Liana Fitriani Hasymi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.488

Abstract

Tigaron leaf methanol extract (Crateva religiosa) was reported to have activity as a very strong antioxidant. Differences in solvents in extracts can affect the results of pharmacological activity, for example, ethyl acetate solvent on antioxidant activity, so the purpose of this study was to determine the results of phytochemical screening and antioxidant activity of the ethyl acetate extract of Tigaron leaves (Crateva religiosa). Phytochemical screening was carried out qualitatively, while antioxidant activity was carried out quantitatively using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) method using a UV-Vis spectrophotometer and quercetin comparator. The ethyl acetate extract of Tigaron leaves (Crateva religiosa) was extracted by maceration method. Phytochemical screening tests obtained positive results for the alkaloids, flavonoids, and steroids. Antioxidant testing using the comparator quercetin obtained IC50 results of 3.4384 ppm and the ethyl acetate extract of Tigaron (Crateva religiosa) leaves obtained IC50 results of 114.0457 ppm. It can be concluded that the ethyl acetate extract of Tigaron leaves (Crateva religiosa) has moderate potential as an antioxidant.

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