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Borneo Journal Of Pharmascientech
Published by Universitas Borneo Lestari
ISSN : 25413651     EISSN : 25483897     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Borneo Journal of Pharmascientech merupakan jurnal resmi Sekolah Tinggi Ilmu Kesehatan Borneo Lestari. Jurnal memuat naskah hasil penelitian dan artikel review bidang kefarmasian, meliputi farmasi klinik, manajemen & farmasi sosial, farmasi bahan alam, teknologi sediaan farmasi dan lain-lain. Naskah dapat berasal dari mahasiswa, dosen, peneliti, dan lembaga riset.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 178 Documents
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Skrining Fitokimia dan Formulasi Sediaan Masker Gel Peel-Off Ekstrak Etanol Temulawak (Curcuma xanthorrhiza Roxb.) Muslikh, Faisal; Aryantini, Dyah; Sari, Fita; Hesturini, Rosa Juwita; Winartiana, Winartiana; Prasetyawan, Fendy
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.519

Abstract

Skin aging is a natural process influenced by intrinsic and extrinsic factors. This process often leads to various skin problems, including wrinkles, sagging, and hyperpigmentation. One of the main triggers of skin aging is oxidative stress, which produces reactive species oxygen (ROS) that can damage various components of the skin. Temulawak, locally known as Curcuma xanthorrhiza Roxb., has been traditionally used in Indonesia for various skin health conditions due to its antioxidant, antibacterial, and anti-aging properties. This research aims to create a new formula of peel-off gel mask from temulawak extract and evaluate the preparation. Two formulations were made, with the second formulation modified by adding the fragrance oleum rosae to reduce the aroma of temulawak. Evaluation was conducted through a series of tests, including The results showed differences between the two formulations, especially in the organoleptic test where Formula 2 experienced changes in color and aroma. However, other parameters were relatively similar between the two formulations. The developed peel-off gel mask has the potential to improve skin health, further research is needed to understand product acceptance by the public, using approaches such as hedonic testing. This will help in developing products that are more suitable for consumer needs and preferences.
NARRATIVE REVIEW : POLA BAKTERI, SENSITIVITAS DAN PENGGUNAAN ANTIBIOTIK PADA INFEKSI SALURAN KEMIH Dita Ayulia Dwi Sandi; Okta Muthia Sari; Muhammad Ridho Maulana
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.520

Abstract

Urinary Tract Infection (UTI) is an infectious disease that ranks second after respiratory tract infections, with a total of 8.1 million cases per year. The cause of UTI lies in the presence of microorganisms in the urinary tract, including the bladder, prostate, kidneys, and collecting ducts. Bacterial microorganisms are the primary cause of UTI. Generally, Urinary Tract Infection (UTI) is caused by common human flora and symbiotic life around the vaginal introitus, penile prepuce, perineum, and the surrounding anus. This study aims to identify bacterial types, treatment methods, and antibiotic sensitivity in urinary tract infections. The chosen method for this research is a narrative review of scientific studies related to urinary tract infections. Data sources were obtained from Google Scholar, ScienceDirect, and PubMed. The research articles used include 5 journals related to UTI bacterial patterns, 7 journals related to UTI therapy patterns, and 4 journals related to antibiotic sensitivity in UTI patients. Based on the analysis of bacterial patterns, Escherichia coli bacteria are the most common cause of UTI. Antibiotic therapy patterns can be used in the treatment of Urinary Tract Infection. The analysis of antibiotic sensitivity indicates that ciprofloxacin and gentamicin have the highest sensitivity to UTI.
Rendemen dan Skrining Fitokimia Simplisia Daun Bayam (Amaranthus viridis) Norhayati; Rizaldi, Gusti; Noorwina, Syifa; Anida
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.522

Abstract

Indonesia is rich in biodiversity. One of the plants that grows widely in Indonesia is spinach (Amaranthus viridis). The aim of this research was to determine the secondary metabolite content of the ethanol extract of spinach leaves (A. viridis) qualitatively. This research consisted of 2 stages. The first stage is making simplicia and the second stage is screening phytochemical simplicia. The yield obtained from making simplicia was 20.83%. Based on the results, it can be concluded that spinach leaves (A. viridis) contain secondary metabolites of alkaloids, tannins, phenols, and saponins. The suggestion for this research is that the secondary metabolites can be isolated and then continued with activity tests.
Studi Pengetahuan Masyarakat Dongkala Terhadap Daun Belimbing Wuluh (Averrhoa bilimbi.L) Sebagai Pencegahan Hipertensi Andi Nurpati Panaungi; Hasma Hasma; Melan Mawarni
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.523

Abstract

Traditional medicine is a type of medicine that is made entirely from plants and is used for therapy. Traditional medicine is also passed down from generation to generation in an effort to preserve the culture that must be preserved. Starfruit is a species in the starfruit family (Averrhoa). Wuluh starfruit leaves are also a traditional medicine used to prevent hypertension. Hypertension is a health problem that is quite dangerous throughout the world because hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure, stroke and kidney disease, of which in 2016 ischemic heart disease and stroke became the two main causes of death in world. This research aims to determine the knowledge of the Dongkala community regarding starfruit leaves as a prevention of hypertension. The type of research carried out was descriptive research carried out in May and June by distributing questionnaires to people who live in Dongkala Village, Pasarwajo District with a population of 2,439 people with a sample of 96 people using a questionnaire. The results obtained from this research are the evel of knowledge for those aged 40-44 years with a percentage of (25%), the level of knowledge based on gender, namely women with a percentage of (62.5%), the level of knowledge based on education, namely SMA/SMK-S1 level with percentage (50%), and the highest level of knowledge for the Dongkala Village community is with a percentage (61.5%).
Antibakteri Ekstrak Etanol 70% Herba Bandotan (Ageratum conyzoides Linn) Terhadap Bakteri Staphylococcus epidermidis Nurbidayah Nurbidayah; Aditya Noviadi Rakhmatullah; Nanda Asysyifa Rivani
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.525

Abstract

Bandotan herb (Ageratum conyzoides Linn) is a plant that has benefits in the health sector, one of which is used as an antibacterial. The ethanol extract of Bandotan Herb (Ageratum conyzoides Linn) has antibacterial properties against Staphylococcus aureus. This research aims to determine the phytochemical compounds in Bandotan Herb (Ageratum conyzoides Linn) and their antibacterial activity. The method used for antibacterial testing is well diffusion with 4 replications with concentrations of 10%, 20%, 40%, 60%, 80% and 100% and two controls, namely positive (Clindamycin 2µg) and negative (Na-CMC 0.5% ). Phytochemical screening is carried out using tube tests. The research results showed that the ethanol extract of Bandotan Herb (Ageratum conyzoides Linn) contains alkaloids, flavonoids, saponins, tannins, terpenoids and steroids. The diameter of the inhibition zone obtained was 3.14 mm, 4.26 mm and 5.77 in the weak category, in the medium category it was 7.44 mm and in the strong category it was 10.52 mm. Based on the results of the phytochemical test, it can be concluded that the ethanol extract of Bandotan Herb (Ageratum conyzoides Linn) is able to inhibit the growth of Staphylococcus epidermidis bacteria.
Pengaruh Kombinasi Antipsikotik Tehadap Efek Samping Sindrom Ekstrapiramidal Pasien Skizofrenia Rawat Inap Rumah Sakit Jiwa Sambang Lihum Banjarbaru wati, Helmina; Hidayati, Rahmi; Wardani, Muhammad Rizky
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.529

Abstract

The most effective therapeutic management in schizophrenia patients is antipsychotic therapy. Antipsychotic groups are divided into two categories: first-generation and second-generation antipsychotics. Antipsychotic administration can cause side effects such as extrapyramidal symptoms. This study aims to determine the effect of giving a combination of antipsychotics on the side effects of extrapyramidal syndrome in hospitalized schizophrenia patients at Sambang Lihum Mental Hospital. This study employed a non-experimental observational analytic approach with prospective data collection. The study population consisted of all schizophrenia patients who were hospitalized between January and February 2022. The sample size was 122 patient medical records, obtained through purposive sampling. The instruments used to measure the variables included respondent characteristics (age, gender, latest education, occupation, marital status, history of diagnosis, and history of extrapyramidal syndrome) and the incidence of extrapyramidal syndrome side effects, which were documented in essays written by the researcher. The data analysis employed univariate (frequency, percentage) and bivariate (chi-square test) techniques. The results of the study yielded a description of the administration of antipsychotic combinations in hospitalized schizophrenia patients at Sambang Lihum Mental Hospital. The most prevalent combination was the Atypical-Typical combination, which was administered to 58.2% of patients. There were no instances of extrapyramidal syndrome side effects from the administration of a combination of antipsychotics, with 86.9% of patients experiencing no adverse effects. The administration of a combination of antipsychotics does not appear to affect the incidence of extrapyramidal syndrome in schizophrenic patients.
Uji Aktivitas Antiseptik Ekstrak Etanol Tanaman Bundung (Scirpus grossus L.) Terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Amalia, Ghina Rezki; Saftia Aryzki; Darini Kurniawati
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.531

Abstract

Bundung Plant (Scirpus grossus L.) is one of the wild plants that is very easy to get, but not many people know its properties. This plant is empirically used by the community as a wound treatment and antimicrobial. This plant is proven to contain several compounds such as tannins, flavonoids, phenolics, saponins, steroids and terpenoids. This study aims to determine the antiseptic activity of ethanol extract of Bundung Plant with various concentrations and the most effective concentration in healing white rat incision wounds (Rattus norvegicus). the method used begins with the extraction process, making extract concentrations, preparing test animals, dividing test animal groups, treating test animals, observing the healing phase and testing antiseptic activity. The results of the group test on the measurement of the average length and healing time of the incision wound, the wound that closed the fastest was the 4% extract group which was seen clinically could be distinguished by its healing speed, from the results of the analysis there was no significant difference in the healing time span and measurement of the average length of the incision wound. The conclusion of this study is that the ethanol extract of the Bundung Plant (Scirpus grossus L.) has antiseptic activity on the healing of incision wounds of white rats (Rattus norvegicus) which is observed through the healing time span and there is no significant difference in changes in wound healing time and the length of the incision wound in the five groups and the most optimal concentration of ethanol extract of the Bundung Plant (Scirpus grossus L.) with the concentration of the extract observed clinically is 4%.
Formulasi dan Evaluasi Pasta Gigi Berbahan Cangkang Keong Sawah (Pila ampullaceae) dengan Variasi Konsentrasi HPMC Aditama, Agnis; Adifa, Wildan Hanifatul; Muzayanah, Arifatul; Choiroh, Afifahtul; Kusumawardani, Arine Giovani; Wahyuni, Ela; Tasya, Pradiva Julias; Eryani, Mikhania Christiningtyas; Muslikh, Faisal Akhmal
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.533

Abstract

The rice field snail (Pila ampullaceae) is a member of the gastropod class commonly found in freshwater habitats and possesses a hard shell that protects its soft body. The shell of the rice field snail is known to be rich in CaCO3 compounds. In this study, the shell of the rice field snail is formulated into toothpaste as an abrasive material. Toothpaste is a semi-solid preparation that functions to remove dirt from the surface of teeth and maintain dental health. This study aims to determine the effect of hydroxypropyl methylcellulose (HPMC) concentration on the physical and hedonic properties of toothpaste based on rice field snail shell (Pila ampullaceae). Using a one shot case study design, three toothpaste samples with different HPMC concentrations, namely 3%, 4%, and 5%, were evaluated. The preparation evaluation included various physical property tests, such as organoleptic tests, homogeneity, pH, spreadability, viscosity, and foam height, as well as hedonic tests. The results of the study showed that variations in HPMC concentration affected several physical properties, including odor, spreadability, viscosity, and foam height. Among the three formulas tested, Formula 3 with a 5% HPMC concentration was the most preferred by respondents.
AKTIVITAS ANTIOKSIDAN DAN KADAR FENOLIK TOTAL DARI EKSTRAK DAUN KACIP FATIMAH (Labisia pumila) MENGGUNAKAN VARIASI PELARUT EKSTRAKSI Rahmatullah, Satrio Wibowo; Rizki, Muhammad Ikhwan; Sari, Anna Khumaira; Triyasmono, Liling; Normaidah, Normaidah; Lingga, Herningtyas Nautika
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.538

Abstract

Secondary metabolite content and extract characterization can be influenced by the solvent used in the extraction process. The content of phenolic compounds and antioxidant activity of Labisia pumila leaves can be influenced by solvents. This research aims to determine three extracts' antioxidant activity and total phenolic content using different solvents. Fresh L. pumila leaf samples were cleaned with running water and then dried using a drying cabinet. The dried leaves are then powdered and extracted using distilled water, 70% ethanol, and 96% ethanol. Extraction with distilled water using the infusion method and ethanol using maceration. Next, the solvent obtained was evaporated using a rotary evaporator and oven until a dry extract was obtained. Total phenolic content was determined using the UV-Vis spectrophorometric method with the Folin-Ciocalteu reagent. The standard used is error-free. Antioxidant activity was determined using the DPPH method with a UV-Vis spectrophotometer, then the IC50 value was calculated. The research showed that the total phenolic content of the distilled water extract was 6.437 ± 0.177 w/w GAE, the 70% ethanol extract was 8.377 ± 0.079 w/w GAE, and the 96% ethanol extract was 17.387 ± 0.621% w/w GAE. Antioxidant activity is known to have an IC50 value of distilled water extract of 59,716 ppm, 70% ethanol extract of 50,543 ppm, and ethanol extract of 43,520 ppm. The conclusion of the research is that of the three extracts, it is known that the antioxidant activity is the strongest, and the total phenolics are the highest in the 96% ethanol extract.
Uji Aktivitas Antioksidan Ekstrak Etanol 96% Daun Tigaron (Crateva religiosa G.Forst.) Asal Kalimantan Selatan Menggunakan Metode DPPH Sari, Rika Amara Widya; Saputri, Revita; Khairunnisa, Khairunnisa
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.495

Abstract

Ethanol extract leaves of Crateva religiosa G.Forst. has antioxidant activity using the FRAF method of 357.9 ± 17.6 μmol/L., but the antioxidant activity of the 96% ethanol extract of C. religiosa G.Forst leaves. from South Kalimantan has not been reported. This study aims to determine the secondary metabolites and antioxidant activity of the 96% ethanol extract of Tigaron (C. religiosa G.Forst.) leaves from South Kalimantan using the DPPH method measured with a UV-Vis spectrophotometer. Tigaron (C. religiosa G.Forst.) leaves 96% ethanol extract was prepared by maceration method. Tigaron (C. religiosa G.Forst.) leaves antioxidant activity test was carried out at concentrations of 50 ppm, 75 ppm, 100 ppm, 125 ppm and 150 ppm using quercetin as a comparison. Phenol, flavonoid, quinone, and tannin were all detected in the phytochemical screening. Testing the antioxidant activity of the quercetin comparator showed an IC50 of 3.0151 (very strong) and the 96% ethanol extract of tigaron (C. religiosa G.Forst.) leaves showed an IC50 of 94.9082 ppm (strong). Based on the results obtained that the 96% ethanol extract of tigaron (C. religiosa G.Forst.) leaves from South Kalimantan has antioxidant activity in the strong category.

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